Home Cart Sign in  
Chemical Structure| 18803-02-6 Chemical Structure| 18803-02-6

Structure of 18803-02-6

Chemical Structure| 18803-02-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 18803-02-6 ]

CAS No. :18803-02-6
Formula : C10H9NO2
M.W : 175.18
SMILES Code : COC1=CC(C2=CC=CC=C2)=NO1
MDL No. :MFCD00464106

Safety of [ 18803-02-6 ]

Application In Synthesis of [ 18803-02-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18803-02-6 ]

[ 18803-02-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 124-41-4 ]
  • [ 3356-89-6 ]
  • [ 18803-02-6 ]
  • 2
  • [ 67-56-1 ]
  • [ 3356-89-6 ]
  • [ 18803-02-6 ]
YieldReaction ConditionsOperation in experiment
89% General procedure: To a stirred suspension of NaH (60% in mineral oil, 440 mg, 11 mmol, prewashed with hexane) in anhydrous THF (20 mL) was added the appropriate alcohol (15 mmol) at r.t. and the reaction mixture was stirred for 0.5 h. Next, <strong>[3356-89-6]5-chloro-3-phenylisoxazole</strong> (2) (1.0 g, 5.6mmol) was introduced as a solid and the mixture was refluxed for 1 h. After cooling to r.t., the mixture was quenched with H2O (20 mL). For 4a and 4b, the resulting precipitate was collected, washed with H2O and recrystallized from hexane-Et2O mixture. For 3a, the reaction mixture was extracted with CH2Cl2 (3 × 20 mL). The combined organic layers were dried (Na2SO4) and concentrated in vacuo to give isoxazole 3a. 5-tert-Butoxy-3-phenylisoxazole (4c) was synthesized analogously using commercially available potassium tert-butoxide. 5-Methoxy-3-phenylisoxazole (3a) Yield according to general procedure A: 877 mg (89%); yield accordingto general procedure B: 745 mg (76%); colorless solid. 1H NMR (400 MHz, CDCl3): delta = 7.82-7.72 (m, 2 ), 7.51-7.41 (m, 3 ),5.55 (s, 1 H), 4.06 (s, 3 ).
 

Historical Records