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Chemical Structure| 19575-07-6 Chemical Structure| 19575-07-6
Chemical Structure| 19575-07-6

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Product Details of Methyl quinoline-2-carboxylate

CAS No. :19575-07-6
Formula : C11H9NO2
M.W : 187.20
SMILES Code : COC(=O)C1=NC2=C(C=CC=C2)C=C1
MDL No. :MFCD00160630
InChI Key :CILJSZLWPHTUIP-UHFFFAOYSA-N
Pubchem ID :421738

Safety of Methyl quinoline-2-carboxylate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Methyl quinoline-2-carboxylate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 19575-07-6 ]

[ 19575-07-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 19575-07-6 ]
  • [ 5760-20-3 ]
  • 2
  • [ 19575-07-6 ]
  • [ 5451-55-8 ]
  • methyl 4-(4-tert-butylcyclohexyl)quinoline-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
21% With ammonium peroxodisulfate; sulfuric acid; silver nitrate; In water; acetonitrile; at 70 - 80℃; for 0.5h; General procedure: A freshly prepared solution of ammonium persulfate (3 mmol) in water (5 mL) was added drop wise to a mixture of methyl 2-quinolinecarboxylate (2, 1 mmol), silver nitrate (0.6 mmol) and cycloalkylcarboxylic acid (3 mmol) in 10% H2SO4 (4 mL) during 15 min at 70-80 C. The heating source was then removed and the reaction proceeded with evolution of carbon dioxide. After another 15 min, pouring the mixture onto a crushed ice terminated reaction. The resulting mixture was made alkaline with 25% NH4OH solution, and extracted with ethyl acetate (3×50 mL). The combined extract was washed with brine (2×10mL) and dried over Na2SO4. The solvent was removed under reduced pressure to afford oil, which on chromatography over silica gel using EtOAc/hexanes (20:80) afforded 3-10.
  • 3
  • [ 19575-07-6 ]
  • [ 5451-55-8 ]
  • 4-(4-tert-butylcyclohexyl)quinoline-2-carbohydrazide [ No CAS ]
 

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