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Chemical Structure| 1809249-37-3 Chemical Structure| 1809249-37-3

Structure of Remdesivir
CAS No.: 1809249-37-3

Chemical Structure| 1809249-37-3

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Remdesivir is an nucleotide-analog antiviral prodrug. Remdesivir could inhibit SARS-CoV-2 3CLpro main protease.

Synonyms: GS-5734; Remdesivir (CRM)

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Ju Hwan Jeong ; Santosh Chokkakula ; Seong Cheol Min ; Beom Kyu Kim ; View ORCID ProfileWon-Suk Choi ; Sol Oh , et al.

Abstract: As the SARS-CoV-2 pandemic remains uncontrolled owing to the continuous emergence of variants of concern, there is an immediate need to implement the most effective antiviral treatment strategies, especially for risk groups. Here, we evaluated the therapeutic potency of nirmatrelvir, remdesivir, and molnupiravir and their combinations in SARS-CoV-2-infected K18-hACE2 transgenic mice. Systemic treatment of mice with each drug (20 mg/kg) resulted in slightly enhanced antiviral efficacy and yielded an increased life expectancy of only about 20–40% survival. However, combination therapy with nirmatrelvir (20 mg/kg) and molnupiravir (20 mg/kg) in lethally infected mice showed profound inhibition of SARS-CoV-2 replication in both the lung and brain and synergistically improved survival times up to 80% compared to those with nirmatrelvir (P= 0.0001) and molnupiravir (P= 0.0001) administered alone. This combination therapy effectively reduced clinical severity score, virus-induced tissue damage, and viral distribution compared to those in animals treated with these monotherapies. Furthermore, all these assessments associated with this combination were also significantly higher than that of mice receiving remdesivir monotherapy (P= 0.0001) and the nirmatrelvir (20 mg/kg) and remdesivir (20 mg/kg) combination (P= 0.0001), underscored the clinical significance of this combination. By contrast, the nirmatrelvir and remdesivir combination showed less antiviral efficacy, with lower survival compared to nirmatrelvir monotherapy, demonstrating the inefficient therapeutic effect of this combination. The combination therapy with nirmatrelvir and molnupiravir contributes to alleviated morbidity and mortality, which can serve as a basis for the design of clinical studies of this combination in the treatment of COVID-19 patients. IMPORTANCE Since SARS-CoV-2 spread rapidly with the emergence of new variants of concerns, it is necessary to develop effective treatment strategies to treat elderly individuals and those with comorbidities. Antiviral therapy using a combination of drugs is more effective in eradicating viruses and will undoubtedly improve the clinical outcome and survival probability of hospitalized SARS-CoV-2 patients. In the current study, we observed three FDA-approved antivirals nirmatrelvir, remdesivir, and molnupiravir have therapeutic significance with moderate survival for their monotherapies against SARS-CoV-2 infected K18-hACE2 mouse model. The combination of nirmatrelvir and molnupiravir showed significant antiviral activity and a higher survival rate of approximately 80%, providing in vivo evidence of the potential utility of this combination. In contrast, nirmatrelvir and remdesivir combination showed less antiviral potency and emphasized the ineffective significance with less survival. The current study suggests that the nirmatrelvir and molnupiravir combination is an effective drug regimen strategy in treating SARS-CoV-2 patients.

Keywords: SARS-CoV-2 ; COVID-19 ; Antiviral ; Nirmatrelvir ; Remdesivir ; Molnupiravir ; Monotherapy ; Combination therapy

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Hanako Reyes ; Yanming Du ; Tianlun Zhou ; Xuping Xie ; Pei Yong Shi ; Susan Weiss , et al.

Abstract: Iminosugar glucosidase inhibitors prevent the folding of a range of viral N-linked glycoproteins, ranging from hepatitis B to Ebola. We recently showed they inhibit folding and function of the ACE2 protein, which is the receptor for SARS-CoV-2, and they have also inhibited the SARS Spike polypeptides. Here we report that the imino sugar glucosidase inhibitors, N-butyl deoxynojirimycin (NBDNJ), which is approved for management of lysosomal storage disease (sold as Zavesca), and ureido-N-hexyl deoxynojirimycine (BSBI-19029), suppress the replication of SARS-ncCoV-2/USA/WA1/2020 strain, in tissue culture. Moreover, combinations of either of these iminosugars with Remdesivir were particularly potent in suppressing SARS-CoV-2. Briefly, NBDNJ, 19029 and Remdesivir suppressed SARS-CoV-2 production in A549ACE2 human lung cells with IC90s of ~130 μM, ~4.0 μM, and 0.006 μM respectively. The combination of as little as 0.037 μM of NBDNJ or 0.04 μM 19029, respectively and 0.002 μM Remdesivir yielded IC90s. Medical strategies to manage SARS-CoV-2 infection of people are urgently needed, and although Remdesivir and Favipiravir have shown efficacy, it is limited. NBDNJ was recently reported by others to have tissue culture activity against SARS-CoV-2, so our report confirms this, and extends the findings to a more potent iminosugar, 19029 and combination with Remdesivir. Since both NBDNJ and Remdesivir are both approved and available for human use, the possibility that NBDNJ has mono therapeutic value against SARS-CoV-2 as well as can enhance Remdesivir, may have clinical implications, which are discussed, here.

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Alternative Products

Product Details of Remdesivir

CAS No. :1809249-37-3
Formula : C27H35N6O8P
M.W : 602.58
SMILES Code : C[C@@H](C(OCC(CC)CC)=O)N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@](C#N)(C3=CC=C4C(N)=NC=NN43)[C@H](O)[C@@H]2O)=O
Synonyms :
GS-5734; Remdesivir (CRM)
MDL No. :MFCD31657351
InChI Key :RWWYLEGWBNMMLJ-YSOARWBDSA-N
Pubchem ID :121304016

Safety of Remdesivir

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
human induced pluripotent stem cell (iPS)-derived cardiomyocytes 1 μM 72 h To evaluate the effect of Remdesivir on cardiomyocyte electrophysiology, results showed that Remdesivir significantly prolonged the action potential duration (APD90), and this prolongation was markedly attenuated by the UTS2R antagonist. PMC10175918
neonatal rat cardiomyocytes (NRCMs) 1 μM 48 h To evaluate the effect of Remdesivir on cardiomyocyte contractility, results showed that Remdesivir significantly reduced cardiomyocyte contractility, and this effect was significantly attenuated by the UTS2R antagonist. PMC10175918
Vero E6 cells 133.2 μM 72 h To evaluate the antiviral activity of Remdesivir against SARS-CoV-2, the results showed that the IC50 value of Remdesivir was 1.42 μM, and the selectivity index (SI) was 94.00. PMC8665848
Vero E6 cells 10 µM 30 h To evaluate the antiviral activity of Remdesivir against SARS-CoV-2, results showed that at 10 µM concentration, Remdesivir protected more than 99% of cells from virus-induced cytopathic effects (CPE). PMC9127501
A549 cells 0.1 μg/ml DiR 1 h, 2 h, 4 h To evaluate the uptake ability of DiR-cyc and DiR-lips in A549 cells. The results showed that DiR-lips had better uptake rate and amount compared to DiR-cyc. PMC8529908
NIH-3T3 cells 12.5, 25, 50 μM 24 h To evaluate the effect of Remdesivir on TGF-β1-induced proliferation and migration of lung fibroblasts. Results showed that Remdesivir dose-dependently inhibited the proliferation and migration of TGF-β1-activated fibroblasts. PMC8427522
A549 cells 12.5, 25, 50 μM 24 h To evaluate the effect of Remdesivir on TGF-β1-induced phenotypic transition in alveolar epithelial cells. Results showed that Remdesivir significantly increased the expression of the epithelial marker E-cadherin and decreased the expression of the mesenchymal markers N-cadherin and vimentin. PMC8427522
Vero cells 10 µM 24 h Evaluate the inhibitory effect of Remdesivir on SARS-CoV-2 replication, results showed significant inhibition at 10 µM concentration PMC8751734
A549ACE2+ cells 10 µM 24 h Evaluate the inhibitory effect of Remdesivir on SARS-CoV-2 replication, results showed significant inhibition at 10 µM concentration PMC8751734
VeroE6 cells 0.74 µM 2 days Evaluate the in vitro antiviral activity of Remdesivir against SARS-CoV-2, showing an EC50 of 0.74 µM. PMC9066064
A549ACE2+ cells 86 nM 24 h To evaluate the inhibitory effect of ACF on SARS-CoV-2 replication, the results showed that the IC50 of ACF in A549ACE2+ cells was 86 nM. PMC8751734
Vero cells 64 nM 24 h To evaluate the inhibitory effect of ACF on SARS-CoV-2 replication, the results showed that the IC50 of ACF in Vero cells was 64 nM. PMC8751734

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
hACE2 transgenic C57BL/6 mice SARS-CoV-2 infection model Oral 50 mg/kg Once daily for 5 days To evaluate the antiviral and anti-inflammatory effects of Remdesivir in SARS-CoV-2 infected mice, the results showed that Remdesivir significantly reduced the mortality of mice and decreased lung virus titers. PMC8665848
BALB/c mice Normal mice Intravenous injection, Transtracheal injection 20 mg/kg Single dose To evaluate the pharmacokinetics and tissue distribution of NTP in the lung under different administration routes. The results showed that the NTP concentration and accumulation in the Rdv-lips transtracheal injection group were significantly higher than those in the Rdv-cyc intravenous injection group, and the NTP conversion rate of Rdv-lips was faster. PMC8529908
C57BL/6 mice Bleomycin-induced pulmonary fibrosis model Intraperitoneal injection 10 mg/kg, 20 mg/kg Once daily for 14 days To evaluate the preventive effect of Remdesivir on bleomycin-induced pulmonary fibrosis. Results showed that Remdesivir significantly alleviated bleomycin-induced collagen deposition and improved pulmonary function. PMC8427522
K18-ACE2 mice SARS-CoV-2 infection model intramuscular 25 mg/kg once daily for 6 days Evaluate the inhibitory effect of Remdesivir on SARS-CoV-2 replication in vivo, results showed significant reduction of viral replication in the brain and lungs PMC8751734
K18-ACE2 mice SARS-CoV-2 infection model Oral and intramuscular 100 mg/kg (oral), 5 mg/kg or 15 mg/kg (intramuscular) Once daily (oral), twice daily (intramuscular), for 6 days To evaluate the inhibitory effect of ACF on SARS-CoV-2 replication in vivo, the results showed that both oral and intramuscular administration of ACF significantly reduced viral replication in the brain and lungs. PMC8751734

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT04431453 COVID-19 PHASE2|PHASE3 COMPLETED 2023-02-10 Children's Hospital of Alabama... More >>, Birmingham, Alabama, 35233, United States|Children's Hospital Los Angeles, Los Angeles, California, 90027, United States|Ronald Reagan University of California, Los Angeles Medical Center, Los Angeles, California, 90095, United States|Valley Children's Hospital, Madera, California, 93636, United States|UC Davis Medical center, Sacramento, California, 95817, United States|Rady Children's Hospital San Diego, San Diego, California, 92123, United States|Tampa General Hospital (Inpatient Visits), Tampa, Florida, 33606, United States|Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois, 60611, United States|Norton Children's Hospital, Louisville, Kentucky, 40202, United States|Tulane University School of Medicine, New Orleans, Louisiana, 70112, United States|Johns Hopkins Children's Center, Baltimore, Maryland, 21287, United States|Boston Children's Hospital, Boston, Massachusetts, 02115, United States|Spectrum Health/Helen De Vos Children's Hospital, Grand Rapids, Michigan, 49503, United States|Children's Minnesota, Minneapolis, Minnesota, 55404, United States|NYC Health + Hospitals/Jacobi Medical Center, Bronx, New York, 10461, United States|Montefiore Medical Center, Bronx, New York, 10467, United States|Northwell Health-Cohen Children's Medical Center, New Hyde Park, New York, 11040, United States|Carolinas Medical Center-Levine Children's Hospital, Charlotte, North Carolina, 28203, United States|Lehigh Valley Hospital/Lehigh Valley Health Network (LVH/LVHN), Allentown, Pennsylvania, 18103, United States|St. Christopher's Hospital for Children, Philadelphia, Pennsylvania, 19134, United States|Children's Medical Center, Dallas, Texas, 75235, United States|Texas Children's Hospital, Houston, Texas, 77030, United States|Azienda Ospedaliero Universitaria Meyer, Florence, 50139, Italy|Azienda Ospedaliera di Padova - Dipartimento Salute della Donna e del Bambino, Padova, 35128, Italy|UO Clinica Pediatrica, Ospedale Pietro Barilla - AOU di Parma, Parma, 43126, Italy|Hospital Universitari Vall D'Hebron, Barcelona, 8035, Spain|Hospital Sant Joan de Déu, Esplugues de llobregat, 8950, Spain|Hospital General Universitario Gregorio Maranon, Madrid, 28009, Spain|Hospital Universitario 12 de Octubre, Madrid, 28041, Spain|Hospital Universitario La Paz, Madrid, 28041, Spain|Hospital Clínico Universitario de Santiago, Santiago de Compostela, 15706, Spain|Alder Hey Children's NHS Foundation Trust, Liverpool, L12 2AP, United Kingdom Less <<
NCT05222113 Duration of Hospitalization|Cl... More >>inical Manifestation of COVID-19 Less << COMPLETED 2021-09-25 Gotong Royong Surabaya Hospita... More >>l, Surabaya, East Java, 60119, Indonesia Less <<
NCT04978259 Covid19 PHASE4 UNKNOWN 2023-12-31 University of Helsinki, Helsin... More >>ki, 00014, Finland Less <<
NCT04582266 COVID-19 COMPLETED 2022-04-13 David Geffen School of Medicin... More >>e at UCLA (Site #: 5112), Los Angeles, California, 90095, United States|Childrens Hospital (U. Colorado, Denver) NICHD CRS (Site #: 5052), Denver, Colorado, 80218-1088, United States|Pediatric Perinatal HIV Clinical Trials Unit (Site #: 5127), Miami, Florida, 33136, United States|Emory University School of Medicine (Site #: 5030), Atlanta, Georgia, 30308, United States|Rush University Cook County Hospital NICHD CRS (Site #: 5083), Chicago, Illinois, 60612, United States|Lurie Children's Hospital of Chicago (LCH) CRS (Site #: 4001), Chicago, Illinois, 60614, United States|Johns Hopkins University NICHD CRS (Site #: 5092), Baltimore, Maryland, 21287, United States|Bronx-Lebanon Hospital Center (Site #: 5114), Bronx, New York, 10457, United States|Stony Brook University Medical Center (Site #: 5040), Stony Brook, New York, 11794, United States|Texas Children's Hospital (Site #: 5128), Houston, Texas, 77030, United States Less <<
NCT04323761 SARS-CoV2 Infection APPROVED_FOR_MARKETING - University of Alabama- Birming... More >>ham, Birmingham, Alabama, 35294, United States|Banner- University Medical Center Phoenix, Phoenix, Arizona, 85006, United States|Community Regional Medical Centers (CRMC), Fresno, California, 93721, United States|St. Jude Medical Center, Fullerton, California, 92835, United States|Scripps Memorial Hospital La Jolla, La Jolla, California, 92037, United States|Long Beach Memorial Medical Center, Long Beach, California, 90806, United States|Huntington Hospital, Pasadena, California, 91105, United States|Scripps Mercy Hospital, San Diego, California, 92064, United States|California Pacific Medical Center, San Francisco, California, 94115, United States|University of California, Medical Center (Parnassus Campus), San Francisco, California, 94143, United States|Regional Medical Center, San Jose, California, 95118, United States|San Mateo Medical Center, San Mateo, California, 94304-1509, United States|Santa Rosa Memorial Hospital, Santa Rosa, California, 95405, United States|Los Robles Regional Medical Center, Thousand Oaks, California, 91360, United States|PIH Health Whittier Hospital, Whittier, California, 90602, United States|The Medical Center Of Aurora, Aurora, Colorado, 80012, United States|Rose Medical Center, Denver, Colorado, 80220, United States|Swedish Medical Center, Englewood, Colorado, 80113, United States|Greenwich Hospital, Greenwich, Connecticut, 06830, United States|Middlesex Health, Middletown, Connecticut, 64587, United States|The Hospital of Central Connecticut, New Britain, Connecticut, 06052, United States|The Stamford Health Medical Group- Pulmonary Associates, Stamford, Connecticut, 06904, United States|George Washington University Hospital, Washington, District of Columbia, 20037, United States|Aventura Hospital and Medical Center, Aventura, Florida, 33180, United States|Lawnwood Regional Medical Center, Fort Pierce, Florida, 34982, United States|Memorial Regional Hospital, Hollywood, Florida, 33021, United States|Mayo Clinic in Florida, Jacksonville, Florida, 32224, United States|Mount Sinai Medical Center, Miami Beach, Florida, 33140, United States|AdventHealth Orlando, Investigational Drug Services, Orlando, Florida, 32803, United States|Sarasota Memorial Hospital, Sarasota, Florida, 34239, United States|Piedmont Atlanta Hospital, Atlanta, Georgia, 30309, United States|Wellstar Atlanta Medical Center, Atlanta, Georgia, 30312, United States|Piedmont Columbus Regional-Midtown Hospital, Columbus, Georgia, 31901, United States|Grady Health System- Grady Memorial Hospital, Decatur, Georgia, 30030, United States|Piedmont Fayette Hospital, Fayetteville, Georgia, 10043, United States|Memorial Health University Medical Center, Savannah, Georgia, 31404, United States|John D. Archbold Memorial Hospital, Thomasville, Georgia, 31792, United States|Swedish Hospital, Chicago, Illinois, 60025, United States|Mercy Hospital & Medical Center, Chicago, Illinois, 60616, United States|Northwestern Lake Forest Hospital, Lake Forest, Illinois, 60045, United States|Loyola University Medical Center, Maywood, Illinois, 60153, United States|Northwestern Medicine Central DuPage Hospital, Winfield, Illinois, 60190, United States|St. Vincent Hospital and Health Care Center, Inc., Carmel, Indiana, 46032, United States|Richard L Roudebush Indianapolis VA, Indianapolis, Indiana, 46202, United States|Riverview Health, Noblesville, Indiana, 46060, United States|Our Lady of the Lakes Regional Medical Center, Baton Rouge, Louisiana, 70808, United States|Touro Infirmary, New Orleans, Louisiana, 70112, United States|Ochsner Clinic Foundation, New Orleans, Louisiana, 70121, United States|Slidell Memorial Hospital, Slidell, Louisiana, 70458, United States|University of Maryland, Baltimore, Maryland, 21201, United States|Mercy Medical Center, Baltimore, Maryland, 21217, United States|CalvertHealth Medical Center, Prince Frederick, Maryland, 20678, United States|University of Maryland St. Joseph Medical Center, Towson, Maryland, 21204, United States|Steward St. Elizabeth's Medical Center of Boston, Inc., Boston, Massachusetts, 02135, United States|Cambridge Health Alliance, Cambridge, Massachusetts, 02141, United States|Charlton Memorial Hospital, Fall River, Massachusetts, 02720, United States|Lawrence General Hospital, Lawrence, Massachusetts, 01841, United States|Lowell General Hospital, Lowell, Massachusetts, 01854, United States|South Shore Hospital, South Weymouth, Massachusetts, 02190, United States|UMass Memorial Medical Center, Worcester, Massachusetts, 01655, United States|St. Joseph Mercy Hospital, Ann Arbor, Michigan, 48106-0995, United States|Huron Valley-Sinai Hospital, Commerce, Michigan, 48382, United States|Wayne Statue University/ Detroit Receiving Hospital, Detroit, Michigan, 48201, United States|Henry Ford Health System, Detroit, Michigan, 48202, United States|McLaren Health Care Corporation, Flint, Michigan, 48532, United States|Bronson Methodist Hospital, Kalamazoo, Michigan, 49007, United States|University of Mississippi Medical Center, Jackson, Mississippi, 39216, United States|Washington University School of Medicine, Saint Louis, Missouri, 63110, United States|CarePoint Health Bayonne Medical Center, Bayonne, New Jersey, 07002, United States|Clara Maass Medical Center, Belleville, New Jersey, 07109, United States|Cooper University Hospital, Camden, New Jersey, 08103, United States|Hackensack Meridian Health - JFK Medical Center, Edison, New Jersey, 08820, United States|Trinitas Regional Medical Center, Elizabeth, New Jersey, 07207, United States|Englewood Health, Englewood, New Jersey, 07631, United States|Hunterdon Medical Center, Flemington, New Jersey, 08822, United States|CentraState Medical Center, Freehold, New Jersey, 07728, United States|Robert Wood Johnson University Hospital Hamilton, Hamilton, New Jersey, 08690, United States|Jersey City Medical Center, Jersey City, New Jersey, 07302, United States|Christ Hospital- Carepoint Health, Jersey City, New Jersey, 07306, United States|Monmouth Medical Center, Long Branch, New Jersey, 07740, United States|Atlantic Health System/ Morristown Medical Center, Morristown, New Jersey, 07960, United States|Jersey Shore University Medical Center, Neptune, New Jersey, 07753, United States|Saint Peter's University Hospital, New Brunswick, New Jersey, 08901, United States|Saint Michael's Medical Center, Newark, New Jersey, 07102, United States|University Hospital, Newark, New Jersey, 07103, United States|Ocean Medical Center, Oakhurst, New Jersey, 07755, United States|Bayshore Medical Center, Red Bank, New Jersey, 07701, United States|The Valley Hospital, Ridgewood, New Jersey, 07450, United States|Atlantic Health System/Overlook Medical Center, Summit, New Jersey, 07901, United States|Holy Name Medical Center, Teaneck, New Jersey, 07666, United States|Capital Health, Trenton, New Jersey, 08638, United States|Virtua Health Voorhees Campus, Voorhees, New Jersey, 08043, United States|St. Peter's Hospital, Albany, New York, 12208, United States|Mount Sinai Queens, Astoria, New York, 11102, United States|Good Samaritan Hospital Medical Center, Bay Shore, New York, 11706, United States|Southside Hospital, Bay Shore, New York, 11706, United States|Lincoln Medical Center, Bronx, New York, 10451, United States|St Barnabus Hospital, Bronx, New York, 10457, United States|Montefiore Medical Center, Weiler Campus, Bronx, New York, 10461, United States|Montefiore Health System Moses Medical Center, Bronx, New York, 10467-2490, United States|The Brooklyn Hospital Center, Brooklyn, New York, 11201, United States|Kingsbrook Jewish Medical Center, Brooklyn, New York, 11203, United States|University Hospital Brooklyn (SUNY Downstate), Brooklyn, New York, 11203, United States|Woodhull Medical Center, Brooklyn, New York, 11206, United States|Kings County Hospital Center, Brooklyn, New York, 11207, United States|New York Harbor VA Medical Center, Brooklyn, New York, 11209, United States|Brookdale University Hospital and Medical Center, Brooklyn, New York, 11212, United States|Interfaith Medical Center, Brooklyn, New York, 11213, United States|NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, 11215, United States|Maimonides Medical Center, Brooklyn, New York, 11219, United States|NYU Langone Hospital - Brooklyn, Brooklyn, New York, 11220, United States|Mount Sinai Brooklyn, Brooklyn, New York, 11234, United States|New York City Health and Hospitals - Coney Island, Brooklyn, New York, 11235, United States|Kaleida Health System, Buffalo, New York, 14203, United States|Nassau University Medical Center, East Meadow, New York, 11554, United States|New York Presbyterian- Queens, Flushing, New York, 11355, United States|Glens Falls Hospital, Glens Falls, New York, 12801, United States|Queens Hospital Center, Jamaica, New York, 11432, United States|NYU Langone Health, New York, New York, 10016, United States|Hospital for Special Surgery, New York, New York, 10021, United States|New York City Health and New York City Health and Hospitals - Metropolitan- Metropolitan, New York, New York, 10029, United States|NewYork-Presyterian/Columbia University Irving Medical Center- Milstein Hospital, New York, New York, 10032, United States|New York City Health + Hospitals / Harlem, New York, New York, 10037, United States|New York Presbyterian Lower Manhattan Hospital, New York, New York, 10038, United States|Memorial Sloan-Kettering Cancer Center, New York, New York, 10065, United States|Mount Sinai South Nassau, Oceanside, New York, 11572, United States|Vassar Brothers Medical Center, Poughkeepsie, New York, 12601, United States|Rochester General Hospital, Rochester, New York, 14621, United States|St. Francis Hospital, Roslyn, New York, 11576, United States|Ellis Hospital, Schenectady, New York, 12308, United States|Staten Island University Hospital- Northwell Health (North Campus), Staten Island, New York, 10305, United States|Stony Brook University Hospital/ Stony Brook Children's, Stony Brook, New York, 11794, United States|Samaritan Hospital, Troy, New York, 12180, United States|UNC Hospitals, Chapel Hill, North Carolina, 27599, United States|Atrium Health- Carolinas Medical Center, Charlotte, North Carolina, 28209, United States|MetroHealth Medical Center, Cleveland, Ohio, 44109, United States|The Ohio State University College of Medicine, Columbus, Ohio, 43210, United States|Kettering Medical Center, Kettering, Ohio, 45429, United States|Saint Francis Hospital, Tulsa, Oklahoma, 74136, United States|St. Luke's Hospital - Bethlehem Campus, Bethlehem, Pennsylvania, 18015, United States|Mercy Catholic Medical Center - Fitzgerald Campus, Darby, Pennsylvania, 19023, United States|St Mary Medical Center, Langhorne, Pennsylvania, 18940, United States|Philadelphia VA Medical Center, Philadelphia, Pennsylvania, 19104, United States|Einstein Medical Center Philadelphia, Philadelphia, Pennsylvania, 19141, United States|Allegheny Health Network, Pittsburgh, Pennsylvania, 15212, United States|UPMC, Pittsburgh, Pennsylvania, 15213, United States|Roger Williams Medical Center, Providence, Rhode Island, 02908, United States|Kent Hospital, Warwick, Rhode Island, 02886, United States|St. Francis Hospital, Greenville, South Carolina, 29607, United States|Lexington Medical Center, West Columbia, South Carolina, 29169, United States|TriStar Centennial Medical Center, Nashville, Tennessee, 37203, United States|St. David's South Austin Medical Center, Austin, Texas, 78705, United States|Texas Health Presbyterian Hospital Dallas, Dallas, Texas, 75231, United States|Texas Department of Criminal Justice Hospital (Hospital Galveston)/University of Texas Medical Branch, Galveston, Texas, 77555-0435, United States|HCA Houston Healthcare West, Houston, Texas, 77082, United States|Covenant Medical Center, Lubbock, Texas, 79410, United States|Methodist Mansfield Medical Center, Mansfield, Texas, 76063, United States|Methodist Healthcare System of San Antonio, Ltd. LLP, dha, Methodist Hospital, San Antonio, Texas, 78229, United States|Saint Mark's Hospital, Salt Lake City, Utah, 84124, United States|Inova Fairfax Medical Campus, Falls Church, Virginia, 22042, United States|Henrico Doctors Hospital, Richmond, Virginia, 23229, United States|Carilion Medical Center, Roanoke, Virginia, 24014, United States|Overlake Hospital Medical Center, Bellevue, Washington, 98004, United States|University of Washington Medical Center- Montlake Campus, Seattle, Washington, 98195, United States|Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, United States|St. Vincent's Hospital Sydney, Darlinghurst, New South Wales, 2010, Australia|Royal Brisbane and Women's Hospital, Herston, Queensland, 4029, Australia|The Alfred Hospital, Melbourne, Victoria, 3004, Australia|The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia|Gold Coast Hospital, Southport, 4215, Australia|Landeskrankenhaus Graz West, Graz, 8020, Austria|Universit?tsklinik für Innere Medizin II, Innsbruck, 06020, Austria|Kepler Universit?tsklinikum, Linz, A-4020, Austria|Medical University and General Hospital Vienna, Vienna, Austria|Sozialmedizinisches Zentrum Süd - Kaiser-Franz-Josef-Spital, Wien, 1100, Austria|Centre Hospitalier Universitaire Saint Pierre, Brussels, 1000, Belgium|Ghent University Hospital, Ghent, 9000, Belgium|Jessa Ziekenhuis, Hasselt, 3500, Belgium|AZ Groeninge, Kortrijk, 8500, Belgium|Universitair Ziekenhuis Leuven, Leuven, 3000, Belgium|Centre Hospitalier Universitaire de Liège, Liège, 4000, Belgium|H?pital Civil Marie Curie, Lodelinsart, Belgium|William Osler Health System, Brampton, Ontario, L6R 3J7, Canada|The Ottowa Hospital, Ottawa, Ontario, K1H 8L6, Canada|Nicosia General Hospital, Nicosia, 2029, Cyprus|V?eobecná fakultní nemocnice v Praze, Prague, 12808, Czechia|Eticka komise pro multicentircke klinicke hodnoceni Fakultni nemocnice v Motole, Praha 5, 150 06, Czechia|Nemocnice Na Bulovce, Praha 8 - Liben, 180 81, Czechia|Rigshospitalet, Copenhagen, 2100, Denmark|P?hja-Eesti Regionaalhaigla, Tallinn, 13419, Estonia|Vilnius University, Tartu, 51014, Estonia|Hopital Avicenne, Bobigny, 93009, France|Centre Hospitalier Regional Universitaire Brest H?pital de la Cavale Blanche à Brest, Brest Cedex, 29609, France|Centre Hospitalier Universitaire Gabriel-Montpied, Clermont Ferrand, 63000, France|H?pitaux Civils de Colmar, Colmar, 68024, France|Centre Hospitalier Sud Francilien, Corbeil Essonnes, 91100, France|H?pital Raymond Poincaré, Garches, 92380, France|Centre Hospitalier Régional d'Orléans, Orléans, 45100, France|Centre Hospitalier Universitaire de Poitiers, Poitiers, 86021, France|H?pital Charles-Nicolle, Rouen, 76031, France|H?pital Purpan, Toulouse, 31300, France|Saint Josef Hospital Ruhr Universitaet Bochum, Bochum, 44791, Germany|Universit?tsklinikum Carl Gustav Carus Dresden, Dresden, 1307, Germany|Universitatsklinikum, Essen, 45147, Germany|Universit?tsklinikum Freiburg, Freiburg, 79106, Germany|Universit?tsmedizin G?ttingen, G?ttingen, 37075, Germany|Medizinische Hochschule Hannover, Hannover, 30625, Germany|Universit?tsklinikum Heidelberg, Heidelberg, 69120, Germany|Universit?tsklinikum des Saarlandes, Homburg, 66421, Germany|Caritas-Krankenhaus St. Josef, Regensburg, 93053, Germany|Klinikum Würzburg Mitte, Würzburg, 97074, Germany|University General Hospital of Patras Panagia I Voithia, Patra, 25404, Greece|General Hospital of Thessaloniki George Papanikolaou, Thessaloniki, 570 10, Greece|Kenézy Gyula Kórház és Rendel?intézet, Debrecen, H-4031, Hungary|Landspítali, Reykjavik, 101, Iceland|Kerry University Hospital, Tralee, Ireland|Shaare Zedek Medical Center, Jerusalem, 9103102, Israel|Hasharon Hospital, Petah Tikva, 49372, Israel|Sheba Medical Center at Tel Hashomer, Ramat Gan, 52621, Israel|Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona, Ancona, 60020, Italy|Azienda Universitaria Ospedaliera Consorziale - Policlinico di Bari, Bari, 70124, Italy|Azienda Ospedaliero Universitaria, Bologna, 40138, Italy|ASST Spedali Civili di Brescia, Brescia, 25123, Italy|Presidio Ospedaliero Garibaldi-Nesima, Catania, 95122, Italy|Azienda Ospedaliero - Universitaria Careggi, Florence, 50134, Italy|Ospedale Policlinico San Martino, Genova, 16132, Italy|Ospedale Maggiore Policlinico, Milano, 20122, Italy|Ospedale San Gerardo di Monza, Monza, 20900, Italy|Azienda Ospedaliera dei Colli, Napoli, 80131, Italy|Azienda Ospedaliero-Universitaria Pisana, Pisa, 56124, Italy|IRCCS Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Roma, 00149, Italy|Azienda Ospedaliero Universitaria, Turin, 10126, Italy|Hospital of Lithuanian University of Health Sciences Kauno klinikos, Kaunas, 50161, Lithuania|Vilnius University, Vilnius, 08661, Lithuania|Radboud Universitair Medisch Centrum, Nijmegen, 6525 GA, Netherlands|HagaZiekenhuis, The Hague, 2545 AA, Netherlands|Szpital Uniwersytecki w Krakowie, Krakow, 30-688, Poland|Wojewódzki Specjalistyczny Szpital im. dr. W?. Biegańskiego, Lodz, 91347, Poland|Wielospecjalistyczny Szpital Miejski Im Józefa Strusia Zak?ad Opiekuńczo Leczniczy, Poznan, 61-285, Poland|Wojewódzki Szpital Specjalistyczny Megrez Sp. z o.o., Tychy, 43-100, Poland|Centro Hospitalar Universitário de Lisboa Central - Hospital Curry Cabral, Lisboa, 1050-099, Portugal|Centro Hospitalar Universitário do Porto E.P.E., Porto, 4099-001, Portugal|Centro Hospitalar Universitário De S?o Jo?o, Porto, 4200-319, Portugal|Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, 4434-502, Portugal|Institutul National de Boli Infectioase Prof. Dr. Matei Bals, Bucharest, 21105, Romania|Spitalul Clinic de Boli Infec?ioase Sfanta Parascheva Ia?i, Iasi, RO-700116, Romania|Clinical hospital for infectious disease, Timisoara, RO-300310, Romania|Univerzitná Nemocnica L. Pasteura Ko?ice - Pracovisko Rastislavova 43, Ko?ice, 041 90, Slovakia|Univerzitetni Klinicni Center Ljubljana, Ljubljana, 1000, Slovenia|Univerzitetni Klinicni Center Maribor, Maribor, SI 2000, Slovenia|Hospital Universitari Germans Trias i Pujol, Badalona, 08916, Spain|Hospital General Universitario Gregorio Maranon, Madrid, 28007, Spain|Hospital Universitario Central de Asturias, Oviedo, 33011, Spain|Hospital Universitario Son Espases, Palma de Mallorca, 07120, Spain|Hospital Clinico Universitario de Salamanca, Salamanca, 37007, Spain|Hospital Universitario Donostia, San Sebastian, 20014, Spain|Hospital Virgen De La Salud, Santa Cruz de Tenerife, 38010, Spain|Hospital Virgen De La Salud, Toledo, 45004, Spain|Hospital Clinico Universitario de Valladolid, Valladolid, 47003, Spain|Hospital Universitario Miguel Servet, Zaragoza, 50009, Spain|Kantonsspital Aarau, Aarau, 5000, Switzerland|University Hospital Basel, Basel, 4051, Switzerland|Spitalzentrum Biel, Biel, 2502, Switzerland|Kantonsspital Graubünden, Chur, 7000, Switzerland|Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne, 1011, Switzerland|Luzerner Kantonsspital, Luzern, 6000, Switzerland|H?pital du Valais -H?pital de Sion, Sion, 1951, Switzerland|University Hospital of Wales, Cardiff and Vale NHS Trust, Cardiff, CF14 4XW, United Kingdom|Barts Health NHS Trust, London, E1 1FR, United Kingdom|Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, United Kingdom|St. George's Hospital, London, SW17 0QT, United Kingdom|Southampton University Hospital, Southampton, SO16 6YD, United Kingdom Less <<
NCT04728880 Pneumonia, Viral UNKNOWN 2021-05-30 Mansoura University Hospital, ... More >>Mansoura, Dakahliya, 35511, Egypt Less <<
NCT04669990 Covid19 UNKNOWN 2021-11-19 Narayani Hospital, Birgunj, Ne... More >>pal|Seti Provincial Hospital, Dhangadi, Nepal|BP Koirala Institute of Health Sciences (BPKIHS), Dharān Bāzār, Nepal|Bheri Provincial Hospital, Nepalgunj, Nepal Less <<
NCT04847622 Covid19 COMPLETED 2021-04-30 CHU de Nantes, Nantes, France|... More >>Hospital Lariboisiere, Paris, 75010, France|Hopital Saint-Louis, Paris, France|Tel Aviv Sourasky Medical Center, Tel Aviv, Israel|Erasmus Medical Center, Rotterdam, 3015, Netherlands|Hospital Germans Trias i Pujol, Barcelona, 08916, Spain|Hospital Clínic de Barcelona, Barcelona, Spain|Hospital Universitari Vall d'Herbon, Barcelona, Spain|Hospital Clinico Universitario San Carlos, Madrid, 28040, Spain|Hospital Universitario 12 de Octubre, Madrid, 28041, Spain|Royal Free Hospital, London, NW3 2QG, United Kingdom|Chelsea & Westminster Hospital, London, SW10 9NH, United Kingdom Less <<
NCT05911906 SARS-CoV-2 Infection|COVID-19 PHASE4 RECRUITING 2025-11-15 Derbyshire Community Health Se... More >>rvices NHS Foundation Trust, Chesterfield, S42 7JE, United Kingdom|Royal Derby Hospital (UHDB), Derby, D22 3NE, United Kingdom|University of Derby, Derby, DE22 1GB, United Kingdom|University of Exeter / Royal Devon University Healthcare NHS FT, Exeter, EX4 4PY, United Kingdom Less <<
NCT04560231 SARS-CoV Infection EARLY_PHASE1 UNKNOWN 2020-11-30 Muhammad Irfan Malik, Lahore, ... More >>Punjab, 54500, Pakistan Less <<
NCT04365725 COVID-19 COMPLETED 2020-06-12 H?pital Cochin, Paris, 75014, ... More >>France Less <<
NCT04385719 Ebola|HIV/AIDS PHASE2 COMPLETED 2021-07-16 Infectious Diseases Institute,... More >> Kampala, Uganda Less <<
NCT04302766 Coronavirus Disease 2019 NO_LONGER_AVAILABLE - Naval Medical Center San Diego... More >>, San Diego, California, 92134-5000, United States|Naval Hospital Jacksonville, Jacksonville, Florida, 32214-5005, United States|Benning Martin Army Community Hospital, Fort Benning, Georgia, 31905, United States|Eisenhower Army Medical Center, Fort Gordon, Georgia, 30905-5741, United States|Tripler Army Medical Center, Tripler AMC, Hawaii, 96859-5000, United States|Blanchfield Army Community Hospital, Fort Campbell North, Kentucky, 42223-5318, United States|Walter Reed National Military Medical Center, Bethesda, Maryland, 20889-0001, United States|Naval Medical Center Camp Lejeune, Camp Lejeune, North Carolina, 28547-2538, United States|Womack Army Medical Center, Fort Bragg, North Carolina, 28310-7324, United States|William Beaumont Army Medical Center, El Paso, Texas, 79920-5001, United States|Carl R. Darnall Army Medical Center, Fort Hood, Texas, 76544-5095, United States|Brooke Army Medical Center, Fort Sam Houston, Texas, 78234-4504, United States|Naval Medical Center Portsmouth, Portsmouth, Virginia, 23708-2197, United States|Madigan Army Medical Center, Tacoma, Washington, 98431-0001, United States|Craig Joint Theater Hospital, Bagrām, 09354, Afghanistan|NATO Role 3 Multinational Medical Unit Kandahar Air Field, Kandahar, Afghanistan|EMF Camp Lemonnier, Djibouti, Djibouti|Landstuhl Regional Medical Center, Landstuhl, APO Ae, 09180, Germany|US Naval Hospital Guam, Aga?a, 96910, Guam|Baghdad Diplomatic Support Center, Baghdad, 09305, Iraq|US Naval Hospital Okinawa, Okinawa, 904-0103, Japan|US Military Hospital Kuwait 411th Hospital Center, Kuwait, 09366-9998, Kuwait Less <<
NCT04854837 Covid19|End Stage Renal Failur... More >>e on Dialysis Less << COMPLETED 2022-09-30 Semmelweis University - Depart... More >>ment of Internal Medicine and Oncology, Budapest, 1083, Hungary Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.66mL

0.33mL

0.17mL

8.30mL

1.66mL

0.83mL

16.60mL

3.32mL

1.66mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories