Alternatived Products of [ 1796-82-3 ]
Product Details of [ 1796-82-3 ]
CAS No. : | 1796-82-3 |
MDL No. : | |
Formula : |
C6H7N3O3
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
169.14
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1796-82-3 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1796-82-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 1796-82-3 ]
- Downstream synthetic route of [ 1796-82-3 ]
- 1
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[ 1678-49-5 ]
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[ 74-89-5 ]
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[ 1796-82-3 ]
Yield | Reaction Conditions | Operation in experiment |
98% |
In tetrahydrofuran; at 20℃; |
To a slurry of 5.00 g (22.8 mmol) of 3-bromo-4- nitropyridine-1-oxide in 50 mL of tetrahydrofuran (THF) was slowly added 68.5 mL (137 mmol) of methylamine (2.0 M solution in THF). The reaction mixture was stirred overnight at room temperature and concentrated in vacuo. The thus obtained residue was dissolved in 250 mL of dichloromethane and washed with 100 mL of saturated aqueous sodium bicarbonate and 100 mL of water. The combined aqueous layers were extracted with 100 mL of dichloromethane. The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo to give 3.78 g (98%) of the title compound. 1H NMR (CDC13) 8 3. 03 (d, J = 5.3 Hz, 3H), 7. 48 (d, J = 7.2 Hz, 1H), 7.94 (s, 1H), 8.02 (d, J = 7.2 Hz, 1H) ; MS Calcd.: 169; Found: 170 (M+H). |
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In ethanol; at 90℃; for 0.333333h; |
To a solution of 3-bromo-4-nitropyridine N-oxide (0.5 g, 2.28 mmol) in 2 ml ethyl alcohol, methylamine (33% weight in ethyl alcohol) (0.57 ml, 4.56 mmol) was added and the mixture was heated by microwave under 900C for 20 minutes. The mixture was concentrated under reduced pressure to yield Methyl-(4-nitro-1-oxy-pyridin-3-yl)-amine (0.38 g); MS+ 170.1. |
- 2
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[ 76439-45-7 ]
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[ 74-89-5 ]
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[ 1796-82-3 ]
- 3
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[ 1796-82-3 ]
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[ 64-19-7 ]
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[ 52538-09-7 ]
Yield | Reaction Conditions | Operation in experiment |
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iron; at 180℃; for 0.5h;Microwave irradiation; |
To a solution of Methyl-(4-nitro-1-oxy-pyridin-3-yl)-amine (0.38 g, 2.28 mmol) in 4 ml acetic acid, iron powder (383 mg, 6.849 mmol) was added and the mixture was heated by microwave under 1800C for 30 minutes. The mixture was basified to pH 12 by 1 N NaOH solution. The resulting mixture was extracted by DCM, dried over Na2SO4, filtered and the solvent was removed in vacuo. The residue purified using silica gel chromatography (0% to 10% MeOH/CH2CI2) to yield 2,3-dimethyl-3H-imidazo[4,5-c]pyridine (0.1 g); GC-MS 147. |
- 4
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[ 1796-82-3 ]
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[ 52538-09-7 ]