[ CAS No. 18992-68-2 ] {[proInfo.proName]}

Name: 18992-68-2|1,3-Dimethyl-9H-carbazole|97%
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Quality Control of [ 18992-68-2 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 18992-68-2 ]

SDS Specification

Alternatived Products of [ 18992-68-2 ]

Product Details of [ 18992-68-2 ]

CAS No. :	18992-68-2	MDL No. :	MFCD21604502
Formula :	C₁₄H₁₃N	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	HIVRNXYEWIPOMU-UHFFFAOYSA-N
M.W :	195.26	Pubchem ID :	177037
Synonyms :

Calculated chemistry of [ 18992-68-2 ]

Physicochemical Properties

Num. heavy atoms :	15
Num. arom. heavy atoms :	13
Fraction Csp3 :	0.14
Num. rotatable bonds :	0
Num. H-bond acceptors :	0.0
Num. H-bond donors :	1.0
Molar Refractivity :	65.74
TPSA :	15.79 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	Yes
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-4.57 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.38
Log Po/w (XLOGP3) :	4.12
Log Po/w (WLOGP) :	3.94
Log Po/w (MLOGP) :	3.37
Log Po/w (SILICOS-IT) :	4.54
Consensus Log Po/w :	3.67

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-4.29
Solubility :	0.0101 mg/ml ; 0.0000516 mol/l
Class :	Moderately soluble
Log S (Ali) :	-4.16
Solubility :	0.0136 mg/ml ; 0.0000695 mol/l
Class :	Moderately soluble
Log S (SILICOS-IT) :	-5.74
Solubility :	0.000358 mg/ml ; 0.00000183 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	1.34

Safety of [ 18992-68-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362	UN#:	N/A
Hazard Statements:	H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 18992-68-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 18992-68-2 ]

[ 18992-68-2 ] Synthesis Path-Downstream 1~46

1
[ 79242-93-6 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
87%	With iodine In dimethyl sulfoxide at 100℃; for 10h;
63%	In various solvent(s) for 5.5h;
	With chloranil; xylene

Reference： [1]Humne, Vivek; Dangat, Yuvraj; Vanka, Kumar; Lokhande, Pradeep [Organic and Biomolecular Chemistry, 2014, vol. 12, # 27, p. 4832 - 4836]
[2]Kuroki, Masanate; Tsunashima, Yutaka [Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 709 - 714]
[3]Anderson; Campbell [Journal of the Chemical Society, 1950, p. 2855]

2
[ 18992-68-2 ]
[ 67-66-3 ]
[ 21240-57-3 ]
[ 132921-82-5 ]
[ 132921-85-8 ]
[ 132921-86-9 ]

Yield	Reaction Conditions	Operation in experiment
1: 19% 2: 8% 3: 7% 4: 28%	With barium dihydroxide Irradiation;

Reference： [1]Chowdhury; Saha; Poddar [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1991, vol. 30, # 1, p. 63 - 65]

3
[ 18992-68-2 ]
[ 74-88-4 ]
[ 82757-41-3 ]

Yield	Reaction Conditions	Operation in experiment
70%	With sodium hydride In N,N-dimethyl-formamide for 3h; Ambient temperature;

Reference： [1]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1985, p. 2725 - 2732]

4
[ 18992-68-2 ]
[ 132921-83-6 ]
[ 21240-57-3 ]
[ 132921-85-8 ]
[ 132921-86-9 ]

Yield	Reaction Conditions	Operation in experiment
1: 28% 2: 8% 3: 19% 4: 7%	With barium dihydroxide; chloroform Irradiation;

Reference： [1]Chowdhury; Saha; Poddar [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1991, vol. 30, # 1, p. 63 - 65]

5
[ 18992-68-2 ]
[ 21240-57-3 ]
[ 132921-82-5 ]
[ 132921-85-8 ]
[ 132921-86-9 ]

Yield	Reaction Conditions	Operation in experiment
1: 28% 2: 19% 3: 7% 4: 8%	With barium dihydroxide; chloroform Irradiation;

Reference： [1]Chowdhury; Saha; Poddar [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1991, vol. 30, # 1, p. 63 - 65]

6
[ 25078-04-0 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
52%	With palladium diacetate; potassium carbonate; PivOH at 100℃; for 31.5h;
26%	In Petroleum ether for 30h; Irradiation;

Reference： [1]Theumer, Gabriele; Bauer, Ingmar; Jäger, Anne; Schwark, Lorenz; Knölker, Hans-Joachim [European Journal of Organic Chemistry, 2022, vol. 2022, # 22]
[2]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1985, p. 2725 - 2732]

7
[ 92194-05-3 ]
[ 18992-68-2 ]
[ 113997-25-4 ]
[ 113997-26-5 ]
[ 113997-28-7 ]
[ 113997-27-6 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride In methanol; acetic acid kinetic isotope effects, the role of solvents;

Reference： [1]Boduszek, Bogdan; Shine, Henry J. [Journal of the American Chemical Society, 1988, vol. 110, # 10, p. 3247 - 3252]

8
[ 92194-05-3 ]
[ 18992-68-2 ]
[ 113997-25-4 ]
[ 113997-26-5 ]
[ 113997-27-6 ]

Yield	Reaction Conditions	Operation in experiment
1: 10% 2: 8.7% 3: 74.5%	With hydrogenchloride In methanol; water for 24h; Ambient temperature; Further byproducts given;

Reference： [1]Boduszek, Bogdan; Shine, Henry J. [Journal of the American Chemical Society, 1988, vol. 110, # 10, p. 3247 - 3252]

9
[ 82757-39-9 ]
[ 613-15-0 ]
[ 105201-11-4 ]
[ 18992-68-2 ]
[ 82757-41-3 ]

Yield	Reaction Conditions	Operation in experiment
1: 15% 2: 39% 3: 5% 4: 5%	at 700℃;

Reference： [1]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1985, p. 2725 - 2732]

10
[ 82757-39-9 ]
[ 18992-68-2 ]
[ 82757-41-3 ]
1,3,8-trimethylcarbazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	at 640℃;

Reference： [1]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Chemical communications, 1982, # 10, p. 548 - 550]

11
[ 82757-39-9 ]
[ 18992-68-2 ]
[ 82757-45-7 ]

Yield	Reaction Conditions	Operation in experiment
1: 14% 2: 64%	In acetonitrile for 22h; Irradiation;
1: 6% 2: 64%	In acetonitrile Irradiation;

Reference： [1]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1985, p. 2725 - 2732]
[2]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Chemical communications, 1982, # 10, p. 548 - 550]

12
2,4-dimethylphenyl 2-azidobenzoate [ No CAS ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
13%	at 280℃;

Reference： [1]Clancy, Michael G.; Hesabi, Massoud M.; Meth-Cohn, Otto [Journal of the Chemical Society. Perkin transactions I, 1984, # 3, p. 429 - 434]

Yield	Reaction Conditions	Operation in experiment
	aus dem Azid (1c) durch Thermolyse in (C2H5)2NH;
	aus dem Azid (1c) durch Photolyse in (C2H5)2NH;
	aus Hydrazon XIIf, 1. Erhitzen in HOAc, 2. Erhitzen mit Chloranil;

Yield	Reaction Conditions	Operation in experiment
	With calcium oxide

15
1-(2,4-dimethyl-phenyl)-1<i>H</i>-benzotriazole-5-carboxylic acid [ No CAS ]
[ 613-15-0 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	bei Destillation;

Reference： [1]Deletra; Ullmann [Chemisches Zentralblatt, 1904, vol. 75, # I, p. 1570] Ullmann,F. [Justus Liebigs Annalen der Chemie, 1904, vol. 332, p. 91]

16
[ 205517-02-8 ]
[ 18992-68-2 ]

Reference： [1]Organic Letters,2015,vol. 17,p. 1597 - 1600
[2]Chemistry Letters,2007,vol. 36,p. 172 - 173

17
[ 95-50-1 ]
[ 95-68-1 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
81%	With caesium carbonate In dimethyl sulfoxide at 180℃; for 0.416667h; Microwave irradiation; Green chemistry;	Synthesis of 9H-Carbazoles under Microwave Irradiation; General Procedure General procedure: Aniline 1 (1.2 mmol), 1,2-dihaloarene 2(1 mmol), Cs2CO3 (3 mmol), PdNPs/mBC (15 mol%, 16 mg of Pd) and DMSO (5 mL) were added to a vessel tube with a magnetic stirring bar. The resulting mixture was heated at 180 °C under microwave irradiation (200 W) for 25 min. The progress of the reaction was monitored by TLC and GC-MS. The crude product was treated with EtOAc. The catalyst was recovered with the aid of a permanent magnet on the outer wall of the reaction flask and washed several times with the same solvent. The reaction mixture was washed with a brine (2 ×) and then dried (anhyd Na2SO4). The solvent was removed under reduced pressure and the desired 9H-carbazole was purified by silica gel column chromatography using PE/EtOAc gradient as eluent.
63%	With potassium phosphate; tricyclohexylphosphine In 1-methyl-pyrrolidin-2-one at 130℃; for 18h;
63%	With potassium phosphate; palladium diacetate; tricyclohexylphosphine In 1-methyl-pyrrolidin-2-one at 130℃; for 18h; Inert atmosphere; regioselective reaction;

Reference： [1]Steingruber, H. Sebastián; Mendioroz, Pamela; Volpe, María A.; Gerbino, Darío C. [Synthesis, 2021, vol. 53, # 21, p. 4048 - 4058]
[2]Ackermann, Lutz; Althammer, Andreas [Angewandte Chemie - International Edition, 2007, vol. 46, # 10, p. 1627 - 1629]
[3]Location in patent: experimental part Ackermann, Lutz; Althammer, Andreas; Mayer, Peter [Synthesis, 2009, # 20, p. 3493 - 3503]

18
[ 15191-36-3 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 88 percent / sodium acetate, Br₂ / acetic acid / 0.17 h / -5 - 0 °C 2: 66 percent / sodium acetate, / ethanol / 0.25 h / -5 - 0 °C 3: HCl / methanol; H₂O / 24 h / Ambient temperature

Reference： [1]Boduszek, Bogdan; Shine, Henry J. [Journal of the American Chemical Society, 1988, vol. 110, # 10, p. 3247 - 3252]

19
[ 83755-88-8 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 66 percent / sodium acetate, / ethanol / 0.25 h / -5 - 0 °C 2: HCl / methanol; H₂O / 24 h / Ambient temperature

Reference： [1]Boduszek, Bogdan; Shine, Henry J. [Journal of the American Chemical Society, 1988, vol. 110, # 10, p. 3247 - 3252]

20
[ 105-67-9 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 64 percent / Br₂ 2: 88 percent / sodium acetate, Br₂ / acetic acid / 0.17 h / -5 - 0 °C 3: 66 percent / sodium acetate, / ethanol / 0.25 h / -5 - 0 °C 4: HCl / methanol; H₂O / 24 h / Ambient temperature

Reference： [1]Boduszek, Bogdan; Shine, Henry J. [Journal of the American Chemical Society, 1988, vol. 110, # 10, p. 3247 - 3252]

21
[ 34897-85-3 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 78 percent / pyridine 2: 13 percent / 280 °C / 1 - 2 Torr

Reference： [1]Clancy, Michael G.; Hesabi, Massoud M.; Meth-Cohn, Otto [Journal of the Chemical Society. Perkin transactions I, 1984, # 3, p. 429 - 434]

22
[ 105-67-9 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 78 percent / pyridine 2: 13 percent / 280 °C / 1 - 2 Torr

Reference： [1]Clancy, Michael G.; Hesabi, Massoud M.; Meth-Cohn, Otto [Journal of the Chemical Society. Perkin transactions I, 1984, # 3, p. 429 - 434]

23
[ 28458-49-3 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 93 percent / H₂ / 10 percent palladium on charcoal / ethanol 2: 96 percent / 1M HCl, NaNO₂ / ethanol; H₂O / 4 h / Ambient temperature 3: 39 percent / 700 °C / 0.07 Torr

Reference： [1]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1985, p. 2725 - 2732]

24
[ 105201-09-0 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 96 percent / 1M HCl, NaNO₂ / ethanol; H₂O / 4 h / Ambient temperature 2: 39 percent / 700 °C / 0.07 Torr

Reference： [1]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1985, p. 2725 - 2732]

25
[ 108-38-3 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 53 percent / trifluoroacetic acid / 26 h / 100 °C 2: 26 percent / light petroleum / 30 h / Irradiation

Reference： [1]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1985, p. 2725 - 2732]

26
[ 1493-27-2 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 62 percent / potassium fluoride / 48 h / 180 °C 2: 93 percent / H₂ / 10 percent palladium on charcoal / ethanol 3: 96 percent / 1M HCl, NaNO₂ / ethanol; H₂O / 4 h / Ambient temperature 4: 39 percent / 700 °C / 0.07 Torr

Reference： [1]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1985, p. 2725 - 2732]

27
[ 88-05-1 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 62 percent / potassium fluoride / 48 h / 180 °C 2: 93 percent / H₂ / 10 percent palladium on charcoal / ethanol 3: 96 percent / 1M HCl, NaNO₂ / ethanol; H₂O / 4 h / Ambient temperature 4: 39 percent / 700 °C / 0.07 Torr

Reference： [1]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1985, p. 2725 - 2732]

28
[ 622-37-7 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 53 percent / trifluoroacetic acid / 26 h / 100 °C 2: 26 percent / light petroleum / 30 h / Irradiation

Reference： [1]Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1985, p. 2725 - 2732]

29
[ 95-68-1 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 61 percent / ethanol / 10 h / Heating 2: 63 percent / 10percent Pd on charcoal / various solvent(s) / 5.5 h

Reference： [1]Kuroki, Masanate; Tsunashima, Yutaka [Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 709 - 714]

30
[ 822-87-7 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 61 percent / ethanol / 10 h / Heating 2: 63 percent / 10percent Pd on charcoal / various solvent(s) / 5.5 h

Reference： [1]Kuroki, Masanate; Tsunashima, Yutaka [Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 709 - 714]

31
[ 40712-95-6 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: ethanol; amalgamated zinc; aqueous hydrochloric acid 2: tetrachloro-<1,4>benzoquinone; xylene
	Multi-step reaction with 2 steps 1.1: methanol / 5 h / Reflux 2.1: magnesium sulfate heptahydrate / dichloromethane; methanol 2.2: 0.07 h / 100 °C / 1551.49 - 2585.81 Torr / Microwave irradiation

Reference： [1]Anderson; Campbell [Journal of the Chemical Society, 1950, p. 2855]
[2]Chakraborty, Suchandra; Chattopadhyay, Gautam; Saha, Chandan [Journal of Heterocyclic Chemistry, 2013, vol. 50, # 1, p. 91 - 98]

32
[ 937807-95-9 ]
[ 18992-68-2 ]
C₃₀H₃₀N₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 62% 2: 8 %Spectr.	Stage #1: N-(2-bromophenyl)-2,4,6-trimethylbenzenamine With 1,3-bis(2,6-diisopropylphenyl)-2-(pentafluorophenyl)imidazolidine; palladium diacetate; sodium t-butanolate In toluene at 100℃; for 18h; Inert atmosphere; Stage #2: With hydrogenchloride In water; toluene

Reference： [1]Bedford, Robin B.; Butts, Craig P.; Haddow, Mairi F.; Osborne, Robert; Sankey, Rosalind F. [Chemical Communications, 2009, # 32, p. 4832 - 4834]

33
[ 1188929-99-8 ]
[ 18992-68-2 ]
C₃₀H₃₀N₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 61 %Spectr. 2: 1 %Spectr.	Stage #1: 2-chloro-N-(2,4,6-trimethylphenyl)aniline With 1,3-bis(2,6-diisopropylphenyl)-2-(pentafluorophenyl)imidazolidine; palladium diacetate; sodium t-butanolate In toluene at 100℃; for 18h; Inert atmosphere; Stage #2: With hydrogenchloride In water; toluene

Reference： [1]Bedford, Robin B.; Butts, Craig P.; Haddow, Mairi F.; Osborne, Robert; Sankey, Rosalind F. [Chemical Communications, 2009, # 32, p. 4832 - 4834]

34
[ 694-80-4 ]
[ 95-68-1 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
66%	With potassium phosphate; palladium diacetate; tricyclohexylphosphine In 1-methyl-pyrrolidin-2-one at 130℃; for 18h; Inert atmosphere; regioselective reaction;

Reference： [1]Location in patent: scheme or table Ackermann, Lutz; Althammer, Andreas; Mayer, Peter [Synthesis, 2009, # 20, p. 3493 - 3503]

35
[ 38974-06-0 ]
[ 88284-48-4 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
54%	With cesium fluoride In acetonitrile at 20℃;

Reference： [1]Chakrabarty, Shyamal; Chatterjee, Indranil; Tebben, Ludger; Studer, Armido [Angewandte Chemie - International Edition, 2013, vol. 52, # 10, p. 2968 - 2971][Angew. Chem., 2013, vol. 125, # 10, p. 3041 - 3044]

36
[ 1451422-98-2 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
90%	Stage #1: C₂₁H₂₃N₃O₂S With magnesium sulfate heptahydrate In methanol; dichloromethane Stage #2: With sodium tetrahydroborate; palladium 10% on activated carbon at 100℃; for 0.0666667h; Microwave irradiation;

Reference： [1]Chakraborty, Suchandra; Chattopadhyay, Gautam; Saha, Chandan [Journal of Heterocyclic Chemistry, 2013, vol. 50, # 1, p. 91 - 98]

37
[ 108-94-1 ]
[ 615-00-9 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: acetic acid / 8.5 h / Reflux 2: iodine / dimethyl sulfoxide / 10 h / 100 °C

Reference： [1]Humne, Vivek; Dangat, Yuvraj; Vanka, Kumar; Lokhande, Pradeep [Organic and Biomolecular Chemistry, 2014, vol. 12, # 27, p. 4832 - 4836]

38
[ 3900-89-8 ]
[ 41825-73-4 ]
[ 18992-68-2 ]
[ 205517-02-8 ]

Reference： [1]Journal of Organic Chemistry,2015,vol. 80,p. 928 - 941

39
2′-chloro-3,5-dimethyl-[1,1′-biphenyl]-2-amine [ No CAS ]
[ 18992-68-2 ]
[ 205517-02-8 ]

Reference： [1]Journal of Organic Chemistry,2015,vol. 80,p. 928 - 941

40
[ 41825-73-4 ]
[ 98-80-6 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / N,N-dimethyl-formamide; water / 24 h / 80 °C / Inert atmosphere 2: bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; Trimethylacetic acid; copper diacetate / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C

Reference： [1]Suzuki, Chiharu; Hirano, Koji; Satoh, Tetsuya; Miura, Masahiro [Organic Letters, 2015, vol. 17, # 6, p. 1597 - 1600]

41
2'-bromo-3,5-dimethyl-[1,1'-biphenyl]-2-amine [ No CAS ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
82%	With potassium <i>tert</i>-butylate In dimethyl sulfoxide at 130℃; for 12h;

Reference： [1]Singha, Raju; Ahmed, Atiur; Nuree, Yasin; Ghosh, Munmun; Ray, Jayanta K. [RSC Advances, 2015, vol. 5, # 62, p. 50174 - 50177]

42
[ 51839-02-2 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
87%	With silica gel In water; acetone at 25℃; for 48h; Irradiation;
73%	With water; palladium diacetate at 110℃; Microwave irradiation;

Reference： [1]Yang, Lizheng; Zhang, Yipin; Zou, Xiaodong; Lu, Hongjian; Li, Guigen [Green Chemistry, 2018, vol. 20, # 6, p. 1362 - 1366]
[2]Yang, Lizheng; Li, Hao; Zhang, Haifei; Lu, Hongjian [European Journal of Organic Chemistry, 2016, vol. 2016, # 34, p. 5611 - 5615]

43
[ 51839-12-4 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: acetic acid; sodium nitrite / water / 2 h / 0 °C 1.2: 25 °C 2.1: water; palladium diacetate / 110 °C / Microwave irradiation
	Multi-step reaction with 2 steps 1: acetic acid; sodium nitrite; sodium azide / water / 0 - 25 °C 2: silica gel / water; acetone / 48 h / 25 °C / Irradiation

Reference： [1]Yang, Lizheng; Li, Hao; Zhang, Haifei; Lu, Hongjian [European Journal of Organic Chemistry, 2016, vol. 2016, # 34, p. 5611 - 5615]
[2]Yang, Lizheng; Zhang, Yipin; Zou, Xiaodong; Lu, Hongjian; Li, Guigen [Green Chemistry, 2018, vol. 20, # 6, p. 1362 - 1366]

44
[ 615-36-1 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: sodium carbonate; palladium diacetate / ethylene glycol; water / 24 h / 80 °C 2.1: acetic acid; sodium nitrite / water / 2 h / 0 °C 2.2: 25 °C 3.1: water; palladium diacetate / 110 °C / Microwave irradiation
	Multi-step reaction with 3 steps 1: palladium diacetate; sodium carbonate / water; ethylene glycol / 24 h / 80 °C 2: acetic acid; sodium nitrite; sodium azide / water / 0 - 25 °C 3: silica gel / water; acetone / 48 h / 25 °C / Irradiation

45
[ 172975-69-8 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: sodium carbonate; palladium diacetate / ethylene glycol; water / 24 h / 80 °C 2.1: acetic acid; sodium nitrite / water / 2 h / 0 °C 2.2: 25 °C 3.1: water; palladium diacetate / 110 °C / Microwave irradiation
	Multi-step reaction with 3 steps 1: palladium diacetate; sodium carbonate / water; ethylene glycol / 24 h / 80 °C 2: acetic acid; sodium nitrite; sodium azide / water / 0 - 25 °C 3: silica gel / water; acetone / 48 h / 25 °C / Irradiation

46
[ 591-50-4 ]
[ 95-68-1 ]
[ 18992-68-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: palladium diacetate; dicyclohexyl({2’,6’-dimethoxy-[1,1‘-biphenyl]-2-yl})phosphane; Cs₂CO₃ / toluene / 26 h / 100 °C / Inert atmosphere 2: palladium diacetate; potassium carbonate; PivOH / 31.5 h / 100 °C

Reference： [1]Theumer, Gabriele; Bauer, Ingmar; Jäger, Anne; Schwark, Lorenz; Knölker, Hans-Joachim [European Journal of Organic Chemistry, 2022, vol. 2022, # 22]

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[ 18992-68-2 ] Synthesis Path-Downstream 1~46

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Carbazole Series

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