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Chemical Structure| 18159-24-5 Chemical Structure| 18159-24-5

Structure of 18159-24-5

Chemical Structure| 18159-24-5

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Product Details of [ 18159-24-5 ]

CAS No. :18159-24-5
Formula : C12H11NO
M.W : 185.22
SMILES Code : O=CC1=CC=CN1CC2=CC=CC=C2
MDL No. :MFCD09674969

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Application In Synthesis of [ 18159-24-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18159-24-5 ]

[ 18159-24-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 18159-24-5 ]
  • [ 6882-68-4 ]
  • 14-(N-benzylpyrrol-2-ylmethylene)sophoridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
42% A 100mL round-bottomed flask was charged with <strong>[6882-68-4]sophoridine</strong> (1.24g, 5mmol), NaH (2.4g, 100mmol) and 50mL anhydrous tetrahydrofuran. The solution was stirred at room temperature for 1h and then N-substituted pyrrole-2-carboxyaldehyde 2 (2a-2u) (5mmol) was added followed by reflux for 48h. Reaction mixture was cooled and poured into water slowly (100mL). Reaction mixture was then extracted with dichloromethane (3×40mL). The organic phase was dried with anhydrous Na2SO4 and concentrated to give crude product. The residue was purified by silica gel flash column chromatography (methanol/dichloromethane, 1%) to afford 3a-3u in 23%-54% yields.
 

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