[ CAS No. 175865-59-5 ] {[proInfo.proName]}

Name: 175865-59-5|(2S)-2-((2-Amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl 2-amino-3-methylbutanoate hydrochloride|98%
Brand: Ambeed
SKU: A247777
Price: 6.0 USD
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Quality Control of [ 175865-59-5 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 175865-59-5 ]

SDS Specification

Alternatived Products of [ 175865-59-5 ]

Product Details of [ 175865-59-5 ]

CAS No. :	175865-59-5	MDL No. :	MFCD08460118
Formula :	C₁₄H₂₃ClN₆O₅	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	ZORWARFPXPVJLW-MTFPJWTKSA-N
M.W :	390.82	Pubchem ID :	135413534
Synonyms :	Valganciclovir (hydrochloride);Ro 107-9070/194;Valganciclovir hydrochloride

Calculated chemistry of [ 175865-59-5 ]

Physicochemical Properties

Num. heavy atoms :	26
Num. arom. heavy atoms :	9
Fraction Csp3 :	0.57
Num. rotatable bonds :	9
Num. H-bond acceptors :	8.0
Num. H-bond donors :	4.0
Molar Refractivity :	95.48
TPSA :	171.37 Å²

Pharmacokinetics

GI absorption :	Low
BBB permeant :	No
P-gp substrate :	Yes
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-8.56 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.0
Log Po/w (XLOGP3) :	0.17
Log Po/w (WLOGP) :	-0.78
Log Po/w (MLOGP) :	-1.02
Log Po/w (SILICOS-IT) :	-0.6
Consensus Log Po/w :	-0.45

Druglikeness

Lipinski :	1.0
Ghose :	None
Veber :	1.0
Egan :	1.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.03
Solubility :	3.63 mg/ml ; 0.00928 mol/l
Class :	Soluble
Log S (Ali) :	-3.33
Solubility :	0.184 mg/ml ; 0.000472 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-1.48
Solubility :	13.0 mg/ml ; 0.0333 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	4.05

Safety of [ 175865-59-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 175865-59-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 175865-59-5 ]
Downstream synthetic route of [ 175865-59-5 ]

[ 175865-59-5 ] Synthesis Path-Upstream 1~1

1
[ 194154-40-0 ]
[ 175865-59-5 ]

Reference： [1] Patent: EP1837336, 2007, A1, . Location in patent: Page/Page column 11

[ 175865-59-5 ] Synthesis Path-Downstream 1~7

1
[ 194154-40-0 ]
[ 175865-59-5 ]

Yield	Reaction Conditions	Operation in experiment
82%	With hydrogenchloride; palladium on activated charcoal; hydrogen; In methanol; water; at 20℃; under 1500.15 Torr; for 18h;	Example 4N- benzyloxycarbonyl -L- valine ganciclovir monoester 45.6g, palladium on carbon catalyst Pd-C3.0g, chilled methanol, 365 ml, 8.4 mL of concentrated hydrochloric acid, and turn to the high pressure into thebottle, evacuated to -0.08Mpa, filled with hydrogen to 0.2Mpa, room temperature for 18 hours, filtered, and thefiltrate was concentrated under reduced pressure to 45 C dry, pure water was added 36.5mL, isopropanol36.5mL, clear solution was stirred heated, filtered, and the filtrate control temperature 60 ~ 70 C solution ofisopropanol 164.3mL, dropwise slow cooling, the precipitated white solid was cooled to -11 C suctionfiltration, the filter cake was dried under reduced pressure to 50 C valganciclovir hydrochloride 30g, yield:82%, purity: 99.4%.
77.5%	With hydrogenchloride; hydrogen;palladium on carbon; In water; isopropyl alcohol; at 25 - 40℃; under 367.786 - 735.572 Torr; for 1h;Product distribution / selectivity;	Example 1: Preparation of Valganciclovir Hydrochloride Using Iso-PropanolHydrochloric acid (13 g) and 10% palladium on carbon (5.5 g) was added to a solution of <strong>[194154-40-0]mono-benzyloxycarbonyl-L-valine ganciclovir</strong> (50 g) in 23% aqueous iso-propanol (Iso- propanol:water::500 mL: 150 mL). The reaction mixture was hydrogenated at about 250C to 4O0C under hydrogen pressure of 0.5-lkg/cm2 for about 1 hour. After completion of the reaction, the reaction mass was filtered and washed with iso-propanol:water mixture (Iso- propanol: water: :45 mL:5 mL). Iso-propanol (500 mL) was added over a period of about 1 hour. The reaction mass was cooled to O0C, maintained at about O0C to about -5C for about 1 hour, filtered, washed with 10% aqueous iso-propanol solution (50 mL) followed by washing with iso-propanol (5OmL) and dried to obtain valganciclovir hydrochloride (3Ig).Yield: 77.5%HPLC Purity: 99.65 % Total unknown impurities: 0.134Total impurities: 0.216
	With hydrogenchloride; hydrogen;palladium 10% on activated carbon; In ethanol; water; at 20 - 40℃;Product distribution / selectivity;	The pure CBZ-protected mono L-valyl ester of ganciclovir (100 g) was suspended in 20% aqueous ethanol (1200 ml) and to this suspension was added concentrated hydrochloric acid (21 ml, 35% w/w) and palladium on carbon (10%, 50% wet, 1 lg). The suspension was stirred at 0.5-1. 0 Kg hydrogen pressure at 20-40C. After completion of reaction, catalyst was filtered through celite bed and the bed was washed with 10% aqueous ethanol. The filtrate obtained was concentrated completely at 35-38C under vacuum and the residue was crystallized using water (0.8 times) and isopropyl alcohol (6.5 times). The crystalline product was washed with isopropyl alcohol and dried under vacuum at 55-60C to get substantially pure mono L-valyl ester of ganciclovir as its hydrochloride salt. Yield: 60-65 g. Purity (by HPLC) : greater than 99%; Bis L-valyl ester of ganciclovir less than 1% ; Ganciclovir less than 1%.EXAMPLE 13: PREPARATION OF ENATIOMERICALLY PURE HYDROCHLORIDE SALT OF MONO L-VALYL ESTER OF GANCICLOVIR The pure CBZ-protected mono L-valyl ester of ganciclovir (100 g) was suspended in 20% aqueous ethanol (1200 ml) and to this suspension was added concentrated hydrochloric acid (21 ml, 35% w/w) and palladium on carbon (10%, 50% wet, 1 lg). The suspension was stirred at 0.5-1. 0 Kg hydrogen pressure at 20-40C. After completion of reaction, catalyst was filtered through celite bed and the bed was washed with 10% aqueous ethanol. The filtrate obtained was concentrated completely at 35-38C under vacuum and the residue was crystallized using water (0.8 times) and isopropyl alcohol (6.5 times). The crystalline product was washed with isopropyl alcohol and dried under vacuum at 55-60C to get enantiomerically pure mono L-valyl ester of ganciclovir as its hydrochloride salt. Yield: 60 g. Purity (by HPLC) : greater than 99%; Bis L-valyl ester of ganciclovir less than 1%; Ganciclovir less than 1 %. Enantiomeric Purity: L-Mono-VGNC: 99.64% D-Mono-VGNC : 0.36%

	With hydrogenchloride; hydrogen;palladium 10% on activated carbon; In ethanol; water; at 25 - 30℃; for 12 - 20h;	Step (d) Preparation of 2-(2-amino 1,6 dihydro-6oxo-purine-9-yl)-methoxy-3 hydroxy-1-propyl-Lvalinate hydrochloride Product from Step (c) (29 gms) was added to mixture of ethyl alcohol (700 ml) and water 170 ml. 10% Palladium on carbon (5.8 gms) was added followed by conc.HCL (5.8 ml). Reaction mass was stirred at 25-30 C. Hydrogen gas was bubbled through the reaction mass for 12 to 20 hours. After completion of reaction, the reaction mass was filtered typically using a diatomaceous earth filter. (for example: Hyflo) filtrate was concentrated to redisue. The residue was dissolved in 50 ml water under stirring and further 600 ml of isoproyl alcohol was charged slowly in 2 hrs. at 25-30 C. The resulting suspension was stirred at 25-30 C. for 30 minutes, and was filtered and washed with 50 ml isopropyl alcohol. The solid was dried under vacuum at 50 C. to get 20 gms of 2-(2-amino 1,6 dihydro 6-oxo-purine 9-yl)-methoxy 3 acetoxy-1-propyl-N-(bezyloxy carbonyl)-L valinate hydrochloride (Valganciclovir Hydrochloride)
		Example 7 PREPARATION OF VALGANCICLOVIR HYDROCHLORIDE SALT. To a solution of mono-(Cbz-L-valyl)-ester of ganciclovir of Formula X (10 g) in methanol (320 mL) in an autoclave vessel is added aqueous HCl (2.33 mL) and 10% palladium on carbon (50% wet, 1.0 g), and a hydrogen pressure of 0.7-1 kg/cm2 is maintained for 17-18 hours at 25-30 C. The mass is filtered and the collected solid is washed with methanol (46 mL). To the filtrate is added triphenylphosphine (25 mg) and charcoal. The reaction mass is maintained for 1-2 hours at 25-30 C. The mass is filtered and the collected solid is washed with methanol (30 mL). To the filtrate is added water (10 mL), the mixture is evaporated below 40 C. to remove methanol, and the volume is adjusted to 13.5 mL with water. The aqueous layer is washed with toluene (318 mL) and 1-butanol (218 mL) at 25-30 C. Isopropyl alcohol (100 mL) is added to the mixture and maintained for 15-18 hours for solid formation at 25-30 C. Cyclohexane (45 mL) is added to the reaction mass. Reaction mass is cooled and maintained for 1-2 hours at 0 to -15 C. The formed solid is collected by filtration at -10 to -15 C., washed with chilled isopropyl alcohol (18 mL), and dried under reduced pressure at 40-50 C. to afford the title compound. Yield: 5.0 g.

Reference： [1]Patent: CN101955481,2016,B .Location in patent: Paragraph 0018; 0036-0038
[2]Patent: WO2011/18771,2011,A2 .Location in patent: Page/Page column 9-10
[3]Patent: WO2005/92891,2005,A2 .Location in patent: Page/Page column 19; 22
[4]Patent: US2007/225305,2007,A1 .Location in patent: Page/Page column 7
[5]Patent: US2011/207931,2011,A1 .Location in patent: Page/Page column 8

2
[ 194154-40-0 ]
[ 175865-59-5 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; hydrogen;palladium 10% on activated carbon; In ethanol; water; for 12 - 20h;	Step (d) Preparation of2-(2-amino 1,6 dihydro-6oxo-purine-9-yl)-methoxy-3 hydroxy-1- propyl- Lvalinate hydrochloride. Product from Step (c) (29 gms) was added to mixture of ethyl alcohol (700 ml) and water 170 ml. 10% Palladium on carbon (5.8 gms) was added followed by conc.HCL (5.8 ml). Reaction mass was stirred at 25 -30 C. Hydrogen gas was bubbled through the reaction mass for 12 to 20 hours. After completion of reaction, the reaction mass was filtered typically using a diatomaceous earth filter. (for example : Hyflo) filtrate was concentrated to redisue. The residue was dissolved in 50 ml water under stirring and further 600 ml of isoproyl alcohol was charged slowly in 2 hrs. at 25-30C. The resulting suspension was stirred at 25-30C for 30 minutes, and was filtered and washed with 50 ml isopropyl alcohol. The solid was dried under vacuum at 50C to get 20gms of 2- (2-amino 1,6 dihydro 6-oxo- purine 9-yl) - methoxy 3 acetoxy -1-propyl-N -(bezyloxy carbonyl)- L valinate hydrochloride (Valganciclovir Hydrochloride)

Reference： [1]Patent: EP1837336,2007,A1 .Location in patent: Page/Page column 11

3
[ 82410-32-0 ]
[ 175865-59-5 ]

Reference： [1]ARKIVOC,2011,vol. 2011,p. 199 - 208
[2]ARKIVOC,2011,vol. 2011,p. 199 - 208
[3]ARKIVOC,2011,vol. 2011,p. 199 - 208
[4]ARKIVOC,2011,vol. 2011,p. 199 - 208
[5]Patent: US2011/207931,2011,A1
[6]Synthetic Communications,2013,vol. 43,p. 425 - 430,6

4
[ 82410-32-0 ]
[ 175865-59-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / dimethyl sulfoxide / 4 h / 25 °C 2: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 5.5 h / 25 - 66 °C 3: hydrogenchloride; 10% Pd/C; hydrogen / methanol / 6 h / 30 °C

Reference： [1]Current Patent Assignee: UNIV HEBEI MEDICAL; HEBEI RENHEYIKANG PHARMACEUTICAL; HEBEI CHEMICAL PHARMACEUTICAL COLLEGE - CN115286632, 2022, A

5
[ 194154-40-0 ]
[ 175865-59-5 ]

Yield	Reaction Conditions	Operation in experiment
88.8 %	With hydrogenchloride; 10% Pd/C; hydrogen In methanol at 30℃;	1.3; 2.3; 3.3 S3: Add 500ml methyl alcohol and 50gCbz-L-valganciclovir in the reaction bottle,Stir, and slowly add 11 g of hydrochloric acid under temperature control at 20°C,Stir to dissolve, add 10g of 10% palladium carbon,Nitrogen replacement three times, hydrogen, 30 ° C hydrogenation reaction 6h,The reaction process control system pH is less than 5,Filter, and the filter cake is washed with 32ml×2 methanol,Add 25g TulsionCH-97 resin in the filtrate,Stir at 20°C for 2.5h,Filtration, the filtrate was concentrated under reduced pressure at 40°C to nearly dryness,Add 41g of purified water, add 328ml of isopropanol dropwise at a temperature of 40-50°C,Cool down to 20-30°C, stir for 1h,Continue to add 328ml of isopropanol dropwise, drop to 5°C for 2 hours to crystallize,Suction filtration, rinse with isopropanol, and vacuum-dry the filter cake at 55°C,Get Valganciclovir hydrochloride 35.5g, yield 88.8%,The purity is 99.3%, the palladium residue is 4ppm, and the purity is equivalent to that of Example 1.
89 %	With hydrogenchloride; palladium-carbon; hydrogen In methanol at 48 - 52℃; Inert atmosphere;	3; 6 The preparation of embodiment 6 valganciclovir hydrochloride Add 50g compound 7 in the hydrogenation reaction bottle,Add methanol 250g, 12wt% concentrated hydrochloric acid 12g, 5% palladium carbon 5g,Nitrogen replacement once, hydrogen replacement once,Raise the temperature to 48-52°C,Maintain hydrogen pressure of 0.5MPa, react for 8h,After completion of the reaction, filter and concentrate, add 100g of purified water to the concentrate,After heating up to 50°C and stirring to dissolve,Add 2.5g activated carbon for decolorization and impurity removal, filter,Slowly add 800ml of isopropanol to the filtrate, cool down to -5-0°C to crystallize,filtered, dried at 50°C,Get Valganciclovir Hydrochloride 37g,Yield 89.0%,Purity 99.3 wt%.

Reference： [1]Current Patent Assignee: UNIV HEBEI MEDICAL; HEBEI RENHEYIKANG PHARMACEUTICAL; HEBEI CHEMICAL PHARMACEUTICAL COLLEGE - CN115286632, 2022, A Location in patent: Paragraph 0035; 0042-0046; 0048-0051; 0055
[2]Current Patent Assignee: HUBEI BAOLE BIOMEDICAL TECH CO LTD - CN116199689, 2023, A Location in patent: Paragraph 0042-0043; 0048-0049

6
[ 88110-89-8 ]
[ 175865-59-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h / 10 - 27 °C / Inert atmosphere 2: hydrogenchloride / 6 h / 20 - 32 °C 3: hydrogenchloride; palladium-carbon; hydrogen / methanol / 8 h / 48 - 52 °C / 3750.38 Torr / Inert atmosphere

Reference： [1]Current Patent Assignee: HUBEI BAOLE BIOMEDICAL TECH CO LTD - CN116199689, 2023, A

7
[ 1149-26-4 ]
[ 175865-59-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h / 10 - 27 °C / Inert atmosphere 2: hydrogenchloride / 6 h / 20 - 32 °C 3: hydrogenchloride; palladium-carbon; hydrogen / methanol / 8 h / 48 - 52 °C / 3750.38 Torr / Inert atmosphere

Reference： [1]Current Patent Assignee: HUBEI BAOLE BIOMEDICAL TECH CO LTD - CN116199689, 2023, A

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[ 175865-59-5 ]

A814512[ 175865-60-8 ]

2-((2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy)-3-hydroxypropyl L-valinate

Reason: Free-salt

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
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P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
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P270	Do not eat, drink or smoke when using this product.
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P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
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P304	IF INHALED:
P305	IF IN EYES:
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P320
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P321
P322
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P337	If eye irritation persists:
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P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
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P378
P380	Evacuate area.
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
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Disposal
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 175865-59-5 ] {[proInfo.proName]}

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