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Chemical Structure| 175205-72-8 Chemical Structure| 175205-72-8

Structure of 175205-72-8

Chemical Structure| 175205-72-8

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Product Details of [ 175205-72-8 ]

CAS No. :175205-72-8
Formula : C4HBrCl2O2S2
M.W : 295.99
SMILES Code : ClC1=CC(Br)=C(S1)S(Cl)(=O)=O
MDL No. :MFCD00052095

Safety of [ 175205-72-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H315-H319-H335
Precautionary Statements:P264-P305+P351+P338
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 175205-72-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 175205-72-8 ]

[ 175205-72-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 175205-72-8 ]
  • [ 21344-90-1 ]
  • [ 376349-77-8 ]
YieldReaction ConditionsOperation in experiment
3-Bromo-5-chloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-2-thiophenesulfonamide The title compound was prepared from <strong>[21344-90-1]4-(2-chlorophenyl)-1,3-thiazol-2-amine</strong> (57 mg) and 3-bromo-5-chlorothiophene-2-sulfonyl chloride (80 mg) as described in the synthetic METHOD B to give a white solid (43.7 mg) with purity >90percent: MS (pos) m/z 469.2, 471.2, 473.2.
  • 2
  • [ 175205-72-8 ]
  • [ 538-28-3 ]
  • N-(3-Bromo-5-chloro-thien-2-ylsulfonyl)-S-benzylisothiourea [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In acetone; toluene; a) N-(3-Bromo-5-chloro-2-thienylsulfonyl)-S-benzylisothiourea S-Benzyl-thiuronium chloride (8.1 g), sodium hydroxide (2.2 g) and acetone (100 ml) were stirred for 5 min before crude 3-bromo-5-chlorothiophene-2-sulfonyl chloride (10 g) was added dropwise during 20 min at room temperature. The reaction mixture was stirred for 24 h. The suspension was evaporated in vacuo and the crude reaction mixture partitioned between 1N hydrochloric acid (30 ml) and dichloromethane (50 ml). The two phases were separated and the aqueous phase extracted with dichloromethane (4*50 ml). The combined organic phases were dried with magnesium sulfate and evaporated in vacuo to give the crude product (12.8 g). The crude product was suspended in toluene and the crystals isolated by filtration (4.0 g); 1H-NMR (CDCl3) delta: 4.23 (s, 2H), 7.15-7.35 (m, 5H), 7.44 (s, 1H), 8.0-8.5 (br s, 1H), 8.8-9.4 (br s, 1H); 13C-NMR (CDCl3) delta: 33.1, 114.8, 125.6, 126.5, 127.1, 134.2, 135.0, 137.1, 157.1.
  • 3
  • [ 175205-72-8 ]
  • [ 24629-25-2 ]
  • 3-Bromo-5-chloro-N-[(1S,2S)-1-(hydroxymethyl)-2-methylbutyl]thiophene-2-sulfonamide [ No CAS ]
 

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