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Chemical Structure| 188562-91-6 Chemical Structure| 188562-91-6

Structure of 188562-91-6

Chemical Structure| 188562-91-6

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Product Details of [ 188562-91-6 ]

CAS No. :188562-91-6
Formula : C18H25NO3
M.W : 303.40
SMILES Code : O=C(N(C1CCC(CC1)=O)CC2=CC=CC=C2)OC(C)(C)C
MDL No. :MFCD24466241

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Application In Synthesis of [ 188562-91-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 188562-91-6 ]

[ 188562-91-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 142009-99-2 ]
  • [ 188562-91-6 ]
YieldReaction ConditionsOperation in experiment
62.5% With dmap; triethylamine; In dichloromethane; for 13h; 500ml three-necked bottle with thermometer and constant pressure dropping funnel4-(benzylamino)cyclohexane-1-one(35.7g, 175.61mmol, 1eq.), DCM (300ml),TEA (21.32g, 210.73mmol, 1.2eq.), DMAP (215mg, 1.76mmol, 0.01eq.),Stir in ice water bath. (Boc)2O (40.24 g,184.39mmol, 1.05eq.) in DCM (50ml).After adding, remove the ice water bath and stir. Overnight (13h),TLC (DCM:MeOH=100:1 and DCM:MeOH=10:1)Shows that the reaction is complete. Add water (200ml), mix, stand still, separate the layers, and extract the aqueous phase with dichloromethane (100+100ml).Combine the organic phases, wash with water (100ml), wash with citric acid solution (100ml),Wash with saturated sodium chloride (100ml), dry with anhydrous magnesium sulfate, filter with suction, and distill off the filtrate under reduced pressure.51.68g of yellow liquid was obtained. Silica gel column chromatography purification (DCM:PEDCM), 33.3g off-white solid was obtained, the yield was 62.5%.
 

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