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Chemical Structure| 198554-64-2 Chemical Structure| 198554-64-2

Structure of 198554-64-2

Chemical Structure| 198554-64-2

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Product Details of [ 198554-64-2 ]

CAS No. :198554-64-2
Formula : C13H14N2O
M.W : 214.26
SMILES Code : N#CC1CCN(C(C2=CC=CC=C2)=O)CC1

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Application In Synthesis of [ 198554-64-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 198554-64-2 ]

[ 198554-64-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24686-78-0 ]
  • [ 38622-91-2 ]
  • [ 198554-64-2 ]
YieldReaction ConditionsOperation in experiment
2.14 g (66%) With potassium tert-butylate; In 1,2-dimethoxyethane; ethanol; ethyl acetate; Example 74A 1-benzoyl-4-piperidinecarbonitrile A mixture of 1-benzoyl-4-piperidone (2.0 g, 9.8 mmol), tosylmethyl isocyanide (2.5 g, 12.8 mmol) and ethanol (1.0 mL, 17.1 mmol) in 30 mL DME was cooled in an ethanol/ice bath, and potassium tert-butoxide was added at such a rate to maintain the reaction temperature at <10° C. The cold bath was removed, and the reaction was allowed to stir overnight at room temperature. The solids were removed by filtration, rinsed with DME, and the filtrate was evaporated. The residue was dissolved in EtOAc, washed with water and brine, dried (MgSO4), filtered through silica gel, and concentrated to give 2.14 g (66percent) of a slightly yellow oil.
 

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