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[ CAS No. 17672-22-9 ]

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Chemical Structure| 17672-22-9
Chemical Structure| 17672-22-9
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Product Details of [ 17672-22-9 ]

CAS No. :17672-22-9 MDL No. :MFCD03788432
Formula : C7H9NO Boiling Point : 232.9°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :123.15 g/mol Pubchem ID :413657
Synonyms :

Safety of [ 17672-22-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 17672-22-9 ]

  • Upstream synthesis route of [ 17672-22-9 ]
  • Downstream synthetic route of [ 17672-22-9 ]

[ 17672-22-9 ] Synthesis Path-Upstream   1~3

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  • [ 13073-29-5 ]
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YieldReaction ConditionsOperation in experiment
85% With hydrogen In ethanol; ethyl acetate B. A mixture of 2-methyl-6-nitrophenol (542 mg, 3.54 mmol), 10percent Pd/C (54 mg) in EtOAc/EtOH (5.5 mL/11 mL) was stirred under hydrogen at atmospheric pressure overnight. The mixture was filtered through Celite and the filtrate was concentrated to give 2-amino-6-methylphenol as a brown solid (373 mg, 85percent).
77% With sodium dithionite In methanol; water for 2 h; Reflux An aqueous solution (50 mL) containing Na2S2O4 (40.93 g, 235 mmol) was slowly added to a solution of methanol (50 mL) containing compound 78 (6.0 g, 39 mmol)The reaction mixture was refluxed and stirred for 2 hours.After cooling at room temperature, the resulting solid was filtered off and the filtrate was concentrated under reduced pressure,EtOAc and water were added, the EtOAc layer was dried over Na2SO4, filtered under reduced pressure, and the filtrate was concentrated under reduced pressure to obtain Compound 79.
Reference: [1] Journal of Organic Chemistry, 2015, vol. 80, # 23, p. 11734 - 11743
[2] Patent: WO2008/110793, 2008, A1, . Location in patent: Page/Page column 104
[3] Patent: KR2018/117068, 2018, A, . Location in patent: Paragraph 0084; 0625; 0628; 0634; 0635
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 23, p. 7974 - 7985
[5] Journal of the American Chemical Society, 2005, vol. 127, # 30, p. 10545 - 10559
[6] Patent: US2002/156081, 2002, A1,
[7] Patent: US6921763, 2005, B2,
[8] Chemische Berichte, 1881, vol. 14, p. 572
[9] Journal of the American Chemical Society, 1930, vol. 52, p. 3978,3982
[10] Gazzetta Chimica Italiana, 1969, vol. 99, p. 1095 - 1106
[11] Journal of Medicinal Chemistry, 1998, vol. 41, # 16, p. 3015 - 3021
[12] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 10, p. 3515 - 3523
[13] Journal of the American Chemical Society, 2009, vol. 131, # 42, p. 15118 - 15119
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Reference: [1] Patent: US2007/10670, 2007, A1, . Location in patent: Page/Page column 84
  • 3
  • [ 95-48-7 ]
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Reference: [1] Journal of Organic Chemistry, 2015, vol. 80, # 23, p. 11734 - 11743
[2] Patent: KR2018/117068, 2018, A,
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