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Chemical Structure| 189321-65-1 Chemical Structure| 189321-65-1

Structure of 189321-65-1

Chemical Structure| 189321-65-1

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Product Details of [ 189321-65-1 ]

CAS No. :189321-65-1
Formula : C16H28N2O6
M.W : 344.40
SMILES Code : O=C(C1(NC(OC(C)(C)C)=O)CCN(C(OC(C)(C)C)=O)CC1)O
MDL No. :MFCD02683116
InChI Key :AFEAWYLBSVKOAY-UHFFFAOYSA-N
Pubchem ID :1268225

Safety of [ 189321-65-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 189321-65-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 189321-65-1 ]

[ 189321-65-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 24424-99-5 ]
  • [ 183673-71-4 ]
  • [ 189321-65-1 ]
YieldReaction ConditionsOperation in experiment
59% 1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)piperidine-4-carboxylic acid4-Amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (3.00 g, 12.3 mmol, Alfa Aesar) was dissolved in NaOH (2 N aqueous solution, 14 mL, 28 mmol) and t-butanol (14 mL). Boc2O (3.21 g, 14.7 mmol) was added in one portion and the reaction mixture was stirred at ambient temperature for about 18 h.The white solid that formed during that time was filtered and washed with Et2O.The filtrate was collected and extracted with water.The aqueous layer was acidified to about pH 2 with 1 N aqueous HCl which triggered the precipitation of a white solid that was collected by filtration.The filter cake was dissolved in EtOAc and the resulting solution was dried over MgSO4, filtered, and evaporated under reduced pressure to give 1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)piperidine-4-carboxylic acid (2.50 g, 59percent): LC/MS (Table 1, Method b) Rt=1.33 min; MS m/z: 345 (M+H)+.
  • 2
  • [ 29181-50-8 ]
  • [ 189321-65-1 ]
  • tert-butyl 4-((tert-butoxycarbonyl)amino)-4-(4,6-dicyanopyridin-3-yl)piperidine-1-carboxylate [ No CAS ]
 

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