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[ CAS No. 186435-66-5 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 186435-66-5
Chemical Structure| 186435-66-5
Structure of 186435-66-5 *Storage: {[proInfo.prStorage]}

Quality Control of [ 186435-66-5 ]

Related Doc. of [ 186435-66-5 ]

SDS

Product Details of [ 186435-66-5 ]

CAS No. :186435-66-5MDL No. :MFCD00068842
Formula : C5H7N3O2 Boiling Point : 390.4±45.0°C at 760 mmHg
Linear Structure Formula :-InChI Key :YRLXSZNYIJKRDL-UHFFFAOYSA-N
M.W :141.13Pubchem ID :135404214
Synonyms :

Computed Properties of [ 186435-66-5 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 186435-66-5 ]

Signal Word:WarningClassN/A
Precautionary Statements:P305+P351+P338UN#:N/A
Hazard Statements:H302-H319Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 186435-66-5 ]

  • Upstream synthesis route of [ 186435-66-5 ]
  • Downstream synthetic route of [ 186435-66-5 ]

[ 186435-66-5 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 52328-05-9 ]
  • [ 105-56-6 ]
  • [ 186435-66-5 ]
YieldReaction ConditionsOperation in experiment
80% With sodium In methanol; water Synthesis of 6-amino-2-methoxy-4-pyrimidone, Compound a
The protocol for synthesizing compound a in the above schematic diagram was that basically as described by W. Pfleiderer (Chem. Ber., 90: 2272 (1957)).
Sodium (15 g, 652 mmol) was dissolved, in small portions, in 200 ml methanol. O-Methylisourea hemisulfate (30.6 g, 248 mmol) and ethyl cyanoacetate (30 g, 265 mmol) were added to the solution.
The mixture was stirred at reflux for 4.5 hours (h).
The mixture was filtered, and the solid was washed carefully with methanol.
The combined filtrates were evaporated to dryness, and the white solid residue was dissolved in 300 ml of hot water.
After neutralization with acetic acid to pH 7, the solid was filtered, washed with water, and dried to give 28 g (80percent) of product as a white solid.
Reference: [1] Patent: US2003/181719, 2003, A1
Historical Records

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