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Chemical Structure| 191861-20-8 Chemical Structure| 191861-20-8

Structure of 191861-20-8

Chemical Structure| 191861-20-8

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Product Details of [ 191861-20-8 ]

CAS No. :191861-20-8
Formula : C9H5FN2O2
M.W : 192.15
SMILES Code : O=[N+](C1=C2C=C(F)C=NC2=CC=C1)[O-]

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Application In Synthesis of [ 191861-20-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 191861-20-8 ]

[ 191861-20-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 396-31-6 ]
  • [ 191861-20-8 ]
  • 3-fluoro-8-nitroquinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; nitric acid; at 0℃; for 2h; A solution of 3: 1 concentrated sulfuric acid/concentrated nitric acid (32 ml) was added dropwise to <strong>[396-31-6]3-fluoroquinoline</strong> (13.04 g, 88.6 mmol) in concentrated sulfuric acid (100 ml) at 00C. After stirring for 2 h, the solution was made alkaline with IO N aq. NaOH and extracted with diethyl ether. The combined organic extracts were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to yield 3-fluoro-8-nitroquinoline and 3-fluoro- 5-nitroquinoline as a yellow solid. Method [7] retention time 3.50 and 3.92 min by HPLC (M+ 193) and (M+ 193).
  • 2
  • [ 396-31-6 ]
  • [ 191861-20-8 ]
 

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