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Chemical Structure| 195302-79-5 Chemical Structure| 195302-79-5

Structure of 195302-79-5

Chemical Structure| 195302-79-5

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Product Details of [ 195302-79-5 ]

CAS No. :195302-79-5
Formula : C18H27NO4
M.W : 321.41
SMILES Code : O=C(O)CCCCCCCCCNC(OCC1=CC=CC=C1)=O
MDL No. :MFCD32263124

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Application In Synthesis of [ 195302-79-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 195302-79-5 ]

[ 195302-79-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13108-19-5 ]
  • [ 501-53-1 ]
  • [ 195302-79-5 ]
YieldReaction ConditionsOperation in experiment
In sodium hydroxide; water; acetonitrile; The crude product (5.7 g) was dissolved in 15.5 mL of 2N NaOH and treated simultaneously with 23 mL of 2N NaOH and 5.8 g of carbobenzoxychloride at 0° C. with vigorous stirring over 0.5 h. Water and 2N NaOH were added as needed to maintain stirring and a pH between 10-14. After stirring for 2.5 h, the reaction was diluted with 400 mL of H2 O and filtered through dicalite. The filtrate was acidified (pH 2) with H2 SO4, then extracted with ether. The combined ether extracts were dried (Na2 SO4), filtered and concentrated. The residue was dissolved in CH3CN, filtered, and the filtrate concentrated to afford 5.3 g of 10-(N-carbobenzoxy)-aminodecanoic acid which was used without further purification: FAB-MS m/z 322 (MH+). Compound 9 was prepared using the general method of Example 1. CBZ-D-PheOH replaced CBZ-D-homophenylalanine in Step 1a and 10-(N-carbobenzoxy)-aminodecanoic acid replaced 8-carbobenzoxyaminooctanoic acid in Step 1c to give the title compound as a solid: FAB-MS m/z 598 (MH+); Anal Calc'd for C31 H47 N7 O5.1.75 C2 HF3 O2.1.75 H2 O; Calc'd: C, 50.00; H, 6.35; N, 11.83; H2 O, 3.80; Found: C, 49.62; H, 6.23; N, 11.93; H2 O, 3.46.
 

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