[ CAS No. 19351-18-9 ] {[proInfo.proName]}

Name: 19351-18-9|2,2-Dimethyltetrahydrothiazole|98%
Brand: Ambeed
SKU: A441341
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Quality Control of [ 19351-18-9 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 19351-18-9 ]

SDS Specification

Alternatived Products of [ 19351-18-9 ]

Product Details of [ 19351-18-9 ]

CAS No. :	19351-18-9	MDL No. :	MFCD00014488
Formula :	C₅H₁₁NS	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	SNPQRYOQWLOTFA-UHFFFAOYSA-N
M.W :	117.21	Pubchem ID :	88015
Synonyms :

Calculated chemistry of [ 19351-18-9 ]

Physicochemical Properties

Num. heavy atoms :	7
Num. arom. heavy atoms :	0
Fraction Csp3 :	1.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	1.0
Num. H-bond donors :	1.0
Molar Refractivity :	38.38
TPSA :	37.33 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.35 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.77
Log Po/w (XLOGP3) :	0.93
Log Po/w (WLOGP) :	0.68
Log Po/w (MLOGP) :	0.76
Log Po/w (SILICOS-IT) :	1.74
Consensus Log Po/w :	1.17

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.15
Solubility :	8.25 mg/ml ; 0.0704 mol/l
Class :	Very soluble
Log S (Ali) :	-1.3
Solubility :	5.87 mg/ml ; 0.0501 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.58
Solubility :	3.07 mg/ml ; 0.0262 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.04

Safety of [ 19351-18-9 ]

Signal Word:	Danger	Class:	3
Precautionary Statements:	P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P303+P361+P353-P332+P313-P362-P403+P235	UN#:	1993
Hazard Statements:	H315-H319-H225	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 19351-18-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 19351-18-9 ]
Downstream synthetic route of [ 19351-18-9 ]

[ 19351-18-9 ] Synthesis Path-Upstream 1~3

1
[ 156-57-0 ]
[ 67-64-1 ]
[ 19351-18-9 ]

Yield	Reaction Conditions	Operation in experiment
348 kg	With sodium hydroxide In ethanol; cyclohexane at 78℃; for 10 h; Large scale	A process for the preparation of 2,2-dimethyltetrahydrothiazole comprising the steps of:1) Refining: 450 kg of 95percent cysteamine hydrochloride and 450 kg of ethanol were injected at a 1: 1 ratioInto the reactor, cooling crystallization, rejection filter solid phase for pure cysteamine hydrochloride 405kg, obtainedLiquid phase distillation recovery of ethanol 425kg;2) Neutralization: 1350 kg of cyclohexane, 405 kg of pure cysteamine hydrochloride and 430 kg of acetoneInto the reactor, adding liquid caustic soda 405kg to neutral; which liquid alkali accounted for in water285 kg, NaOH 120 kg;3) azeotropic dehydration: the reactor temperature rose to 78 , reflux azeotropic dehydration, anti-heatShould be 10 hours;4) filtration: the end of the reaction, cooling to 33 , 182kg filter salt;5) Distillation: The filtrate was distilled to recover 1225 kg of cyclohexane and 230 kg of acetone;Acetone solvent distillation are carried out in the reactor; distillation and condensation are water-cooled plus frozen saltWater freezing;6) Rectification: distillation of the remaining crude oil distillation column distillation products 2,2 - dimethyl tetrahydrothiophene348 kg.

Reference： [1] Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1953, vol. 19, p. 523,527[2] Chem.Abstr., 1955, p. 8255
[3] Agricultural and Biological Chemistry, 1989, vol. 53, # 8, p. 2273 - 2274
[4] Journal of the American Chemical Society, 2008, vol. 130, # 2, p. 428 - 429
[5] Patent: CN106146427, 2016, A, . Location in patent: Paragraph 0038; 0039; 0040; 0041; 0042-0046

2
[ 151-56-4 ]
[ 67-64-1 ]
[ 19351-18-9 ]

Reference： [1] Justus Liebigs Annalen der Chemie, 1950, vol. 566, p. 210,231
[2] DRP/DRBP Org.Chem.,

3
[ 151-56-4 ]
[ 7783-06-4 ]
[ 67-64-1 ]
[ 19351-18-9 ]

Reference： [1] DRP/DRBP Org.Chem.,
[2] DRP/DRBP Org.Chem.,

[ 19351-18-9 ] Synthesis Path-Downstream 1~32

3
[ 19351-18-9 ]
[ 4702-13-0 ]
[ 113238-61-2 ]
[ 3057-83-8 ]

Reference： [1]Chemische Berichte,1964,vol. 97,p. 2996 - 3007

4
[ 19351-18-9 ]
1-chloro-2-formylsulfanyl-ethane [ No CAS ]
[ 3963-48-2 ]

Reference： [1]Journal of medicinal chemistry,1965,vol. 8,p. 862 - 864

5
[ 19351-18-9 ]
[ 50-00-0 ]
[ 98-86-2 ]
[ 133913-49-2 ]

Reference： [1]Bulletin de la Societe Chimique de France,1964,p. 2493 - 2499

6
[ 19351-18-9 ]
[ 148312-30-5 ]
cyclopropyl-[4-cyclopropyl-6-(2,2-dimethyl-thiazolidin-3-yl)-[1,3,5]triazin-2-yl]-amine [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 509 - 516

9
[ 151-56-4 ]
[ 7783-06-4 ]
[ 67-64-1 ]
[ 19351-18-9 ]

Reference： [1]Patent: DE747733,1939,
DRP/DRBP Org.Chem.,

10
[ 19351-18-9 ]
cyclopropyl-[4-cyclopropyl-6-(2,2-dimethyl-1,1-dioxo-1λ⁶-thiazolidin-3-yl)-[1,3,5]triazin-2-yl]-amine [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 509 - 516

11
[ 19351-18-9 ]
[ 3963-49-3 ]

Reference： [1]Journal of medicinal chemistry,1965,vol. 8,p. 862 - 864

12
[ 19351-18-9 ]
Diaion SK-104 resin [ No CAS ]
[ 2127-05-1 ]
PET/DMT-modified Diaion SK-104 resin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; for 2.0h;	In a 1000-cc flask, 200 cc of an ion-exchange resin (Mitsubishi Chemical's trade name, Diaion SK-104-this was swollen with water) and 400 cc of methanol were stirred in suspension, to which were dropwise added a solution of 6.6 g of PET in 50 cc of methanol and a solution of 5.6 g of DMT in 50 cc of methanol within a period of 60 minutes. After the addition, this was stirred for 1 hour, and then the ion-exchange resin was taken out through filtration, and washed twice with 100 cc of ion-exchanged water. A part of the thus-separated ion-exchange resin was dried, and analyzed for acidity through titration. The resin were modified with PET by 20% and with DMT by 20%.

Reference： [1]Patent: US2004/127753,2004,A1 .Location in patent: Page 4

13
[ 19351-18-9 ]
AET-modified Diaion SK-104 resin [ No CAS ]
AET/DMT-modified Diaion SK-104 resin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In water; for 1.5h;	In a 1000-cc flask, 200 cc of an ion-exchange resin (Mitsubishi Chemical's trade name, Diaion SK-104-this was swollen with water) and 400 cc of ion-exchanged water were stirred in suspension, to which was dropwise added a solution of 2.8 g AET in 50 cc of ion-exchanged water within a period of 30 minutes. After the addition, this was stirred for 1 hour, and then the ion-exchange resin was taken out through filtration, and washed twice with 100 cc of ion-exchanged water. A part of the thus-separated ion-exchange resin was dried, and analyzed for acidity through titration. As a result, 15% of the acid points of the resin were modified with AET. Next, in a 1000-cc flask, the AET-modified resin and 400 cc of ion-exchanged water were stirred in suspension, to which was dropwise added a solution of 4.2 g of DMT in 50 cc of ion-exchanged water within a period of 30 minutes. After the addition, this was stirred for 1 hour, and then the ion-exchange resin was taken out through filtration, and washed twice with 100 cc of ion-exchanged water. A part of the thus-separated ion-exchange resin was dried, and analyzed for acidity through titration. 30% of the acid points of the resin were modified. This means that the degree of modification with DMT is 15%.

Reference： [1]Patent: US2004/127753,2004,A1 .Location in patent: Page 6

14
[ 19351-18-9 ]
AET/PET-modified Diaion SK-104 resin [ No CAS ]
PET/AET/DMT-modified Diaion SK-104 resin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In water; for 1.5h;	In a 1000-cc flask, 200 cc of an ion-exchange resin (Mitsubishi Chemical's trade name, Diaion SK-104-this was swollen with water) and 400 cc of methanol were stirred in suspension, to which was dropwise added a solution of 3.3 g PET in 50 cc of methanol within a period of 30 minutes. After the addition, this was stirred for 1 hour, and then the ion-exchange resin was taken out through filtration, and washed twice with 100 cc of ion-exchanged water. A part of the thus-separated ion-exchange resin was dried, and analyzed for acidity through titration. As a result, 10% of the acid points of the resin were modified with PET. Next, in a 1000-cc flask, the PET-modified resin and 400 cc of ion-exchanged water were stirred in suspension, to which was dropwise added a solution of 2.8 g of AET in 50 cc of ion-exchanged water within a period of 30 minutes. After the addition, this was stirred for 1 hour, and then the ion-exchange resin was taken out through filtration, and washed twice with 100 cc of ion-exchanged water. A part of the thus-separated ion-exchange resin was dried, and analyzed for acidity through titration. 25% of the acid points of the resin were modified. This means that the degree of modification with AET is 15%. Next, the PET/AET-modified resin and 400 cc of ion-exchanged water were stirred in suspension in a 1000-cc flask, to which was added a solution of 4.2 g of DMT in 50 cc of ion-exchanged water within a period of 30 minutes. After the addition, this was stirred for 1 hour, and then the ion-exchange resin was taken out through filtration, and washed twice with 100 cc of ion-exchanged water. A part of the thus-separated ion-exchange resin was dried, and analyzed for acidity through titration. 40% of the acid points of the resin were modified. This means that the degree of modification with DMT is 15%.

Reference： [1]Patent: US2004/127753,2004,A1 .Location in patent: Page 5

15
[ 19351-18-9 ]
PET-modified Diaion SK-104 resin [ No CAS ]
PET/DMT-modified Diaion SK-104 resin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In water; for 1.5h;	In a 1000-cc flask, 200 cc of an ion-exchange resin (Mitsubishi Chemical's trade name, Diaion SK-104-this was swollen with water) and 400 cc of methanol were stirred in suspension, to which was dropwise added a solution of 2.7 g of 4-mercaptoethylpyridine (this may be referred to as 4-pyridine-ethanethiol, and will be hereinunder abbreviated as PET) in 50 cc of methanol within a period of 30 minutes. After the addition, this was stirred for 1 hour, and then the ion-exchange resin was taken out through filtration, and washed twice with 100 cc of ion-exchanged water. A part of the thus-separated ion-exchange resin was dried, and analyzed for acidity through titration. As a result, 8% of the acid points of the resin were modified (neutralized) with PET. Next, in a 1000-cc flask, the PET-modified resin and 400 cc of ion-exchanged water were stirred in suspension, to which was dropwise added a solution of 2.0 g of <strong>[19351-18-9]2,2-<strong>[19351-18-9]dimethylthiazolidine</strong></strong> (hereinafter this will be abbreviated as DMT) in 50 cc of ion-exchanged water within a period of 30 minutes. After the addition, this was stirred for 1 hour, and then the ion-exchange resin was taken out through filtration, and washed twice with 100 cc of ion-exchanged water. A part of the thus-separated ion-exchange resin was dried, and analyzed for acidity through titration. 15% of the acid points of the resin were modified (neutralized). This means that the degree of modification with DMT is 7%.
	In water; for 1.5h;	In a 1000-cc flask, 200 cc of an ion-exchange resin (Mitsubishi Chemical's trade name, Diaion SK-104-this was swollen with water) and 400 cc of methanol were stirred in suspension, to which was dropwise added a solution of 9.9 g PET in 100 cc of methanol within a period of 30 minutes. After the addition, this was stirred for 1 hour, and then the ion-exchange resin was taken out through filtration, and washed twice with 100 cc of ion-exchanged water. A part of the thus-separated ion-exchange resin was dried, and analyzed for acidity through titration. As a result, 30% of the acid points of the resin were modified with PET. Next, in a 1000-cc flask, the PET-modified resin and 400 cc of ion-exchanged water were stirred in suspension, to which was dropwise added a solution of 2.8 g of DMT in 50 cc of ion-exchanged water within a period of 30 minutes. After the addition, this was stirred for 1 hour, and then the ion-exchange resin was taken out through filtration, and washed twice with 100 cc of ion-exchanged water. A part of the thus-separated ion-exchange resin was dried, and analyzed for acidity through titration. 40% of the acid points of the resin were modified. This means that the degree of modification with DMT is 10%.

Reference： [1]Patent: US2004/127753,2004,A1 .Location in patent: Page 2
[2]Patent: US2004/127753,2004,A1 .Location in patent: Page 4

16
[ 19351-18-9 ]
[ 79-36-7 ]
[ 52836-66-5 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In diethyl ether; dichloromethane;	EXAMPLE III Preparation of 2,2-dimethyl-3-dichloroacetyl thiazolidine. Four and seven-tenths grams of <strong>[19351-18-9]2,2-dimethyl thiazolidine</strong> and 4.5 g. of triethylamine were dissolved in 50 ml. of methylene chloride and 5.9 g. of dichloroacetyl chloride was added dropwise with stirring. The mixture was cooled in a water bath at room temperature. When reaction was complete, the mixture was poured into water and the solvent layer separated, dried over anhydrous magnesium sulfate, and the solvent removed under vacuum. Yield was 3.6 g. of a waxy solid. Recrystallization of another sample from diethyl ether gave a white solid, m.p. 109-111C.

Reference： [1]Patent: US3959304,1976,A

17
[ 19351-18-9 ]
[ 5302-76-1 ]
2,2-dimethyl-3-dibromoacetyl thiazolidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In triethylamine; benzene;	EXAMPLE V Preparation of 2,2-dimethyl-3-dibromoacetyl thiazolidine. To a mixture of 3.5 g. of <strong>[19351-18-9]2,2-dimethyl thiazolidine</strong>, 50 ml. of benzene and 7.1 g. of dibromoacetyl chloride mixed in an ice bath was added 3.1 g. of triethylamine dropwise with stirring and continued cooling. When reaction was complete, the mixture was poured into water and the benzene layer separated, dried over magnesium sulfate and the benzene removed under vacuum. Yield was 8.5 g. of a dark oil.
	In triethylamine; benzene;	EXAMPLE V Preparation of 2,2-dimethyl-3-dibromoacetyl thiazolidine To a mixture of 3.5 g. of <strong>[19351-18-9]2,2-dimethyl thiazolidine</strong>, 50 ml. of benzene and 7.1 g. of dibromoacetyl chloride mixed in an ice bath was added 3.1 g. of triethylamine dropwise with stirring and continued cooling. When reaction was complete, the mixture was poured into water and the benzene layer separated, dried over magnesium sulfate and the benzene removed under vacuum. Yield was 8.5 g. of a dark oil.

Reference： [1]Patent: US3959304,1976,A
[2]Patent: US3989503,1976,A

18
[ 19351-18-9 ]
[ 3303-84-2 ]
[ 915702-18-0 ]

Yield	Reaction Conditions	Operation in experiment
8%	With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; at 20.0℃; for 48.0h;	To a mixture of <strong>[19351-18-9]2,2-<strong>[19351-18-9]dimethylthiazolidine</strong></strong> (234.4 mg; 2 mmol; 1 eq) and boc-beta-alanine(416.3 mg; 2.20 mmol; 1.10 eq) in DCM (30 ml), are added triethylamine (832 mul; 6 mmol; 3 eq) and 2-chloro-1-methylpyridinium iodide (1533 mg; 6 mmol; 3 eq). The mixture is stirred 2 days at RT. The reaction is followed by TLC (cyclohexane/EtOAc 1:1). The reaction mixture is then washed twice with NH4Cl sat. solution and twice with NaHCO3 sat. solution. The organic layer is dried over Na2SO4, filtered and concentrated to give 497 mg of an orange oil, which is purified by flash chromatography (cyclohexane / EtOAc gradient, from 9/1 to 1/1 over 30 min). The title product is isolated as a white-off solid (45.5 mg; 8%).1K NMR (DMSO-d6, 300 MHz) delta 1.42 (s, 9H), 1.81 (s, 6H), 2.45 (t, J= 6 Hz, 2H), 2.97 (t, J= 6 Hz, 2H), 3.38 (m, 2H), 3.82 (t, J= 6 Hz, 2H), 5.21 (br s, 1H). M+(ESI): 289.2.

Reference： [1]Patent: WO2006/125805,2006,A1 .Location in patent: Page/Page column 65

19
[ 19351-18-9 ]
borane tetrahydrofuran [ No CAS ]
[ 112590-90-6 ]

Reference： [1]Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,1987,vol. 43,p. 43 - 50

20
[ 19351-18-9 ]
[ 1365917-18-5 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 628 - 633

21
[ 19351-18-9 ]
[ 1356679-49-6 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 628 - 633

22
[ 19351-18-9 ]
[ 1365911-70-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 628 - 633

23
[ 19351-18-9 ]
[ 1202077-22-2 ]
[ 1365903-06-5 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 628 - 633

24
[ 19351-18-9 ]
C₅₄H₅₈N₂O₁₂ [ No CAS ]
C₅₂H₇₀N₂O₆S₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
26.2%	With dmap; triethylamine; In dichloromethane; at 45.0℃;	bis(4-nitrophenyl)(((1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadecane-1,3,5,7,9,11,13,15,17-nonenylene-1,18-diyl)bis(3,5,5-trimethyl-2-oxocyclohex-3-ene-4,1-diyl))di(carbonyl) (380 mg, 0.41 mmol)Dissolved in dichloromethane (20 ml) and added triethylamine (83 mg, 0.82 mmol).DMAP (59 mg, 0.41 mmol) and 2,2-dimethylthiazole (1.44 g, 12.3 mmol).The reaction solution was stirred at 45 C overnight. After the reaction was completed, water (40 ml) was added and extracted with dichloromethane (40 ml×3).The organic phases were combined and washed with saturated brine (40 ml). Then distilled under reduced pressure to give a red oil.The crude product is purified by silica gel column chromatography (eluent is dichloromethane).Obtained a red solid (95 mg, 26.2%).

Reference： [1]Patent: CN107021961,2018,B .Location in patent: Paragraph 0091-0093

25
[ 19351-18-9 ]
C₄₅H₅₅N₅O₁₂S₅ [ No CAS ]

Reference： [1]Patent: CN107021961,2018,B

26
[ 19351-18-9 ]
C₃₉H₄₆N₄O₁₁S₄ [ No CAS ]

Reference： [1]Patent: CN107021961,2018,B

27
[ 19351-18-9 ]
[ 32315-10-9 ]
2,2-dimethylthiazolidine-3-carbonyl chloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20.0℃; for 0.5h;Cooling with ice;	2,2-dimethylthiazole(1.17 g, 10.0 mmol) was dissolved in anhydrous dichloromethane (40 mL).To the ice water bath was added triphosgene (1.50 g, 5 mmol), followed by dropwise addition of DIPEA (2.58 g, 20.0 mmol). Remove the ice water bath and stir at room temperature for half an hour.After completion of the reaction, water (20 ml) was added and extracted with dichloromethane (30 ml×3).The organic phases were combined and washed with brine (20 mL).Vacuum drying to give a crude orange oil(1.8 g, 99%) was used directly in the next step.

Reference： [1]Patent: CN107021961,2018,B .Location in patent: Paragraph 0064-0067

28
[ 19351-18-9 ]
N-[2-(cyanomethyl)-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl]-N-[3-(2,2-dimethyl-1,3-thiazolidin-3-yl)-3-oxopropyl]urea [ No CAS ]

Reference： [1]Patent: WO2006/125805,2006,A1

29
[ 19351-18-9 ]
[ 915702-17-9 ]

Reference： [1]Patent: WO2006/125805,2006,A1

30
[ 19351-18-9 ]
[ 4083-64-1 ]
2,2-dimethyl-N-[(p-methylphenyl)sulfonyl]-thiazolidine-3-formamide [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2019,vol. 56,p. 180 - 187

31
[ 19351-18-9 ]
[ 27761-19-9 ]

Yield	Reaction Conditions	Operation in experiment
87 %		2 Preparation of Crude Cysteamine Bitartrate (I) from 2,2-dimethylthiazolidine (II) 102 Kg of crude Cysteamine Bitartrate were obtained after drying at 40-60° C. with a yield of about 87% mol vs 2,2-dimethylthiazolidine 100%. Analysis: Crude Cysteamine Bitartrate was characterized as shown in the Table 4 below:

Reference： [1]Current Patent Assignee: RECORDATI SPA - US2023/202975, 2023, A1

32
[ 19351-18-9 ]
[ 51-85-4 ]
[ 27761-19-9 ]

Yield	Reaction Conditions	Operation in experiment
85 %		8 Example 8 Example 8 Preparation of Crude Cysteamine Bitartrate According to IN202041000697A (Example 9) but using of 2,2-dimethylthiazolidine (DMT) instead of 2-methyl-2-ethyl thiazolidine (MET) as starting material. Crude Cysteamine Bitartrate was prepared by following the same procedure of Example 7C but starting from 100 g of 2,2-dimethylthiazolidine (DMT) prepared according to Example 1. The final crude Cysteamine Bitartrate showed HPLC purity of 98.5% (Yield: 85%).

Reference： [1]Current Patent Assignee: RECORDATI SPA - US2023/202975, 2023, A1

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
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P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 19351-18-9 ] {[proInfo.proName]}

Quality Control of [ 19351-18-9 ]

Related Doc. of [ 19351-18-9 ]

Product Details of [ 19351-18-9 ]

Calculated chemistry of [ 19351-18-9 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 19351-18-9 ]

Application In Synthesis of [ 19351-18-9 ]

[ 19351-18-9 ] Synthesis Path-Upstream 1~3

[ 19351-18-9 ] Synthesis Path-Downstream 1~32

Related Parent Nucleus of [ 19351-18-9 ]

Thiazolidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Parent Nucleus of
[ 19351-18-9 ]