Alternatived Products of [ 1779974-61-6 ]
Product Details of [ 1779974-61-6 ]
CAS No. : | 1779974-61-6 |
MDL No. : | MFCD30723719 |
Formula : |
C9H7F3N2O
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
216.16
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 1779974-61-6 ]
Application In Synthesis of [ 1779974-61-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1779974-61-6 ]
- 1
-
[ 1260885-46-8 ]
-
[ 1779974-61-6 ]
Yield | Reaction Conditions | Operation in experiment |
453 mg |
With diisobutylaluminium hydride In tetrahydrofuran; hexane at -40 - 20℃; |
A13.B Step B: (5-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)methanol
Diisobutylaluminum hydride (1M in hexane) (11 ml_, 11.0 mmol) was added to a solution of ethyl 5-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate (860 mg, 2.99 mmol) in THF (9.0 ml_) at -40 °C. The reaction mixture was allowed to warm to RT overnight. At 0 °C, MeOH (5.0 ml_), followed by water (5.0 ml_) and aq. 1M HCI (5.0 ml_) were added. The mixture was stirred vigorously for 30 min and extracted with ethyl acetate (3 x 15 ml_). The combined organic layers were washed with brine (15 ml_), dried over MgSCL, and concentrated in vacuo to give the title compound (453 mg, 2.0 mmol, 57% yield, 95% purity as a brown oil. UPLC/MS (Method 5): m/z 217 (M+H)+, RT 0.82 min. |