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[ CAS No. 193274-82-7 ]

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Chemical Structure| 193274-82-7
Chemical Structure| 193274-82-7
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Product Details of [ 193274-82-7 ]

CAS No. :193274-82-7 MDL No. :MFCD08460960
Formula : C17H23NO3 Boiling Point : 409°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :289.37 g/mol Pubchem ID :44607713
Synonyms :

Safety of [ 193274-82-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 193274-82-7 ]

  • Upstream synthesis route of [ 193274-82-7 ]
  • Downstream synthetic route of [ 193274-82-7 ]

[ 193274-82-7 ] Synthesis Path-Upstream   1~2

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YieldReaction ConditionsOperation in experiment
87% With hydrogenchloride In methanol; water at 110℃; for 48 h; A mixture of the compound (6.0 g) obtained in Process 1, methanol (100 ml) and 6 N hydrochloric acid (250 ml) was stirred at 110°C for 24 hours. To the reaction solution, concentrated hydrochloric acid (100 ml) was added, and the reaction mixture was further stirred at 110°C for 24 hours. The solvent was evaporated under reduced pressure, and then an aqueous 4 N sodium hydroxide solution-ice was added to the residue to make it basic, and the mixture was extracted with dichloromethane. The extract was washed with saturated brine, dried, and then the solvent was evaporated under reduced pressure. The obtained residue was dissolved in THF (60 ml), cooled to 0°C, and then di-tert-butyl dicarbonate (5.0 ml) was added thereto, and the reaction mixture was stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and then the obtained residue was isolated and purified by silica gel column chromatography (hexane : ethyl acetate = 4 : 1) to obtain 3-benzyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester as white crystals (4.20 g, 87percent). Melting point: 74 - 75°C. 1H-NMR (CDCl3): δ 1.42 (9H, s), 2.43-2.60 (3H, m), 2.70 (1H, m), 2.97 (1H, dd, J=13.2, 9.8 Hz), 3.14-3.41 (2H, m), 3.9-4.2 (2H, m), 7.15-7.35 (5H, m).
Reference: [1] Patent: EP1553084, 2005, A1, . Location in patent: Page/Page column 54
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Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 20, p. 5704 - 5708
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