Alternatived Products of [ 184289-85-8 ]
Product Details of [ 184289-85-8 ]
CAS No. : | 184289-85-8 |
MDL No. : | MFCD22124870 |
Formula : |
C20H20N2O2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
320.39
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 184289-85-8 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 184289-85-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 184289-85-8 ]
- 1
-
[ 184289-85-8 ]
-
[ 167484-18-6 ]
- 2
-
[ 184289-85-8 ]
-
[ 159634-47-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 7 steps
1: NaBH4 / toluene / 0.5 h / -2 °C
2: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C
3: 93 percent / H2 / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr
4: DCC, HOBt / H2O; various solvent(s) / 5 h / Ambient temperature
5: MsOH / ethanol / 7.5 h / 35 - 40 °C
6: DCC, HOBt / various solvent(s) / 2 h / Ambient temperature
7: MsOH / ethanol / 35 - 40 °C |
|
Reference:
[1]Maligres, Peter E.; Houpis, Ioannis; Rossen, Kai; Molina, Audrey; Sager, Jess; Upadhyay, Veena; Wells, Kenneth M.; Reamer, Robert A.; Lynch, Joseph E.; Askin, David; Volante; Reider, Paul J.; Houghton, Peter
[Tetrahedron, 1997, vol. 53, # 32, p. 10983 - 10992]
- 3
-
[ 184289-85-8 ]
-
[ 159752-10-0 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 8 steps
1: NaBH4 / toluene / 0.5 h / -2 °C
2: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C
3: 93 percent / H2 / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr
4: DCC, HOBt / H2O; various solvent(s) / 5 h / Ambient temperature
5: MsOH / ethanol / 7.5 h / 35 - 40 °C
6: DCC, HOBt / various solvent(s) / 2 h / Ambient temperature
7: MsOH / ethanol / 35 - 40 °C
8: ethanol; ethyl acetate / 55 °C |
|
|
Multi-step reaction with 6 steps
1: sodium tetrahydroborate / methanol
2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran
3: palladium 10% on activated carbon; hydrogen / ethanol
4: benzotriazol-1-ol; dicyclohexyl-carbodiimide / Isopropyl acetate; water
5: benzotriazol-1-ol; dicyclohexyl-carbodiimide / Isopropyl acetate; water
6: ethanol |
|
Reference:
[1]Maligres, Peter E.; Houpis, Ioannis; Rossen, Kai; Molina, Audrey; Sager, Jess; Upadhyay, Veena; Wells, Kenneth M.; Reamer, Robert A.; Lynch, Joseph E.; Askin, David; Volante; Reider, Paul J.; Houghton, Peter
[Tetrahedron, 1997, vol. 53, # 32, p. 10983 - 10992]
[2]Qi, Xian Liang; Yang, Er Qun; Zhang, Jun Tao; Wang, Tao; Cao, Xiao Ping
[Chinese Chemical Letters, 2012, vol. 23, # 6, p. 661 - 664]
- 4
-
[ 7188-38-7 ]
-
[ 480-63-7 ]
-
[ 184289-85-8 ]
-
C35H41N3O4
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
70% |
In dichloromethane; at 20℃; for 24h; |
General procedure: Indolenine 3 (1 equiv) was dissolved in CH2Cl2 (1 M) followed bythe addition of the corresponding acid (1.05 equiv) and isocyanide(1.05 equiv). The reaction mixture was stirred for 24 h at r.t. Afterwards, CH2Cl2 was evaporated under vacuum to achievethe crude residue that was subjected to column chromatography(SiO2, CH2Cl2-EtOAc = 4:1) |