* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Reference:
[1] Journal of the American Chemical Society, 1946, vol. 68, p. 452
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 452
[3] Journal of Organic Chemistry, 1979, vol. 44, p. 3063 - 3065
[4] Liebigs Annalen der Chemie, 1990, # 12, p. 1175 - 1183
[5] Agricultural and Biological Chemistry, 1982, vol. 46, # 9, p. 2319 - 2324
[6] Helvetica Chimica Acta, 1997, vol. 80, # 4, p. 1280 - 1300
[7] Patent: WO2006/45119, 2006, A2, . Location in patent: Page/Page column 61-62
2
[ 773837-37-9 ]
[ 124-19-6 ]
[ 17702-88-4 ]
Yield
Reaction Conditions
Operation in experiment
0.487 g
Stage #1: With ammonium chloride In 1,2-dimethoxyethane; water at 50℃; for 20 h; Autoclave Stage #2: at 40℃; for 6 h;
General procedure: Following the typical procedure described above, Rh(acac)(CO)2 (2.6 mg, 0.01 mmol), xantphos (28.9 mg, 0.05 mmol) were placed in the autoclave. Then a solution of olefin (5 mmol) in DME (8 mL) was added via cannula, the autoclave was pressurized with 20 bar of CO/H2 equimolar mixture and the reaction was conducted for 18 h, upon stirring, at 80°C. After this period, the reactor was cooled to room temperature, an aqueous solution (2 mL) of NH4Cl (5.5 mmol) and NaCN (5.5 mmol) was added via inlet cannula and the reaction was kept at 50°C for 20 h. After work-up and purification, the resulting α-aminonitrile (4.1 mmol) was suspended in a concentrated HCl solution and stirred for 6 h at 40°C. The product was dissolved in methanol. After adjustment of the pH to the isoelectric point, using NH4OH (aq), the solvent was evaporated and the amino acid was obtained.
Reference:
[1] Journal of Medicinal Chemistry, 1989, vol. 32, # 2, p. 289 - 297
[2] Journal of Biological Chemistry, 1953, vol. 203, p. 333,334
[3] Bl.Nagoya Inst.Technol., 1954, vol. 6, p. 271,273[4] Chem.Abstr., 1956, p. 11943
[5] Journal of Biological Chemistry, 1953, vol. 203, p. 333,334
[6] Bl.Nagoya Inst.Technol., 1954, vol. 6, p. 271,273[7] Chem.Abstr., 1956, p. 11943
[8] Patent: US2109929, 1937, ,
4
[ 111-83-1 ]
[ 1068-90-2 ]
[ 17702-88-4 ]
Reference:
[1] Journal of Organic Chemistry, 2007, vol. 72, # 14, p. 5146 - 5151
[2] Journal of the American Chemical Society, 2000, vol. 122, # 17, p. 4032 - 4038
5
[ 70562-45-7 ]
[ 17702-88-4 ]
Reference:
[1] Journal of Organic Chemistry, 1979, vol. 44, p. 3063 - 3065
6
[ 629-27-6 ]
[ 17702-88-4 ]
Reference:
[1] Journal of the American Chemical Society, 1946, vol. 68, p. 452
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 452
[3] Journal of Organic Chemistry, 1976, vol. 41, # 21, p. 3491 - 3493
7
[ 855212-43-0 ]
[ 17702-88-4 ]
Reference:
[1] Journal of the American Chemical Society, 1946, vol. 68, p. 452
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 452
8
[ 111-83-1 ]
[ 17702-88-4 ]
Reference:
[1] Tetrahedron Letters, 1982, vol. 23, # 41, p. 4255 - 4258
[2] Liebigs Annalen der Chemie, 1990, # 12, p. 1175 - 1183
9
[ 111-66-0 ]
[ 17702-88-4 ]
Reference:
[1] Journal of the Chemical Society, Chemical Communications, 1985, # 17, p. 1168 - 1169
[2] Tetrahedron, 2017, vol. 73, # 17, p. 2389 - 2395
[3] Tetrahedron, 2017, vol. 73, # 17, p. 2389 - 2395
10
[ 334-48-5 ]
[ 17702-88-4 ]
Reference:
[1] Patent: US2109929, 1937, ,
[2] Journal of Biological Chemistry, 1953, vol. 203, p. 333,334
General procedure: To a stirred solution of the amino acid 3j (0.0100 g, 0.058 mmol) in anhydrous MeOH (1.5 mL) was added thionyl chloride (0.33 g, 2.77 mmol) at 0 C in 5 min. The mixture was warmed to room temperature and stirred overnight. The solvent was removed via rotary evaporation in vacuo to give an amino acid methyl ester 19 as apale yellow oil. The crude amino acid methyl ester 19 was dissolve in dry THF (0.50mL). To the solution were successively added Et3N (0.0175 g, 0.17 mmol) and benzoyl chloride (0.0122 g, 0.087 mmol). The mixture was stirred room temperature for 1 h, concentrated, and purified by thin layer chromatography (silica gel, petroleum ether / ethyl acetate = 10:1) to give compound 20 (0.0083 g, 49%) as a colorless oil
With sodium hydroxide; In 1,4-dioxane; water; at 20℃; for 2h;
<strong>[17702-88-4]2-Aminodecanoic acid</strong> (1.00 g) was added to 1 M sodium hydroxide (5.86 ML) with stirring to give an off-white suspension. The mixture was diluted with 1,4-dioxane (15 mi) to furnish a turbid mixture to which di-tert-butyl dicarbonate (1.16 g) was added portionwise over 1 minute. Stirring was continued at room temperature for 2 hours and the reaction was monitored by TLC (ethyl acetate /METHANOL/WATER 5: 1: 1); Rf (SM) 0.01, Rf (product) ca 0.6). The reaction mixture was concentrated under vacuum, ethyl acetate was added and the mixture was acidified to pH 3-4 with 0.5 M citric acid solution. Some undissolved solid was removed by filtration and the organic phase separated. The aqueous phase was extracted with ethyl acetate (2 x 25 ml) and the combined organic phases were washed with water (2 x 25 mi) and dried (MGS04). Evaporation of solvent gave the product as a pale yellow oil, 1.39 g (90%), HPIC/MS (ELS detection) Rt 4.85 M/Z 288.
[1-(4,5-dihydro-1<i>H</i>-imidazol-2-yl)-1-methyl-ethyl]-[1-methyl-1-(5-octyl-4,5-dihydro-1<i>H</i>-imidazol-2-yl)-ethyl]-diazene; compound with trifluoro-acetic acid[ No CAS ]
2-{1-[1-(1-tert-Butoxycarbonyl-4,5-dihydro-1H-imidazol-2-yl)-1-methyl-ethylazo]-1-methyl-ethyl}-5-octyl-4,5-dihydro-imidazole-1-carboxylic acid tert-butyl ester[ No CAS ]