[ CAS No. 174180-95-1 ] {[proInfo.proName]}

Name: 174180-95-1|tert-Butyl 3-(bromomethyl)-6-fluoro-1H-indazole-1-carboxylate|97%
Brand: Ambeed
SKU: A542310
Rating: 95 (40 reviews)

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Cat. No.: {[proInfo.prAm]}

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Quality Control of [ 174180-95-1 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 174180-95-1 ]

Product Details of [ 174180-95-1 ]

CAS No. :	174180-95-1	MDL No. :	MFCD10696846
Formula :	C₁₃H₁₄BrFN₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	ONVPTCZPLVIMLP-UHFFFAOYSA-N
M.W :	329.16	Pubchem ID :	10568325
Synonyms :

Calculated chemistry of [ 174180-95-1 ]

Physicochemical Properties

Num. heavy atoms :	19
Num. arom. heavy atoms :	9
Fraction Csp3 :	0.38
Num. rotatable bonds :	4
Num. H-bond acceptors :	4.0
Num. H-bond donors :	0.0
Molar Refractivity :	74.73
TPSA :	44.12 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	Yes
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.79 cm/s

Lipophilicity

Log Po/w (iLOGP) :	3.21
Log Po/w (XLOGP3) :	3.54
Log Po/w (WLOGP) :	4.12
Log Po/w (MLOGP) :	3.38
Log Po/w (SILICOS-IT) :	3.01
Consensus Log Po/w :	3.45

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-4.2
Solubility :	0.0209 mg/ml ; 0.0000635 mol/l
Class :	Moderately soluble
Log S (Ali) :	-4.15
Solubility :	0.0232 mg/ml ; 0.0000706 mol/l
Class :	Moderately soluble
Log S (SILICOS-IT) :	-4.5
Solubility :	0.0105 mg/ml ; 0.000032 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.84

Safety of [ 174180-95-1 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P501-P260-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405	UN#:	3261
Hazard Statements:	H314	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 174180-95-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 174180-95-1 ]

[ 174180-95-1 ] Synthesis Path-Downstream 1~18

1
[ 174180-45-1 ]
[ 174180-95-1 ]
[ 1026677-37-1 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hexamethyldisilazane; sodium hydride 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h; Multistep reaction;

2
[ 174180-43-9 ]
[ 174180-95-1 ]

Yield	Reaction Conditions	Operation in experiment
57%	With N-Bromosuccinimide; Perbenzoic acid In tetrachloromethane for 4.5h; Heating;
250 mg	With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane for 12h; Reflux; Inert atmosphere;	4 Example 4 - [(6-fluoro-benzo-pyrazol-3-yl) methyl] -aminosulfonamideA solution of 6-fluoro-N-Boc-3-methylbenzothenazole (compound 4-1) (500 mg, 2.15 mmol)Dry carbon tetrachloride (10 ml) was added to the reaction flask,NBS (490 mg, 2.15 mmol) was added,Benzoyl peroxide (55 mg, 0.22 mmol),After the addition, the reaction mixture was heated to reflux for 12 hours under nitrogen atmosphere. After the reaction was completed, the reaction solution was cooled to room temperature, filtered, and the filtrate was concentrated to dryness to give 4-2 (250 mg) as a pale yellow solid.

Reference： [1]Henke, Brad R.; Aquino, Christopher J.; Birkemo, Larry S.; Croom, Dallas K.; Dougherty Jr., Robert W.; Ervin, Gregory N.; Grizzle, Mary K.; Hirst, Gavin C.; James, Michael K.; Johnson, Michael F.; Queen, Kennedy L.; Sherrill, Ronald G.; Sugg, Elizabeth E.; Suh, Edward M.; Szewczyk, Jerzy W.; Unwalla, Rayomand J.; Yingling, Jeff; Willson, Timothy M. [Journal of Medicinal Chemistry, 1997, vol. 40, # 17, p. 2706 - 2725]
[2]Current Patent Assignee: TOPHARMAN SHANGHAI CO., LTD.; CHINESE ACADEMY OF SCIENCES; SUZHOU VIGONVITA LIFE SCIENCES; Shanghai Institute of Materia Medica (in: CAS) - CN105399697, 2016, A Location in patent: Paragraph 0171-0172

3
[ 24424-99-5 ]
[ 174180-95-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: DMAP, Et₃N / acetonitrile 2: 57 percent / NBS, benzoyl peroxide / CCl₄ / 4.5 h / Heating

4
[ 159305-16-5 ]
[ 174180-95-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: DMAP, Et₃N / acetonitrile 2: 57 percent / NBS, benzoyl peroxide / CCl₄ / 4.5 h / Heating

5
[ 174180-95-1 ]
2-{3-[(6-fluoro-1H-indazol-3-yl)methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl}-N-isopropyl-N-(4-methoxyphenyl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 1.) NaH, NaN(TMS)2 / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h 2: TFA / CH₂Cl₂ / 2 h

Yield	Reaction Conditions	Operation in experiment
		D D. D. 3-Bromomethyl-6-fluoro-1-tert-butoxycarbonyl-1H-indazole 12.68 g (50.7 mmol) 6-Fluoro-3-methyl-indazole-1-carboxylic acid tert-butyl ester, prepared as in Part C, is combined with 9.92 g (55.7 mmol, 1.1 equiv) N-Bromosuccinimide and 1.23 g (5.1 mmol, 0.1 equiv) Benzoyl peroxide in 600 mL CCl4 and refluxed 10 h. The reaction mixture is filtered and the filtrate concentrated in vacuo and purified by flash chromatography on 300 g silica gel eluted successively with DCM/Hexanes (1:2, 3 L), (1:1, 3 L). Appropriate fractions were combined and concentrated in vacuo to give 10.18 g (30.9 mmol) of 3-Bromomethyl-6-fluoro-1-tert-butoxycarbonyl-1H-indazole as an amber oil: 1 H NMR (CDCl3, 300 MHz) δ7.82 (m, 2H), 7.13 (m, 1H), 4.76 (s, 2H), 1.72 (s, 9H); TLC Rf =0.17 (EtOAc/Hexanes, 1:19).

7
[ 174180-45-1 ]
[ 174180-95-1 ]
2-[3-(6-Fluoro-1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl-acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene	2-[3-(6-Fluoro-1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl-acetamide 2-[3-(6-Fluoro-1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl-acetamide To a solution of 427 mg of 2-(2,4-Dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-(4-methoxy-phenyl) acetamide in 5 mL of dry DMF at 0° C. is added 2.2 mL of a 0.5M solution of potassium bis(trimethylsilyl)amide in toluene. The reaction mixture is stirred for 30 min at 0° C. and a solution of 329 mg of 3-Bromomethyl-6-fluoro-1-tert-butoxycarbonyl indazole in 2 mL of dry DMF is added dropwise. The reaction mixture is stirred overnight at RT, poured into water and the product extracted with ethyl acetate (2*15 mL). The solvent is removed in vacuo and the residue is purified by silica gel flash column chromatography (MeOH 1%:CHCl3 99%) to afford 410 mg of the title compound: 1 H NMR (400 MHz, CDCl3) δ7.85-6.91 (m, 17H), 5.01 (m, 1H,J=6.8), 4.22 (m, 3H), 3.81 (dd, 1H, J=16.5, 8.9), 3.51 (dd, 1H, J=16.5, 4.7), 1.68 (s, 9H), 1.07 (d, 6H, J=6.8).

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - US5859007, 1999, A

8
[ 174180-95-1 ]
[ 174180-89-3 ]
6-Fluoro-3-{1-[(4-fluoro-phenyl)-isopropyl-carbamoylmethyl]-2,4-dioxo-5-phenyl-2,3,4,5,-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In ethyl acetate; N,N-dimethyl-formamide	6-Fluoro-3-{1-[(4-fluoro-phenyl)-isopropyl-carbamoylmethyl]-2,4-dioxo-5-phenyl-2,3,4,5,-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester 6-Fluoro-3-{1-[(4-fluoro-phenyl)-isopropyl-carbamoylmethyl]-2,4-dioxo-5-phenyl-2,3,4,5,-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester To a stirred solution of 800 mg (1.79 mmol) 2-(2,4-Dioxo-5-phenyl-2,3,4,5,-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-(4-fluoro-phenyl)-N-isopropyl-acetamide in 15 mL DMF cooled to 0° C. is added 86 mg (2.16 mmol, 1.2 equiv) 60 wt % NaH and stirred 0.5 h. To this solution is added 591 mg (1.79 mmol, 1.0 equiv) 3-Bromomethyl-6-fluoro-1-tert-butoxycarbonyl-1H-indazole and the resultant reaction mixture stirred 1 h at 0° C. followed by 18 h at ambient temperature. The solvent is removed in vacuo and the residue taken into EtOAc (80 mL), washed with H2 O (30 mL) and brine (30 mL), dried (MgSO4), filtered and concentrated in vacuo. The crude product is purified by flash chromatography on 40 g silica gel eluted with EtOAc/Hexanes (1:3, 800 mL) Appropriate fractions were combined and concentrated in vacuo to give 730 mg (1.05 mmol) of the title compound as a white glass: 1 H NMR (CDCl3, 300 MHz) δ7.83 (m, 1H), 7.72 (d, 1H, J=9.2), 7.41-7.03 (m, 13H), 6.95 (d, 1H, J=7.4), 5.02 (m, 1H), 4.26 (m, 1H), 4.22 (s, 2H), 3.82 (m, 1H), 3.51 (m, 1H), 1.65 (s, 9H), 1.07 (d, 6H, J=6.9); TLC Rf =0.36 (EtOAc/Hexanes, 2:3).

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - US5859007, 1999, A

9
C₂₁H₃₂FN₃O₅ [ No CAS ]
[ 174180-95-1 ]
C₃₄H₄₅F₂N₅O₇ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: C₂₁H₃₂FN₃O₅ With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene at 0℃; for 0.5h; Stage #2: tert-butyl 3-(bromomethyl)-6-fluoro-1H-indazole-1-carboxylate In N,N-dimethyl-formamide; toluene at 0 - 20℃;

Reference： [1]Location in patent: experimental part Szewczyk, Jerzy R.; Laudeman, Chris P.; Sammond, Doug M.; Villeneuve, Manon; Minick, Douglas J.; Grizzle, Mary K.; Daniels, Alejandro J.; Andrews, John L.; Ignar, Diane M. [Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 5, p. 1822 - 1833]

10
[ 179083-73-9 ]
[ 174180-95-1 ]
C₄₀H₅₀FN₅O₈ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: N-(2,2-diethoxyethyl)-N-phenyl-N'-(2-(isopropyl(4-methoxyphenyl)amino)-2-oxoethyl)malonamide With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene at 0℃; for 0.5h; Stage #2: tert-butyl 3-(bromomethyl)-6-fluoro-1H-indazole-1-carboxylate In N,N-dimethyl-formamide; toluene at 0 - 20℃;

11
C₂₇H₃₅N₃O₅ [ No CAS ]
[ 174180-95-1 ]
C₄₀H₄₈FN₅O₇ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: C₂₇H₃₅N₃O₅ With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene at 0℃; for 0.5h; Stage #2: tert-butyl 3-(bromomethyl)-6-fluoro-1H-indazole-1-carboxylate In N,N-dimethyl-formamide; toluene at 0 - 20℃;

12
C₂₆H₃₅N₃O₅ [ No CAS ]
[ 174180-95-1 ]
C₃₉H₄₈FN₅O₇ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: C₂₆H₃₅N₃O₅ With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene at 0℃; for 0.5h; Stage #2: tert-butyl 3-(bromomethyl)-6-fluoro-1H-indazole-1-carboxylate In N,N-dimethyl-formamide; toluene at 0 - 20℃;

13
C₂₆H₃₄FN₃O₅ [ No CAS ]
[ 174180-95-1 ]
C₃₉H₄₇F₂N₅O₇ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: C₂₆H₃₄FN₃O₅ With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene at 0℃; for 0.5h; Stage #2: tert-butyl 3-(bromomethyl)-6-fluoro-1H-indazole-1-carboxylate In N,N-dimethyl-formamide; toluene at 0 - 20℃;

14
C₂₆H₃₆N₄O₆ [ No CAS ]
[ 174180-95-1 ]
C₃₉H₄₉FN₆O₈ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: C₂₆H₃₆N₄O₆ With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene at 0℃; for 0.5h; Stage #2: tert-butyl 3-(bromomethyl)-6-fluoro-1H-indazole-1-carboxylate In N,N-dimethyl-formamide; toluene at 0 - 20℃;

15
[ 174180-95-1 ]
C₁₃H₁₆FN₃O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: acetonitrile / 2 h / Reflux 2: hydrazine hydrate / methanol / 1 h / Reflux

Reference： [1]Current Patent Assignee: TOPHARMAN SHANGHAI CO., LTD.; CHINESE ACADEMY OF SCIENCES; SUZHOU VIGONVITA LIFE SCIENCES; Shanghai Institute of Materia Medica (in: CAS) - CN105399697, 2016, A

16
[ 174180-95-1 ]
C₁₈H₂₅FN₄O₆S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: acetonitrile / 2 h / Reflux 2: hydrazine hydrate / methanol / 1 h / Reflux 3: triethylamine / dichloromethane / Cooling with ice

17
[ 174180-95-1 ]
[(6-fluoro-benzo-pyrazol-3-yl)methyl]-aminosulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: acetonitrile / 2 h / Reflux 2: hydrazine hydrate / methanol / 1 h / Reflux 3: triethylamine / dichloromethane / Cooling with ice 4: trifluoroacetic acid / dichloromethane / 1 h / 40 °C

18
[ 85-41-6 ]
[ 174180-95-1 ]
C₂₁H₁₈FN₃O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
250 mg	In acetonitrile for 2h; Reflux;	4 The compound 4-2 (250 mg, 0. 8 mmol) and acetonitrile (10 ml) were added to the reaction flask and phthalimide (170 mg, 0.8 mol) was added. The mixture was heated to reflux for 2 hours. The reaction was complete. The reaction mixture was concentrated to dryness, then dichloromethane was added, washed with water, once with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give a pale red solidThe product, 4-3 (250 mg), was used directly in the next step without purification.

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Precautionary Statements-General
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P222	Do not allow contact with air.
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P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 174180-95-1 ] {[proInfo.proName]}

Quality Control of [ 174180-95-1 ]

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Application In Synthesis of [ 174180-95-1 ]

[ 174180-95-1 ] Synthesis Path-Downstream 1~18

Related Functional Groups of [ 174180-95-1 ]

Fluorinated Building Blocks

Bromides

Amides

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[ 174180-95-1 ]

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[ 174180-95-1 ]