Home Cart 0 Sign in  

[ CAS No. 632352-56-8 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 632352-56-8
Chemical Structure| 632352-56-8
Structure of 632352-56-8 * Storage: {[proInfo.prStorage]}

Quality Control of [ 632352-56-8 ]

Related Doc. of [ 632352-56-8 ]

SDS
Alternatived Products of [ 632352-56-8 ]
Alternatived Products of [ 632352-56-8 ]

Product Details of [ 632352-56-8 ]

CAS No. :632352-56-8 MDL No. :MFCD08669341
Formula : C16H21NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :275.34 g/mol Pubchem ID :23643714
Synonyms :

Safety of [ 632352-56-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 632352-56-8 ]

  • Upstream synthesis route of [ 632352-56-8 ]
  • Downstream synthetic route of [ 632352-56-8 ]

[ 632352-56-8 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 76041-09-3 ]
  • [ 24424-99-5 ]
  • [ 632352-56-8 ]
YieldReaction ConditionsOperation in experiment
71% With triethylamine In acetonitrile at 20℃; for 14 h; To a solution of the compound (3.47 g) obtained in Process 4 and Et3N (2.76 ml) in acetonitrile (50 ml), di-tert-butyl dicarbonate (6.55 g) was added, and the reaction mixture was stirred at room temperature for 14 hours.
The reaction mixture was poured into water, and then the product was extracted with ethyl acetate.
The organic layer was washed with an aqueous 10percent citric acid solution and saturated brine, dried, and then the solvent was evaporated under reduced pressure.
The obtained residue was isolated and purified by silica gel column chromatography (hexane: ethyl acetate = 10: 1) to obtain 4-oxo-3-phenylpiperidine-1-carboxylic acid tert-butyl ester as white powder (3.90 g, 71percent).
The obtained product was used in the next process without further purification.
Reference: [1] European Journal of Organic Chemistry, 2007, # 26, p. 4376 - 4382
[2] Patent: EP1553084, 2005, A1, . Location in patent: Page/Page column 44
  • 2
  • [ 910875-39-7 ]
  • [ 24424-99-5 ]
  • [ 632352-56-8 ]
YieldReaction ConditionsOperation in experiment
5.46 g With triethylamine In acetonitrile for 14 h; The obtained powder of crude 7 (5.00 g, 23.6 mmol) was dissolved in a mixture of CH3CN (100 mL) and Et3N (4.94 mL, 35.4 mmol) and then di-tert-butoxycarbonate (7.73 g, 35.4 mmol) was slowly added thereto. After stirring for 14 h, the reaction mixture was concentrated in vacuo, and then the residue was dissolved in EtOAc and H2O. The organic layer was washed with aqueous NH4Cl and brine, dried and concentrated to provide 8 (5.46 g, 84percent) as white solids. 1H NMR (CDCl3) δ: 1.50 (9H, s), 2.57 (2H, t, J = 6.1 Hz), 3.45-3.74 (3H, m), 4.10-4.40 (2H, m), 7.15-7.21 (2H, m), 7.28-7.41 (3H, m).
Reference: [1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 21, p. 6430 - 6446
  • 3
  • [ 591-50-4 ]
  • [ 79099-07-3 ]
  • [ 632352-56-8 ]
Reference: [1] Journal of the American Chemical Society, 2014, vol. 136, # 14, p. 5225 - 5228
  • 4
  • [ 446302-83-6 ]
  • [ 632352-56-8 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 21, p. 6430 - 6446
  • 5
  • [ 1384264-55-4 ]
  • [ 632352-56-8 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 21, p. 6430 - 6446
  • 6
  • [ 1345345-81-4 ]
  • [ 632352-56-8 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 21, p. 6430 - 6446
Historical Records

Related Functional Groups of
[ 632352-56-8 ]

Aryls

Chemical Structure| 193274-82-7

[ 193274-82-7 ]

tert-Butyl 3-benzyl-4-oxopiperidine-1-carboxylate

Similarity: 0.97

Chemical Structure| 193480-28-3

[ 193480-28-3 ]

1-Boc-2-Benzyl-4-piperidinone

Similarity: 0.90

Chemical Structure| 339539-81-0

[ 339539-81-0 ]

(R)-3-Benzyl-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid

Similarity: 0.87

Chemical Structure| 227940-70-7

[ 227940-70-7 ]

tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Similarity: 0.87

Chemical Structure| 849928-30-9

[ 849928-30-9 ]

1-Boc-2-Phenyl-4-piperidinone

Similarity: 0.85

Ketones

Chemical Structure| 193274-82-7

[ 193274-82-7 ]

tert-Butyl 3-benzyl-4-oxopiperidine-1-carboxylate

Similarity: 0.97

Chemical Structure| 241819-85-2

[ 241819-85-2 ]

tert-Butyl 2-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

Similarity: 0.96

Chemical Structure| 159634-59-0

[ 159634-59-0 ]

tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

Similarity: 0.90

Chemical Structure| 193480-28-3

[ 193480-28-3 ]

1-Boc-2-Benzyl-4-piperidinone

Similarity: 0.90

Chemical Structure| 227940-70-7

[ 227940-70-7 ]

tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Similarity: 0.87

Amides

Chemical Structure| 193274-82-7

[ 193274-82-7 ]

tert-Butyl 3-benzyl-4-oxopiperidine-1-carboxylate

Similarity: 0.97

Chemical Structure| 241819-85-2

[ 241819-85-2 ]

tert-Butyl 2-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

Similarity: 0.96

Chemical Structure| 159634-59-0

[ 159634-59-0 ]

tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

Similarity: 0.90

Chemical Structure| 193480-28-3

[ 193480-28-3 ]

1-Boc-2-Benzyl-4-piperidinone

Similarity: 0.90

Chemical Structure| 339539-81-0

[ 339539-81-0 ]

(R)-3-Benzyl-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid

Similarity: 0.87

Related Parent Nucleus of
[ 632352-56-8 ]

Piperidines

Chemical Structure| 193274-82-7

[ 193274-82-7 ]

tert-Butyl 3-benzyl-4-oxopiperidine-1-carboxylate

Similarity: 0.97

Chemical Structure| 241819-85-2

[ 241819-85-2 ]

tert-Butyl 2-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

Similarity: 0.96

Chemical Structure| 159634-59-0

[ 159634-59-0 ]

tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

Similarity: 0.90

Chemical Structure| 193480-28-3

[ 193480-28-3 ]

1-Boc-2-Benzyl-4-piperidinone

Similarity: 0.90

Chemical Structure| 339539-81-0

[ 339539-81-0 ]

(R)-3-Benzyl-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid

Similarity: 0.87