[ CAS No. 186593-42-0 ] {[proInfo.proName]}

Name: 186593-42-0|3-Bromo-2-methyl-5-nitropyridine|98%
Brand: Ambeed
SKU: A112374
Price: 10.0 USD
Availability: InStock
Rating: 92 (35 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 186593-42-0

Structure of 186593-42-0 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 186593-42-0 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 186593-42-0 ]

SDS Specification

Alternatived Products of [ 186593-42-0 ]

Product Details of [ 186593-42-0 ]

CAS No. :	186593-42-0	MDL No. :	MFCD08688606
Formula :	C₆H₅BrN₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	QWAOQTGMEGSRLN-UHFFFAOYSA-N
M.W :	217.02	Pubchem ID :	18458822
Synonyms :

Calculated chemistry of [ 186593-42-0 ]

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.17
Num. rotatable bonds :	1
Num. H-bond acceptors :	3.0
Num. H-bond donors :	0.0
Molar Refractivity :	45.73
TPSA :	58.71 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.37 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.51
Log Po/w (XLOGP3) :	1.77
Log Po/w (WLOGP) :	2.06
Log Po/w (MLOGP) :	1.2
Log Po/w (SILICOS-IT) :	0.34
Consensus Log Po/w :	1.38

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.64
Solubility :	0.499 mg/ml ; 0.0023 mol/l
Class :	Soluble
Log S (Ali) :	-2.62
Solubility :	0.52 mg/ml ; 0.00239 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.65
Solubility :	0.484 mg/ml ; 0.00223 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	2.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.01

Safety of [ 186593-42-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 186593-42-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 186593-42-0 ]
Downstream synthetic route of [ 186593-42-0 ]

[ 186593-42-0 ] Synthesis Path-Upstream 1~9

1
[ 186593-42-0 ]
[ 186593-43-1 ]

Reference： [1] Journal of the American Chemical Society, 2016, vol. 138, # 34, p. 10730 - 10733
[2] Patent: US9604978, 2017, B2, . Location in patent: Page/Page column 255

2
[ 186593-42-0 ]
[ 7439-89-6 ]
[ 186593-43-1 ]

Reference： [1] Patent: US6133253, 2000, A,

3
[ 5470-17-7 ]
[ 105-53-3 ]
[ 186593-42-0 ]

Yield	Reaction Conditions	Operation in experiment
81%	Stage #1: With sodium hydride In diethyl ether at 15℃; for 0.0833333 h; Stage #2: at 26 - 114℃; for 1.5 h; Stage #3: With sulfuric acid In water for 8 h; Heating / reflux	Step 3: To a cooled (15° C.) solution of diethyl malonate (8.8 mL; 58 mmol) in diethyl ether (110 mL) was added NaH (as a 60percent dispersion in oil; 2.32 g; 58 mmol) over 5 min and 3-bromo-2-chloro-5-nitropyridine (12.5 g; 52.6 mmol) in four portions over 15 min (an exotherm to 26° C. was observed), followed by removal of diethyl ether in vacuo to give a red oil. After stirring the resulting red oil at 114° C. for 1 h 15 min, H₂SO₄(6M, 67 mL) was added. The resulting mixture was heated at reflux for 8 h then cooled to 0° C. and the pH value was adjusted to 7 with 25percent KOH aqueous solution (135 mL). The resulting mixture was stirred in an ice bath for 25 min and the crude product was collected and washed with water (50 mL) by filtration. The crude product was stirred in CH₂Cl₂(350 mL) for 30 min and the impurity was removed by filtration. The organic layer was dried over Na₂SO₄, filtered and concentrated to give 11.1 g of the impure product as red oil. The red oil was dissolved in CH₂Cl₂(100 mL) and hexanes (200 mL). The resulting mixture was filtered and the organic portion was concentrated to give 9.3 g of 3-bromo-2-methyl-5-nitropyridine as an orange crystalline solid (81percent yield). ¹H NMR (CDCl₃) δ 9.25 (d, J=2.3 Hz, 1H), 8.61 (d, J=2.3 Hz, 1H), 2.80 (s, 3H).
81%	Stage #1: With sodium hydride In diethyl ether at 15℃; for 0.0833333 h; Stage #2: at 26 - 114℃; for 1.5 h; Stage #3: With sulfuric acid In diethyl ether; water for 8 h; Heating / reflux	To a cooled (15° C.) solution of diethyl malonate (8.8 mL, 58.0 mmol) in diethyl ether (110 mL) was added NaH (60percent dispersion in oil, 2.32 g, 58.0 mmol) over 5 min and 3-bromo-2-chloro-5-nitropyridine (12.5 g, 52.6 mmol) in four portions over 15 min (an exotherm to 26° C. was observed), followed by removal of diethyl ether in vacuo to give a red oil. After stirring the resulting red oil at 114° C. for 1 h 15 min, H₂SO₄(6M, 67.0 mL) was added. The resulting mixture was heated at reflux for 8 h then cooled to 0° C. and the pH value was adjusted to 7 with 25percent KOH aqueous solution (135 mL). The resulting mixture was stirred in an ice bath for 25 min and the crude product was collected and washed with water (50 mL) by filtration. The crude product was stirred in CH₂Cl₂(350 mL) for 30 min and the impurity was removed by filtration. The organic layer was dried over Na₂SO₄, filtered and concentrated to give the impure product as red oil (11.1 g). The red oil was dissolved in CH₂Cl₂(100 mL) and hexanes (200 mL). The resulting mixture was filtered and the organic portion was concentrated in vacuo to give 3-bromo-2-methyl-5-nitropyridine as an orange crystalline solid (9.30 g, 81percent yield). ¹H NMR (CDCl₃) δ 9.25 (d, J=2.3 Hz, 1H), 8.61 (d, J=2.3 Hz, 1H), 2.80 (s, 3H).
81%	Stage #1: With sodium hydride In diethyl ether at 15℃; for 0.0833333 h; Stage #2: at 26 - 114℃; for 1.5 h; Stage #3: With sulfuric acid In water for 8 h; Heating / reflux	Step 3: To a cooled (15° C.) solution of diethyl malonate (8.8 mL, 58 mmol) in diethyl ether (110 mL) was added NaH (as a 60percent dispersion in oil, 2.32 g, 58 mmol) over 5 min and 3-bromo-2-chloro-5-nitropyridine (12.5 g, 52.6 mmol) was added in four portions over ~15 min (an exotherm to 26° C. was observed), followed by removal of diethyl ether in vacuo to give a red oil. After stirring the resulting red oil at 114° C. for 1 h 15 min, H₂SO₄ (6M, 67 mL) was added. The resulting mixture was heated at reflux for 8 h then cooled to 0° C. and the pH value was adjusted to 7 with 25percent KOH aqueous solution (135 mL). The resulting mixture was stirred in an ice bath for 25 min and the crude product was collected and washed with water (50 mL) by filtration. The crude product was stirred in CH₂Cl₂ (350 mL) for 30 min and the impurity was removed by filtration. The organic layer was dried over Na₂SO₄, filtered and concentrated to give 11.1 g of the impure product as red oil. The red oil was dissolved in CH₂Cl₂ (100 mL) and hexanes (200 mL). The resulting mixture was filtered and the organic portion was concentrated to give 9.3 g of 3-bromo-2-methyl-5-nitropyridine as an orange crystalline solid (81percent yield). ¹H NMR (CDCl₃) δ 9.25 (d, J=2.3 Hz, 1H), 8.61 (d, J=2.3 Hz, 1H), 2.80 (s, 3H).

81%	Stage #1: With sodium hydride In diethyl ether at 15 - 114℃; for 1.58333 h; Stage #2: With sulfuric acid In water	To a cooled (15° C.) solution of diethyl malonate (8.8 mL; 58.0 mmol) in diethyl ether (110 mL) was added NaH (as a 60percent dispersion in oil; 2.32 g; 58.0 mmol) over 5 min and 3-bromo-2-chloro-5-nitropyridine (12.5 g; 52.6 mmol) in four portions over 15 min (an exotherm to 26° C. was observed), followed by removal of diethyl ether in vacuo to give a red oil. After stirring the resulting red oil at 114° C. for 1 h 15 min, H₂SO₄(6M, 67.0 mL) was added. The resulting mixture was heated at reflux for 8 h then cooled to 0° C. and the pH value was adjusted to 7 with 25percent KOH aqueous solution (135 mL). The resulting mixture was stirred in an ice bath for 25 min and the crude product was collected and washed with water (50 mL) by filtration. The crude product was stirred in CH₂Cl₂(350 mL) for 30 min and the impurity was removed by filtration. The organic layer was dried over Na₂SO₄, filtered and concentrated to give 11.1 g of the impure product as red oil. The red oil was dissolved in CH₂Cl₂(100 mL) and hexanes (200 mL). The resulting mixture was filtered and the organic portion was concentrated to give 9.30 g of 3-bromo-2-methyl-5-nitropyridine as an orange crystalline solid (81percent). ¹H NMR (CDCl₃) δ 9.25 (d, J=2.3Hz, 1H), 8.61 (d, J=2.3Hz, 1H), 2.80 (s, 3H).
0.65 mg	Stage #1: With sodium hydroxide In diethyl ether for 0.0833333 h; Stage #2: With sulfuric acid In diethyl ether for 8 h; Reflux	intothe mixture of Diethyl ether (30 ml) solution having diethyl Malonate (5 mmol)was added into the Sodium hydroxide (5 mmol)and stirred for 5mins. Again slowlyadded 3-bromo-2-cholro - 5- Nitropyridine (4.2mmol)and after stirring for 5 min the solvent was removed to give ared oily compound. At 114 ° C the oily mixture was stirred for 1.5 hours, 6Msulfuric acid (5.8 ml) and at reflux stirred for 8 hours. After cooling to 0 °C, with 25percent aqueous potassium hydroxide solution adjusted pH to 7 .theresulting precipitate was collected by filtration then it was washed with water and dried to give 0.65 g ofthe title compound

Reference： [1] Patent: US2006/79522, 2006, A1, . Location in patent: Page/Page column 8; 13
[2] Patent: US2006/79523, 2006, A1, . Location in patent: Page/Page column 9; 13-14
[3] Patent: US2006/79524, 2006, A1, . Location in patent: Page/Page column 13
[4] Patent: US2006/79683, 2006, A1, . Location in patent: Page/Page column 8; 12
[5] Patent: CN103130792, 2016, B, . Location in patent: Paragraph 0722-0724

4
[ 5418-51-9 ]
[ 5470-17-7 ]
[ 7664-93-9 ]
[ 105-53-3 ]
[ 186593-42-0 ]

Reference： [1] Patent: US6133253, 2000, A,

5
[ 5470-17-7 ]
[ 28290-06-4 ]
[ 186593-42-0 ]

Reference： [1] Patent: US6127386, 2000, A,
[2] Patent: US6437138, 2002, B1,

6
[ 15862-33-6 ]
[ 186593-42-0 ]

Reference： [1] Patent: CN103130792, 2016, B,
[2] Patent: US9604978, 2017, B2,

7
[ 5418-51-9 ]
[ 186593-42-0 ]

Reference： [1] Patent: CN103130792, 2016, B,
[2] Patent: US9604978, 2017, B2,

8
[ 5470-17-7 ]
[ 186593-42-0 ]

Reference： [1] Patent: WO2017/151489, 2017, A1,

9
[ 15862-36-9 ]
[ 186593-42-0 ]

Reference： [1] Patent: US9604978, 2017, B2,

[ 186593-42-0 ] Synthesis Path-Downstream 1~15

1
[ 186593-42-0 ]
[ 208399-66-0 ]
3-(4-methoxyphenyl)-2-methyl-5-nitropyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate;PdCl2(PPh2(CH2)4PPh2); In N,N-dimethyl-formamide; toluene; at 150℃; for 0.166667h;Microwave irradiation;	Route B: Via cross-coupling of L2-Q to the protected core template.[00434] 3-(4-Methoxyphenyl)2-methyl-5-nitropyridine.; A mixture of 2-methyl-3- bromo-5-nitropyridine (115.3 mg, 0.5 mmol), 2-methyl-4-methoxyphenyl-boronic acid (91.2 mg, 0.5 mmol), Pd(dppb)Cl2 (16.3 mg, 0.03 mmol) and K2CO3 (359 mg, 2.6 mmol) in toluene/DMF (4 ml, 9:1) was heated at 1500C for 10 min under microwave irradiation. The mixture was filtered (celite), the solids were washed with DCM and the filtrate was concentrated. The residue was chromatographed on silica gel using Hex/EtOAc (gradient: 0 to 80% EtOAc) as eluents to afford the target compound. 1H-NMR (500 MHz, CD3OD) delta (ppm) 9.27 (d, J= 2.59 Hz, IH), 8.28 (d, J= 2.62 Hz, IH), 7.09 (d5 J= 8.37 Hz, IH), 6.94 (d, J= 2.56 Hz, IH), 6.89 (dd, J= 2.64 and 8.00 Hz, IH), 3.85 (s, 3H), 2.41 (s, 3H), 2.07 (s, 3H).

Reference： [1]Patent: WO2008/21388,2008,A1 .Location in patent: Page/Page column 186

2
[ 186593-42-0 ]
[ 99768-12-4 ]
[ 1008138-81-5 ]

Yield	Reaction Conditions	Operation in experiment
61%	With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; ethanol; toluene; at 90℃; for 7h;Product distribution / selectivity;	Methyl 4-(2-methyI-5-nitropyridin-3-yl)benzoate.; Method A. In a 40 ml vial with a magnetic stir bar were placed 4-carboxymethylphenyl boronic acid (414 mg, 2.30 mmol), <strong>[186593-42-0]3-bromo-2-methyl-5-nitropyridine</strong> (500 mg, 2.30 mmol) and tetraks(triphenylphosphine) palladium(O) (664 mg, 0.58 mmol). Dimethoxyethane (18 ml), toluene (2 ml) and EtOH (2 ml) were added, and the solution was sonicated until the solids were dissolved. A 2M Na2COs solution (3.6 ml) was added while stirring rapidly under N2. The vial was capped and stirred at 900C for 7 h. The solvents were removed in vacuo and the residue was partitioned between H2O and DCM. The organic layer was extracted with DCM and dried over Na2SO4. The solvents were removed and the residue was purified on silica gel chromatography eluting with 0-50% EtOAc/Hex to afford 381 mg (61% yield) of methyl 4- (2-methyl-5-nitropyridin-3-yl)benzoate. (CaIc. mass: 272, obs. mass: 314 (M + AcN)+).
	With potassium carbonate;PdCl2(PPh2(CH2)4PPh2); In N,N-dimethyl-formamide; toluene; at 135℃; for 5h;Product distribution / selectivity;	Method B. A mixture of <strong>[186593-42-0]3-bromo-2-methyl-5-nitropyridine</strong> (100 mg, 0.5 mmol), 4-carboxymethylphenyl boronic acid (90 mg. 0.5 mmbl), Pd(dppb)Cl2 (10 mol%) and K2CO3 (3 eq.) in toluene/DMF (2 ml, 9:1) was heated at 1350C for 5 hr under microwave irradiation. The mixture was filtered (celite), the solids were washed with DCM and the filtrate was concentrated. The residue was chromato graphed on silica gel, eluting with EtOAc/Hex (gradient: 0-50%) to afford the target compound. (CaIc. mass: 272, obs. mass: 314 (M + AcN)+).

Reference： [1]Patent: WO2008/21388,2008,A1 .Location in patent: Page/Page column 187
[2]Patent: WO2008/21388,2008,A1 .Location in patent: Page/Page column 187-188

3
[ 186593-42-0 ]
[ 1008138-90-6 ]
[ 1008138-91-7 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; ethanol; at 80℃; for 24h;	4-(2-Methyl-5-nitropyridin-3-yl)-N-neopentyIbenzenesulfonamide. The compound obtained above (30 mg, 0.085 mmol), 3-bromo-5-nitro-2-methylpyridine (1.0 eq., 18 mg), K2CO3 (3 eq., 35 mg) and Pd(PPh3)4 (10 mol %, 10 mg) were dissolved in 3 ml DMErEtOH (9: 1). The solution was stirred at 800C for 24 hr under nitrogen. The mixture was concentrated in vacuo. Column chromatography (SiOa; 3:1 Hex: EtOAc) yielded 20 mg of the target compound. (CaIc. mass: 364, obs. mass 364).

Reference： [1]Patent: WO2008/21388,2008,A1 .Location in patent: Page/Page column 193-194

4
[ 5470-17-7 ]
[ 105-53-3 ]
[ 186593-42-0 ]

Yield	Reaction Conditions	Operation in experiment
81%		Step 3: To a cooled (15 C.) solution of diethyl malonate (8.8 mL; 58 mmol) in diethyl ether (110 mL) was added NaH (as a 60% dispersion in oil; 2.32 g; 58 mmol) over 5 min and <strong>[5470-17-7]3-bromo-2-chloro-5-nitropyridine</strong> (12.5 g; 52.6 mmol) in four portions over 15 min (an exotherm to 26 C. was observed), followed by removal of diethyl ether in vacuo to give a red oil. After stirring the resulting red oil at 114 C. for 1 h 15 min, H2SO4 (6M, 67 mL) was added. The resulting mixture was heated at reflux for 8 h then cooled to 0 C. and the pH value was adjusted to 7 with 25% KOH aqueous solution (135 mL). The resulting mixture was stirred in an ice bath for 25 min and the crude product was collected and washed with water (50 mL) by filtration. The crude product was stirred in CH2Cl2 (350 mL) for 30 min and the impurity was removed by filtration. The organic layer was dried over Na2SO4, filtered and concentrated to give 11.1 g of the impure product as red oil. The red oil was dissolved in CH2Cl2 (100 mL) and hexanes (200 mL). The resulting mixture was filtered and the organic portion was concentrated to give 9.3 g of 3-bromo-2-methyl-5-nitropyridine as an orange crystalline solid (81% yield). 1H NMR (CDCl3) delta 9.25 (d, J=2.3 Hz, 1H), 8.61 (d, J=2.3 Hz, 1H), 2.80 (s, 3H).
81%		To a cooled (15 C.) solution of diethyl malonate (8.8 mL, 58.0 mmol) in diethyl ether (110 mL) was added NaH (60% dispersion in oil, 2.32 g, 58.0 mmol) over 5 min and <strong>[5470-17-7]3-bromo-2-chloro-5-nitropyridine</strong> (12.5 g, 52.6 mmol) in four portions over 15 min (an exotherm to 26 C. was observed), followed by removal of diethyl ether in vacuo to give a red oil. After stirring the resulting red oil at 114 C. for 1 h 15 min, H2SO4 (6M, 67.0 mL) was added. The resulting mixture was heated at reflux for 8 h then cooled to 0 C. and the pH value was adjusted to 7 with 25% KOH aqueous solution (135 mL). The resulting mixture was stirred in an ice bath for 25 min and the crude product was collected and washed with water (50 mL) by filtration. The crude product was stirred in CH2Cl2 (350 mL) for 30 min and the impurity was removed by filtration. The organic layer was dried over Na2SO4, filtered and concentrated to give the impure product as red oil (11.1 g). The red oil was dissolved in CH2Cl2 (100 mL) and hexanes (200 mL). The resulting mixture was filtered and the organic portion was concentrated in vacuo to give 3-bromo-2-methyl-5-nitropyridine as an orange crystalline solid (9.30 g, 81% yield). 1H NMR (CDCl3) delta 9.25 (d, J=2.3 Hz, 1H), 8.61 (d, J=2.3 Hz, 1H), 2.80 (s, 3H).
81%		Step 3: To a cooled (15 C.) solution of diethyl malonate (8.8 mL, 58 mmol) in diethyl ether (110 mL) was added NaH (as a 60% dispersion in oil, 2.32 g, 58 mmol) over 5 min and <strong>[5470-17-7]3-bromo-2-chloro-5-nitropyridine</strong> (12.5 g, 52.6 mmol) was added in four portions over ~15 min (an exotherm to 26 C. was observed), followed by removal of diethyl ether in vacuo to give a red oil. After stirring the resulting red oil at 114 C. for 1 h 15 min, H2SO4 (6M, 67 mL) was added. The resulting mixture was heated at reflux for 8 h then cooled to 0 C. and the pH value was adjusted to 7 with 25% KOH aqueous solution (135 mL). The resulting mixture was stirred in an ice bath for 25 min and the crude product was collected and washed with water (50 mL) by filtration. The crude product was stirred in CH2Cl2 (350 mL) for 30 min and the impurity was removed by filtration. The organic layer was dried over Na2SO4, filtered and concentrated to give 11.1 g of the impure product as red oil. The red oil was dissolved in CH2Cl2 (100 mL) and hexanes (200 mL). The resulting mixture was filtered and the organic portion was concentrated to give 9.3 g of 3-bromo-2-methyl-5-nitropyridine as an orange crystalline solid (81% yield). 1H NMR (CDCl3) delta 9.25 (d, J=2.3 Hz, 1H), 8.61 (d, J=2.3 Hz, 1H), 2.80 (s, 3H).

81%		To a cooled (15 C.) solution of diethyl malonate (8.8 mL; 58.0 mmol) in diethyl ether (110 mL) was added NaH (as a 60% dispersion in oil; 2.32 g; 58.0 mmol) over 5 min and <strong>[5470-17-7]3-bromo-2-chloro-5-nitropyridine</strong> (12.5 g; 52.6 mmol) in four portions over 15 min (an exotherm to 26 C. was observed), followed by removal of diethyl ether in vacuo to give a red oil. After stirring the resulting red oil at 114 C. for 1 h 15 min, H2SO4 (6M, 67.0 mL) was added. The resulting mixture was heated at reflux for 8 h then cooled to 0 C. and the pH value was adjusted to 7 with 25% KOH aqueous solution (135 mL). The resulting mixture was stirred in an ice bath for 25 min and the crude product was collected and washed with water (50 mL) by filtration. The crude product was stirred in CH2Cl2 (350 mL) for 30 min and the impurity was removed by filtration. The organic layer was dried over Na2SO4, filtered and concentrated to give 11.1 g of the impure product as red oil. The red oil was dissolved in CH2Cl2 (100 mL) and hexanes (200 mL). The resulting mixture was filtered and the organic portion was concentrated to give 9.30 g of 3-bromo-2-methyl-5-nitropyridine as an orange crystalline solid (81%). 1H NMR (CDCl3) delta 9.25 (d, J=2.3Hz, 1H), 8.61 (d, J=2.3Hz, 1H), 2.80 (s, 3H).
0.65 mg		intothe mixture of Diethyl ether (30 ml) solution having diethyl Malonate (5 mmol)was added into the Sodium hydroxide (5 mmol)and stirred for 5mins. Again slowlyadded 3-bromo-2-cholro - 5- Nitropyridine (4.2mmol)and after stirring for 5 min the solvent was removed to give ared oily compound. At 114 C the oily mixture was stirred for 1.5 hours, 6Msulfuric acid (5.8 ml) and at reflux stirred for 8 hours. After cooling to 0 C, with 25% aqueous potassium hydroxide solution adjusted pH to 7 .theresulting precipitate was collected by filtration then it was washed with water and dried to give 0.65 g ofthe title compound

Reference： [1]Patent: US2006/79522,2006,A1 .Location in patent: Page/Page column 8; 13
[2]Patent: US2006/79523,2006,A1 .Location in patent: Page/Page column 9; 13-14
[3]Patent: US2006/79524,2006,A1 .Location in patent: Page/Page column 13
[4]Patent: US2006/79683,2006,A1 .Location in patent: Page/Page column 8; 12
[5]Patent: CN103130792,2016,B .Location in patent: Paragraph 0722-0724

5
[ 5470-17-7 ]
[ 186593-42-0 ]

Reference： [1]Patent: WO2017/151489,2017,A1

6
[ 5470-17-7 ]
[ 28290-06-4 ]
[ 186593-42-0 ]

Yield	Reaction Conditions	Operation in experiment
17.1 g (78.8 mmol, 75%)		196a. 3-Bromo-2-methyl-5-nitropyridine <strong>[5470-17-7]3-Bromo-2-chloro-5-nitropyridine</strong> (25 g, 105 mmol; prepared from 2-hydroxy-5-nitropyridine according to the procedure of V. Koch and S. Schnatterer, Synthesis 1990, 499-501) was treated with the sodium salt of diethylmalonate (17.6 mL, 116 mmol) according to the procedure of Odashima et al Bull Chem Soc Jpn 1993, 66, 797-803) to provide 17.1 g (78.8 mmol, 75%) of dark red oil: TLC Rf 0.5 (4:1 hexanes/EtOAc); 1 H NMR (CDCl3, 300 MHz) delta 2.81 (s, 3H), 8.61 (d, 1H, J=2.0 Hz), 9.26 (d, 1H, J=2.0 Hz).
17.1 g (78.8 mmol, 75%)		196a. 3-Bromo-2-methyl-5-nitropyridine <strong>[5470-17-7]3-Bromo-2-chloro-5-nitropyridine</strong> (25 g, 105 mmol; prepared from 2-hydroxy-5-nitropyridine according to the procedure of V. Koch and S. Schnatterer, Synthesis 1990, 499-501) was treated with the sodium salt of diethylmalonate (17.6 mL, 116 mmol) according to the procedure of Odashima et al Bull Chem Soc Jpn 1993, 66, 797-803) to provide 17.1 g (78.8 mmol, 75%) of dark red oil: TLC Rf 0.5 (4:1 hexanes/EtOAc); 1H NMR (CDCl3, 300 MHz) delta: 2.81 (s, 3H), 8.61 (d, 1H, J=2.0 Hz), 9.26 (d, 1H, J=2.0 Hz).

Reference： [1]Patent: US6127386,2000,A
[2]Patent: US6437138,2002,B1

7
[ 186593-42-0 ]
[ 7439-89-6 ]
[ 186593-43-1 ]

Yield	Reaction Conditions	Operation in experiment
12.65 g (86%)	In water; acetic acid;	34c. 5-amino-3-bromo-2-methylpyridine The compound of Example 34b above (17.1 g, 78.8 mmol) was dissolved in HOAc (50 mL) and water (150 mL) and treated with iron powder (13.3 g, 236 mmol) added in portions over 2 hours. The mixture was filtered, and the filter cake was washed with EtOAc. The layers were separated, and the aqueous phase was extracted with EtOAc. The combined organic fractions were washed with 1 M sodium bicarbonate and water, then dried (MgSO4) and concentrated to afford 12.65 g (86%) of the title compound: MS (CI/NH3) m/z: 187 (M+H)+, 204 (M+NH4)+.

Reference： [1]Patent: US6133253,2000,A

8
[ 186593-42-0 ]
[ 66521-66-2 ]
2-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino-5-nitropyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene;tris-(dibenzylideneacetone)dipalladium(0); In toluene; at 90℃; for 16h;Inert atmosphere;	EXAMPLE 1:4-((4-ethylpiperazin-l-yl)methyl)-N-(6-methyl-5-(4-(pyridin-3-yl)pyrimidin-2- ylamino)pyridin-3-yl)benzamide(a) (2-Methyl-5-nitro-pyridin-3-yl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine[0121] To a mixture of 3-bromo-2-methyl-5-nitro-pyridine (380mg, 1.75mmol) and 4-pyridin-3-yl-pyrimidin-2-ylamine (250mg, 1.45mmol) in dry toluene (2OmL) were added Cs2CO3 (710mg, 2.18mmol), Pd2(dba)3 (26mg, 0.028mmol) and Xantphos (50mg, 0.086mmol). The mixture was evacuated and purged with N2 (3 cycles), heated to 9O0C under N2 for 16h. After completion (monitored by TLC), the reaction mixture was cooled to rt, diluted with EtOAc and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (SiO2) using CH2Cl2-MeOH (98:2) to afford product (225mg, 50percent). 1H NMR (200 MHz, CDCl3): delta 2.76 (s, 3H), 7.23 (m, IH), 7.38 (d, J= 6.0 Hz, IH), 7.51 (m, IH), 8.51 (m, IH), 8.63 ( d, J= 6.0 Hz, IH), 8.77 (m, IH), 9.04 (d, J= 2.0 Hz, IH), 9.28 (d, J= 2.0 Hz, IH), 9.77 (d, J= 2.0 Hz, IH); Mass [M+H]+: 309.

Reference： [1]Patent: WO2008/153974,2008,A1 .Location in patent: Page/Page column 30

9
[ 186593-42-0 ]
[ 186593-43-1 ]

Yield	Reaction Conditions	Operation in experiment
	With iron; ammonium chloride; In methanol; at 90℃; for 1h;	Into a 1000 ml 3-necked round bottom flask, was placed 3-bromo-2-methyl-5-nitropyridine (4 g, 17.59 mmol, 1.00 equiv, 95%). To this was added NH4Cl (5 g). Addition of MeOH (200 ml) was next. To the mixture was added Fe (2 g). The resulting solution was allowed to react, with stirring, for 1 hour while the temperature was maintained at 90 C.. The reaction progress was monitored by TLC (EtOAc/PE=1:1). A filtration was performed. The filtrate was concentrated by evaporation under vacuum using a rotary evaporator. The residue was purified by eluting through a column with a 1:3 EtOAc/PE solvent system. This resulted in 3.6 g (99%) of 5-bromo-6-methylpyridin-3-amine as a Yellow solid.

Reference： [1]Journal of the American Chemical Society,2016,vol. 138,p. 10730 - 10733
[2]Patent: US9604978,2017,B2 .Location in patent: Page/Page column 255

10
[ 186593-42-0 ]
[ 186593-45-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: iron; ammonium chloride / methanol / Reflux 2.1: sodium nitrite; tetrafluoroboric acid / water / 1.5 h / 0 °C 2.2: 100 °C
	Multi-step reaction with 3 steps 1.1: ammonium chloride; iron / methanol / 1 h / 90 °C 2.1: sodium nitrite; tetrafluoroboric acid / water / 1 h / 0 °C 2.2: 1 h / 80 °C 3.1: sodium hydroxide; water / 20 °C
	Multi-step reaction with 3 steps 1: water; acetic acid 2: BF_3.OEt₂; acetic anhydride 3: sodium hydroxide / ethyl acetate

Multi-step reaction with 2 steps 1: iron; ammonium chloride / water; methanol / 2 h / 90 °C 2: sodium nitrite; fluoroboric acid / water / 13 h / 0 - 100 °C

Reference： [1]Liu, Yong Ethan; Lu, Zhaole; Li, Bo; Tian, Jiaxin; Liu, Feng; Zhao, Junyu; Hou, Chengkang; Li, Yingkun; Niu, Lili; Zhao, Baoguo [Journal of the American Chemical Society, 2016, vol. 138, # 34, p. 10730 - 10733]
[2]Current Patent Assignee: PRCL RESEARCH - US9604978, 2017, B2
[3]Current Patent Assignee: ABBVIE INC - US6133253, 2000, A
[4]Current Patent Assignee: FULCRUM THERAPEUTICS, INC - WO2020/190754, 2020, A1

11
[ 15862-33-6 ]
[ 186593-42-0 ]

Reference： [1]Patent: US9604978,2017,B2
[2]Patent: CN103130792,2016,B

12
[ 15862-36-9 ]
[ 186593-42-0 ]

Reference： [1]Patent: US9604978,2017,B2

13
[ 186593-42-0 ]
[ 401816-16-8 ]
C₁₁H₇F₂N₃O₂ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2019

14
[ 5470-17-7 ]
[ 105-53-3 ]
[ 186593-42-0 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; In diethyl ether; mineral oil;	34b. 3-bromo-2-methyl-5-nitropyridine A solution of diethyl malonate (17.6 mL, 0.116 mol) in diethyl ether (250 mL) at ambient temperature was treated with sodium hydride (80% in mineral oil, 3.5 g, 0.116 mol), and the mixture was stirred for 1 hour. Then <strong>[5470-17-7]3-bromo-2-chloro-5-nitropyridine</strong> (25 g, 105 mmol; prepared from 2-hydroxy-5-nitropyridine according to the procedure of V. Koch and S. Schnatterer, Synthesis 1990, 499-501) was added in portions over 5 minutes. After the mixture had stirred for 1 hour, the solvent was evaporated, and the residue was heated at 100 C. for 1 hour. After the mixture had cooled, 12 N H2 SO4 was added, and the mixture was heated at reflux for about 16 hours. The mixture was allowed to cool to ambient temperature, then further cooled as it was treated with 50% NaOH to give an alkaline pH. The resulting solution was extracted with CHCl3 (3*), and the organic extracts were washed with H2 O, dried (MgSO4) and evaporated to afford 17.1 g of the title compound as a red oil: 1 H NMR (CDCl3, 300 MHz) delta 2.81 (s, 3H), 8.61 (d, J=2 Hz, 1H), 9.26 (d, J=2 Hz, 1H).

Reference： [1]Patent: US6133253,2000,A

15
[ 186593-42-0 ]
[ 1621225-24-8 ]

Reference： [1]Patent: WO2020/190754,2020,A1

Same Skeleton Products

Related Products

Historical Records

Related Functional Groups of
[ 186593-42-0 ]

Bromides

[ 15862-30-3 ]

3-Bromo-5-nitropyridine

Similarity: 0.90

[ 69872-15-7 ]

3-Bromo-4-methyl-5-nitropyridine

Similarity: 0.81

[ 186413-75-2 ]

3-Bromo-6-chloro-2-methyl-5-nitropyridine

Similarity: 0.79

[ 2229221-49-0 ]

2-(2-Bromoethyl)-5-nitropyridine

Similarity: 0.79

[ 186593-43-1 ]

5-Amino-3-bromo-2-methylpyridine

Similarity: 0.79

Nitroes

[ 15862-30-3 ]

3-Bromo-5-nitropyridine

Similarity: 0.90

[ 69872-15-7 ]

3-Bromo-4-methyl-5-nitropyridine

Similarity: 0.81

[ 21203-68-9 ]

2-Methyl-5-nitropyridine

Similarity: 0.80

[ 186413-75-2 ]

3-Bromo-6-chloro-2-methyl-5-nitropyridine

Similarity: 0.79

[ 2229221-49-0 ]

2-(2-Bromoethyl)-5-nitropyridine

Similarity: 0.79

Related Parent Nucleus of
[ 186593-42-0 ]

Pyridines

[ 15862-30-3 ]

3-Bromo-5-nitropyridine

Similarity: 0.90

[ 69872-15-7 ]

3-Bromo-4-methyl-5-nitropyridine

Similarity: 0.81

[ 21203-68-9 ]

2-Methyl-5-nitropyridine

Similarity: 0.80

[ 186413-75-2 ]

3-Bromo-6-chloro-2-methyl-5-nitropyridine

Similarity: 0.79

[ 2229221-49-0 ]

2-(2-Bromoethyl)-5-nitropyridine

Similarity: 0.79

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 186593-42-0 ] {[proInfo.proName]}

Quality Control of [ 186593-42-0 ]

Related Doc. of [ 186593-42-0 ]

Product Details of [ 186593-42-0 ]

Calculated chemistry of [ 186593-42-0 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 186593-42-0 ]

Application In Synthesis of [ 186593-42-0 ]

[ 186593-42-0 ] Synthesis Path-Upstream 1~9

[ 186593-42-0 ] Synthesis Path-Downstream 1~15

Related Functional Groups of [ 186593-42-0 ]

Bromides

Nitroes

Related Parent Nucleus of [ 186593-42-0 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 186593-42-0 ]

Related Parent Nucleus of
[ 186593-42-0 ]