Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 188672-83-5 | MDL No. : | MFCD18813190 |
Formula : | C8H3N3O2S | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 205.19 | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | at 20℃; for 24 h; | Iron powder (68.05 g, 1218.55 mmol) was added to a suspension of 6-nitro-1,3-benzothiazole-2-carbonitrile (13, 5.00 g,24.37 mmol) in acetic acid (500 mL). The reaction mixture was stirred at room temperature for 24 h, diluted with water (1 L)and unreacted iron was removed by filtration through celite.The aqueous solution was extracted with EtOAc (4 × 500 mL).The combined organic layers were washed with brine (2 ×300 mL), dried (Na2SO4) and concentrated in vacuo. The crudeproduct was loaded onto a short plug of silica gel, flushedthrough with CHCl3(ca. 1 L) and concentrated in vacuo to give8as yellow microcrystals (3.02 g, 17.24 mmol, 71percent). A sample of 13was crystallised from EtOH for melting point analysis.Rf0.2 (SiO2, DCM); mp 219–220 °C (EtOH); 1H NMR(500 MHz, CDCl3) δ7.95 (d, J= 8.9 Hz, 1H, CH-4), 7.08 (d, J= 2.2 Hz, 1H, CH-7), 6.95 (dd, J= 8.8, 2.2 Hz, 1H, CH-5), 4.14(s, 2H, NH2); 13C NMR (125 MHz, CDCl3) δ147.8 (C-6),145.7 (C-7a), 138.3 (C-3a), 131.2(C-2), 126.1 (CH-4), 117.8(CH-5), 113.7 (C≡N), 104.0 (CH-7). |
[ 188672-84-6 ]
5-Nitrobenzo[d]thiazole-2-carbonitrile
Similarity: 0.99
[ 188672-86-8 ]
7-Nitrobenzo[d]thiazole-2-carbonitrile
Similarity: 0.92
[ 2941-66-4 ]
2-Methyl-5-nitrobenzo[d]thiazole
Similarity: 0.89
[ 831-44-7 ]
6-Nitrobenzo[d]thiazole-2-carbaldehyde
Similarity: 0.85
[ 188672-84-6 ]
5-Nitrobenzo[d]thiazole-2-carbonitrile
Similarity: 0.99
[ 188672-86-8 ]
7-Nitrobenzo[d]thiazole-2-carbonitrile
Similarity: 0.92
[ 2602-85-9 ]
Benzo[d]thiazole-2-carbonitrile
Similarity: 0.73
[ 39785-46-1 ]
Naphtho[1,2-d]thiazole-2-carbonitrile
Similarity: 0.71
[ 188672-84-6 ]
5-Nitrobenzo[d]thiazole-2-carbonitrile
Similarity: 0.99
[ 188672-86-8 ]
7-Nitrobenzo[d]thiazole-2-carbonitrile
Similarity: 0.92
[ 2941-66-4 ]
2-Methyl-5-nitrobenzo[d]thiazole
Similarity: 0.89
[ 831-44-7 ]
6-Nitrobenzo[d]thiazole-2-carbaldehyde
Similarity: 0.85