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Chemical Structure| 19817-92-6 Chemical Structure| 19817-92-6

Structure of 19817-92-6

Chemical Structure| 19817-92-6

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Uridine-5'-triphosphoric acid trisodium salt is a pyrimidine nucleoside triphosphate, a substrate for the synthesis of RNA during transcription.

Synonyms: UTP; NSC 20260; UTP sodium salt

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Product Details of Uridine triphosphate trisodium salt

CAS No. :19817-92-6
Formula : C9H12N2Na3O15P3
M.W : 550.09
SMILES Code : O[C@@H]([C@H]([C@H](N1C(NC(C=C1)=O)=O)O2)O)[C@H]2COP([O-])(OP([O-])(OP([O-])(O)=O)=O)=O.[Na+].[Na+].[Na+]
Synonyms :
UTP; NSC 20260; UTP sodium salt
MDL No. :MFCD00044310

Safety of Uridine triphosphate trisodium salt

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P280-P305+P351+P338-P310

Related Pathways of Uridine triphosphate trisodium salt

DNA

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Schwannoma cell line RT4-D6P2T 250 µM 12 hours To investigate the effect of UTP on Schwannoma cell migration and wound closure, it was found that UTP induces cell migration through activation of P2Y2 receptors and increased MMP-2 activation and expression PLoS One. 2014 Jun 6;9(6):e98998
Primary Schwann cells 250 µM 24 hours To study the effect of UTP on primary Schwann cell migration and MMP-2 expression, it was found that UTP significantly increases MMP-2 expression and activity PLoS One. 2014 Jun 6;9(6):e98998
Rat cardiomyocytes 50 µM 30 min or 24 hours To investigate the effect of UTP on mitochondrial calcium levels in cardiomyocytes under hypoxic conditions, results showed that UTP pretreatment significantly reduced mitochondrial calcium levels. Biochem Pharmacol. 2006 Oct 16;72(8):949-55

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Wistar rats Myocardial infarction model Intravenous injection 0.44 µg/kg or 4.4 µg/kg Single dose, 30 min or 24 h before MI To investigate the protective effect of UTP pretreatment on cardiac function in rats with myocardial infarction, results showed that UTP pretreatment significantly reduced infarct size and improved cardiac function. Biochem Pharmacol. 2006 Oct 16;72(8):949-55

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.82mL

0.36mL

0.18mL

9.09mL

1.82mL

0.91mL

18.18mL

3.64mL

1.82mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
 

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