Alternatived Products of [ 178419-47-1 ]
Product Details of [ 178419-47-1 ]
CAS No. : | 178419-47-1 |
MDL No. : | |
Formula : |
C9H14N2O2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
182.22
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 178419-47-1 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 178419-47-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 178419-47-1 ]
- 1
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[ 62323-44-8 ]
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[ 178419-47-1 ]
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C15H20N2O2S
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 130℃; for 12h; |
|
Reference:
[1]Tatsumi, Ryo; Fujio, Masakazu; Satoh, Hiroyuki; Katayama, Jiro; Takanashi, Shin-Ichi; Hashimoto, Kenji; Tanaka, Hiroshi
[Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2678 - 2686]
- 2
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[ 2873-18-9 ]
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[ 178419-47-1 ]
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C13H15ClN2O2S
[ No CAS ]
- 3
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[ 54008-77-4 ]
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[ 178419-47-1 ]
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C17H18N2O3
[ No CAS ]
- 4
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[ 53119-60-1 ]
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[ 178419-47-1 ]
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C14H18N2O2S
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With 2-bromo-3-methylthiophene; copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 130℃; for 12h; |
|
Reference:
[1]Tatsumi, Ryo; Fujio, Masakazu; Satoh, Hiroyuki; Katayama, Jiro; Takanashi, Shin-Ichi; Hashimoto, Kenji; Tanaka, Hiroshi
[Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2678 - 2686]
- 5
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[ 63837-11-6 ]
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[ 178419-47-1 ]
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(R)-3'-(2-methylbenzothiazol-5-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one
[ No CAS ]
- 6
-
[ 66826-78-6 ]
-
[ 178419-47-1 ]
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(R)-3'-(2,3-dihydrobenzo[b]furan-5-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one
[ No CAS ]
- 7
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[ 67927-44-0 ]
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[ 178419-47-1 ]
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(R)-3'-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one
[ No CAS ]
- 8
-
[ 6134-54-9 ]
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[ 178419-47-1 ]
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(R)-3'-(indan-5-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 130℃; |
|
Reference:
[1]Tatsumi, Ryo; Fujio, Masakazu; Takanashi, Shin-Ichi; Numata, Atsushi; Katayama, Jiro; Satoh, Hiroyuki; Shiigi, Yasuyuki; Maeda, Jun-Ichi; Kuriyama, Makoto; Horikawa, Takashi; Murozono, Takahiro; Hashimoto, Kenji; Tanaka, Hiroshi
[Journal of Medicinal Chemistry, 2006, vol. 49, # 14, p. 4374 - 4383]
- 9
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[ 128851-73-0 ]
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[ 178419-47-1 ]
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(R)-3'-(benzo[b]furan-6-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one
[ No CAS ]
- 10
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[ 501901-98-0 ]
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[ 178419-47-1 ]
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(R)-3'-(3-ethyl-2-methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 130℃; |
|
Reference:
[1]Tatsumi, Ryo; Fujio, Masakazu; Takanashi, Shin-Ichi; Numata, Atsushi; Katayama, Jiro; Satoh, Hiroyuki; Shiigi, Yasuyuki; Maeda, Jun-Ichi; Kuriyama, Makoto; Horikawa, Takashi; Murozono, Takahiro; Hashimoto, Kenji; Tanaka, Hiroshi
[Journal of Medicinal Chemistry, 2006, vol. 49, # 14, p. 4374 - 4383]
- 11
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[ 4175-78-4 ]
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[ 178419-47-1 ]
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[ 892548-09-3 ]
Yield | Reaction Conditions | Operation in experiment |
|
|
Sodium hydride (60% suspension in mineral oil) (15 mg, 0.36 mmol) was added to a solution of (3delta)-spiro[l-azabicyclo[2.2.2]octan-3,5'-oxazolidin-2'-one] (55 mg, 0.30 mmol) in anhydrous N,N-dimethylformamide (0.8 mL), and the resulting mixture was stirred for 30 min at 50 C. 2,5-Dibromothiazole (87 mg, 0.36 mmole) was added into the reaction mixture, which was then stirred at 50 C overnight. The solution was allowed to cool to room temperature, and then saturated aqueous ammonium chloride was added. The resulting mixture was extracted with chloroform, and the chloroform layer was washed with saturated aqueous potassium carbonate, then dried (MgSO4), filtered, and evaporated. The residue was purified by flash chromatography using a gradient of ammoniated methanol in chloroform to give the title compound as a yellow oil (11 mg); m/z 344, 346(MH+). |
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