Alternatived Products of [ 186413-74-1 ]
Product Details of [ 186413-74-1 ]
CAS No. : | 186413-74-1 |
MDL No. : | MFCD09839284 |
Formula : |
C6H5BrN2O3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | OEBQKJOFOWLDME-UHFFFAOYSA-N |
M.W : |
233.02
|
Pubchem ID : | 10633371 |
Synonyms : |
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Safety of [ 186413-74-1 ]
Application In Synthesis of [ 186413-74-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 186413-74-1 ]
- Downstream synthetic route of [ 186413-74-1 ]
- 1
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[ 68957-50-6 ]
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[ 186413-74-1 ]
- 2
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[ 186413-74-1 ]
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[ 186413-75-2 ]
- 3
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[ 186413-74-1 ]
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[ 186413-79-6 ]
- 4
-
[ 186413-74-1 ]
-
[ 186413-76-3 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: 75 percent / POCl3, pyridine / chlorobenzene / 1 h / Heating
2: 90 percent / Et3N / 144 h / Heating |
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- 5
-
[ 186413-74-1 ]
-
[ 186413-82-1 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 4 steps
1: 75 percent / POCl3, pyridine / chlorobenzene / 1 h / Heating
2: 90 percent / Et3N / 144 h / Heating
3: 95 percent / H2 / 10percent Pd/C / ethanol / 760 Torr
4: 95 percent / Et3N / diethyl ether / 1 h / Ambient temperature |
|
- 6
-
[ 186413-74-1 ]
-
[ 186413-98-9 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 6 steps
1: 75 percent / POCl3, pyridine / chlorobenzene / 1 h / Heating
2: 90 percent / Et3N / 144 h / Heating
3: 95 percent / H2 / 10percent Pd/C / ethanol / 760 Torr
4: 95 percent / Et3N / diethyl ether / 1 h / Ambient temperature
5: 1.) n-BuLi, tetramethylethylenediamine, 2.) I2 / 1.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 45 min, 2.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 3 h
6: 80 percent / BBr3 / CH2Cl2 / 10 h / Ambient temperature |
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- 7
-
[ 186413-74-1 ]
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5-bromo-6-dibromomethyl-2-methoxy-3-nitropyridine
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1: 75 percent / POCl3, pyridine / chlorobenzene / 1 h / Heating
2: 90 percent / Et3N / 144 h / Heating
3: 10 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 168 h / Heating |
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- 8
-
[ 186413-74-1 ]
-
[ 186413-96-7 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 5 steps
1: 75 percent / POCl3, pyridine / chlorobenzene / 1 h / Heating
2: 90 percent / Et3N / 144 h / Heating
3: 95 percent / H2 / 10percent Pd/C / ethanol / 760 Torr
4: 95 percent / Et3N / diethyl ether / 1 h / Ambient temperature
5: 1.) n-BuLi, tetramethylethylenediamine, 2.) I2 / 1.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 45 min, 2.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 3 h |
|
- 9
-
[ 186413-74-1 ]
-
[ 186413-99-0 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 7 steps
1: 75 percent / POCl3, pyridine / chlorobenzene / 1 h / Heating
2: 90 percent / Et3N / 144 h / Heating
3: 95 percent / H2 / 10percent Pd/C / ethanol / 760 Torr
4: 95 percent / Et3N / diethyl ether / 1 h / Ambient temperature
5: 1.) n-BuLi, tetramethylethylenediamine, 2.) I2 / 1.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 45 min, 2.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 3 h
6: 80 percent / BBr3 / CH2Cl2 / 10 h / Ambient temperature
7: 91 percent / pyridine / 25 h / Ambient temperature |
|
- 10
-
[ 186413-74-1 ]
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Diethyl-carbamic acid 6-[3-(2,2-dimethyl-propionylamino)-6-methyl-2-quinolin-2-yl-pyridin-4-yl]-2,3-dimethoxy-phenyl ester
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 9 steps
1: 75 percent / POCl3, pyridine / chlorobenzene / 1 h / Heating
2: 90 percent / Et3N / 144 h / Heating
3: 95 percent / H2 / 10percent Pd/C / ethanol / 760 Torr
4: 95 percent / Et3N / diethyl ether / 1 h / Ambient temperature
5: 1.) n-BuLi, tetramethylethylenediamine, 2.) I2 / 1.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 45 min, 2.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 3 h
6: 80 percent / BBr3 / CH2Cl2 / 10 h / Ambient temperature
7: 91 percent / pyridine / 25 h / Ambient temperature
8: 85 percent / K2CO3, Pd(PPh3)4 / toluene; ethanol / 2 h / 110 °C
9: 45 percent / LiCl, CuBr2, Pd(PPh3)4 / dioxane / 48 h / Heating |
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- 11
-
[ 186413-74-1 ]
-
[ 186414-01-7 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 8 steps
1: 75 percent / POCl3, pyridine / chlorobenzene / 1 h / Heating
2: 90 percent / Et3N / 144 h / Heating
3: 95 percent / H2 / 10percent Pd/C / ethanol / 760 Torr
4: 95 percent / Et3N / diethyl ether / 1 h / Ambient temperature
5: 1.) n-BuLi, tetramethylethylenediamine, 2.) I2 / 1.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 45 min, 2.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 3 h
6: 80 percent / BBr3 / CH2Cl2 / 10 h / Ambient temperature
7: 91 percent / pyridine / 25 h / Ambient temperature
8: 85 percent / K2CO3, Pd(PPh3)4 / toluene; ethanol / 2 h / 110 °C |
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