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Chemical Structure| 1762-34-1 Chemical Structure| 1762-34-1
Chemical Structure| 1762-34-1

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Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. In vitro and ex vivo research has demonstrated that abametapir not only kills the lice, but also prevents hatching of their eggs. Xeglyze Lotion is emerging as a differentiated development candidate to treat head lice infestations.

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Product Details of Abametapir

CAS No. :1762-34-1
Formula : C12H12N2
M.W : 184.23
SMILES Code : CC1=CN=C(C=C1)C1=NC=C(C)C=C1
MDL No. :MFCD01740554
InChI Key :PTRATZCAGVBFIQ-UHFFFAOYSA-N
Pubchem ID :15664

Safety of Abametapir

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Abametapir

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1762-34-1 ]
  • Downstream synthetic route of [ 1762-34-1 ]

[ 1762-34-1 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 1762-34-1 ]
  • [ 1762-46-5 ]
References: [1] European Journal of Inorganic Chemistry, 1999, # 9, p. 1507 - 1521.
[2] Journal of Medicinal Chemistry, 1993, vol. 36, # 24, p. 3853 - 3858.
[3] Journal of the American Chemical Society, 1982, vol. 104, # 26, p. 7519 - 7526.
[4] Journal of the American Chemical Society, 2012, vol. 134, # 2, p. 968 - 978.
[5] Chemistry - A European Journal, 2012, vol. 18, # 23, p. 7030 - 7035.
[6] Chemistry - A European Journal, 2013, vol. 19, # 40, p. 13369 - 13375.
[7] Dalton Transactions, 2016, vol. 45, # 3, p. 881 - 885.
[8] Chemistry - A European Journal, 2018, .
  • 2
  • [ 1762-34-1 ]
  • [ 64-17-5 ]
  • [ 1762-46-5 ]
References: [1] Inorganic Chemistry, 2018, vol. 57, # 16, p. 9880 - 9891.
 

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