Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	175136-67-1
Formula :	C₄H₅N₃OS
M.W :	143.17
SMILES Code :	O=C(C1=C(C)N=NS1)N
English Name :	4-Methyl-1,2,3-thiadiazole-5-carboxamide
MDL No. :	MFCD00052214

GHS Pictogram:
Signal Word:
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UN#:
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Yield	Reaction Conditions	Operation in experiment
59%	With dmap; N,O-dimethylhydroxylamine*hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 3h; Cooling with ice;	2 Example 2: Preparation of Compound II Method 2: Add 50.50 mmol to a 100 ml single-mouth round bottom flask.Ie 10 g of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid, 20 ml of dry dichloromethane,Then add 1.1 equivalents of triethylamine dropwise, stir, after the solution is clarified,50.50 mmol of O,N-dimethylhydroxylamine hydrochloride was added under ice water bath.Then divide it 10 times and add 55.55 millimoles of EDCI in 20 minutes.8.58 mmol of DMAP was added and stirred at room temperature for 3 h. TLC monitors the extent of the reaction,After the reaction was completed, the mixture was filtered, and the filtrate was taken, washed twice with water and twice with saturated brine.The layers were back-extracted with dichloromethane (20 mL × 3).Concentration, the residue is purified by silica gel column chromatography from 200 to 300 mesh.The eluent is petroleum ether: ethyl acetate at 60-90 degrees Celsius, and the volume ratio is 8:1.The yield was 59%.
	Stage #1: 4-methyl-[1,2,3]thiadiazole-5-carboxylic acid With thionyl chloride for 0.6h; Reflux; Stage #2: With ammonia	6 In 100 ml round-bottom flask, by adding intermediate 4-methyl -1, 2, 3-thiadiazol-5-carboxylic acid 2.0 g, in other words, 13.87 mmol, then adding thionyl chloride 10.0 g, in other words, 83.2 mmol, reflux reaction is about 6 hours; distillation to remove the surplus thionyl chloride; ammonia slowly adding 0.47 g, in other words, 27.7 mmol, prepared 4-methyl -1, 2, 3-thiadiazol-5-carboxamide;

Precautionary Statements-General
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P103	Read label before use
Prevention
Code	Phrase
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P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
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P263	Avoid contact during pregnancy/while nursing.
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P321
P322
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P342	If experiencing respiratory symptoms:
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P378
P380	Evacuate area.
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire:
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P401
P402	Store in a dry place.
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Disposal
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P501	Dispose of contents/container to ...
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CAS No.: 175136-67-1

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CAS No.: 175136-67-1

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Product Details of [ 175136-67-1 ]

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[ 175136-67-1 ] Synthesis Path-Downstream 1~3

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed