1997302-16-5 | tert-Butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate | Esters | Ambeed.com

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Catalysts Ligands

Materials Science

Pharmaceutical Intermediate

Catalysts Ligands

Achiral Nitrogen Ligands

Pyridine and Phenanthroline Ligands (277)

Other Achiral Nitrogen Ligands (52)

Achiral Oxygen Ligands

Achiral Oxygen Ligand (55)

Achiral Phosphine Ligands

Alkyl-phosphine Ligands (18)

Aryl-phosphine Ligands (85)

2-(Diphenylphosphaneyl)Benzaldehyde (5)[1,1'-Biphenyl]-2-Yldi-Tert-Butylphosphane (4)Triphenylphosphine Oxide (7)

Bis-phosphine Ligands (90)

Monophosphine Ligands (255)

Multi-phosphine Ligands (5)

Chiral Nitrogen Ligands

BINAM Ligands (14)

Chiral Bis-nitrogen Ligands (82)

Salen Ligands (7)

Other Chiral Nitrogen Ligands (62)

Chiral Oxazoline Ligands

BOX Ligands (526)

Chiral Mono Oxazoline Ligands (382)

Ferrocenyl-oxazoline Ligands (10)

PHOX Ligands (231)

TOX Ligands (6)

Other Oxazoline Ligands (18)

Chiral Oxygen Ligands

Chiral Diphenols (112)

Other Chiral Oxygen Ligands (24)

Chiral Phosphine Ligands

Atropisomeric Bisphosphine Ligands (219)

BIDIME and BIBOP Ligands (86)

BIDIME-BIBOP (7)

2,2',3,3'-Tetrahydro-4,4'-Bibenzo[D][1,3]Oxaphosphole (7)

Chiral Aminophosphine Ligands (48)

Chiral Ferrocenyl Phosphine Ligands (130)

Chiral Phosphoramidite Ligands (191)

Duphos and BPE Ligands (35)

PHOX Ligands (231)

Sadphos Ligands (294)

Other C-Chiral Ligands (76)

Other P-Chiral Ligands (16)

Main-Group Metals

Photoredox Catalysts

Organic-dye Photoredox Catalysts (80)

Photoredox Acridinium Catalysts (22)

Photoredox Carbazole Catalysts (9)

Photoredox Iridiums Catalysts (100)

Photoredox Rutheniums Catalysts (37)

Other Photoredox Catalysts (12)

Asymmetric Synthesis

Chiral Building Blocks (18089)

Chiral Resolution Reagents (63)

Boronic Acids/Esters

1,3,2-Dioxaborinane (392)

Boronic Acids (13046)

MIDA Boronates (363)

Pinacol Boronates (16046)

Pinanediol Boronates (98)

Potassium Organotrifluoroborate Salts (1072)

Other Boronates (132)

Chemical Biology

Glycoscience (184)

Monosaccharide (148)Polysaccharide (11)

Peptide Chemistry (460)

Amino Acid (111)Peptides (134)Resins for Solid Phase Peptide Synthesis (51)

Fluorine Chemistry

Aliphatic Fluorinated Building Blocks (763)

Aromatic Fluorinated Building Blocks (9406)

Bis(trifluoromethane)sulfonimides (49)

Difluoromethoxylated Building Blocks (231)

Difluoromethylated Building Blocks (350)

Hexafluorophosphates (62)

Monofluoromethylated Building Blocks (73)

Polyfluoroalkanes (85)

SF5-Containing Building Blocks (72)

Sulfonyl Fluorides (66)

Tetrafluoroborates (138)

Trifluoroborates (212)

Trifluoromethoxylated Building Blocks (560)

Trifluoromethylated Building Blocks (4499)

Trifluoromethylthiolated Building Blocks (49)

Heterocyclic Building Blocks

Acridines (640)

1,2,3,4-Tetrahydroacridine (9)9,10-Diphenylacridin-10-Ium (6)Acridine (45)

Aliphatic Heterocycles (379)

(1R,5S)-3-Azabicyclo[3.1.0]Hexane (11)1,2-Dithiolane (5)1,4-Diazepan-2-One (5)1,4-Diazepan-5-One (9)1,4-Dioxane (17)1,4-Oxazepane (8)10,11-Dihydro-5H-Dibenzo[B,F]Azepine (9)11,12-Didehydro-5,6-Dihydrodibenz[B,F]Azocine (14)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Glycyl)-2,2-Dimethyloxazolidine-4-Carboxylic Acid (9)3H-Diazirine (10)4-Benzyl-1,4-Oxazepane (5)Tetrahydro-2H-Thiopyran 1,1-Dioxide (8)

Aromatic Heterocycles (118)

1,2,4,5-Tetrazine (8)3,4-Dihydronaphthalen-2(1H)-One (23)

Azetidines (2937)

1-(Azetidin-1-Yl)-2-Bromoethan-1-One (3)1-(Azetidin-3-Yl)-1H-Pyrazole (7)1-(Phenylsulfonyl)Azetidine (7)1-Benzhydrylazetidine (13)1-Benzylazetidine (6)1-Methylazetidine (6)1-Phenylazetidine (8)2,7-Diazaspiro[3.5]Nonane (7)2-Azaspiro[3.3]Heptane (11)2-Imino-N-((6R,7R)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-(Thiazol-4-Yl)Acetamide (3)3-Bromoazetidine (3)3-Methylazetidin-3-Ol (3)3-Methyleneazetidine (8)4-(Azetidin-1-Yl)Piperidine (6)Azetidin-2-One (11)Azetidin-2-Ylmethanol (7)Azetidin-3-Amine (4)Azetidin-3-Ol (11)Azetidin-3-Yl Acetate (3)Azetidin-3-Ylmethanamine (3)Azetidine-2-Carboxylic Acid (6)Azetidine-3-Carboxylic Acid (5)Benzyl Azetidine-1-Carboxylate (9)Methyl Azetidine-2-Carboxylate (3)N-((6R,7R)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-Phenylacetamide (5)Tert-Butyl Azetidine-1-Carboxylate (64)Alcohols (18)Amides (102)Amines (17)Aryls (44)Bromides (7)Carboxylic Acids (17)Chlorides (10)Esters (11)Ethers (18)Fluorinated Building Blocks (20)Ketones (16)Nitriles (5)Sulfamides (5)Oxetanes (9)Piperidines (16)Pyridines (4)Pyrimidines (4)Pyrrolidines (12)Spiroes (85)Tetrahydropyrans (6)

Benzimidazoles (4398)

(1H-Benzo[D]Imidazol-2-Yl)Methanamine (7)(1H-Benzo[D]Imidazol-2-Yl)Methanol (14)1,2-Diphenyl-1H-Benzo[D]Imidazole (7)1-Benzyl-1H-Benzo[D]Imidazole (6)1-Ethyl-1H-Benzo[D]Imidazole (4)1-Methyl-1H-Benzo[D]Imidazole (47)1-Phenyl-1H-Benzo[D]Imidazole (4)1H-Benzo[D]Imidazol-2-Amine (7)1H-Benzo[D]Imidazol-5-Amine (4)1H-Benzo[D]Imidazol-6-Amine (6)1H-Benzo[D]Imidazole-2-Carbaldehyde (5)1H-Benzo[D]Imidazole-2-Carboxylic Acid (7)1H-Benzo[D]Imidazole-2-Thiol (10)1H-Benzo[D]Imidazole-4-Carboxylic Acid (6)1H-Benzo[D]Imidazole-5-Carboxylic Acid (4)2-((Pyridin-2-Ylmethyl)Thio)-1H-Benzo[D]Imidazole (7)2-(1H-Benzo[D]Imidazol-2-Yl)Ethan-1-Amine (6)2-(Chloromethyl)-1H-Benzo[D]Imidazole (9)2-Benzyl-1H-Benzo[D]Imidazole (7)2-Bromo-1H-Benzo[D]Imidazole (4)2-Chloro-1H-Benzo[D]Imidazole (17)2-Methyl-1H-Benzo[D]Imidazole (20)4-Bromo-1H-Benzo[D]Imidazole (14)4-Methyl-1H-Benzo[D]Imidazole (7)5,6-Dichloro-1H-Benzo[D]Imidazole (4)5-Bromo-1H-Benzo[D]Imidazole (13)5-Chloro-1H-Benzo[D]Imidazole (14)5-Methoxy-1H-Benzo[D]Imidazole (2)5-Methyl-1H-Benzo[D]Imidazole (10)6-Chloro-1H-Benzo[D]Imidazole (25)Methyl (1H-Benzo[D]Imidazol-2-Yl)Carbamate (5)Methyl 1H-Benzo[D]Imidazole-2-Carboxylate (3)Tert-Butyl 1H-Benzo[D]Imidazole-1-Carboxylate (3)Alcohols (11)Aldehydes (5)Amides (26)Amines (19)Aryls (40)Bromides (8)Carboxylic Acids (6)Chlorides (15)Esters (12)Ethers (17)Fluorinated Building Blocks (14)Sulfides (7)Benzimidazole-Carboxylic Acid (42)Piperidines (18)Pyridines (6)

Benzisoxazoles (1232)

3-Chlorobenzo[D]Isoxazole (7)3-Methylbenzo[D]Isoxazole (8)6-Bromobenzo[D]Isoxazole (5)Benzo[C]Isoxazole (5)Benzo[D]Isoxazol-3-Amine (8)Amides (4)Amines (4)Fluorinated Building Blocks (4)Piperidines (4)

Benzodioxans (693)

(2,3-Dihydrobenzo[B][1,4]Dioxin-2-Yl)Methanamine (3)2,3-Dihydrobenzo[B][1,4]Dioxine-2-Carboxylic Acid (3)2,3-Dihydrobenzo[B][1,4]Dioxine-6-Carboxylic Acid (3)6-Bromo-2,3-Dihydrobenzo[B][1,4]Dioxine (6)Alcohols (8)Amines (5)

Benzofurans (3729)

1-(Benzofuran-2-Yl)Ethan-1-One (3)2,2-Dimethyl-2,3-Dihydrobenzofuran (7)2,3-Dihydrobenzofuran-3-Amine (11)2,3-Dihydrobenzofuran-5-Amine (3)2,3-Dihydrobenzofuran-7-Amine (5)2-(Benzofuran-3-Yl)Acetic Acid (3)2-Bromodibenzo[B,D]Furan (6)2-Ethylbenzofuran (3)2-Methylbenzofuran (5)3-Methylbenzofuran (4)4-Bromobenzofuran (3)4-Phenyldibenzo[B,D]Furan (8)5,7,8-Trimethylchromane (3)5-Bromo-2,3-Dihydrobenzofuran (6)5-Chloro-2,3-Dihydrobenzofuran (5)5-Fluoro-2,3-Dihydrobenzofuran (5)5-Methoxyisobenzofuran-1(3H)-One (5)6-Bromo-2,3-Dihydrobenzofuran (7)6-Fluoro-2,3-Dihydrobenzofuran (6)6-Methoxybenzofuran (4)7-Bromo-2,3-Dihydrobenzofuran (6)7-Bromobenzofuran (6)7-Fluoro-2,3-Dihydrobenzofuran (6)Benzofuran-2(3H)-One (7)Benzofuran-2-Carbaldehyde (5)Benzofuran-2-Carboxylic Acid (21)Benzofuran-2-Ylboronic Acid (8)Benzofuran-3(2H)-One (15)Benzofuran-3-Carboxylic Acid (6)Benzofuran-3-Yl(Phenyl)Methanone (11)Methyl Benzofuran-2-Carboxylate (6)Alcohols (18)Aldehydes (4)Amides (7)Amines (13)Anhydrides (13)Aryls (12)Bromides (18)Carboxylic Acids (9)Chlorides (14)Esters (33)Ethers (2)Fluorinated Building Blocks (11)Iodides (4)Ketones (10)Nitroes (5)Benzofuran-Carboxylic Acid (67)Dimethoxyisobenzofuran (4)Fluorobenzofuran (19)Fluoroisobenzofuran (5)Methoxyisobenzofuran (4)Methylbenzofuran (25)Piperidines (5)Spiroes (5)

Benzothiazoles (2480)

2-(Methylthio)Benzo[D]Thiazole (6)2-Bromobenzo[D]Thiazole (28)2-Chlorobenzo[D]Thiazole (21)2-Methylbenzo[D]Thiazole (26)4-Bromobenzo[D]Thiazole (9)4-Chlorobenzo[D]Thiazole (7)4-Fluorobenzo[D]Thiazole (6)4-Methylbenzo[D]Thiazole (10)5-Chlorobenzo[D]Thiazole (5)5-Nitrobenzo[D]Thiazole (3)6-Bromobenzo[D]Thiazole (7)6-Chlorobenzo[D]Thiazole (6)6-Fluorobenzo[D]Thiazole (5)6-Methoxybenzo[D]Thiazole (6)6-Methylbenzo[D]Thiazole (6)6-Nitrobenzo[D]Thiazole (3)7-Bromobenzo[D]Thiazole (8)7-Chlorobenzo[D]Thiazole (6)7-Fluorobenzo[D]Thiazole (9)Benzo[D]Thiazol-2-Amine (30)Benzo[D]Thiazol-5-Amine (3)Benzo[D]Thiazol-6-Amine (3)Benzo[D]Thiazol-6-Ol (2)Benzo[D]Thiazole-2-Carbonitrile (11)Benzo[D]Thiazole-2-Thiol (11)Benzo[D]Thiazole-6-Carboxylic Acid (5)Methyl Benzo[D]Thiazole-6-Carboxylate (5)Alcohols (6)Aldehydes (5)Amides (23)Amines (30)Aryls (10)Bromides (11)Carboxylic Acids (5)Chlorides (6)Esters (5)Ethers (15)Fluorinated Building Blocks (7)Nitroes (5)Sulfamides (6)Thioesters (12)Benzothiazole-Carboxylic Acid (26)Bromobenzothiazole (7)Dichlorobenzothiazole (10)Methoxybenzothiazole (4)Methylbenzothiazole (7)Morpholines (4)

Carbazole Series (501)

1-Methyl-9H-Carbazole (7)2,3,4,9-Tetrahydro-1H-Carbazol-1-One (7)2-Bromo-9H-Carbazole (4)3,9-Diphenyl-9H-Carbazole (7)3-(Tert-Butyl)-9H-Carbazole (3)3-Bromo-9-Phenyl-9H-Carbazole (16)3-Bromo-9H-Carbazole (4)3-Chloro-9H-Carbazole (3)3-Methyl-9H-Carbazole (3)7H-Benzo[C]Carbazole (5)9-([1,1'-Biphenyl]-4-Yl)-9H-Carbazole (9)9-(P-Tolyl)-9H-Carbazole (5)9-Benzyl-9H-Carbazole (7)9-Ethyl-9H-Carbazole (9)Carbazolyl-Phenyl-Boronic Acid/Ester (14)

Cinnolines (355)

7-Oxabicyclo[4.1.0]Heptane (7)Ethyl Oxirane-2-Carboxylate (4)Oxiran-2-Ylmethanol (3)Aliphatic Chain Hydrocarbons (7)Amides (10)Aryls (25)Esters (9)Ethers (13)Ketones (4)Nitroes (5)Sulfonates (7)Epoxy (5)Oxirane (61)Spiroes (5)Other Aliphatic Heterocycles (11)

2,3-Dihydrofuran-3-One (9)2-(Bromomethyl)Furan (3)2-(Chloromethyl)Furan (3)2-(Furan-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (6)2-Bromofuran (21)2-Chlorofuran (3)2-Methylfuran (37)2-Nitrofuran (9)3-Bromofuran (13)4-Methylisobenzofuran-1(3H)-One (3)5-Nitro-2,3-Dihydrobenzofuran (3)5-Phenylfuran-2-Carbaldehyde (9)5-Phenylfuran-2-Carboxylic Acid (6)6-Chloro-2,3-Dihydrobenzofuran (3)6-Fluoroisobenzofuran-1(3H)-One (3)7-Chloro-2,3-Dihydrobenzofuran (3)Ethyl Furan-2-Carboxylate (6)Furan-2,5-Dione (8)Furan-2-Carbaldehyde (21)Furan-2-Carbonitrile (8)Furan-2-Carboxylic Acid (30)Furan-2-Ylmethanol (7)Furan-3-Carboxylic Acid (11)Furo[3,2-B]Pyridine (7)Furo[3,2-C]Pyridine (7)Methyl Furan-2-Carboxylate (20)N-(Furan-2-Ylmethyl)Aniline (5)Alcohols (8)Aldehydes (15)Alkenyls (9)Amides (30)Amines (22)Aryls (39)Bromides (13)Carboxylic Acids (35)Chlorides (9)Esters (21)Ethers (10)Fluorinated Building Blocks (4)Ketones (10)Nitriles (7)Nitroes (8)Sulfides (6)Aminodihydrofuran (7)Bromofuran (32)Chlorofuran (2)Chlorofuro (11)Cyanofuran (53)Dibromofuran (5)Dihydrofuran (31)Dihydrofuro (16)Dihydroxydihydrofuran (8)Dimethylfuran (10)Formylfuran (10)Hexahydrofuro (6)Hydroxydihydrofuran (31)Methyldihydrofuran (11)Methylfuran (58)Nitrofuran (10)Piperazines (4)Quinolines (3)

Imidazoles (2745)

Biimidazole (5)Bromoimidazo (102)Dibromoimidazo (8)Dichloroimidazo (9)Dihydroimidazo (25)Imidazopyridine (263)Methoxyimidazo (13)Methylimidazo (121)Tetrahydroimidazo (37)1,1'-Diphenyl-4,4',5,5'-Tetrahydro-1H,1'H-2,2'-Biimidazole (11)1,2-Dimethyl-1H-Imidazole (6)1,3-Diphenyl-1H-Imidazol-3-Ium (14)1,3-Diphenyl-4,5-Dihydro-1H-Imidazol-3-Ium (5)1-(Imidazo[1,2-A]Pyridin-3-Yl)Ethan-1-One (3)1-(Phenylsulfonyl)-1H-Imidazole (5)1-Benzyl-1H-Imidazole (20)1-Decyl-3-Methyl-1H-Imidazol-3-Ium (14)1-Ethyl-1H-Imidazole (3)1-Isopropyl-1H-Imidazole (5)1-Phenyl-1H-Imidazole-4-Carboxylic Acid (5)1-Trityl-1H-Imidazole (15)1H-Imidazo[4,5-B]Pyridine (14)1H-Imidazo[4,5-C]Pyridine (12)1H-Imidazol-2-Amine (6)1H-Imidazole-2-Carboxylic Acid (7)1H-Imidazole-4-Carbonitrile (2)1H-Imidazole-4-Carboxylic Acid (4)2-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole (5)2-Bromo-1H-Imidazole (13)2-Bromoimidazo[1,2-A]Pyridine (5)2-Ethyl-1H-Imidazole (3)2-Methyl-1-Phenyl-1H-Imidazole (11)2-Methylimidazo[1,2-A]Pyridine (8)2-Phenyl-1H-Benzo[D]Imidazole (26)2-Phenyl-1H-Imidazole (26)2-Phenylimidazo[1,2-A]Pyridine (12)2-Propyl-1H-Imidazole (5)3-Bromoimidazo[1,2-A]Pyrazine (6)3-Bromoimidazo[1,2-A]Pyridine (26)3-Bromoimidazo[1,2-A]Pyrimidine (6)3-Iodoimidazo[1,2-A]Pyridine (10)3-Methylimidazo[1,2-A]Pyridine (3)4,5,6,7-Tetrahydro-3H-Imidazo[4,5-C]Pyridine (5)4-(1H-Imidazol-1-Yl)Benzaldehyde (7)4-Bromo-1-Phenyl-1H-Imidazole (9)4-Methyl-1-Phenyl-1H-Imidazole (7)4-Methyl-1H-Imidazole (6)4-Phenyl-1H-Imidazole (8)5,6,7,8-Tetrahydroimidazo[1,2-A]Pyrazine (15)5,6,7,8-Tetrahydroimidazo[1,2-A]Pyridine (11)5,6,7,8-Tetrahydroimidazo[1,5-A]Pyrazine (11)5-Benzyl-1H-Imidazole (1)5-Bromoimidazo[1,2-A]Pyridine (6)5-Chloro-1H-Imidazole (2)5-Fluoro-1H-Benzo[D]Imidazole (12)5-Iodo-1H-Imidazole (4)5-Methylimidazo[1,2-A]Pyridine (4)5-Phenyl-1H-Imidazole (6)6,7-Dihydro-5H-Pyrrolo[1,2-A]Imidazole (9)6-Bromoimidazo[1,2-A]Pyrazine (11)6-Bromoimidazo[1,2-A]Pyridine (14)6-Bromoimidazo[1,2-A]Pyrimidine (5)6-Chloroimidazo[1,2-A]Pyridine (4)6-Chloroimidazo[1,2-B]Pyridazine (30)7-Methylimidazo[1,2-A]Pyridine (3)8-Bromoimidazo[1,2-A]Pyrazine (7)8-Bromoimidazo[1,2-A]Pyridine (15)8-Chloroimidazo[1,2-A]Pyrazine (8)8-Chloroimidazo[1,2-A]Pyridine (7)8-Fluoroimidazo[1,2-A]Pyridine (3)8-Methylimidazo[1,2-A]Pyridine (9)Ethyl 1H-Imidazole-2-Carboxylate (6)Ethyl 2-(Imidazo[1,2-A]Pyridin-3-Yl)Acetate (3)Ethyl Imidazo[1,2-A]Pyridine-2-Carboxylate (26)Ethyl Imidazo[1,2-A]Pyridine-3-Carboxylate (13)Imidazo[1,2-A]Pyridin-3-Amine (7)Imidazo[1,2-A]Pyridin-8-Amine (7)Imidazo[1,2-A]Pyridin-8-Ol (3)Imidazo[1,2-A]Pyridine-2-Carbaldehyde (8)Imidazo[1,2-A]Pyridine-2-Carboxylic Acid (21)Imidazo[1,2-A]Pyridine-3-Carbaldehyde (9)Imidazo[1,2-A]Pyridine-3-Carboxylic Acid (14)Imidazo[1,2-A]Pyridine-7-Carboxylic Acid (5)Imidazo[1,2-A]Pyridine-8-Carboxylic Acid (6)Imidazo[1,2-A]Pyrimidine-3-Carboxylic Acid (5)Imidazo[1,2-C]Pyrimidine (6)Imidazo[1,5-A]Pyrazine (9)Imidazo[2,1-B]Thiazole (14)Methyl 1H-Imidazole-2-Carboxylate (4)Methyl 1H-Imidazole-5-Carboxylate (8)Methyl Imidazo[1,2-A]Pyridine-8-Carboxylate (3)Tert-Butyl 1H-Imidazole-1-Carboxylate (6)Alcohols (27)Aldehydes (21)Alkenyls (7)Amides (26)Amines (38)Aryls (50)Bromides (16)Carboxylic Acids (42)Chlorides (15)Esters (34)Ethers (6)Fluorinated Building Blocks (25)Iodides (12)Ketones (7)Nitroes (13)Sulfamides (7)Trifluoromethyls (12)Pyridines (4)Pyrrolidines (2)

Imidazolidines (1118)

Methylimidazolidine (3)Oxoimidazolidine (8)Thioxoimidazolidin (9)(3Ar,6As)-Tetrahydro-1H-Thieno[3,4-D]Imidazol-2(3H)-One (18)1-Phenylimidazolidin-2-One (8)3-Phenyl-2-Thioxoimidazolidin-4-One (6)3-Phenylimidazolidine-2,4-Dione (4)Imidazolidin-2-One (16)Imidazolidine-2,4-Dione (17)Amides (18)Aryls (9)Carboxylic Acids (3)Spiroes (4)

Imidazolines (679)

Amides (16)Amines (4)Aryls (14)Spiroes (4)

Indazoles (3029)

(1H-Indazol-4-Yl)Boronic Acid (3)(1H-Indazol-6-Yl)Boronic Acid (4)1-(1H-Indazol-1-Yl)Ethan-1-One (7)1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole (17)1-Benzyl-1H-Indazole (5)1-Ethyl-1H-Indazole (6)1H-Indazol-3-Amine (23)1H-Indazol-3-Ol (10)1H-Indazol-4-Amine (12)1H-Indazol-4-Ol (4)1H-Indazol-5-Amine (3)1H-Indazol-6-Amine (5)1H-Indazol-6-Ol (6)1H-Indazol-7-Amine (6)1H-Indazole-3-Carbaldehyde (19)1H-Indazole-3-Carbonitrile (9)1H-Indazole-3-Carboxylic Acid (23)1H-Indazole-4-Carboxylic Acid (9)1H-Indazole-5-Carboxylic Acid (4)1H-Indazole-7-Carboxylic Acid (6)2,3-Dimethyl-2H-Indazole (4)2-Methyl-2H-Indazole (34)3-(Piperidin-4-Yl)-1H-Indazole (5)3-Chloro-1H-Indazole (13)4,5,6,7-Tetrahydro-1H-Indazole (9)4-Chloro-1H-Indazole (18)4-Fluoro-1H-Indazole (22)4-Methoxy-1H-Indazole (7)4-Methyl-1H-Indazole (12)4-Nitro-1H-Indazole (10)5-Bromo-1H-Indazole (12)5-Chloro-1H-Indazole (8)5-Methoxy-1H-Indazole (4)5-Nitro-1H-Indazole (5)6-(Trifluoromethyl)-1H-Indazole (6)6-Bromo-1H-Indazole (22)6-Chloro-1H-Indazole (13)6-Fluoro-1H-Indazole (15)6-Methoxy-1H-Indazole (14)6-Methyl-1H-Indazole (9)6-Nitro-1H-Indazole (9)7-Bromo-1H-Indazole (17)7-Chloro-1H-Indazole (7)7-Fluoro-1H-Indazole (12)7-Methoxy-1H-Indazole (5)7-Nitro-1H-Indazole (11)Methyl 1H-Indazole-4-Carboxylate (10)Methyl 1H-Indazole-5-Carboxylate (3)Methyl 1H-Indazole-6-Carboxylate (9)Methyl 1H-Indazole-7-Carboxylate (8)Methyl 2-Methyl-2H-Indazole-3-Carboxylate (3)Tert-Butyl 1H-Indazole-1-Carboxylate (29)Alcohols (17)Aldehydes (9)Amides (6)Amines (18)Aryls (7)Bromides (25)Carboxylic Acids (19)Chlorides (9)Esters (8)Ethers (9)Fluorinated Building Blocks (10)Iodides (12)Nitriles (7)Nitroes (7)Indazol-Amide (3)

(1-(Tert-Butoxycarbonyl)-1H-Indol-2-Yl)Boronic Acid (17)(1H-Indol-2-Yl)Boronic Acid (3)(1H-Indol-2-Yl)Methanol (8)(3As,7As)-Octahydro-1H-Indole (5)(9H-Fluoren-9-Yl)Methyl (2-(1H-Indol-3-Yl)Ethyl)Carbamate (12)1,2,3,4-Tetrahydrocyclopenta[B]Indole (5)1,2-Dimethyl-1H-Indole (3)1-(1H-Indol-1-Yl)Ethan-1-One (9)1-(Phenylsulfonyl)-1H-Indole (26)1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine (8)1-Benzyl-1H-Indole (9)1-Ethyl-1H-Indole (7)1-Methyl-1H-Indole (81)1-Methyl-1H-Indole-2-Carboxylic Acid (8)1-Methyl-1H-Indole-3-Carbaldehyde (9)1-Methyl-1H-Pyrrolo[2,3-B]Pyridine (14)1-Phenyl-1H-Indole (5)1H-Indol-3-Ol (5)1H-Indol-3-Yl Acetate (4)1H-Indol-4-Amine (10)1H-Indol-4-Ol (7)1H-Indol-5-Ol (4)1H-Indol-6-Amine (21)1H-Indol-6-Ol (6)1H-Indol-7-Amine (10)1H-Indole-2-Carbaldehyde (20)1H-Indole-2-Carbonitrile (9)1H-Indole-3-Carbonitrile (17)1H-Indole-3-Carboxylic Acid (28)1H-Indole-4-Carboxylic Acid (10)1H-Indole-5-Carbonitrile (5)1H-Indole-5-Carboxylic Acid (4)1H-Indole-6-Carbonitrile (4)1H-Indole-6-Carboxylic Acid (5)1H-Indole-7-Carbonitrile (6)1H-Indole-7-Carboxylic Acid (7)1H-Pyrrolo[2,3-B]Pyridine-3-Carbaldehyde (14)1H-Pyrrolo[2,3-B]Pyridine-5-Carbaldehyde (5)2,3,4,5-Tetrahydro-1H-Pyrido[4,3-B]Indole (12)2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole (13)2,3-Dimethyl-1H-Indole (9)2-(1,3,2-Dioxaborolan-2-Yl)-1-Methyl-1H-Indole (6)2-(1H-Indol-1-Yl)Acetic Acid (5)2-(1H-Indol-3-Yl)Acetic Acid (28)2-(1H-Indol-3-Yl)Ethan-1-Amine (4)2-(1H-Indol-3-Yl)Ethan-1-Ol (10)2-(2-Methyl-1H-Indol-3-Yl)Acetic Acid (5)2-(4-Fluorophenyl)-1H-Indole (4)2-Methyl-1H-Indole-3-Carbaldehyde (3)2-Methyl-1H-Pyrrolo[2,3-B]Pyridine (12)3-(1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione (21)3-(1H-Indol-3-Yl)Propanoic Acid (3)3-(Piperidin-4-Yl)-1H-Indole (8)3-Iodo-1H-Pyrrolo[2,3-B]Pyridine (11)3-Methyl-1H-Indole (40)3H-Indole (8)4-Bromo-1H-Indole (25)4-Chloro-1H-Indole (21)4-Fluoro-1H-Indole (24)4-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (6)4-Fluoroindoline-2,3-Dione (3)4-Methoxy-1H-Indole (11)4-Methyl-1H-Indole (22)4-Nitro-1H-Indole (6)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole (4)5-(Benzyloxy)-1H-Indole (7)5-Bromo-1-Methyl-1H-Indole (3)5-Chloro-1H-Indole (61)5-Chloro-1H-Indole-2-Carboxylic Acid (6)5-Chloro-1H-Pyrrolo[2,3-B]Pyridine (12)5-Fluoro-1H-Indole (48)5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (9)5-Fluoroindolin-2-One (4)5-Methoxy-1H-Indole (11)5-Methoxy-2-Methyl-1H-Indole (4)5-Methyl-1H-Indole (32)5-Nitro-1H-Indole (6)6-(Trifluoromethyl)-1H-Indole (5)6-Bromo-1-Methyl-1H-Indole (3)6-Bromo-1H-Indole (15)6-Bromo-1H-Pyrrolo[2,3-B]Pyridine (5)6-Chloro-1H-Indole (19)6-Chloro-1H-Pyrrolo[2,3-B]Pyridine (13)6-Fluoro-1H-Indole (17)6-Methoxy-1H-Indole (12)6-Methyl-1H-Indole (27)6-Methyl-1H-Pyrrolo[2,3-B]Pyridine (8)6-Nitro-1H-Indole (8)7-Bromo-1H-Indole (27)7-Bromoindoline-2,3-Dione (3)7-Chloro-1H-Indole (29)7-Fluoro-1H-Indole (24)7-Fluoro-1H-Indole-2-Carboxylic Acid (5)7-Methoxy-1H-Indole (8)7-Methyl-1H-Indole (33)7-Nitro-1H-Indole (11)9H-Pyrido[3,4-B]Indole (5)Benzo[Cd]Indol-2(1H)-One (5)Ethyl 5-Chloro-1H-Indole-2-Carboxylate (5)Ethyl 5-Fluoro-1H-Indole-2-Carboxylate (5)Ethyl 6-Chloro-1H-Indole-2-Carboxylate (5)Ethyl 7-Chloro-1H-Indole-2-Carboxylate (5)Methyl 1H-Indole-4-Carboxylate (9)Methyl 1H-Indole-5-Carboxylate (7)Methyl 1H-Indole-6-Carboxylate (9)Methyl 1H-Indole-7-Carboxylate (7)Methyl 2-(1H-Indol-3-Yl)Acetate (3)N-(2-(1H-Indol-3-Yl)Ethyl)Acetamide (5)Spiro[Indoline-3,4'-Piperidin]-2-One (18)Tert-Butyl 1H-Indole-1-Carboxylate (18)Tert-Butyl 1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate (9)Tert-Butyl 2-(1,3,2-Dioxaborolan-2-Yl)-1H-Indole-1-Carboxylate (6)Tert-Butyl 3-(Hydroxymethyl)-1H-Indole-1-Carboxylate (10)Tert-Butyl 3-Bromo-1H-Indole-1-Carboxylate (9)Tert-Butyl 3-Iodo-1H-Indole-1-Carboxylate (7)Tert-Butyl 5-Methoxy-1H-Indole-1-Carboxylate (6)Tryptophan (22)Alcohols (25)Aldehydes (21)Alkenyls (4)Amides (41)Amines (29)Aryls (50)Bromides (35)Carboxylic Acids (50)Chlorides (26)Esters (56)Ethers (54)Fluorinated Building Blocks (37)Iodides (10)Ketones (15)Nitriles (29)Nitroes (10)Sulfamides (6)Trifluoromethyls (5)Azaindole (41)Benzyloxyindole (1)Biindolinylidene (1)Bromo-Indole-Carboxylic Acid (25)Cyanoindole (5)Dihydroindolo (14)Fluoroindole (5)Formylindole (44)Hydroxyindole (7)Hydroxyisoindoline (2)Isoindole (26)Methoxyindole (8)Nitroindole (5)Piperazines (5)Piperidines (3)Pyridines (5)Pyrimidines (7)

Indolines (4539)

(E)-[3,3'-Biindolinylidene]-2,2'-Dione (5)(Z)-3-((1H-Pyrrol-2-Yl)Methylene)Indolin-2-One (8)(Z)-3-(Phenyl(Phenylamino)Methylene)Indolin-2-One (5)(Z)-3-Benzylideneindolin-2-One (7)1-(Indolin-1-Yl)Ethan-1-One (9)1-Benzylindoline-2,3-Dione (5)1-Methylindolin-2-One (14)1-Methylindoline (3)1-Methylindoline-2,3-Dione (8)2-(1,3-Dioxoisoindolin-2-Yl)Propanoic Acid (3)2-Methylindoline (7)2-Methylisoindolin-1-One (7)3,3-Dimethylindolin-2-One (5)3,3-Dimethylindoline (7)4-Bromoindoline (4)4-Chloroindoline-2,3-Dione (6)4-Methylindoline (3)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indoline (5)5-Bromoindolin-2-One (5)5-Bromoindoline (8)5-Bromoisoindoline-1,3-Dione (3)5-Chloroindolin-2-One (3)5-Fluoroindoline (3)5-Methoxyindoline (4)5-Methylindolin-2-One (3)5-Methylindoline (3)6-Bromoindolin-2-One (8)6-Bromoindoline-2,3-Dione (4)6-Chloroindolin-2-One (5)6-Chloroindoline (3)6-Chloroindoline-2,3-Dione (5)6-Fluoroindolin-2-One (5)6-Fluoroindoline-2,3-Dione (3)7-Bromoindoline (3)7-Fluoroindolin-2-One (3)7-Fluoroindoline-2,3-Dione (6)7-Methylindoline-2,3-Dione (7)Indoline-2-Carboxylic Acid (3)Methyl Indoline-6-Carboxylate (3)Spiro[Cyclopropane-1,3'-Indolin]-2'-One (6)Tert-Butyl Indoline-1-Carboxylate (24)Alcohols (13)Alkenyls (3)Amides (73)Amines (9)Aryls (20)Bromides (16)Carboxylic Acids (16)Chlorides (14)Esters (9)Ethers (5)Fluorinated Building Blocks (11)Ketones (11)Nitriles (5)Nitroes (9)Aminoindoline (10)Bromoindoline (17)Bromoisoindolin (5)Bromoisoindoline (6)Chloroindolin (4)Chloroisoindoline (3)Dibromoindoline (12)Dichloroindoline (16)Difluoroindoline (1)Dimethylindoline (21)Dioxoindoline (8)Dioxoisoindolin (72)Fluoroindolin (9)Fluoroindoline (9)Fluoroisoindoline (10)Hydroxyindolin (5)Isoindoline (22)Methoxyindoline (12)Methoxyisoindoline (9)Methylindoline (45)Methylisoindoline (18)Nitroindolin (6)Nitroindoline (11)Nitroisoindoline (8)Oxoindoline (32)Oxoisoindoline (16)Spiro-Indoline-Piperidine (34)Spiroes (5)

Isoquinolines (2761)

1,3-Dichloroisoquinoline (14)1-Bromoisoquinoline (20)1-Chloroisoquinoline (20)1-Methylisoquinoline (9)1H-Benzo[De]Isoquinoline-1,3(2H)-Dione (14)2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One (6)3-Bromoisoquinoline (10)3-Chloroisoquinoline (20)3-Methylisoquinoline (8)4-Bromoisoquinolin-1(2H)-One (3)4-Bromoisoquinoline (33)4-Chloroisoquinoline (11)4-Fluoroisoquinoline (6)5-Bromoisoquinoline (17)5-Chloroisoquinoline (6)5-Methoxyisoquinoline (6)5-Nitroisoquinoline (7)6-Bromo-3,4-Dihydroisoquinolin-1(2H)-One (6)6-Bromoisoquinoline (9)6-Methoxy-3,4-Dihydroisoquinolin-1(2H)-One (3)7-Bromo-3,4-Dihydroisoquinolin-1(2H)-One (6)7-Bromoisoquinoline (6)7-Chloroisoquinoline (6)7-Fluoroisoquinoline (3)7-Methoxyisoquinoline (5)8-Bromoisoquinoline (17)8-Chloroisoquinoline (7)8-Fluoroisoquinolin-1(2H)-One (3)8-Fluoroisoquinoline (10)8-Methoxyisoquinoline (7)Isoquinolin-1-Amine (18)Isoquinolin-1-Ol (9)Isoquinolin-3-Amine (13)Isoquinolin-3-Ol (6)Isoquinolin-4-Amine (16)Isoquinolin-4-Ol (9)Isoquinolin-4-Ylboronic Acid (3)Isoquinolin-5-Amine (9)Isoquinolin-5-Ol (7)Isoquinolin-8-Amine (6)Isoquinoline-1-Carbonitrile (7)Isoquinoline-1-Carboxylic Acid (10)Isoquinoline-3-Carboxylic Acid (7)Isoquinoline-4-Carboxylic Acid (12)Isoquinoline-5-Carboxylic Acid (5)Isoquinoline-5-Sulfonyl Chloride (3)Isoquinoline-6-Carboxylic Acid (3)Methyl Isoquinoline-3-Carboxylate (3)Methyl Isoquinoline-4-Carboxylate (6)Tert-Butyl 3,4-Dihydroisoquinoline-2(1H)-Carboxylate (19)Alcohols (4)Amides (10)Amines (12)Bromides (11)Carboxylic Acids (4)Chlorides (14)Esters (7)Ethers (8)Fluorinated Building Blocks (7)Nitriles (4)Bromoisoquinoline (69)Chloroisoquinoline (101)Dibromoisoquinoline (9)Dichloroisoquinoline (14)Dihydroisoquinoline (107)Fluoroisoquinoline (78)Methoxyisoquinoline (59)Methylisoquinoline (59)Nitroisoquinoline (23)

Isothiazoles (359)

Benzo[D]Isothiazol-3(2H)-One 1,1-Dioxide (10)Benzo[D]Isothiazole (12)Isothiazole (47)Bromides (4)Methylisothiazole (5)

Isoxazoles (3433)

(3-Phenylisoxazol-5-Yl)Methanol (7)3-Bromoisoxazole (7)3-Methyl-5-Phenylisoxazole (6)3-Methylisoxazole (30)3-Phenylisoxazol-5-Amine (8)5-(Thiophen-2-Yl)Isoxazole (5)5-Cyclopropylisoxazole (5)5-Methyl-3-Phenylisoxazole (4)5-Methylisoxazole (16)5-Phenylisoxazole-3-Carboxylic Acid (15)Ethyl Isoxazole-3-Carboxylate (8)Ethyl Isoxazole-4-Carboxylate (5)Isoxazol-3-Amine (7)Isoxazol-3-Ylmethanol (3)Isoxazol-5-Amine (15)Isoxazol-5-Ylmethanol (5)Isoxazole-3-Carboxylic Acid (8)Isoxazole-5-Carboxylic Acid (7)Methyl 5-Phenylisoxazole-3-Carboxylate (6)N-((5R,6R)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptan-6-Yl)-3-Phenylisoxazole-4-Carboxamide (1)Alcohols (8)Aldehydes (9)Amides (16)Amines (25)Aryls (54)Bromides (11)Carboxylic Acids (18)Chlorides (19)Esters (11)Ethers (12)Fluorinated Building Blocks (12)Aminoisoxazole (7)Bromoisoxazole (5)Dihydroisoxazol (2)Dimethylisoxazole (16)Phenylisoxazole (28)

Morpholines (4791)

(R)-3-Phenylmorpholine (7)(S)-3-Phenylmorpholine (10)2,2-Dimethylmorpholine (5)2,6-Dimethylmorpholine (1)2-(Methoxymethyl)Morpholine (4)2-(Morpholin-2-Yl)Acetic Acid (5)2-Ethylmorpholine (3)2-Isopropylmorpholine (4)2-Methylmorpholine (7)3-(4-Morpholinophenyl)Oxazolidin-2-One (5)3-(Methoxymethyl)Morpholine (4)3-Ethylmorpholine (4)3-Isopropylmorpholine (5)3-Methylmorpholine (13)3-Phenylmorpholine (8)4-(2-Fluorophenyl)Morpholine (8)4-(3-Phenoxypropyl)Morpholine (7)4-(O-Tolyl)Morpholine (6)4-(Pyrazin-2-Yl)Morpholine (5)4-(Pyridin-4-Yl)Morpholine (5)4-(Pyrimidin-2-Yl)Morpholine (9)4-Benzylmorpholin-3-One (6)4-Morpholinoaniline (4)4-Morpholinobenzaldehyde (8)4-Morpholinobenzoic Acid (5)4-Phenylmorpholin-3-One (6)6,6-Dimethylmorpholine-3-Carboxylic Acid (5)Benzyl Morpholine-4-Carboxylate (5)Ethyl Morpholine-2-Carboxylate (4)Methyl 2-(Morpholin-3-Yl)Acetate (3)Methyl Morpholine-2-Carboxylate (4)Methyl Morpholine-3-Carboxylate (10)Morpholin-2-Ylmethanamine (8)Morpholin-2-Ylmethanol (12)Morpholin-3-Ylmethanol (14)Morpholine-2-Carbonitrile (4)Morpholine-2-Carboxylic Acid (12)Morpholine-3-Carboxylic Acid (10)Morpholino(Phenyl)Methanone (11)Tert-Butyl (Morpholin-2-Ylmethyl)Carbamate (3)Tert-Butyl 2-(Bromomethyl)Morpholine-4-Carboxylate (3)Tert-Butyl Morpholine-4-Carboxylate (23)Alcohols (23)Aldehydes (9)Amides (95)Amines (54)Aryls (137)Bromides (30)Carboxylic Acids (34)Chlorides (24)Esters (31)Ethers (17)Fluorinated Building Blocks (17)Ketones (8)Nitriles (5)Nitroes (12)Phenols (3)Sulfamides (11)Trifluoromethyls (5)Ureas (4)Benzylmorpholine (19)Cyanomorpholine (6)Dimorpholine (3)Ethylmorpholine (9)Isopropylmorpholine (9)Methylmorpholine (59)Morpholinobenzaldehyde (11)Morpholinobenzo (13)Morpholinobenzoic (8)Morpholinoethanone (5)Morpholinoethoxy (1)Morpholinoethyl (5)Morpholinomethyl (16)Morpholinophenyl (14)Morpholinopropoxy (6)Morpholinopyrimidin (6)Morpholinosulfonyl (7)Oxomorpholine (6)Benzothiazoles (4)Piperidines (30)Pyridazines (4)Pyridines (24)Pyrimidines (4)Spiroes (33)Thiazoles (5)

Naphthyridines (956)

1,5-Naphthyridine-3-Carboxylic Acid (6)1,6-Naphthyridine (22)1,7-Naphthyridine (23)2,7-Naphthyridine (5)3-Bromo-1,5-Naphthyridine (8)4-Bromo-1,5-Naphthyridine (5)4-Chloro-1,5-Naphthyridine (6)5,6,7,8-Tetrahydro-1,6-Naphthyridine (22)5,6,7,8-Tetrahydro-1,7-Naphthyridine (6)Bromides (4)Carboxylic Acids (3)Fluorinated Building Blocks (4)Ketones (4)

Oxadiazoles (3576)

1,2,4-Oxadiazole (19)1,2,5-Oxadiazole (12)1,3,4-Oxadiazole (25)2,5-Diphenyl-1,3,4-Oxadiazole (6)2-Phenyl-1,3,4-Oxadiazole (26)3-Phenyl-1,2,4-Oxadiazole (23)Benzo[C][1,2,5]Oxadiazole (17)Amides (10)Amines (16)Aryls (12)Bromides (4)Carboxylic Acids (4)Piperidines (4)

2,2-Dimethyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)2-Methyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One (8)3,4-Dihydro-2H-Pyrido[3,2-B][1,4]Oxazine (5)6-Amino-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)6-Bromo-2H-Benzo[B][1,4]Oxazin-3(4H)-One (7)6-Bromo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (5)6-Chloro-2H-Benzo[B][1,4]Oxazin-3(4H)-One (8)6-Chloro-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (5)7-Bromo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (7)Spiro[Benzo[D][1,3]Oxazine-4,4'-Piperidin]-2(1H)-One (5)Phenoxazine (7)

Oxazolines (1570)

(3Ar,8As)-2-(Pyridin-2-Yl)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole (6)(3As,8Ar)-2-(Pyridin-2-Yl)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole (7)(4R,5S)-4,5-Diphenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (5)(R)-4-Benzyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (7)(R)-4-Phenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (7)(S)-4-Benzyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (8)(S)-4-Phenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (6)1,3-Bis(4,5-Dihydrooxazol-2-Yl)Benzene (8)2,2'-(1,3-Diphenylpropane-2,2-Diyl)Bis(4,5-Dihydrooxazole) (5)2,2'-(2-Phenylethane-1,1-Diyl)Bis(4,5-Dihydrooxazole) (5)2,3-Dihydropyrazolo[5,1-B]Oxazole (7)2,6-Bis(4,5-Dihydrooxazol-2-Yl)Pyridine (12)2-(6-Benzhydrylpyridin-2-Yl)-4,5-Dihydrooxazole (10)2-(6-Cyclopropylpyridin-2-Yl)-4,5-Dihydrooxazole (10)2-(Benzo[B]Thiophen-2-Yl)-4,5-Dihydrooxazole (6)2-(Pyridin-2-Ylmethyl)-4,5-Dihydrooxazole (14)2-(Quinolin-2-Yl)-4,5-Dihydrooxazole (7)2-Phenyl-4,5-Dihydrooxazole (17)4,4',5,5'-Tetrahydro-2,2'-Bioxazole (10)4-(Tert-Butyl)-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (16)4-Isopropyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (16)Bis((3Ar,8As)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazol-2-Yl)Methane (5)Bis((3As,8Ar)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazol-2-Yl)Methane (5)Bis(4,5-Dihydrooxazol-2-Yl)Methane (22)Amides (4)Aryls (8)Esters (6)

Alcohols (24)Alkenyls (4)Amides (14)Amines (28)Aryls (20)Bromides (9)Carboxylic Acids (7)Esters (10)Ethers (6)Fluorinated Building Blocks (5)Iodides (6)Sulfonates (5)Methyloxetane (11)Azetidines (9)Piperidines (8)Pyrrolidines (4)Spiroes (26)

Phthalazines (420)

Phthalazine (36)Amides (6)Dihydrophthalazine (12)

Piperazines (5922)

(9H-Fluoren-9-Yl)Methyl Piperazine-1-Carboxylate (7)1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperazine (6)1-(Methylsulfonyl)Piperazine (5)1-(Phenylsulfonyl)Piperazine (17)1-(Piperidin-4-Yl)Piperazine (6)1-(Pyridin-3-Yl)Piperazine (13)1-(Pyridin-3-Ylmethyl)Piperazine (6)1-Benzyl 4-(Tert-Butyl) Piperazine-1,4-Dicarboxylate (10)1-Ethylpiperazine (6)1-Isopropylpiperazine (4)1-Methyl-4-(Pyridin-2-Yl)Piperazine (5)1-Methylpiperazin-2-One (6)1-Methylpiperazine (21)10-(3-(Piperazin-1-Yl)Propyl)-10H-Phenothiazine (2)2-(4-(Benzyloxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (10)2-(Piperazin-1-Yl)Ethan-1-Amine (8)2-(Piperazin-1-Yl)Ethan-1-Ol (10)2-(Piperazin-1-Yl)Pyrazine (9)2-(Piperazin-1-Yl)Pyrimidine (11)2-Phenylpiperazine (3)3-(Piperazin-1-Yl)Pyridazine (7)3-Methylpiperazin-2-One (7)4-(Piperazin-1-Yl)Pyrimidine (13)Benzyl 2-Methylpiperazine-1-Carboxylate (7)Benzyl 3-(Hydroxymethyl)Piperazine-1-Carboxylate (6)Benzyl 3-Methylpiperazine-1-Carboxylate (5)Piperazine-2,5-Dione (9)Tert-Butyl 3-Oxopiperazine-1-Carboxylate (7)Tert-Butyl 4-(Pyridin-2-Yl)Piperazine-1-Carboxylate (12)Tert-Butyl 4-Benzylpiperazine-1-Carboxylate (2)Tert-Butyl Piperazine-1-Carboxylate (30)Alcohols (24)Alkenyls (8)Amides (259)Amines (26)Aryls (85)Bromides (8)Carboxylic Acids (26)Chlorides (21)Esters (33)Ethers (26)Fluorinated Building Blocks (22)Nitriles (14)Nitroes (6)Phenols (1)Sulfamides (12)Sulfones (1)Trifluoromethyls (7)Ureas (5)Isobutylpiperazine (6)Propylpiperazine (10)Furans (4)Indoles (5)Piperidines (4)Pyridines (16)Pyrimidines (23)Spiroes (14)

Piperidines (21719)

Bipiperidine (12)Chloropiperidine (6)Dimethylpiperidine (46)Ethynylpiperidine (5)Fluoropiperidine (33)Formylpiperidine (9)Isopropylpiperidine (11)Piperidine-Carboxylate (3)Piperidineacetic (5)Piperidinecarboxylic (6)Piperidinyl-Phenyl-Boronic Acid/Ester (32)Propylpiperidine (8)Tetramethylpiperidine (14)(9H-Fluoren-9-Yl)Methyl Piperidine-1-Carboxylate (16)(E)-N-(3-Oxo-1-Phenyl-3-(Piperidin-1-Yl)Prop-1-En-2-Yl)Benzamide (6)(R)-2-Phenylpiperidine (10)(R)-3-Aminopiperidin-2-One (3)(R)-N-(Piperidin-3-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine (5)(S)-2-Phenylpiperidine (11)(S)-N-Phenylpiperidine-2-Carboxamide (1)1,3-Dihydrospiro[Indene-2,4'-Piperidine] (5)1,4'-Bipiperidine (8)1-((Benzyloxy)Carbonyl)Piperidine-2-Carboxylic Acid (5)1-((Benzyloxy)Carbonyl)Piperidine-3-Carboxylic Acid (3)1-(Methylsulfonyl)Piperidine (5)1-(Phenylsulfonyl)Piperidine (23)1-(Piperidin-1-Yl)Ethan-1-One (13)1-(Piperidin-4-Yl)Piperazine (6)1-Benzyl 3-Methyl Piperidine-1,3-Dicarboxylate (3)1-Benzyl-N-Methylpiperidin-3-Amine (6)1-Benzylpiperidin-3-One (5)1-Benzylpiperidin-4-Amine (8)1-Benzylpiperidin-4-One (5)1-Isopropylpiperidine (5)1-Methyl-4-Phenylpiperidine (4)1-Methylpiperidin-2-One (3)1-Oxa-8-Azaspiro[4.5]Decane (4)1-Phenylpiperidin-2-One (8)2,2-Dimethylpiperidin-4-One (6)2,2-Dimethylpiperidine (20)2,7-Diazaspiro[3.5]Nonane (7)2,8-Diazaspiro[4.5]Decan-3-One (6)2,8-Diazaspiro[4.5]Decane (5)2-(Piperidin-1-Yl)Ethan-1-Amine (8)2-(Piperidin-1-Yl)Ethan-1-Ol (10)2-(Piperidin-1-Yl)Pyridine (11)2-(Piperidin-1-Yl)Pyrimidine (16)2-(Piperidin-2-Yl)Ethan-1-Ol (8)2-(Piperidin-4-Yl)Ethan-1-Ol (5)2-(Piperidin-4-Yl)Pyridine (5)2-Methylpiperidin-4-One (6)2-Methylpiperidine (12)2-Phenylpiperidine (14)3,3-Difluoropiperidin-4-One (3)3,3-Difluoropiperidine (29)3,3-Dimethylpiperidin-4-One (3)3,3-Dimethylpiperidine (5)3-(1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione (21)3-(Piperidin-1-Yl)Pyridine (5)3-(Piperidin-4-Yl)-1H-Indazole (5)3-(Piperidin-4-Yl)-1H-Indole (8)3-(Piperidin-4-Yl)Pyridine (5)3-Fluoropiperidin-4-One (3)3-Fluoropiperidine (26)3-Methoxypiperidine (7)3-Methylpiperidin-4-One (2)3-Methylpiperidine (10)4,4-Difluoropiperidine (5)4-(1H-Pyrazol-1-Yl)Piperidine (11)4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine (11)4-(Azetidin-1-Yl)Piperidine (6)4-(Piperidin-1-Yl)Pyrimidine (9)4-(Pyrrolidin-1-Yl)Piperidine (6)4-Benzylpiperidine (18)4-Hydrazineylpiperidine (5)4-Hydroxypiperidin-2-One (3)4-Methyl-1-Phenylpiperidine (6)4-Methylenepiperidine (14)4-Oxopiperidine-2-Carboxylic Acid (3)4-Phenylpiperidin-4-Ol (10)5-Hydroxypiperidin-2-One (3)6-Azaspiro[2.5]Octane (10)6-Oxopiperidine-2-Carboxylic Acid (3)7-Azaspiro[3.5]Nonane (7)Azepane (25)Benzyl 3-Hydroxypiperidine-1-Carboxylate (7)Benzyl 4-Oxopiperidine-1-Carboxylate (9)Benzyl Piperidin-4-Ylcarbamate (7)Benzyl Piperidine-1-Carboxylate (50)Benzyl-3-Aminopiperidine-1-Carboxylate (6)Ethyl Piperidine-1-Carboxylate (5)Ethyl Piperidine-2-Carboxylate (8)Ethyl Piperidine-3-Carboxylate (14)Ethyl Piperidine-4-Carboxylate (10)Methyl 4-Oxopiperidine-2-Carboxylate (3)Methyl Piperidine-2-Carboxylate (12)Methyl Piperidine-3-Carboxylate (19)N-Benzylpiperidin-4-Amine (3)N-Methylpiperidin-3-Amine (5)N-Phenylpiperidine-2-Carboxamide (2)Phenyl(Piperidin-1-Yl)Methanone (21)Phenyl(Piperidin-4-Yl)Methanone (21)Piperidin-2-Ylmethanamine (6)Piperidin-2-Ylmethanol (11)Piperidin-3-Amine (17)Piperidin-3-Ol (27)Piperidin-3-One (13)Piperidin-3-Ylmethanamine (5)Piperidin-3-Ylmethanol (15)Piperidin-4-Amine (14)Piperidin-4-Ol (44)Piperidin-4-Ylmethanamine (7)Piperidin-4-Ylmethanol (11)Piperidine-2,4-Dione (5)Piperidine-2,6-Dione (13)Piperidine-2-Carboxylic Acid (26)Piperidine-3-Carboxamide (5)Piperidine-3-Carboxylic Acid (14)Piperidine-4-Carboxylic Acid (12)Quinuclidine (5)Spiro[Benzo[D][1,3]Oxazine-4,4'-Piperidin]-2(1H)-One (5)Spiro[Chromane-2,4'-Piperidin]-4-One (6)Spiro[Indene-2,4'-Piperidin]-1(3H)-One (5)Spiro[Indoline-3,4'-Piperidin]-2-One (18)Spiro[Indoline-3,4'-Piperidine] (5)Tert-Butyl (2-Oxopiperidin-3-Yl)Carbamate (4)Tert-Butyl (6-Oxopiperidin-3-Yl)Carbamate (3)Tert-Butyl (Piperidin-3-Ylmethyl)Carbamate (5)Tert-Butyl 2-Oxopiperidine-1-Carboxylate (3)Tert-Butyl 3-Bromopiperidine-1-Carboxylate (4)Tert-Butyl 4-Oxopiperidine-1-Carboxylate (14)Tert-Butyl 4-Phenoxypiperidine-1-Carboxylate (12)Tert-Butyl 4-Phenylpiperidine-1-Carboxylate (16)Tert-Butyl Piperidin-3-Ylcarbamate (9)Alcohols (126)Aldehydes (17)Alkenyls (18)Amides (433)Amines (176)Aryls (304)Bromides (31)Carboxylic Acids (89)Chlorides (67)Esters (67)Ethers (81)Fluorinated Building Blocks (95)Iodides (4)Ketones (66)Nitriles (54)Nitroes (13)Oximes (5)Phenols (4)Sulfamides (24)Sulfonates (10)Sulfones (6)Sulfonyl Chlorides (4)Trifluoromethyls (8)Azetidines (16)Benzimidazoles (18)Benzisoxazoles (4)Benzofurans (5)Indoles (3)Morpholines (30)Oxadiazoles (4)Oxetanes (8)Piperazines (4)Pyrazines (8)Pyridines (15)Pyrimidines (4)Pyrrolidines (36)Spiroes (139)Tetrahydrofurans (9)Tetrahydropyrans (5)Thiophenes (9)Other Aromatic Heterocycles (13)

(R)-N-(9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide (5)2-(Acetoxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3,4-Diyl Diacetate (6)2-(Hydroxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3,4-Diol (28)2-Chloro-7H-Purine (3)2-Chloro-9H-Purine (5)7H-Purin-2-Amine (6)7H-Purin-6-Amine (9)9-((3As,4R,6Ar)-Tetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)-9H-Purine (7)9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Amine (28)9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Ol (4)9-(Tetrahydrofuran-2-Yl)-9H-Purine (2)9H-Purin-6-Amine (3)Amides (7)Amines (12)Aryls (4)Chlorides (6)

(S)-2-Phenylchroman-4-One (16)1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole (17)2,2-Dimethylchromane (5)2-(2-Oxo-2H-Chromen-4-Yl)Acetic Acid (4)2-Oxo-2H-Chromene-3-Carbonitrile (4)2-Oxo-2H-Chromene-3-Carboxylic Acid (15)2H-Chromene (16)3,4-Dihydro-2H-Pyran (11)3,6-Dihydro-2H-Pyran (8)3-Acetyl-2H-Chromen-2-One (3)3-Hydroxy-2-Phenyl-4H-Chromen-4-One (20)4-(Trifluoromethyl)-2H-Chromen-2-One (7)4-Hydroxy-2H-Chromen-2-One (10)4-Methyl-2H-Chromen-2-One (27)5-Fluorochroman-4-One (3)5-Fluorochromane (6)5-Hydroxy-2-Phenyl-4H-Chromen-4-One (35)5-Methoxy-2-Phenyl-4H-Chromen-4-One (9)6-Bromochroman-4-One (6)6-Chlorochroman-4-One (6)6-Chlorochromane (6)6-Fluorochroman-4-One (5)6-Fluorochromane (6)6-Methoxychromane (5)7-(Diethylamino)-2H-Chromen-2-One (9)7-Bromochroman-4-One (4)7-Bromochromane (7)7-Chlorochromane (4)7-Fluorochroman-4-One (5)7-Hydroxy-2H-Chromen-2-One (23)7-Methoxy-2H-Chromen-2-One (12)7-Methoxychroman-4-One (3)8-Bromochroman-4-One (4)8-Bromochromane (6)8-Chlorochromane (5)8-Fluorochromane (5)8-Methylchroman-4-One (4)8-Methylchromane (11)Chroman-2-One (5)Chroman-2-Ylmethanamine (3)Chroman-4-Amine (20)Chroman-4-Ol (4)Chromane-2-Carboxylic Acid (6)Chromane-3-Carboxylic Acid (4)Dihydro-2H-Pyran-2,6(3H)-Dione (5)Ethyl 2-Oxo-2H-Chromene-3-Carboxylate (5)Isochromane (11)Spiro[Chromane-2,4'-Piperidin]-4-One (6)Tetrahydro-2H-Pyran-2-One (14)Tetrahydro-2H-Thiopyran (10)Tetrahydro-4H-Pyran-4-One (12)Thiochroman-4-One (10)Aryls (3)Carboxylic Acids (2)Esters (5)Ethers (5)Ketones (7)Chromen-One (1)Thioglucopyranoside (4)

Pyrazines (3412)

Dibromopyrazine (7)Dichloropyrazine (21)Dihydropyrazine (6)Dimethylpyrazine (30)Ethoxypyrazine (5)Ethylpyrazine (7)Fluoropyrazine (6)Hydroxypyrazine (4)Iodopyrazine (17)Methoxypyrazine (36)Phenylpyrazin (5)Pyrazino (5)Pyrazino-Nitrile (50)1,2,3,4-Tetrahydropyrido[2,3-B]Pyrazine (5)1-(Pyrazin-2-Yl)Ethan-1-One (5)1H-Pyrazolo[3,4-B]Pyrazine (5)2,3-Diphenylpyrazine (5)2,5-Dibromopyrazine (4)2,5-Dichloropyrazine (4)2,6-Dibromopyrazine (9)2,6-Dichloropyrazine (14)2-(Piperazin-1-Yl)Pyrazine (9)2-(Trifluoromethyl)Pyrazine (6)2-Bromo-3-Methoxypyrazine (5)2-Bromo-3-Methylpyrazine (5)2-Bromo-5-Chloropyrazine (6)2-Bromo-6-Chloropyrazine (5)2-Bromo-6-Methylpyrazine (5)2-Bromopyrazine (15)2-Chloro-3-Methylpyrazine (7)2-Chloro-6-Methylpyrazine (12)2-Chloropyrazine (24)2-Ethoxypyrazine (3)2-Ethylpyrazine (9)2-Fluoropyrazine (7)2-Iodopyrazine (25)2-Methoxypyrazine (45)2-Methylpyrazine (15)2-Phenylpyrazine (12)3-Chloropyrazin-2-Amine (6)3-Chloropyrazine-2-Carbonitrile (6)4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine (7)4-(Pyrazin-2-Yl)Morpholine (5)5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine (11)5,6,7,8-Tetrahydroimidazo[1,2-A]Pyrazine (15)5,6,7,8-Tetrahydroimidazo[1,5-A]Pyrazine (11)5-Bromopyrazin-2-Amine (13)5-Bromopyrazin-2-Ol (5)5-Chloropyrazin-2-Amine (9)5H-Pyrrolo[2,3-B]Pyrazine (14)6-Bromopyrazin-2-Amine (5)6-Chloropyrazin-2-Amine (11)[1,2,4]Triazolo[1,5-A]Pyrazine (9)[1,2,4]Triazolo[4,3-A]Pyrazine (11)Ethyl Pyrazine-2-Carboxylate (10)Imidazo[1,5-A]Pyrazine (9)Methyl 3-Bromopyrazine-2-Carboxylate (5)Methyl 6-Bromopyrazine-2-Carboxylate (7)Methyl 6-Chloropyrazine-2-Carboxylate (5)Methyl Pyrazine-2-Carboxylate (19)Pyrazin-2-Amine (22)Pyrazin-2-Ol (7)Pyrazin-2-Ylmethanamine (12)Pyrazine-2-Carbaldehyde (17)Pyrazine-2-Carbohydrazide (3)Pyrazine-2-Carbonitrile (15)Pyrazine-2-Carboxamide (10)Pyrazine-2-Carboxylic Acid (33)Pyrazolo[1,5-A]Pyrazine (5)Pyrido[2,3-B]Pyrazine (12)Pyrido[3,4-B]Pyrazine (11)Tert-Butyl Pyrazin-2-Ylcarbamate (8)Alcohols (6)Aldehydes (4)Alkynyls (6)Amides (17)Amines (19)Aryls (13)Bromides (9)Carboxylic Acids (12)Chlorides (31)Esters (9)Ethers (19)Fluorinated Building Blocks (8)Trifluoromethyls (5)Piperidines (8)

Pyrazoles (15811)

(1-Methyl-1H-Pyrazol-3-Yl)Methanol (7)(1-Phenyl-1H-Pyrazol-4-Yl)Boronic Acid (4)1,3-Dimethyl-1H-Pyrazole (29)1,3-Diphenyl-1H-Pyrazole (5)1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazole (6)1,5-Diphenyl-1H-Pyrazole (11)1-(2-Chlorophenyl)-1H-Pyrazole (3)1-(3-Chlorophenyl)-1H-Pyrazole (3)1-(4-Methoxybenzyl)-1H-Pyrazole (5)1-(Azetidin-3-Yl)-1H-Pyrazole (7)1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazole (9)1-(Tetrahydro-2H-Pyran-4-Yl)-1H-Pyrazole (6)1-Benzyl-1H-Pyrazolo[3,4-B]Pyridine (9)1-Benzyl-4-Bromo-1H-Pyrazole (5)1-Benzyl-4-Iodo-1H-Pyrazole (5)1-Cyclopentyl-1H-Pyrazole (5)1-Cyclopropyl-1H-Pyrazole (9)1-Methyl-1H-Pyrazol-3-Amine (14)1-Methyl-3-Phenyl-1H-Pyrazole (20)1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole (6)1-Methyl-5-Phenyl-1H-Pyrazole (7)1-Phenyl-1H-Pyrazol-3-Amine (3)1-Phenyl-1H-Pyrazol-3-Ol (3)1-Phenyl-1H-Pyrazol-5-Amine (4)1-Phenyl-1H-Pyrazole-3-Carboxylic Acid (10)1-Phenyl-1H-Pyrazole-4-Carbaldehyde (8)1-Phenyl-1H-Pyrazole-4-Carbonitrile (17)1-Phenyl-1H-Pyrazole-4-Carboxylic Acid (19)1-Phenyl-1H-Pyrazole-5-Carboxylic Acid (3)1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazole (5)1-Trityl-1H-Pyrazole (5)1H-Pyrazol-4-Amine (6)1H-Pyrazol-4-Ol (3)1H-Pyrazol-5-Amine (19)1H-Pyrazole-4-Carbaldehyde (30)1H-Pyrazole-4-Carbonitrile (5)1H-Pyrazole-4-Carboxylic Acid (9)1H-Pyrazole-4-Sulfonyl Chloride (8)1H-Pyrazole-5-Carboxamide (3)1H-Pyrazole-5-Carboxylic Acid (10)1H-Pyrazolo[3,4-B]Pyrazine (5)1H-Pyrazolo[3,4-B]Pyridin-5-Amine (3)1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine (5)1H-Pyrazolo[4,3-D]Pyrimidine (5)2,3-Dihydropyrazolo[5,1-B]Oxazole (7)2,4-Dihydro-3H-Pyrazol-3-One (10)2,6-Di(1H-Pyrazol-1-Yl)Pyridine (5)2-(1H-Pyrazol-1-Yl)Pyridine (16)2-(1H-Pyrazol-1-Yl)Pyrimidine (6)2-(1H-Pyrazol-3-Yl)Pyridine (4)2-Phenyl-2,4-Dihydro-3H-Pyrazol-3-One (24)3-(Tert-Butyl)-1-Phenyl-1H-Pyrazole (4)3-Bromo-1-Methyl-1H-Pyrazole (16)3-Bromopyrazolo[1,5-A]Pyridine (6)3-Bromopyrazolo[1,5-A]Pyrimidine (11)3-Chloro-1-Methyl-1H-Pyrazole (7)3-Cyclopropyl-1H-Pyrazole (5)3-Iodo-1-Methyl-1H-Pyrazole (6)3-Iodo-1H-Pyrazolo[3,4-B]Pyridine (4)3-Methyl-1-Phenyl-1H-Pyrazole (23)3-Phenyl-1H-Pyrazol-5-Amine (11)4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine (7)4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridine (14)4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine (7)4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyridine (6)4-(1H-Pyrazol-1-Yl)Benzoic Acid (3)4-(1H-Pyrazol-1-Yl)Piperidine (11)4-Bromo-1-Methyl-1H-Pyrazole (14)4-Bromo-1-Phenyl-1H-Pyrazole (11)4-Bromo-1H-Pyrazolo[3,4-B]Pyridine (4)4-Bromopyrazolo[1,5-A]Pyridine (8)4-Chloro-1H-Pyrazole (10)4-Chloro-1H-Pyrazolo[3,4-B]Pyridine (5)4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine (5)4-Iodo-1H-Pyrazole (9)4-Methyl-1-Phenyl-1H-Pyrazole (6)4-Methyl-1H-Pyrazole (10)4-Nitro-1H-Pyrazole (8)4-Phenyl-1H-Pyrazole (17)5,6-Dihydro-4H-Pyrrolo[1,2-B]Pyrazole (8)5-(Difluoromethyl)-1H-Pyrazole (6)5-Bromo-1H-Pyrazole (11)5-Bromo-1H-Pyrazolo[3,4-B]Pyridine (11)5-Bromo-1H-Pyrazolo[3,4-C]Pyridine (5)5-Chloro-1H-Pyrazole (8)5-Chloro-1H-Pyrazolo[3,4-B]Pyridine (3)5-Chloropyrazolo[1,5-A]Pyrimidine (24)5-Cyclopropyl-1H-Pyrazole (6)5-Iodo-1H-Pyrazole (4)5-Nitro-1H-Pyrazole (9)5-Nitro-1H-Pyrazolo[3,4-B]Pyridine (3)5-Phenyl-1H-Pyrazole-3-Carboxylic Acid (15)6,7-Dihydro-5H-Pyrazolo[5,1-B][1,3]Oxazine (12)6-Bromopyrazolo[1,5-A]Pyridine (8)6-Bromopyrazolo[1,5-A]Pyrimidine (7)6-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine (12)7-Chloropyrazolo[1,5-A]Pyrimidine (8)Ethyl 1-Phenyl-1H-Pyrazole-3-Carboxylate (3)Ethyl 1-Phenyl-1H-Pyrazole-4-Carboxylate (13)Ethyl 1H-Pyrazole-4-Carboxylate (11)Ethyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate (11)Ethyl Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate (6)Methyl 1H-Pyrazole-4-Carboxylate (10)Methyl 1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate (3)Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate (16)Pyrazolo[1,5-A]Pyrazine (5)Pyrazolo[1,5-A]Pyridine-2-Carboxylic Acid (5)Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid (13)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid (7)Tert-Butyl 1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate (7)Tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-1-Carboxylate (3)Alcohols (42)Aldehydes (41)Amides (46)Amines (159)Aryls (121)Bromides (38)Carboxylic Acids (71)Chlorides (26)Difluoromethyls (11)Esters (29)Ethers (39)Fluorinated Building Blocks (52)Iodides (17)Ketones (13)Nitriles (39)Nitroes (28)Sulfamides (4)Sulfonyl Chlorides (4)Trifluoromethyls (26)Bipyrazole (5)Chloropyrazolo (33)Dichloropyrazolo (11)Dihydropyrazolo (28)Dimethylpyrazolo (6)Ethylpyrazole (7)Fluoropyrazolo (9)Hydroxypyrazolo (10)Methoxypyrazolo (16)Methyl-Pyrazole-Carboxylic Acid (147)Methyl-Pyrazolone (85)Methylpyrazolo (32)Pyrazol-Methanol (1)Pyrazolopyridine-Carboxylic Acid (48)Tetrahydropyrazolo (23)Tetrahydropyrans (4)Thiophenes (11)

Pyridazines (2784)

2-Methylpyridazin-3(2H)-One (7)3,6-Dichloropyridazine (20)3-(Piperazin-1-Yl)Pyridazine (7)3-(Trifluoromethyl)Pyridazine (3)3-Bromopyridazine (25)3-Chloro-4-Methylpyridazine (7)3-Chloropyridazine (45)3-Iodopyridazine (5)3-Methoxypyridazine (17)3-Methylpyridazine (6)3-Phenylpyridazine (8)4-Aminopyridazin-3(2H)-One (4)4-Bromopyridazin-3(2H)-One (3)4-Bromopyridazine (5)4-Chloropyridazin-3(2H)-One (4)4-Chloropyridazine (16)4-Methoxypyridazine (8)4-Methylpyridazine (3)6-Chloropyridazin-3(2H)-One (5)6-Chloropyridazin-3-Amine (5)[1,2,4]Triazolo[4,3-B]Pyridazine (10)Ethyl Pyridazine-3-Carboxylate (6)Methyl Pyridazine-3-Carboxylate (7)Pyridazin-3-Amine (18)Pyridazin-3-Ol (3)Pyridazin-4-Amine (10)Pyridazine-3-Carboxylic Acid (7)Alcohols (8)Amides (20)Amines (10)Aryls (15)Bromides (10)Carboxylic Acids (10)Chlorides (32)Esters (11)Ethers (7)Fluorinated Building Blocks (4)Ketones (4)Nitriles (5)Aminopyridazine (12)Dihydropyridazine (26)Dimethylpyridazine (9)Hexahydropyridazines (10)Morpholines (4)

Pyridines (71397)

Acetylpyridin (5)Aminopicolinate (8)Aminopyridine (74)Benzyloxypyridine (36)Bipyridine (198)Bromopicolinate (19)Bromopicolinic (4)Bromopicolinic Acid (5)Bromopicolinonitrile (6)Bromopyrido (13)Butylpyridine (5)Chloroisonicotinic Acid (5)Chloronicotinaldehyde (23)Chloronicotinamide (11)Chloronicotinate (45)Chloronicotinic (41)Cyanopicolinate (7)Cyanopicolinic (6)Cyanopyridine (34)Cyclopropoxypyridine (6)Cyclopropylpyridine (30)Dibromopicolinate (4)Dibromopicolinic Acid (3)Dibromopyridine (36)Dichloropicolinate (9)Dichloropicolinonitrile (4)Dichloropyridine (120)Difluoropicolinic Acid (3)Difluoropyridine (58)Dihydropyrido (27)Diiodopyridine (13)Dimethoxypicolinic Acid (5)Dimethoxypyridine (33)Dimethylpyridine (142)Diphenylpyridine (6)Dipyridine (29)Ethoxypicolinic Acid (3)Ethoxypyridine (35)Ethylpyridine (36)Ethynylpicolinate (3)Fluoro-Pyridine--Boronate (79)Fluoropicolinaldehyde (8)Fluoropicolinamide (8)Fluoropicolinate (22)Fluoropyridine (287)Fluoropyrido (3)Formylpyridine (23)Hexahydropyrido (7)Hydrazinylpyridine (22)Hydroxymethylpyridine (26)Hydroxypicolinate (13)Hydroxypicolinic (9)Hydroxypicolinonitrile (7)Imidazopyridine (263)Iodopicolinate (5)Iodopicolinic Acid (4)Iodopyridine (167)Isopropoxypyridine (20)Isopropylpyridine (32)Methoxyisonicotinaldehyde (10)Methoxynicotinaldehyde (18)Methoxypicolinaldehyde (13)Methoxypicolinamide (13)Methoxypicolinate (21)Methoxypicolinic (18)Methoxypicolinic Acid (16)Methoxypicolinimidamide (5)Methoxypicolinonitrile (13)Methoxypyridine (339)Methylisonicotinamide (8)Methylnicotinaldehyde (30)Methylnicotinamide (13)Methylpicolinaldehyde (16)Methylpicolinamide (15)Methylpicolinate (27)Methylpicolinic (23)Methylpicolinonitrile (28)Methylpyrido (13)Nitropyridine (392)Oxopyridin (2)Picolinate (41)Pyridinecarbonitrile (50)Pyridyl-Benzene-Boronic Acid/Ester (16)Pyridyl-Phenyl-Boronate (2)Pyridylmethyl (6)Pyrrolopyridine (4)Terpyridine (32)Tetrachloropyridine (5)Tetrafluoropyridine (21)Tetrahydropyridine (48)Tetrahydropyrido (32)Thiazolopyridine (24)Tribromopyridine (9)Trichloropyridine (17)Trifluoropyridine (8)Trimethylpyridine (5)(2-Chloropyridin-4-Yl)Boronic Acid (6)(3-Bromopyridin-2-Yl)Methanol (7)(3-Chloropyridin-2-Yl)Methanamine (6)(3-Fluoropyridin-2-Yl)Methanamine (5)(3-Methylpyridin-2-Yl)Methanamine (5)(3-Methylpyridin-2-Yl)Methanol (10)(3Ar,8As)-2-(Pyridin-2-Yl)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole (6)(3As,8Ar)-2-(Pyridin-2-Yl)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole (7)(4R,5S)-4,5-Diphenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (5)(5-(Trifluoromethyl)Pyridin-3-Yl)Boronic Acid (4)(5-Bromopyridin-2-Yl)Methanamine (5)(5-Bromopyridin-2-Yl)Methanol (5)(5-Chloropyridin-2-Yl)Methanamine (5)(6-Methylpyridin-2-Yl)Methanamine (6)(6-Methylpyridin-2-Yl)Methanol (5)(6-Phenoxypyridin-3-Yl)Boronic Acid (5)(R)-3-(Pyrrolidin-2-Yl)Pyridine (9)(R)-4-Benzyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (7)(R)-4-Phenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (7)(S)-4-Benzyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (8)(S)-4-Phenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (6)1,1'-Diphenyl-[4,4'-Bipyridine]-1,1'-Diium (7)1,10-Phenanthrolin-4-Ol (3)1,2,3,4-Tetrahydropyrido[2,3-B]Pyrazine (5)1,2,3,6-Tetrahydropyridine (22)1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One (19)1,3-Dihydro-2H-Pyrrolo[2,3-C]Pyridin-2-One (5)1,3-Dihydro-2H-Pyrrolo[3,2-B]Pyridin-2-One (11)1,4-Di(Pyridin-4-Yl)Benzene (5)1-(5-Bromopyridin-2-Yl)Piperazine (6)1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine (30)1-(Pyridin-2-Yl)Ethan-1-Amine (15)1-(Pyridin-2-Yl)Ethan-1-One (36)1-(Pyridin-2-Yl-L2-Azaneyl)Ethan-1-One (12)1-(Pyridin-3-Yl)Ethan-1-Amine (17)1-(Pyridin-3-Yl)Ethan-1-One (29)1-(Pyridin-3-Yl)Piperazine (13)1-(Pyridin-3-Ylmethyl)Piperazine (6)1-(Pyridin-4-Yl)Ethan-1-Amine (23)1-(Pyridin-4-Yl)Ethan-1-One (14)1-Benzyl-1,2,3,6-Tetrahydropyridine (9)1-Benzyl-1H-Pyrazolo[3,4-B]Pyridine (9)1-Methyl-4-(Pyridin-2-Yl)Piperazine (5)1-Methylpyridin-1-Ium Iodide (5)1-Phenyl-3-(4-(Pyridin-4-Yloxy)Phenyl)Urea (8)1H-Imidazo[4,5-B]Pyridine (14)1H-Imidazo[4,5-C]Pyridine (12)1H-Pyrazolo[3,4-B]Pyridin-5-Amine (3)1H-Pyrrolo[2,3-C]Pyridin-7-Ol (3)1H-Pyrrolo[2,3-C]Pyridine-2-Carboxylic Acid (4)1H-Pyrrolo[3,2-B]Pyridine-3-Carboxylic Acid (6)2,2':6',2''-Terpyridine (15)2,2-Dimethyl-1-(Pyridin-2-Yl-L2-Azaneyl)Propan-1-One (7)2,3'-Bipyridine (11)2,3,4,5-Tetrahydro-1H-Pyrido[4,3-B]Indole (12)2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole (13)2,3,5-Trichloropyridine (13)2,3,6-Trichloropyridine (16)2,3-Dibromopyridine (21)2,3-Dichloropyridine (38)2,3-Difluoropyridine (13)2,3-Dihydro-1H-Pyrrolo[2,3-B]Pyridine (10)2,3-Dihydro-1H-Pyrrolo[2,3-C]Pyridine (5)2,3-Dihydro-1H-Pyrrolo[3,2-C]Pyridine (7)2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine (6)2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine (5)2,3-Dihydropyridin-2-One (5)2,3-Dimethoxypyridine (7)2,3-Dimethylpyridine (8)2,4,6-Trichloropyridine (5)2,4,6-Triphenylpyridine (7)2,4-Dibromopyridine (5)2,4-Dichloro-6-Methylpyridine (8)2,4-Dichloropyridine (50)2,4-Dimethylpyridine (5)2,5-Dibromopyridine (26)2,5-Dichloropyridine (32)2,5-Difluoropyridine (8)2,6-Bis(4,5-Dihydrooxazol-2-Yl)Pyridine (12)2,6-Di(1H-Pyrazol-1-Yl)Pyridine (5)2,6-Dibromo-3-Fluoropyridine (3)2,6-Dibromopyridin-4-Amine (3)2,6-Dibromopyridine (28)2,6-Dichloro-3-Fluoropyridine (10)2,6-Dichloro-3-Methylpyridine (5)2,6-Dichloro-3-Nitropyridine (6)2,6-Dichloro-4-Iodopyridine (4)2,6-Dichloro-4-Methylpyridine (5)2,6-Dichloronicotinonitrile (8)2,6-Dichloropyridin-3-Amine (11)2,6-Dichloropyridine (49)2,6-Difluoropyridine (29)2,6-Dimethoxypyridine (11)2,6-Dimethylpyridin-4-Ol (4)2,6-Dimethylpyridine (26)2-(1H-Pyrazol-1-Yl)Pyridine (16)2-(1H-Pyrazol-3-Yl)Pyridine (4)2-(2,2,2-Trifluoroethoxy)Pyridine (8)2-(2-Chlorophenyl)Pyridine (3)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)2-(4-Fluorophenyl)Pyridine (11)2-(6-Benzhydrylpyridin-2-Yl)-4,5-Dihydrooxazole (10)2-(6-Cyclopropylpyridin-2-Yl)-4,5-Dihydrooxazole (10)2-(Benzyloxy)Pyridine (18)2-(Bromomethyl)Pyridine (27)2-(Chloromethyl)-3-Methylpyridine (12)2-(Chloromethyl)Pyridine (12)2-(Chloromethyl)Pyridine 1-Oxide (4)2-(Difluoromethyl)Pyridine (21)2-(Methylsulfonyl)Pyridine (11)2-(Methylthio)Pyridine (5)2-(P-Tolyl)Pyridine (6)2-(Phenoxymethyl)Pyridine (5)2-(Piperidin-1-Yl)Pyridine (11)2-(Piperidin-4-Yl)Pyridine (5)2-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole (5)2-(Pyridin-2-Yl)Acetonitrile (8)2-(Pyridin-2-Yl)Pyrimidine (8)2-(Pyridin-2-Ylmethyl)-4,5-Dihydrooxazole (14)2-(Pyridin-3-Yl)Acetic Acid (14)2-(Pyridin-3-Yl)Acetonitrile (6)2-(Pyrrolidin-2-Yl)Pyridine (5)2-(Thiophen-2-Yl)Pyridine (5)2-(Trifluoromethoxy)Pyridine (6)2-(Trifluoromethyl)Pyridine (6)2-Aminonicotinonitrile (6)2-Benzylpyridine (12)2-Bromo-3-(Trifluoromethyl)Pyridine (4)2-Bromo-3-Chloropyridine (25)2-Bromo-3-Fluoropyridine (26)2-Bromo-3-Iodopyridine (6)2-Bromo-3-Methoxypyridine (7)2-Bromo-3-Methylpyridine (25)2-Bromo-3-Nitropyridine (5)2-Bromo-4-Chloropyridine (7)2-Bromo-4-Methylpyridine (6)2-Bromo-5-(Trifluoromethyl)Pyridine (6)2-Bromo-5-Chloropyridine (22)2-Bromo-5-Fluoropyridine (33)2-Bromo-5-Methoxypyridine (11)2-Bromo-5-Methylpyridine (19)2-Bromo-5-Nitropyridine (11)2-Bromo-6-(Trifluoromethyl)Pyridine (6)2-Bromo-6-Chloropyridine (23)2-Bromo-6-Fluoropyridine (21)2-Bromo-6-Iodopyridine (5)2-Bromo-6-Methoxypyridine (15)2-Bromo-6-Methylpyridine (17)2-Bromo-6-Phenylpyridine (4)2-Bromonicotinic Acid (5)2-Bromopyridin-3-Amine (10)2-Bromopyridin-3-Ol (7)2-Bromopyridine (10)2-Bromopyridine 1-Oxide (6)2-Chloro-3,6-Dimethylpyridine (4)2-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (4)2-Chloro-3-(Trifluoromethyl)Pyridine (12)2-Chloro-3-Fluoropyridin-4-Amine (3)2-Chloro-3-Fluoropyridine (20)2-Chloro-3-Iodopyridin-4-Amine (3)2-Chloro-3-Iodopyridine (13)2-Chloro-3-Methoxypyridine (12)2-Chloro-3-Methylpyridine (17)2-Chloro-3-Nitropyridine (10)2-Chloro-4,6-Dimethylpyridine (7)2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (14)2-Chloro-4-(Trifluoromethyl)Pyridine (9)2-Chloro-4-Ethoxypyridine (5)2-Chloro-4-Fluoropyridine (10)2-Chloro-4-Iodopyridine (19)2-Chloro-4-Methoxypyridine (22)2-Chloro-4-Methylpyridine (31)2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)2-Chloro-5-(Trifluoromethyl)Pyridine (4)2-Chloro-5-Fluoropyridin-4-Amine (3)2-Chloro-5-Fluoropyridine (16)2-Chloro-5-Iodopyridine (18)2-Chloro-5-Methylpyridine (11)2-Chloro-5-Nitropyridine (8)2-Chloro-6-(Trifluoromethyl)Pyridine (16)2-Chloro-6-Fluoropyridine (14)2-Chloro-6-Iodopyridine (9)2-Chloro-6-Methoxypyridine (24)2-Chloro-6-Methyl-3-Nitropyridine (4)2-Chloro-6-Methylnicotinonitrile (10)2-Chloro-6-Methylpyridine (49)2-Chloroisonicotinaldehyde (19)2-Chloroisonicotinic Acid (17)2-Chloroisonicotinonitrile (7)2-Chloronicotinic Acid (7)2-Chloronicotinonitrile (9)2-Chloropyridin-3-Amine (11)2-Chloropyridin-3-Ol (9)2-Chloropyridin-4-Amine (28)2-Chloropyridine 1-Oxide (10)2-Cyclopropyl-4-Phenylquinoline (12)2-Cyclopropylpyridine (20)2-Ethoxypyridine (20)2-Ethylpyridine (9)2-Ethynylpyridine (31)2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)2-Fluoro-3-Iodopyridine (8)2-Fluoro-3-Methylpyridine (14)2-Fluoro-4-Methylpyridine (6)2-Fluoro-5-Methoxypyridine (4)2-Fluoro-5-Methylpyridine (6)2-Fluoro-6-Methoxypyridine (6)2-Fluoro-6-Methylpyridine (20)2-Fluoropyridine (15)2-Hydrazineylpyridine (32)2-Iodo-6-Methylpyridine (5)2-Iodopyridine (27)2-Isopropoxypyridine (16)2-Isopropylpyridine (14)2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)2-Methoxy-3-(Trifluoromethyl)Pyridine (6)2-Methoxy-4-Methylpyridine (5)2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)2-Methoxy-5-(Trifluoromethyl)Pyridine (4)2-Methoxy-5-Methylpyridine (5)2-Methoxy-5-Nitropyridine (8)2-Methoxy-6-Methylpyridine (14)2-Methoxyisonicotinic Acid (13)2-Methoxypyridin-3-Amine (6)2-Methoxypyridine (434)2-Methyl-1,10-Phenanthroline (3)2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)2-Methyl-3-Nitropyridine (9)2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (3)2-Methylimidazo[1,2-A]Pyridine (8)2-Methylpyridin-3-Ol (9)2-Methylpyridin-4-Amine (7)2-Methylpyridine 1-Oxide (9)2-Nitropyridine (40)2-Phenoxy-5-(Trifluoromethyl)Pyridine (7)2-Phenylimidazo[1,2-A]Pyridine (12)2-Propoxypyridine (9)2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One (8)3,3'-Bipyridine (7)3,4-Dihydro-2H-Pyrido[3,2-B][1,4]Oxazine (5)3,5-Dibromopyridine (12)3,5-Dichloropyridine (16)3,5-Difluoropyridine (12)3,5-Dimethoxypyridine (4)3,5-Dimethylpyridine (8)3,5-Diphenylpyridine (5)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Pyridine (3)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (74)3-(Benzyloxy)Pyridine (19)3-(Bromomethyl)Pyridine (18)3-(Chloromethyl)Pyridine (22)3-(Cyclopropylmethyl)Pyridine (6)3-(Difluoromethyl)Pyridine (5)3-(Methylsulfonyl)Pyridine (5)3-(Piperidin-1-Yl)Pyridine (5)3-(Piperidin-4-Yl)Pyridine (5)3-(Pyrrolidin-2-Yl)Pyridine (6)3-(Tert-Butyl)Pyridine (5)3-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine (3)3-(Trifluoromethyl)Pyridin-2-Ol (5)3-(Trifluoromethyl)Pyridine (51)3-Bromo-1H-Pyrrolo[3,2-B]Pyridine (6)3-Bromo-2-Chloropyridin-4-Amine (3)3-Bromo-2-Chloropyridine (20)3-Bromo-2-Fluoropyridine (21)3-Bromo-2-Methoxypyridine (20)3-Bromo-2-Methylpyridine (27)3-Bromo-4-Methylpyridine (13)3-Bromo-5-Chloropyridine (14)3-Bromo-5-Fluoropyridine (18)3-Bromo-5-Methylpyridine (14)3-Bromo-5-Nitropyridine (10)3-Bromopicolinic Acid (9)3-Bromopicolinonitrile (13)3-Bromopyrazolo[1,5-A]Pyridine (6)3-Bromopyridin-2-Amine (30)3-Bromopyridin-2-Ol (17)3-Bromopyridine 1-Oxide (8)3-Chloro-2-Fluoropyridine (13)3-Chloro-2-Methoxypyridine (16)3-Chloro-2-Methylpyridine (4)3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)3-Chloro-5-Fluoropyridine (10)3-Chloro-5-Methylpyridine (7)3-Chloro-5-Nitropyridine (5)3-Chloroimidazo[1,2-A]Pyridine (3)3-Chloropicolinic Acid (9)3-Chloropicolinonitrile (6)3-Chloropyridin-2-Amine (17)3-Chloropyridin-2-Ol (10)3-Cyclopropylpyridine (28)3-Ethoxypyridine (12)3-Ethylpyridine (11)3-Ethynylpyridine (22)3-Fluoro-2-Methoxypyridine (14)3-Fluoro-2-Methylpyridine (15)3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)3-Fluoropicolinic Acid (6)3-Fluoropicolinonitrile (5)3-Fluoropyridin-2-Amine (12)3-Fluoropyridin-4-Amine (4)3-Hydrazineylpyridine (8)3-Iodo-1H-Pyrazolo[3,4-B]Pyridine (4)3-Iodo-1H-Pyrrolo[3,2-B]Pyridine (6)3-Iodo-1H-Pyrrolo[3,2-C]Pyridine (4)3-Iodopyridin-2-Amine (12)3-Iodopyridin-2-Ol (4)3-Iodopyridin-4-Amine (6)3-Iodopyridin-4-Ol (4)3-Iodopyridine (37)3-Methoxypyridin-2-Amine (5)3-Methoxypyridine (51)3-Methyl-1H-Pyrrolo[2,3-B]Pyridine (5)3-Methyl-2-Phenylpyridine (3)3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)3-Methyl-5-Nitropyridine (4)3-Methylimidazo[1,2-A]Pyridine (3)3-Methylpicolinic Acid (13)3-Methylpyridin-2-Amine (7)3-Methylpyridine (49)3-Methylpyridine 1-Oxide (7)3-Nitropyridin-2-Ol (11)3-Nitropyridin-4-Amine (5)3-Nitropyridine (54)3-Phenoxypyridine (12)4'-Phenyl-2,2':6',2''-Terpyridine (13)4,4'-Bipyridine (10)4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine (7)4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridine (14)4,5,6,7-Tetrahydro-3H-Imidazo[4,5-C]Pyridine (5)4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine (10)4,5,6,7-Tetrahydrothieno[2,3-C]Pyridine (10)4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine (9)4,6-Dichloropyridin-2-Amine (6)4,6-Dichloropyridin-3-Amine (4)4,7-Diphenyl-1,10-Phenanthroline (4)4-(2,4-Diphenyl-1H-Imidazol-5-Yl)Pyridine (5)4-(Benzyloxy)Pyridine (8)4-(Bromomethyl)Pyridine (8)4-(Pyridin-2-Yl)Morpholine (21)4-(Pyridin-3-Yl)Pyrimidine (5)4-(Pyridin-4-Yl)Morpholine (5)4-(Tert-Butyl)-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (16)4-(Tert-Butyl)Pyridine (5)4-(Trifluoromethyl)Nicotinic Acid (3)4-(Trifluoromethyl)Pyridine (14)4-Bromo-2-Chloropyridine (29)4-Bromo-2-Fluoropyridine (4)4-Bromo-2-Methoxypyridine (4)4-Bromo-3-Methylpyridine (5)4-Bromopyrazolo[1,5-A]Pyridine (8)4-Bromopyridine (31)4-Chloro-1H-Pyrazolo[4,3-C]Pyridine (7)4-Chloro-1H-Pyrrolo[2,3-B]Pyridine (13)4-Chloro-1H-Pyrrolo[3,2-C]Pyridine (10)4-Chloro-2,6-Dimethylpyridine (4)4-Chloro-2-Methoxypyridine (6)4-Chloro-3-Methylpyridine (7)4-Chloronicotinic Acid (4)4-Chloropyridin-2-Amine (6)4-Chloropyridine (31)4-Cyclopropylpyridine (7)4-Ethoxypyridine (7)4-Ethynylpyridine (10)4-Iodopyridine (17)4-Isopropyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (16)4-Methoxypyridine (136)4-Methyl-2,2'-Bipyridine (8)4-Methyl-2-Phenylpyridine (3)4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)4-Methyl-3-Nitropyridine (8)4-Methylnicotinic Acid (5)4-Methylpyridine (24)4-Nitropyridine (11)4-Phenoxypyridine (7)4-Phenyl-1,2,3,6-Tetrahydropyridine (7)4-Phenyl-1,4-Dihydropyridine (10)5,6,7,8-Tetrahydroimidazo[1,2-A]Pyridine (11)5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine (7)5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine (17)5,6-Dichloropyridin-2-Amine (4)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile (4)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine (9)5-(Trifluoromethyl)Pyridin-2-Amine (5)5-(Trifluoromethyl)Pyridin-2-Ol (8)5-Benzyl-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine (7)5-Bromo-2-Chloro-4-Methylpyridine (5)5-Bromo-2-Chloropyridine (40)5-Bromo-2-Fluoropyridine (22)5-Bromo-2-Iodopyridine (5)5-Bromo-2-Methoxypyridine (29)5-Bromo-2-Methylpyridine (23)5-Bromo-2-Phenylpyridine (3)5-Bromo-4-Methylpyridin-2-Amine (5)5-Bromo-6-Chloropyridin-2-Amine (3)5-Bromonicotinaldehyde (12)5-Bromonicotinic Acid (6)5-Bromonicotinonitrile (6)5-Bromopicolinic Acid (11)5-Bromopicolinonitrile (13)5-Bromopyridin-2-Amine (35)5-Bromopyridin-2-Ol (18)5-Bromopyridin-3-Amine (10)5-Bromopyridin-3-Ol (6)5-Chloro-1H-Pyrazolo[3,4-B]Pyridine (3)5-Chloro-1H-Pyrazolo[4,3-B]Pyridine (6)5-Chloro-1H-Pyrrolo[2,3-C]Pyridine (5)5-Chloro-1H-Pyrrolo[3,2-B]Pyridine (6)5-Chloro-2-Fluoropyridine (13)5-Chloro-2-Methoxypyridine (10)5-Chloro-2-Methylpyridine (10)5-Chloroimidazo[1,2-A]Pyridine (3)5-Chloropicolinic Acid (7)5-Chloropicolinonitrile (6)5-Chloropyridin-2-Amine (26)5-Chloropyridin-2-Ol (15)5-Chloropyridin-3-Amine (7)5-Fluoro-2-Methoxypyridine (15)5-Fluoro-2-Methylpyridine (8)5-Fluoropicolinonitrile (5)5-Fluoropyridin-2-Amine (15)5-Iodopyridin-2-Amine (17)5-Iodopyridin-2-Ol (8)5-Methoxy-1H-Pyrrolo[2,3-C]Pyridine (4)5-Methoxypyridin-3-Amine (4)5-Methylimidazo[1,2-A]Pyridine (4)5-Methylpyridin-2-Amine (7)5-Methylpyridin-3-Amine (4)5-Nitronicotinic Acid (5)5-Nitropyridin-2-Amine (6)5-Phenylpicolinic Acid (4)6,7-Dihydro-5H-Cyclopenta[B]Pyridine (18)6,7-Dihydro-5H-Cyclopenta[C]Pyridine (7)6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine (5)6-(Trifluoromethyl)Pyridin-2-Amine (11)6-(Trifluoromethyl)Pyridin-3-Amine (5)6-Bromo-1H-Pyrazolo[4,3-B]Pyridine (4)6-Bromo-1H-Pyrrolo[3,2-B]Pyridine (6)6-Bromo-1H-Pyrrolo[3,2-C]Pyridine (5)6-Bromoimidazo[1,2-A]Pyridine (14)6-Bromonicotinaldehyde (10)6-Bromonicotinic Acid (9)6-Bromonicotinonitrile (7)6-Bromopicolinic Acid (5)6-Bromopyrazolo[1,5-A]Pyridine (8)6-Bromopyridin-2-Amine (8)6-Bromopyridin-3-Amine (12)6-Bromopyridin-3-Ol (13)6-Chloro-1H-Pyrazolo[4,3-C]Pyridine (8)6-Chloro-1H-Pyrrolo[3,2-C]Pyridine (11)6-Chloro-3-Nitropyridin-2-Amine (4)6-Chloro-5-(Trifluoromethyl)Pyridin-2-Amine (3)6-Chloro-5-Iodopyridin-2-Amine (3)6-Chloroimidazo[1,2-A]Pyridine (4)6-Chloronicotinaldehyde (24)6-Chloronicotinic Acid (4)6-Chloropicolinic Acid (12)6-Chloropicolinonitrile (9)6-Chloropyridin-2-Amine (21)6-Chloropyridin-2-Ol (9)6-Chloropyridin-3-Amine (4)6-Chloropyridine-3-Sulfonyl Chloride (5)6-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (3)6-Fluoropyridin-2-Amine (8)6-Fluoropyridin-3-Amine (4)6-Methoxy-1H-Pyrrolo[2,3-B]Pyridine (3)6-Methoxynicotinaldehyde (4)6-Methoxypicolinic Acid (9)6-Methoxypyridin-2-Amine (14)6-Methoxypyridin-3-Amine (8)6-Methylnicotinic Acid (6)6-Methylnicotinonitrile (7)6-Methylpicolinic Acid (12)6-Methylpicolinonitrile (10)6-Methylpyridin-2-Amine (46)6-Methylpyridin-2-Ol (23)6-Methylpyridin-3-Amine (5)6-Methylpyridin-3-Ol (7)6-Phenoxypyridin-3-Amine (5)6-Phenylnicotinic Acid (8)6-Phenylpicolinic Acid (3)7-Bromo-1H-Pyrrolo[2,3-C]Pyridine (4)7-Chloro-1H-Pyrrolo[2,3-C]Pyridine (5)7-Methoxy-1H-Pyrrolo[2,3-C]Pyridine (5)7-Methylimidazo[1,2-A]Pyridine (3)9H-Pyrido[3,4-B]Indole (5)Bis(Pyridin-2-Ylmethyl)Amine (6)Dimethyl Pyridine-2,6-Dicarboxylate (7)Dimethyl(Pyridin-2-Yl)Phosphine Oxide (8)Dimethyl(Pyridin-3-Yl)Phosphine Oxide (7)Ethyl 2-(Pyridin-2-Yl)Acetate (15)Ethyl 2-Methylnicotinate (6)Ethyl 4,6-Dichloronicotinate (4)Ethyl 6-Chloropicolinate (7)Ethyl Isonicotinate (12)Ethyl Nicotinate (25)Ethyl Picolinate (41)Ethyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate (11)Furo[3,2-B]Pyridine (7)Furo[3,2-C]Pyridine (7)Imidazo[1,2-A]Pyridin-2-Ylmethanol (4)Imidazo[1,2-A]Pyridine-5-Carboxylic Acid (3)Imidazo[1,2-A]Pyridine-6-Carbonitrile (3)Isonicotinaldehyde (68)Isonicotinamide (12)Isonicotinic Acid (23)Isonicotinohydrazide (6)Isonicotinonitrile (16)Methyl 1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate (3)Methyl 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylate (3)Methyl 2-(Pyridin-2-Yl)Acetate (9)Methyl 2-Chloroisonicotinate (11)Methyl 2-Chloronicotinate (6)Methyl 3-Bromopicolinate (9)Methyl 3-Chloropicolinate (9)Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinate (4)Methyl 5-Hydroxypicolinate (5)Methyl 6-Bromonicotinate (6)Methyl 6-Chloropicolinate (11)Methyl 6-Fluoronicotinate (4)Methyl 6-Methoxynicotinate (4)Methyl Isonicotinate (16)Methyl Nicotinate (52)Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate (16)N,N-Dimethylpyridin-2-Amine (10)N,N-Dimethylpyridin-4-Amine (6)N-(Pyridin-2-Yl)Benzamide (9)N-Benzylpyridin-2-Amine (9)N-Methylpicolinamide (10)N-Methylpyridin-2-Amine (47)N-Methylpyridin-3-Amine (15)N-Phenyl-4-(Pyridin-3-Yl)Pyrimidin-2-Amine (5)N-Phenylpicolinamide (8)N-Phenylpyridin-2-Amine (9)Nicotinaldehyde (152)Nicotinamide (61)Nicotinic Acid (53)Nicotinonitrile (82)Oxazolo[4,5-B]Pyridine (7)Oxazolo[5,4-B]Pyridine (5)Phenyl(Pyridin-2-Yl)Methanone (10)Phenyl(Pyridin-3-Yl)Methanone (9)Picolinaldehyde (98)Picolinamide (26)Picolinic Acid (22)Picolinimidamide (11)Picolinohydrazide (5)Pyrazolo[1,5-A]Pyridine-2-Carboxylic Acid (5)Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid (13)Pyridin-2-Amine (29)Pyridin-2-Ol (170)Pyridin-2-Ylboronic Acid (9)Pyridin-2-Ylmethanamine (38)Pyridin-2-Ylmethanol (65)Pyridin-3-Amine (21)Pyridin-3-Ol (13)Pyridin-3-Ylboronic Acid (49)Pyridin-3-Ylmethanamine (29)Pyridin-3-Ylmethanol (39)Pyridin-4-Amine (22)Pyridin-4-Ol (16)Pyridin-4-Ylboronic Acid (21)Pyridin-4-Ylmethanamine (12)Pyridin-4-Ylmethanol (16)Pyridine 1-Oxide (32)Pyridine-2,3-Diamine (5)Pyridine-2,6-Diamine (12)Pyridine-2,6-Dicarboxylic Acid (9)Pyridine-2,6-Diol (6)Pyridine-2-Sulfonamide (6)Pyridine-2-Sulfonyl Chloride (9)Pyridine-2-Thiol (8)Pyridine-3-Sulfonic Acid (6)Pyridine-3-Sulfonyl Chloride (25)Pyrido[2,3-B]Pyrazine (12)Pyrido[2,3-D]Pyrimidine (8)Pyrido[3,2-D]Pyrimidine (14)Pyrido[3,4-B]Pyrazine (11)Pyrido[3,4-D]Pyrimidine (10)Tert-Butyl (2-Chloropyridin-4-Yl)Carbamate (4)Tert-Butyl 1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate (7)Tert-Butyl 4-(Pyridin-2-Yl)Piperazine-1-Carboxylate (12)Tert-Butyl Pyridin-2-Ylcarbamate (37)Tert-Butyl Pyridin-3-Ylcarbamate (16)Tert-Butyl Pyridin-4-Ylcarbamate (6)Thiazolo[4,5-B]Pyridine (12)Thiazolo[5,4-B]Pyridine (13)Thiazolo[5,4-C]Pyridine (5)Thieno[2,3-B]Pyridine (22)Thieno[2,3-C]Pyridine (14)Thieno[3,2-B]Pyridine (18)Thieno[3,2-C]Pyridine (13)Acyl Chlorides (13)Alcohols (160)Aldehydes (54)Alkenyls (36)Alkynyls (17)Amides (267)Amidines (13)Amines (393)Aryls (178)Bromides (398)Carboxylic Acids (172)Chlorides (372)Difluoromethyls (56)Esters (230)Ethers (238)Fluorinated Building Blocks (296)Hydrazides (17)Hydrazines (27)Iodides (78)Ketones (98)Nitriles (126)Nitroes (61)Oximes (11)Phenols (4)Sulfamides (19)Sulfides (18)Sulfones (14)Sulfonyl Chlorides (5)Thioureas (4)Trifluoromethyls (39)Azetidines (4)Benzimidazoles (6)Imidazoles (4)Indoles (5)Morpholines (24)Piperazines (16)Piperidines (15)Pyrroles (7)Pyrrolidines (2)Thiadiazoles (7)Thiophenes (19)Thiophenols (6)Triazoles (13)Other Aromatic Heterocycles (2)

Pyrimidines (14900)

Bipyrimidine (4)Dibromopyrimidine (15)Methoxypyrimidine (107)Pyrimidinone (2)Tetraoxatetradecan (10)Trichloropyrimidine (11)(R)-7-(Tetrahydrofuran-2-Yl)-7H-Pyrrolo[2,3-D]Pyrimidine (8)(R)-N-(Piperidin-3-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine (5)1,4,5,6-Tetrahydropyrimidine (4)1-(3-Fluorotetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (9)1-(5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (30)1-(Pyrimidin-2-Yl)Ethan-1-One (5)1-(Pyrimidin-4-Yl)Ethan-1-One (6)1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (48)1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine (5)1H-Pyrazolo[4,3-D]Pyrimidine (5)2,4,5-Trichloropyrimidine (6)2,4,6-Trichloropyrimidine (14)2,4,6-Triphenylpyrimidine (9)2,4-Dichloro-6-Methylpyrimidine (7)2,4-Dichloropyrimidin-5-Amine (6)2,4-Dimethoxypyrimidine (13)2,4-Dimethylpyrimidine (7)2-(1H-Pyrazol-1-Yl)Pyrimidine (6)2-(Chloromethyl)Pyrimidine (5)2-(Methylsulfonyl)Pyrimidine (25)2-(Methylthio)Pyrimidin-4-Amine (10)2-(Methylthio)Pyrimidine (19)2-(Piperazin-1-Yl)Pyrimidine (11)2-(Piperidin-1-Yl)Pyrimidine (16)2-(Propylthio)Pyrimidine (5)2-(Pyridin-2-Yl)Pyrimidine (8)2-(Pyrrolidin-1-Yl)Pyrimidine (8)2-(Trifluoromethyl)Pyrimidine (27)2-Aminopyrimidin-4(3H)-One (11)2-Bromopyrimidine (22)2-Chloro-4-(Trifluoromethyl)Pyrimidine (6)2-Chloro-4-Methoxypyrimidine (14)2-Chloro-4-Methylpyrimidine (16)2-Chloro-4-Phenylpyrimidine (7)2-Chloro-5-Fluoropyrimidine (6)2-Chloro-5-Methylpyrimidine (5)2-Chloro-5-Nitropyrimidine (5)2-Chloro-7H-Pyrrolo[2,3-D]Pyrimidine (13)2-Chloropyrimidin-4-Amine (22)2-Cyclopropylpyrimidine (10)2-Ethoxypyrimidine (7)2-Ethylpyrimidine (6)2-Fluoropyrimidine (9)2-Hydrazineylpyrimidine (6)2-Iodopyrimidine (8)2-Methoxypyrimidin-4-Amine (6)2-Methoxypyrimidine (59)2-Methylpyrimidin-4-Amine (22)2-Methylpyrimidin-4-Ol (11)2-Phenoxypyrimidine (8)2-Phenylpyrimidin-5-Amine (5)3-Methylpyrimidin-4(3H)-One (6)4,5-Dichloropyrimidine (7)4,6-Dichloro-2-(Methylthio)Pyrimidine (9)4,6-Dichloro-2-Methylpyrimidine (7)4,6-Dichloropyrimidin-2-Amine (9)4,6-Dichloropyrimidine (14)4,6-Diphenylpyrimidine (7)4-(Dimethoxymethyl)Pyrimidine (5)4-(Piperazin-1-Yl)Pyrimidine (13)4-(Piperidin-1-Yl)Pyrimidine (9)4-(Pyridin-3-Yl)Pyrimidine (5)4-(Pyrimidin-2-Yl)Morpholine (9)4-(Pyrimidin-4-Yl)Morpholine (13)4-(Trifluoromethyl)Pyrimidin-2-Amine (6)4-(Trifluoromethyl)Pyrimidine (12)4-Amino-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (22)4-Bromopyrimidine (24)4-Chloro-2-(Methylthio)Pyrimidine (29)4-Chloro-2-Methoxypyrimidine (12)4-Chloro-2-Phenylpyrimidine (5)4-Chloro-5-Fluoro-2-Methylpyrimidine (5)4-Chloro-5-Iodopyrimidine (6)4-Chloro-5-Methoxypyrimidine (7)4-Chloro-5-Methylpyrimidine (8)4-Chloro-6-Methoxypyrimidine (5)4-Chloropyrimidin-2-Amine (23)4-Chloropyrimidin-5-Amine (7)4-Chloropyrimidine-5-Carbonitrile (6)4-Ethoxypyrimidine (6)4-Fluoropyrimidine (8)4-Iodopyrimidine (9)4-Methoxy-2-Methylpyrimidine (8)4-Methoxypyrimidin-2-Amine (6)4-Methoxypyrimidine (102)4-Methyl-2-(Methylthio)Pyrimidine (7)4-Methylpyrimidin-2-Amine (9)4-Methylpyrimidine (22)4-Phenoxypyrimidine (5)4-Phenylpyrimidin-2-Amine (15)5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine (7)5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine (17)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine (27)5-(Benzyloxy)Pyrimidine (5)5-Benzylpyrimidine (7)5-Bromo-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (4)5-Bromo-2-(Methylthio)Pyrimidine (6)5-Bromo-2-Chloropyrimidine (6)5-Bromo-2-Methylpyrimidine (5)5-Bromo-4-Chloropyrimidine (4)5-Bromo-7H-Pyrrolo[2,3-D]Pyrimidine (3)5-Bromopyrimidin-4(3H)-One (3)5-Chloropyrimidin-4(3H)-One (4)5-Chloropyrimidine (8)5-Chloropyrimidine-2,4(1H,3H)-Dione (3)5-Ethylpyrimidine (5)5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (6)5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (3)5-Fluoropyrimidin-4(3H)-One (3)5-Fluoropyrimidine (11)5-Fluoropyrimidine-2,4(1H,3H)-Dione (3)5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine (4)5-Iodopyrimidine (5)5-Methylpyrimidine (3)5-Phenylpyrimidine (16)5H-Pyrrolo[3,2-D]Pyrimidine (16)6,7-Dihydro-5H-Cyclopenta[D]Pyrimidine (5)6,7-Dihydro-5H-Pyrrolo[3,4-D]Pyrimidine (8)6-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine (12)6-Chloropyrimidin-4-Amine (8)7-(Phenylsulfonyl)-7H-Pyrrolo[2,3-D]Pyrimidine (7)7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine (5)7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine (3)[1,2,4]Triazolo[1,5-A]Pyrimidine (14)Ethyl 4-Chloropyrimidine-5-Carboxylate (5)Ethyl Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate (6)Ethyl Pyrimidine-4-Carboxylate (7)Ethyl Pyrimidine-5-Carboxylate (5)Imidazo[1,2-C]Pyrimidine (6)Methyl Pyrimidine-2-Carboxylate (10)Methyl Pyrimidine-4-Carboxylate (11)Methyl Pyrimidine-5-Carboxylate (5)N,N-Dimethylpyrimidin-2-Amine (10)N-(9-((2R,5S)-5-((Trityloxy)Methyl)Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide (5)N-Benzyl-9H-Purin-6-Amine (6)N-Cyclopropylpyrimidin-2-Amine (5)N-Methyl-N-(4-Phenylpyrimidin-2-Yl)Methanesulfonamide (7)N-Methylpyrimidin-2-Amine (10)N-Methylpyrimidin-4-Amine (10)N-Phenyl-4-(Pyridin-3-Yl)Pyrimidin-2-Amine (5)N-Phenylpyrimidin-2-Amine (5)N-Phenylpyrimidin-4-Amine (7)N2,N4-Diphenylpyrimidine-2,4-Diamine (5)Pyrido[2,3-D]Pyrimidine (8)Pyrido[3,2-D]Pyrimidine (14)Pyrido[3,4-D]Pyrimidine (10)Pyrimidin-2-Ol (21)Pyrimidin-2-Ylmethanamine (7)Pyrimidin-2-Ylmethanol (5)Pyrimidin-4-Amine (29)Pyrimidin-4-Ol (25)Pyrimidin-5-Amine (6)Pyrimidin-5-Ol (5)Pyrimidin-5-Ylboronic Acid (9)Pyrimidine-2,4-Diamine (14)Pyrimidine-2-Carbonitrile (14)Pyrimidine-2-Carboxylic Acid (11)Pyrimidine-2-Thiol (6)Pyrimidine-4,6(1H,5H)-Dione (3)Pyrimidine-4-Carbonitrile (9)Pyrimidine-4-Carboxylic Acid (17)Pyrimidine-5-Carbaldehyde (38)Pyrimidine-5-Carbonitrile (6)Pyrimidine-5-Carboxylic Acid (7)Tetrahydropyrimidin-2(1H)-One (6)Thiazolo[5,4-D]Pyrimidine (5)Thieno[2,3-D]Pyrimidine (30)Thieno[3,2-D]Pyrimidine (24)Alcohols (63)Aldehydes (11)Alkenyls (10)Alkynyls (7)Amides (119)Amidines (4)Amines (191)Aryls (77)Bromides (71)Carboxylic Acids (46)Chlorides (209)Difluoromethyls (9)Esters (63)Ethers (113)Fluorinated Building Blocks (38)Hydrazines (8)Iodides (15)Ketones (8)Nitriles (15)Nitroes (13)Sulfamides (1)Sulfides (53)Sulfones (7)Trifluoromethyls (6)Azetidines (4)Indoles (7)Morpholines (4)Piperazines (23)Piperidines (4)Pyrrolidines (31)Thiophenols (4)

Pyrroles (4948)

(9H-Fluoren-9-Yl)Methyl Pyrrolidine-1-Carboxylate (26)(Z)-3-((1H-Pyrrol-2-Yl)Methylene)Indolin-2-One (8)1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One (19)1,3-Dihydro-2H-Pyrrolo[3,2-B]Pyridin-2-One (11)1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazole (6)1-(Phenylsulfonyl)-1H-Pyrrole (24)1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine (30)1-Benzylpyrrolidin-2-One (17)1-Methyl-1H-Pyrrole (43)1H-Pyrrol-1-Amine (7)1H-Pyrrole-2-Carbaldehyde (21)1H-Pyrrole-2-Carbonitrile (7)1H-Pyrrole-2-Carboxylic Acid (30)1H-Pyrrole-3-Carbaldehyde (9)1H-Pyrrole-3-Carbonitrile (9)1H-Pyrrolo[2,3-B]Pyridin-6-Amine (4)1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid (5)1H-Pyrrolo[2,3-C]Pyridin-7-Ol (3)2,3-Dihydro-1H-Pyrrolo[2,3-B]Pyridine (10)2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine (6)2-Bromo-1H-Pyrrole (11)2-Methyl-1H-Pyrrole (49)2-Nitro-1H-Pyrrole (5)2-Phenyl-1H-Pyrrole (24)3,6-Di(Thiophen-2-Yl)-2,5-Dihydropyrrolo[3,4-C]Pyrrole-1,4-Dione (17)3-Bromo-1H-Pyrrole (16)3-Bromo-1H-Pyrrolo[2,3-B]Pyridine (7)3-Iodo-1H-Pyrrolo[3,2-C]Pyridine (4)3-Methyl-1H-Pyrrolo[2,3-B]Pyridine (5)3-Phenyl-1H-Pyrrole (4)3-Phenylpyrrolidine (1)4-Bromo-1H-Pyrrolo[2,3-B]Pyridine (9)4-Chloro-1H-Pyrrolo[2,3-B]Pyridine (13)4H-Thieno[3,2-B]Pyrrole (6)5-Bromo-1H-Pyrrolo[2,3-B]Pyridine (13)5-Chloro-1H-Pyrrolo[2,3-C]Pyridine (5)5-Methoxy-1H-Pyrrolo[2,3-C]Pyridine (4)5H-Pyrrolo[2,3-B]Pyrazine (14)5H-Pyrrolo[3,2-D]Pyrimidine (16)7-(Phenylsulfonyl)-7H-Pyrrolo[2,3-D]Pyrimidine (7)7-Methoxy-1H-Pyrrolo[2,3-C]Pyridine (5)Ethyl 1H-Pyrrole-2-Carboxylate (24)Ethyl 1H-Pyrrole-3-Carboxylate (8)Methyl 1H-Pyrrole-2-Carboxylate (30)Methyl 1H-Pyrrole-3-Carboxylate (5)Methyl 1H-Pyrrolo[2,3-B]Pyridine-6-Carboxylate (3)Pyrrolo[2,1-F][1,2,4]Triazine (14)Tert-Butyl 1H-Pyrrole-1-Carboxylate (8)Tert-Butyl 1H-Pyrrole-2-Carboxylate (3)Alcohols (2)Aldehydes (12)Amides (15)Amines (10)Aryls (30)Bromides (5)Carboxylic Acids (28)Chlorides (13)Esters (21)Fluorinated Building Blocks (8)Ketones (16)Nitriles (6)Nitroes (8)Trifluoromethyls (4)Bromopyrrolo (8)Chloropyrrolo (10)Dihydropyrrolo (15)Octahydropyrrolo (6)Pyrrolopyridine (4)Pyrrolopyridine-Methylamine (6)Pyridines (7)Thiophenes (5)

Pyrrolidines (14433)

(3Ar,6As)-Octahydrocyclopenta[C]Pyrrole (5)(9H-Fluoren-9-Yl)Methyl Pyrrolidine-1-Carboxylate (26)(R)-3-(Pyrrolidin-2-Yl)Pyridine (9)(R)-3-Benzylpyrrolidine (6)(S)-N-(((S)-Tetrahydro-2H-Pyran-2-Yl)Methyl)Pyrrolidine-2-Carboxamide (4)(S)-N-(4-(Thiazol-5-Yl)Benzyl)Pyrrolidine-2-Carboxamide (7)(S)-N-Phenethyl-3-(Pyrrolidin-2-Yl)Propanamide (5)1-((Benzyloxy)Carbonyl)Pyrrolidine-3-Carboxylic Acid (6)1-(3-Chlorophenyl)Pyrrolidine (3)1-(Phenylsulfonyl)Pyrrolidine (15)1-(Pyrrolidin-1-Yl)Ethan-1-One (9)1-Benzyl 2-Methyl Pyrrolidine-1,2-Dicarboxylate (7)1-Benzylpyrrolidin-2-One (17)1-Benzylpyrrolidine (26)1-Methylpyrrolidin-2-One (13)1-Phenylpyrrolidin-2-One (18)2,2-Dimethylpyrrolidine (4)2,5-Dioxopyrrolidin-1-Yl ((Benzyloxy)Carbonyl)Glycinate (8)2,5-Dioxopyrrolidin-1-Yl Benzoate (8)2,8-Diazaspiro[4.5]Decan-3-One (6)2-(2-Chlorophenyl)Pyrrolidine (17)2-(2-Fluorophenyl)Pyrrolidine (16)2-(3-Fluorophenyl)Pyrrolidine (5)2-(Methoxymethyl)Pyrrolidine (6)2-(Pyrrolidin-1-Yl)Benzoic Acid (3)2-(Pyrrolidin-1-Yl)Pyridine (11)2-(Pyrrolidin-1-Yl)Pyrimidine (8)2-(Pyrrolidin-2-Yl)Acetic Acid (8)2-(Pyrrolidin-2-Yl)Pyridine (5)2-(Pyrrolidin-3-Yl)Acetic Acid (6)2-Amino-1-(Pyrrolidin-1-Yl)Ethan-1-One (5)2-Azabicyclo[2.2.1]Heptane (6)2-Methyl-1-Phenyl-1H-Pyrrole (8)2-Methylpyrrolidine (21)3,3-Difluoropyrrolidine (29)3-(Pyrrolidin-2-Yl)Pyridine (6)3-Aminopyrrolidin-2-One (5)3-Bromopyrrolidine (6)3-Hydroxypyrrolidin-2-One (4)3-Phenoxypyrrolidine (5)3-Phenyl-1-(Pyrrolidin-1-Yl)Propan-1-One (1)3-Phenylpyrrolidine (1)4-(Hydroxymethyl)Pyrrolidin-2-One (4)4-(Pyrrolidin-1-Yl)Aniline (3)4-(Pyrrolidin-1-Yl)Piperidine (6)4-Hydroxypyrrolidin-2-One (7)4H-Thieno[3,4-C]Pyrrole-4,6(5H)-Dione (7)5-(Aminomethyl)Pyrrolidin-2-One (3)5-(Hydroxymethyl)Pyrrolidin-2-One (7)5-Azaspiro[2.4]Heptane (13)5-Oxopyrrolidine-2-Carboxylic Acid (4)6-Azaspiro[3.4]Octane (4)Benzyl (S)-Pyrrolidin-3-Ylcarbamate (7)Benzyl 3-Hydroxypyrrolidine-1-Carboxylate (5)Benzyl-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate (9)Benzyl-3-Aminopyrrolidine-1-Carboxylate (7)Ethyl 5-Oxopyrrolidine-2-Carboxylate (3)Hexahydro-1H-Pyrrolizine (12)Methyl 5-Oxopyrrolidine-2-Carboxylate (3)Methyl Prolinate (43)Methyl Pyrrolidine-3-Carboxylate (9)N,N-Dimethylpyrrolidin-3-Amine (7)N-Methylpyrrolidin-3-Amine (6)Octahydrocyclopenta[C]Pyrrole (6)Phenyl(Pyrrolidin-1-Yl)Methanone (12)Proline (13)Pyrrolidin-2-Ylmethanamine (12)Pyrrolidin-2-Ylmethanol (26)Pyrrolidin-3-Ol (59)Pyrrolidin-3-Ylmethanamine (6)Pyrrolidin-3-Ylmethanol (13)Pyrrolidine-2-Carbonitrile (9)Pyrrolidine-2-Carboxamide (12)Pyrrolidine-3-Carbonitrile (6)Pyrrolidine-3-Carboxylic Acid (14)Tert-Butyl (2-Oxopyrrolidin-3-Yl)Carbamate (3)Tert-Butyl (5-Oxopyrrolidin-3-Yl)Carbamate (3)Tert-Butyl 2-Oxopyrrolidine-1-Carboxylate (15)Tert-Butyl 3-((Methylsulfonyl)Oxy)Pyrrolidine-1-Carboxylate (5)Tert-Butyl 3-Hydroxypyrrolidine-1-Carboxylate (20)Tert-Butyl 3-Methoxypyrrolidine-1-Carboxylate (6)Tert-Butyl Pyrrolidin-3-Ylcarbamate (12)Tert-Butyl Pyrrolidine-1-Carboxylate (21)Alcohols (82)Alkenyls (14)Alkynyls (8)Amides (307)Amines (81)Aryls (141)Bromides (25)Carboxylic Acids (25)Chlorides (49)Esters (32)Ethers (56)Fluorinated Building Blocks (38)Hydrazines (3)Ketones (23)Nitriles (11)Nitroes (12)Sulfamides (10)Sulfides (7)Sulfonates (4)Trifluoromethyls (4)Ureas (2)Acetylpyrrolidine (9)Benzylpyrrolidine (31)Bipyrrolidine (8)Bromopyrrolidine (7)Carbamoylpyrrolidine (5)Difluoropyrrolidine (16)Dimethylpyrrolidine (31)Dioxopyrrolidin (131)Ethylpyrrolidine (9)Fluoropyrrolidine (26)Formylpyrrolidine (10)Mercaptopyrrolidine (4)Methoxypyrrolidine (19)Methylenepyrrolidine (2)Methylpyrrolidine (128)Phenoxypyrrolidine (3)Pyrrolidine-Benzene-Boronic Acid/Ester (20)Azetidines (12)Imidazoles (2)Oxetanes (4)Piperidines (36)Pyridines (2)Pyrimidines (31)Spiroes (86)Tetrahydropyrans (6)

Pyrrolines (1766)

1,3-Dihydro-2H-Pyrrolo[2,3-C]Pyridin-2-One (5)1-Phenyl-1H-Pyrrole-2,5-Dione (12)2,3-Dihydro-1H-Pyrrolo[2,3-C]Pyridine (5)2,3-Dihydro-1H-Pyrrolo[3,2-C]Pyridine (7)2,5-Dihydro-1H-Pyrrol-2-One (5)2,5-Dihydro-1H-Pyrrole (13)2-Phenyl-2,5,6,7-Tetrahydropyrrolo[2,1-C][1,2,4]Triazol-4-Ium (6)3,4-Dihydro-2H-Pyrrole (5)3-Bromo-1H-Pyrrole-2,5-Dione (3)5,6-Dihydro-4H-Pyrrolo[1,2-B]Pyrazole (8)6,7-Dihydro-5H-Pyrrolo[1,2-A]Imidazole (9)6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine (5)6,7-Dihydro-5H-Pyrrolo[3,4-D]Pyrimidine (8)Amides (24)Aryls (14)Bromides (6)Esters (2)

Quinazolines (3172)

2,4-Dichloroquinazoline (19)2-(Trifluoromethyl)Quinazoline (4)2-Bromoquinazoline (4)2-Chloroquinazolin-4(3H)-One (4)2-Cyclopropylquinazoline (5)2-Mercaptoquinazolin-4(3H)-One (3)2-Methylquinazoline (19)4-Chloroquinazoline (39)4-Methylquinazoline (4)5,6,7,8-Tetrahydroquinazoline (8)5-Chloroquinazoline (4)6-Bromoquinazoline (7)7-Bromoquinazolin-4(3H)-One (4)7-Fluoroquinazolin-4(3H)-One (4)7-Methoxy-N-Phenylquinazolin-4-Amine (12)8-Bromoquinazoline (8)8-Chloroquinazoline (5)8-Fluoroquinazoline (4)8-Methoxyquinazoline (3)8-Methylquinazoline (3)Ethyl Quinazoline-2-Carboxylate (4)N-(3-Chlorophenyl)Quinazolin-4-Amine (10)Quinazolin-2-Amine (13)Quinazolin-2-Ol (7)Quinazolin-4-Amine (8)Quinazolin-4-Ol (10)Alcohols (12)Amides (42)Amines (9)Aryls (7)Bromides (13)Carboxylic Acids (4)Chlorides (20)Esters (5)Ethers (17)Fluorinated Building Blocks (5)Nitroes (4)Dichloroquinazoline (14)Iodoquinazoline (10)Methylquinazoline (45)Nitroquinazoline (20)Trichloroquinazoline (5)

Quinolines (12117)

Dihydroquinoline (111)Iodoquinoline (32)1,2-Dihydroquinoline (5)1-Cyclopropyl-3-(4-(Quinolin-4-Yloxy)Phenyl)Urea (6)2,2'-Biquinoline (3)2,3,6,7-Tetrahydro-1H,5H-Pyrido[3,2,1-Ij]Quinoline (7)2-(Quinolin-2-Yl)-4,5-Dihydrooxazole (7)2-Hydroxyquinolin-4(1H)-One (3)2-Phenylquinoline (18)3,4-Dihydroisoquinoline (11)4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid (3)4-Phenoxyquinoline (5)4-Phenylquinoline (9)6-Bromo-3,4-Dihydroquinolin-2(1H)-One (4)7,8-Dihydroquinolin-5(6H)-One (5)7-(Benzyloxy)Quinoline (6)7-Methoxy-3,4-Dihydroquinolin-2(1H)-One (3)N-Phenyl-N-(4-(Quinolin-4-Yloxy)Phenyl)Cyclopropane-1,1-Dicarboxamide (5)N-Phenylquinolin-4-Amine (11)Alcohols (79)Aldehydes (23)Alkenyls (10)Amides (33)Amines (79)Aryls (24)Bromides (106)Carboxylic Acids (90)Chlorides (110)Esters (73)Ethers (81)Fluorinated Building Blocks (50)Hydrazines (4)Iodides (12)Ketones (50)Nitriles (19)Nitroes (19)Sulfonyl Chlorides (6)Trifluoromethyls (7)Furans (3)Quinuclidines (8)

Quinuclidines (212)

Alcohols (5)Alkenyls (6)Amines (5)Aryls (2)Esters (3)Ethers (2)Quinolines (8)

1,3-Dihydrospiro[Indene-2,4'-Piperidine] (5)1,4-Dioxaspiro[4.5]Decane (17)2,8-Diazaspiro[4.5]Decane (5)2-Oxa-8-Azaspiro[4.5]Decane (5)3-Phenyloxetane (11)6-Azaspiro[3.4]Octane (4)7-Azaspiro[3.5]Nonane (7)9,9'-Spirobi[Fluorene] (19)Spiro[Cyclopropane-1,3'-Indolin]-2'-One (6)Spiro[Indene-2,4'-Piperidin]-1(3H)-One (5)Spiro[Indoline-3,4'-Piperidine] (5)Alcohols (15)Aliphatic Cyclic Hydrocarbons (19)Alkenyls (4)Amides (190)Amines (13)Aryls (36)Bromides (11)Carboxylic Acids (20)Chlorides (3)Esters (18)Fluorinated Building Blocks (9)Ketones (47)Nitriles (2)Aminospiro (4)Azaspiro (240)Bromospiro (11)Diazaspiro (182)Dihydrospiro (18)Dioxaspiro (39)Fluorospiro (4)Oxospiro (22)Triazaspiro (13)Azetidines (85)Benzofurans (5)Dioxolanes (23)Epoxides (5)Imidazolidines (4)Imidazolines (4)Indolines (5)Morpholines (33)Oxazolidines (6)Oxetanes (26)Piperazines (14)Piperidines (139)Pyrrolidines (86)Tetrahydrofurans (17)Tetrahydropyrans (24)Other Aliphatic Heterocycles (14)Other Aromatic Heterocycles (11)

Tetrahydrofurans (2310)

(2R,3S)-2-((Benzoyloxy)Methyl)Tetrahydrofuran-3-Yl Benzoate (8)(3Ar,6Ar)-Hexahydrofuro[3,2-B]Furan (5)(3As,6As)-Tetrahydrofuro[3,4-D][1,3]Dioxole (6)(R)-7-(Tetrahydrofuran-2-Yl)-7H-Pyrrolo[2,3-D]Pyrimidine (8)(R)-N-(9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide (5)(Tetrahydrofuran-2-Yl)Methanamine (2)(Tetrahydrofuran-2-Yl)Methanol (6)(Tetrahydrofuran-3-Yl)Methanamine (3)1,3-Dihydrobenzo[C][1,2]Oxaborole (20)1-(3-Fluorotetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (9)1-(5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (30)1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (48)1-Oxa-8-Azaspiro[4.5]Decane (4)2-(Acetoxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3,4-Diyl Diacetate (6)2-(Hydroxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3,4-Diol (28)2-Oxa-8-Azaspiro[4.5]Decane (5)2-Oxabicyclo[2.1.1]Hexane (6)3-Aminodihydrofuran-2(3H)-One (4)3-Iodotetrahydrofuran (3)4-Amino-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (22)4-Fluoro-2-(Hydroxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3-Ol (4)4-Hydroxydihydrofuran-2(3H)-One (14)5-(Hydroxymethyl)Dihydrofuran-2(3H)-One (7)5-Bromo-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (4)5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (6)5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (3)5-Oxotetrahydrofuran-2-Carboxylic Acid (4)9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Amine (28)9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Ol (4)9-(Tetrahydrofuran-2-Yl)-9H-Purine (2)Dihydrofuran-3(2H)-One (8)Tert-Butyl (Tetrahydrofuran-3-Yl)Carbamate (4)Tetrahydrofuran-2-Carboxylic Acid (4)Tetrahydrofuran-3-Amine (6)Tetrahydrofuran-3-Carboxylic Acid (4)Tetrahydrofuran-3-Ol (7)Alcohols (11)Amides (19)Amines (7)Anhydrides (3)Aryls (12)Bromides (4)Carboxylic Acids (7)Chlorides (3)Esters (22)Ethers (1)Ketones (6)Hydroxytetrahydrofuran (16)Iodotetrahydrofuran (3)Methoxytetrahydrofuran (11)Oxotetrahydrofuran (26)Piperidines (9)Spiroes (17)

Tetrahydroisoquinolines (1316)

(9H-Fluoren-9-Yl)Methyl 3,4-Dihydroisoquinoline-2(1H)-Carboxylate (7)1,2,3,4-Tetrahydroisoquinolin-5-Amine (4)1,2,3,4-Tetrahydroisoquinolin-5-Ol (3)1,2,3,4-Tetrahydroisoquinolin-6-Amine (3)1,2,3,4-Tetrahydroisoquinolin-6-Ol (6)1,2,3,4-Tetrahydroisoquinolin-7-Amine (3)1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid (19)1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid (12)1,4-Dihydroisoquinolin-3(2H)-One (5)1-Methyl-1,2,3,4-Tetrahydroisoquinoline (4)2-Methyl-1,2,3,4-Tetrahydroisoquinoline (13)4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline (3)5,6,7,8-Tetrahydroisoquinoline (5)5-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)5-Chloro-1,2,3,4-Tetrahydroisoquinoline (3)5-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)5-Methyl-1,2,3,4-Tetrahydroisoquinoline (4)6-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)6-Chloro-1,2,3,4-Tetrahydroisoquinoline (3)6-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)6-Methoxy-1,2,3,4-Tetrahydroisoquinoline (3)6-Nitro-1,2,3,4-Tetrahydroisoquinoline (3)7-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)7-Chloro-1,2,3,4-Tetrahydroisoquinoline (5)7-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)7-Methoxy-1,2,3,4-Tetrahydroisoquinoline (6)7-Nitro-1,2,3,4-Tetrahydroisoquinoline (3)Isoquinoline-1,3(2H,4H)-Dione (7)Amides (7)Amines (3)Aryls (3)Chlorides (4)Tetrahydroisoquinoline-Carboxylic Acid (48)

Tetrahydropyrans (3405)

(1S,4Ar,7Ar)-1-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-1,4A,5,7A-Tetrahydrocyclopenta[C]Pyran (3)(6-Phenoxytetrahydro-2H-Pyran-2-Yl)Methanol (16)(R)-2-Phenoxytetrahydro-2H-Pyran (7)(S)-2-(Phenylthio)Tetrahydro-2H-Pyran (5)(S)-7-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-7,8,9,10-Tetrahydrotetracene-5,12-Dione (5)(S)-N-(((S)-Tetrahydro-2H-Pyran-2-Yl)Methyl)Pyrrolidine-2-Carboxamide (4)1-(Tetrahydro-2H-Pyran-4-Yl)-1H-Pyrazole (6)2-(Phenoxymethyl)Tetrahydro-2H-Pyran (5)2-Phenoxytetrahydro-2H-Pyran (6)2-Phenoxytetrahydro-2H-Pyran-4-Yl Acetate (6)4-Phenoxytetrahydro-2H-Pyran (5)9-Bromoanthracene (5)Alcohols (36)Aldehydes (6)Alkenyls (7)Amides (15)Amines (3)Aryls (28)Bromides (6)Carboxylic Acids (12)Chlorides (5)Esters (25)Ethers (24)Fluorinated Building Blocks (8)Hydrazines (4)Iodides (4)Ketones (7)Nitriles (9)Sulfides (3)Difluorochroman (16)Azetidines (6)Piperidines (5)Pyrazoles (4)Pyrrolidines (6)Spiroes (24)

Tetrahydroquinolines (1454)

1-Ethyl-1,2,3,4-Tetrahydroquinoline (6)1-Methyl-1,2,3,4-Tetrahydroquinoline (6)2,3-Dihydroquinolin-4(1H)-One (19)2-Methyl-1,2,3,4-Tetrahydroquinoline (3)4,4-Dimethyl-1,2,3,4-Tetrahydroquinoline (3)4-Methyl-1,2,3,4-Tetrahydroquinoline (2)5,6,7,8-Tetrahydroquinoline (17)6-Bromo-1,2,3,4-Tetrahydroquinoline (6)6-Chloro-1,2,3,4-Tetrahydroquinoline (3)6-Fluoro-1,2,3,4-Tetrahydroquinoline (3)7-Fluoro-1,2,3,4-Tetrahydroquinoline (3)Tert-Butyl 3,4-Dihydroquinoline-1(2H)-Carboxylate (11)Amides (14)Amines (5)Bromides (6)Fluorinated Building Blocks (6)Tetrahydroquinoline-Carboxylic Acid (18)

Tetrazoles (140)

1-Phenyl-1H-Tetrazole (6)5-Phenyl-1H-Tetrazole (23)5-Phenyl-2H-Tetrazole (9)Aryls (5)Esters (5)

Thiazoles (6800)

1-(Thiazol-2-Yl)Ethan-1-One (9)2,4-Dibromothiazole (5)2,4-Dichlorothiazole (4)2,4-Dimethylthiazole (7)2,5-Dibromothiazole (5)2,5-Dimethylthiazole (4)2-(Chloromethyl)Thiazole (5)2-(Methylthio)Thiazole (5)2-(Thiazol-4-Yl)Acetic Acid (9)2-(Trifluoromethyl)Thiazole (11)2-Bromo-4-Methylthiazole (7)2-Bromo-5-Methylthiazole (7)2-Chloro-4-Methylthiazole (5)2-Chloro-5-Methylthiazole (5)2-Chlorothiazole (32)2-Imino-N-((6R,7R)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-(Thiazol-4-Yl)Acetamide (3)2-Isopropylthiazole (11)2-Methyl-4-Phenylthiazole (6)2-Phenoxythiazole (5)2-Phenylbenzo[D]Thiazole (16)2-Phenylthiazole-4-Carbaldehyde (9)4,5,6,7-Tetrahydrobenzo[D]Thiazole (7)4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine (10)4,5-Dihydrothiazole (8)4-(4-Fluorophenyl)Thiazole (9)4-(Trifluoromethyl)Thiazole (7)4-Bromothiazole (10)4-Cyclopropylthiazole (6)4-Methyl-2-Phenylthiazole (6)4-Methylthiazol-2-Amine (7)4-Methylthiazole (5)4-Phenylthiazol-2-Amine (37)5,6-Dihydrobenzo[D]Thiazol-7(4H)-One (5)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole (7)5-Bromothiazol-2-Amine (6)5-Bromothiazole (8)5-Methyl-4-Phenylthiazole (5)5-Methylthiazol-2-Amine (6)5-Phenylthiazole (20)Ethyl 2-Aminothiazole-4-Carboxylate (6)Ethyl 2-Aminothiazole-5-Carboxylate (5)Ethyl 2-Phenylthiazole-4-Carboxylate (12)Ethyl 2-Phenylthiazole-5-Carboxylate (9)Ethyl Thiazole-2-Carboxylate (7)Ethyl Thiazole-4-Carboxylate (7)Ethyl Thiazole-5-Carboxylate (7)Methyl 2-Aminothiazole-4-Carboxylate (6)Methyl Thiazole-2-Carboxylate (6)Methyl Thiazole-4-Carboxylate (6)N-(Thiazol-2-Yl)Acetamide (9)N-(Thiazol-2-Yl)Benzamide (9)N-Phenylthiazol-2-Amine (9)Tert-Butyl Thiazol-2-Ylcarbamate (22)Thiazol-2-Ylmethanamine (5)Thiazol-2-Ylmethanol (9)Thiazol-5-Amine (6)Thiazole-2-Carbaldehyde (9)Thiazole-2-Carboxylic Acid (9)Thiazole-4-Carboxylic Acid (5)Thiazole-5-Carbaldehyde (19)Thiazole-5-Carbonitrile (7)Thiazole-5-Carboxylic Acid (10)Thiazolo[4,5-B]Pyridine (12)Thiazolo[5,4-B]Pyridine (13)Thiazolo[5,4-C]Pyridine (5)Thiazolo[5,4-D]Pyrimidine (5)Alcohols (32)Aldehydes (15)Amides (40)Amines (102)Aryls (98)Bromides (70)Carboxylic Acids (62)Chlorides (29)Esters (70)Ethers (16)Fluorinated Building Blocks (9)Iodides (4)Ketones (19)Nitriles (7)Nitroes (8)Sulfides (8)Acetylthiazole (7)Bromothiazolo (9)Chlorothiazole (32)Chlorothiazolo (18)Cyanothiazole (7)Cyclopropylthiazole (11)Dibromothiazole (7)Dichlorothiazole (8)Dihydrothiazole (14)Dihydrothiazolo (14)Dimethylthiazole (22)Ethylthiazole (8)Formylthiazole (7)Methylthiazole (109)Nitrothiazol (8)Tetrahydrothiazolo (8)Thiazolopyridine (24)Morpholines (5)Thiophenols (4)

Thiazolidines (1287)

(E)-5-Benzylidenethiazolidine-2,4-Dione (6)1,2,3-Oxathiazolidine 2,2-Dioxide (14)2-Thioxothiazolidin-4-One (6)Thiazolidine (62)Amides (16)Aryls (8)Carboxylic Acids (10)Thioesters (8)Thioxothiazolidin (21)

Thiomorpholines (446)

Thiomorpholine (10)Thiomorpholine 1,1-Dioxide (6)Sulfones (8)

Thiophenes (1942)

(9H-Fluoren-9-Yl)Methyl (2-(Thiophen-2-Yl)Ethyl)Carbamate (5)1-(Thiophen-2-Yl)Ethan-1-One (17)2,2'-Bithiophene (24)2,2':5',2''-Terthiophene (9)2,3-Dihydrothieno[3,4-B][1,4]Dioxine (9)2,5-Dibromothiophene (18)2,5-Diphenylthiophene (5)2-(Thiophen-2-Yl)Pyridine (5)2-(Trifluoromethyl)Thiophene (10)2-Chlorothiophene (20)2-Ethynylthiophene (8)2-Iodothiophene (14)2-Methoxythiophene (7)2-Nitrothiophene (20)3-Bromothiophene (6)3-Chlorothiophene (17)3-Fluorothiophene (6)3-Methoxythiophene (9)3-Methylthiophene (14)3-Nitrothiophene (6)3-Phenylthiophene (13)4,4,5,5-Tetramethyl-2-(Thiophen-2-Yl)-1,3,2-Dioxaborolane (23)4,4,5,5-Tetramethyl-2-(Thiophen-3-Yl)-1,3,2-Dioxaborolane (10)4,5,6,7-Tetrahydrothieno[2,3-C]Pyridine (10)4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine (9)4,7-Di(Thiophen-2-Yl)Benzo[C][1,2,5]Thiadiazole (8)4,8-Di(Thiophen-2-Yl)Benzo[1,2-B:4,5-B']Dithiophene (8)4-Phenyl-6H-Thieno[3,2-F][1,2,4]Triazolo[4,3-A][1,4]Diazepine (5)4H-Cyclopenta[2,1-B:3,4-B']Dithiophene (8)4H-Thieno[3,2-B]Pyrrole (6)4H-Thieno[3,4-C]Pyrrole-4,6(5H)-Dione (7)5,6-Dihydro-4H-Cyclopenta[B]Thiophene (7)5-(Thiophen-2-Yl)Isoxazole (5)5-Benzyl-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine (7)5-Phenylthiophen-2-Amine (5)Benzo[1,2-B:4,5-B']Dithiophene (7)Dibenzo[B,D]Thiophene (22)Dihydrothiophen-3(2H)-One (4)Dithieno[3,2-B:2',3'-D]Thiophene (5)Ethyl Thiophene-2-Carboxylate (19)Ethyl Thiophene-3-Carboxylate (11)Methyl Thiophene-3-Carboxylate (35)N,N-Diphenyl-4-(Thiophen-2-Yl)Aniline (5)Phenyl(Thiophen-2-Yl)Methanone (6)Thieno[2,3-B]Pyridine (22)Thieno[2,3-C]Pyridine (14)Thieno[2,3-D]Pyrimidine (30)Thieno[3,2-B]Pyridine (18)Thieno[3,2-B]Thiophene (17)Thieno[3,2-C]Pyridine (13)Thieno[3,2-D]Pyrimidine (24)Thieno[3,4-B]Thiophene (5)Thiophen-2-Ylboronic Acid (20)Thiophen-2-Ylmethanol (11)Thiophen-3-Amine (18)Thiophen-3-Ol (6)Thiophene-2-Carbaldehyde (43)Thiophene-2-Carbonitrile (23)Thiophene-3-Carbaldehyde (17)Thiophene-3-Carbonitrile (13)Thiophene-3-Carboxamide (5)Thiophene-3-Carboxylic Acid (8)Acetylthiophene (5)Aminothiophene (23)Bromothieno (29)Chlorothieno (41)Chlorothiophene (60)Cyanothiophene (5)Dibromothieno (5)Dibromothiophene (17)Dichlorothieno (10)Dichlorothiophene (13)Dihydrothieno (24)Dihydrothiophene (1)Dihydroxythiophene (7)Dimethylthieno (10)Dimethylthiophene (21)Dithiophene (39)Fluorothiophene (18)Formylthiophene (16)Hydroxythiophene (7)Iodothieno (6)Iodothiophene (13)Methylthieno (26)Methylthiophene (28)Nitrothiophene (27)Terthiophene (10)Tetrahydrothieno (17)Thiophenecarboxaldehyde (10)Thiphen-Amine-Hydrochloride (53)Trithiophene (5)

Triazines (1408)

1,2,4-Triazine (10)1,3,5-Triazin-2-Amine (3)2,4,6-Triphenoxy-1,3,5-Triazine (4)2,4,6-Triphenyl-1,3,5-Triazine (24)2,4-Diphenyl-1,3,5-Triazine (6)2-Chloro-1,3,5-Triazine (10)2-Methoxy-1,3,5-Triazine (10)2-Phenyl-1,3,5-Triazine (6)N2,N4,N6-Triphenyl-1,3,5-Triazine-2,4,6-Triamine (4)Pyrrolo[2,1-F][1,2,4]Triazine (14)Amides (11)Amines (13)Aryls (12)Chlorides (13)

Triazoles (7841)

(5As,10Br)-2-Phenyl-2,5A,6,10B-Tetrahydro-4H-Indeno[2,1-B][1,2,4]Triazolo[4,3-D][1,4]Oxazin-11-Ium (6)1-(Phenylsulfonyl)-1H-1,2,4-Triazole (6)1-Benzyl-1H-1,2,3-Triazole (8)1-Benzyl-1H-1,2,4-Triazole (6)1-Methyl-1H-1,2,3-Triazole (9)1-Methyl-1H-1,2,4-Triazole (17)1-Methyl-1H-Benzo[D][1,2,3]Triazole (10)1-Phenyl-1H-1,2,3-Triazole (7)1-Phenyl-1H-1,2,4-Triazole (20)1H-1,2,4-Triazol-3-Amine (6)1H-1,2,4-Triazol-5-Amine (5)2-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (6)2-Phenyl-2,5,6,7-Tetrahydropyrrolo[2,1-C][1,2,4]Triazol-4-Ium (6)2-Phenyl-2H-1,2,3-Triazole (7)2-Phenyl-2H-Benzo[D][1,2,3]Triazole (8)2H-1,2,3-Triazole (7)4-(4-Cyclopropylnaphthalen-1-Yl)-4H-1,2,4-Triazole (7)4-Phenyl-4H-1,2,4-Triazole (6)4-Phenyl-6H-Thieno[3,2-F][1,2,4]Triazolo[4,3-A][1,4]Diazepine (5)4H-1,2,4-Triazole (12)5-Bromo-1H-1,2,4-Triazole (6)5-Bromo-1H-Benzo[D][1,2,3]Triazole (5)5-Fluoro-1H-Benzo[D][1,2,3]Triazole (4)6-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (12)6-Bromo-[1,2,4]Triazolo[4,3-A]Pyridine (8)8-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (6)[1,2,4]Triazolo[1,5-A]Pyrazine (9)[1,2,4]Triazolo[1,5-A]Pyridin-2-Amine (17)[1,2,4]Triazolo[4,3-A]Pyridin-3-Ylmethanamine (5)Ethyl 1H-1,2,4-Triazole-3-Carboxylate (3)Amides (8)Amines (21)Aryls (24)Carboxylic Acids (10)Esters (9)Ethers (5)Hydrazines (3)Sulfides (3)Pyridines (13)Thiophenols (8)

Achiral NHCs Catalysts (35)

Achiral NHCs Ligands (111)

Chiral NHCs Catalysts (138)

Chiral NHCs Ligands (84)

Organic Building Blocks

Acyl Chlorides (3031)

2-Chlorobenzoyl Chloride (13)2-Phenoxyacetyl Chloride (3)2-Phenylacetyl Chloride (9)Aliphatic Chain Hydrocarbons (24)Aliphatic Cyclic Hydrocarbons (10)Alkenyls (7)Amides (13)Aryls (28)Bromides (5)Chlorides (88)Esters (22)Pyridines (13)

Alcohols (45477)

(1-Methyl-1H-Pyrazol-3-Yl)Methanol (7)(1-Phenylcyclopropyl)Methanol (3)(1H-Benzo[D]Imidazol-2-Yl)Methanol (14)(1H-Indol-2-Yl)Methanol (8)(2-(Trifluoromethyl)Phenyl)Methanol (10)(2-Bromo-6-Fluorophenyl)Methanol (4)(2-Bromophenyl)Methanol (39)(2-Chlorophenyl)Methanol (40)(2-Fluorophenyl)Methanol (60)(2-Iodophenyl)Methanol (12)(2-Nitrophenyl)Methanol (29)(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol (7)(3-(Trifluoromethoxy)Phenyl)Methanol (4)(3-(Trifluoromethyl)Phenyl)Methanol (22)(3-Chlorophenyl)Methanol (38)(3-Fluorophenyl)Methanol (58)(3-Iodophenyl)Methanol (13)(3-Methylpyridin-2-Yl)Methanol (10)(3-Nitrophenyl)Methanol (31)(3-Phenoxyphenyl)Methanol (3)(3-Phenylisoxazol-5-Yl)Methanol (7)(4-Fluorophenyl)Methanol (29)(4-Nitrophenyl)Methanol (17)(6-Methylpyridin-2-Yl)Methanol (5)(Tetrahydrofuran-2-Yl)Methanol (6)1,2-Diphenylethan-1-Ol (8)1-Phenyl-1H-Pyrazol-3-Ol (3)1-Phenylethan-1-Ol (102)2,2,2-Trifluoro-1-Phenylethan-1-Ol (27)2-(1H-Indol-3-Yl)Ethan-1-Ol (10)2-(2-Chlorophenyl)Ethan-1-Ol (8)2-(Piperazin-1-Yl)Ethan-1-Ol (10)2-(Piperidin-1-Yl)Ethan-1-Ol (10)2-(Piperidin-2-Yl)Ethan-1-Ol (8)2-(Piperidin-4-Yl)Ethan-1-Ol (5)2-Amino-2-(2-Fluorophenyl)Ethan-1-Ol (7)2-Amino-2-(Anthracen-9-Yl)Ethan-1-Ol (4)2-Amino-2-Phenylethan-1-Ol (196)2-Hydroxy-1,2-Diphenylethan-1-One (3)2-Hydroxy-1-Phenylethan-1-One (8)2-Hydroxyethyl Benzoate (3)2-Phenoxyethan-1-Ol (14)2-Phenylethan-1-Ol (78)2-Phenylpropan-2-Ol (21)3-Phenylpropan-1-Ol (24)4-Fluoro-2-(Hydroxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3-Ol (4)4-Phenylpiperidin-4-Ol (10)Azetidin-2-Ylmethanol (7)Azetidin-3-Ol (11)Benzyl 3-(Hydroxymethyl)Piperazine-1-Carboxylate (6)Benzyl-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate (9)Bicyclo[1.1.1]Pentan-1-Ylmethanol (3)Cyclobutanol (46)Cyclobutylmethanol (15)Cyclohexanol (70)Cyclohexylmethanol (31)Cyclopentanol (51)Diphenylmethanol (20)Isoxazol-3-Ylmethanol (3)Isoxazol-5-Ylmethanol (5)M-Tolylmethanol (34)Morpholin-2-Ylmethanol (12)Morpholin-3-Ylmethanol (14)Naphthalen-1-Ylmethanol (8)O-Tolylmethanol (35)Oxiran-2-Ylmethanol (3)Piperidin-2-Ylmethanol (11)Piperidin-3-Ol (27)Piperidin-3-Ylmethanol (15)Piperidin-4-Ylmethanol (11)Pyridin-2-Ylmethanol (65)Pyridin-3-Ylmethanol (39)Pyridin-4-Ylmethanol (16)Pyrimidin-2-Ylmethanol (5)Pyrrolidin-2-Ylmethanol (26)Pyrrolidin-3-Ylmethanol (13)Quinazolin-2-Ol (7)Tert-Butyl 3-(Hydroxymethyl)-1H-Indole-1-Carboxylate (10)Thiazol-2-Ylmethanol (9)Thiophen-2-Ylmethanol (11)Triphenylmethanol (13)Aldehydes (19)Aliphatic Chain Hydrocarbons (390)Aliphatic Cyclic Hydrocarbons (117)Alkenyls (101)Alkynyls (34)Amides (364)Amines (287)Aryls (626)Azetidines (18)Benzimidazoles (11)Benzodioxans (8)Benzofurans (18)Benzothiazoles (6)Bromides (147)Carboxylic Acid Salts (16)Carboxylic Acids (162)Chlorides (150)Difluoromethyls (10)Dioxolanes (4)Esters (236)Ethers (224)Fluorinated Building Blocks (168)Furans (8)Hydrazides (5)Hydrazines (5)Imidazoles (27)Indazoles (17)Indoles (25)Indolines (13)Iodides (16)Isoquinolines (4)Isoxazoles (8)Ketones (62)Morpholines (23)Nitriles (44)Nitroes (42)Oxazoles (9)Oxazolidines (6)Oxetanes (24)Phenols (15)Piperazines (24)Piperidines (126)Pyrazines (6)Pyrazoles (42)Pyridazines (8)Pyridines (160)Pyrimidines (63)Pyrroles (2)Pyrrolidines (82)Quinazolines (12)Quinolines (79)Quinoxalines (6)Quinuclidines (5)Spiroes (15)Sulfamides (27)Sulfides (27)Sulfones (7)Tetrahydrofurans (11)Tetrahydropyrans (36)Thiazoles (32)Thiols (5)Thiophenes (23)Trifluoromethyls (71)Ureas (5)Other Aliphatic Heterocycles (39)Other Aromatic Heterocycles (107)Amino-Propanol (6)Cyclopropylethanol (6)Diethanol (23)Dihydroxybenzylidene (4)Dihydroxynaphthalene (7)Dihydroxypropanoate (7)Dihydroxyterephthalic Acid (3)Hydroxyacetamide (1)Hydroxyacetimidamide (3)Hydroxyadamantan (4)Hydroxyazetidine (7)Hydroxybenzyl (16)Hydroxybenzylidene (5)Hydroxybicyclo (7)Hydroxybutan (4)Hydroxybutanoate (34)Hydroxybutanoic (30)Hydroxycarbamimidoyl (2)Hydroxycinnamic Acid (2)Hydroxycyclobutyl (3)Hydroxycyclohexyl (7)Hydroxycyclopentyl (1)Hydroxydiphenylmethyl (1)Hydroxyethoxy (22)Hydroxyhexanoate (8)Hydroxyhexanoic (6)Hydroxyimino (11)Hydroxyisonicotinaldehyde (7)Hydroxyisonicotinate (5)Hydroxyisonicotinic (5)Hydroxyisonicotinic Acid (4)Hydroxymethyl-Phenyl-Boronic-Acid (32)Hydroxynaphthalene (27)Hydroxynicotinaldehyde (7)Hydroxynicotinate (13)Hydroxynicotinonitrile (6)Hydroxyoctadec (1)Hydroxyoctadecanoic (7)Hydroxypentanoate (6)Hydroxypropanoic (35)Pentahydroxyhexanal (7)Propanediol (9)Pyrazol-Methanol (1)Tetrahydroxy (20)Tetrahydroxyhexanal (9)Tetrahydroxypentanal (5)Trihydroxy (237)

Aldehydes (18929)

1-Methyl-1H-Indole-3-Carbaldehyde (9)1-Naphthaldehyde (23)1-Phenyl-1H-Pyrazole-4-Carbaldehyde (8)1H-Benzo[D]Imidazole-2-Carbaldehyde (5)1H-Indazole-3-Carbaldehyde (19)1H-Indole-2-Carbaldehyde (20)1H-Pyrazole-4-Carbaldehyde (30)1H-Pyrrole-2-Carbaldehyde (21)1H-Pyrrole-3-Carbaldehyde (9)1H-Pyrrolo[2,3-B]Pyridine-3-Carbaldehyde (14)1H-Pyrrolo[2,3-B]Pyridine-5-Carbaldehyde (5)2,3-Dichlorobenzaldehyde (7)2,3-Difluorobenzaldehyde (18)2,4-Dichlorobenzaldehyde (8)2,4-Difluorobenzaldehyde (19)2,6-Dibromobenzaldehyde (4)2,6-Difluorobenzaldehyde (25)2-(Benzyloxy)Benzaldehyde (13)2-(Phenylethynyl)Benzaldehyde (9)2-(Trifluoromethoxy)Benzaldehyde (7)2-(Trifluoromethyl)Benzaldehyde (27)2-Bromo-3-Hydroxybenzaldehyde (4)2-Bromo-3-Methoxybenzaldehyde (4)2-Bromo-6-Fluorobenzaldehyde (15)2-Chloro-3-Hydroxybenzaldehyde (4)2-Chloro-3-Methoxybenzaldehyde (7)2-Chloro-4-Fluorobenzaldehyde (10)2-Fluoro-3-Methylbenzaldehyde (8)2-Fluorobenzaldehyde (175)2-Hydroxy-3-Iodobenzaldehyde (3)2-Iodobenzaldehyde (17)2-Methyl-1H-Indole-3-Carbaldehyde (3)2-Naphthaldehyde (12)2-Nitrobenzaldehyde (53)2-Oxo-2-Phenylacetaldehyde (12)2-Phenylacetaldehyde (20)3-(Benzyloxy)Benzaldehyde (13)3-(Trifluoromethoxy)Benzaldehyde (10)3-(Trifluoromethyl)Benzaldehyde (31)3-Bromo-2-Chlorobenzaldehyde (4)3-Bromo-2-Fluorobenzaldehyde (9)3-Bromo-2-Hydroxybenzaldehyde (10)3-Bromo-4-Fluorobenzaldehyde (7)3-Bromo-4-Hydroxybenzaldehyde (9)3-Bromo-4-Methoxybenzaldehyde (9)3-Chloro-2-Fluorobenzaldehyde (9)3-Chloro-2-Hydroxybenzaldehyde (5)3-Chloro-4-Methoxybenzaldehyde (7)3-Chlorobenzaldehyde (106)3-Fluorobenzaldehyde (137)3-Iodobenzaldehyde (28)3-Methoxy-2-Nitrobenzaldehyde (3)3-Nitrobenzaldehyde (49)3-Phenoxybenzaldehyde (6)4-(1H-Imidazol-1-Yl)Benzaldehyde (7)4-(Benzyloxy)Benzaldehyde (23)4-Fluorobenzaldehyde (78)4-Hydroxy-3-Nitrobenzaldehyde (5)4-Morpholinobenzaldehyde (8)4-Nitrobenzaldehyde (18)4-Phenoxybenzaldehyde (12)5-Phenylfuran-2-Carbaldehyde (9)6-Methoxynicotinaldehyde (4)[1,1'-Biphenyl]-3-Carbaldehyde (20)[1,1'-Biphenyl]-4-Carbaldehyde (31)Benzo[B]Thiophene-2-Carbaldehyde (7)Benzo[B]Thiophene-3-Carbaldehyde (6)Benzo[D][1,3]Dioxole-5-Carbaldehyde (6)Benzofuran-2-Carbaldehyde (5)Furan-2-Carbaldehyde (21)Imidazo[1,2-A]Pyridine-2-Carbaldehyde (8)Imidazo[1,2-A]Pyridine-3-Carbaldehyde (9)Isonicotinaldehyde (68)Methyl 3-Formylbenzoate (23)Nicotinaldehyde (152)Picolinaldehyde (98)Pyrazine-2-Carbaldehyde (17)Pyrimidine-5-Carbaldehyde (38)Thiazole-2-Carbaldehyde (9)Thiazole-5-Carbaldehyde (19)Thiophene-2-Carbaldehyde (43)Thiophene-3-Carbaldehyde (17)Alcohols (19)Aliphatic Chain Hydrocarbons (55)Aliphatic Cyclic Hydrocarbons (12)Alkenyls (29)Alkynyls (6)Amides (56)Amines (29)Aryls (346)Benzimidazoles (5)Benzofurans (4)Benzothiazoles (5)Bromides (78)Carboxylic Acids (18)Chlorides (88)Esters (47)Ethers (130)Fluorinated Building Blocks (79)Furans (15)Imidazoles (21)Indazoles (9)Indoles (21)Isoxazoles (9)Ketones (19)Morpholines (9)Nitriles (12)Nitroes (22)Phenols (13)Piperidines (17)Pyrazines (4)Pyrazoles (41)Pyridines (54)Pyrimidines (11)Pyrroles (12)Quinolines (23)Sulfamides (6)Sulfides (8)Tetrahydropyrans (6)Thiazoles (15)Thiophenes (13)Trifluoromethyls (10)Other Aromatic Heterocycles (40)Aminonicotinaldehyde (5)Carboxyaldehyde (1091)Dicarbaldehyde (37)Formylisonicotinate (7)Tetracarbaldehyde (8)Tricarbaldehyde (10)

Aliphatic Chain Hydrocarbons (13485)

Acyl Chlorides (24)Alcohols (390)Aldehydes (55)Alkenyls (380)Alkynyls (23)Amides (455)Amidines (21)Amines (304)Anhydrides (11)Bromides (148)Carboxylic Acid Salts (58)Carboxylic Acids (153)Chlorides (137)Difluoromethyls (13)Epoxides (7)Esters (447)Ethers (199)Fluorinated Building Blocks (167)Guanidines (18)Hydrazides (48)Hydrazines (60)Hydroxylamines (11)Iodides (36)Ketones (182)Nitriles (92)Nitroes (7)Sulfamides (37)Sulfides (28)Sulfonates (4)Sulfones (18)Sulfonyl Chlorides (19)Thioesters (4)Thiols (27)Thioureas (19)Trifluoromethyls (67)Ureas (28)Acetylthio (7)Azanonadecan (7)Azanylylidene (1)Azapentadecan (10)Azatridecan (4)Butyloctyl (4)Carbonylbis (1)Diazirine (13)Didodecyl (7)Diethyl (72)Dihydroxypropan (5)Diisobutyl (2)Diisopropyl (26)Dimethoxy (297)Dimethyladamantane (13)Dimethylalkanes (7)Dioctyl (1)Dioxide (442)Ethoxy (702)Ethoxyethoxy (5)Ethoxyethyl (15)Ethoxymethyl (11)Ethoxymethylene (1)Isopropylidenebis (2)Isopropylsulfonyl (10)Methoxybut (2)Methoxyethoxy (64)Methoxyethyl (65)Methoxyisonicotinic (11)Methoxymethoxy (23)Methoxymethyl (117)Methoxynicotinic (26)Methoxynicotinic Acid (20)Methoxypropan (24)Methoxypropoxy (8)Methoxypropyl (10)Methoxytetrahydro (14)Methyladamantan (4)Methylisonicotinic (13)Oxoethoxy (1)Oxopropane (10)Oxopropyl (32)Pentyloxy (7)Tetramethoxy (6)Trimethoxy (15)Yldisulfanyl (7)

Aliphatic Cyclic Hydrocarbons (11865)

(1-Phenylcyclobutyl)Methanamine (9)(1-Phenylcyclopropyl)Methanamine (12)(1-Phenylcyclopropyl)Methanol (3)(3Ar,E)-4-((Z)-2-(2-Methylenecyclohexylidene)Ethylidene)Octahydro-1H-Indene (7)(4-Cyclohexylphenyl)Boronic Acid (7)(4-Pentylcyclohexyl)Benzene (5)(4-Propylcyclohexyl)Benzene (5)(9H-Fluoren-2-Yl)Boronic Acid (6)(9H-Fluoren-9-Yl)Methyl (4-Methoxybenzyl)Carbamate (7)(Cyclopropylmethoxy)Benzene (18)1,1-Difluorocyclobutane (14)1,1-Difluorocyclohexane (18)1,1-Difluorocyclopentane (5)1-Bromo-2-Cyclopropylbenzene (3)1-Bromo-3-Cyclopropylbenzene (6)1-Chloro-2-Cyclopropylbenzene (7)1-Cyclohexyl-2-Fluorobenzene (4)1-Cyclopropyl-3-Methylbenzene (3)1-Methylcyclohex-1-Ene (24)1-Phenylcyclobutan-1-Amine (5)1-Phenylcyclobutane-1-Carbonitrile (7)1-Phenylcyclobutane-1-Carboxylic Acid (16)1-Phenylcyclohexane-1-Carboxylic Acid (6)1-Phenylcyclopropan-1-Amine (26)1-Phenylcyclopropane-1-Carbonitrile (19)1-Phenylcyclopropane-1-Carboxylic Acid (23)2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-2-Phenylacetic Acid (5)2-Bromo-9,9-Diphenyl-9H-Fluorene (5)2-Bromo-9H-Fluorene (15)2-Cyclohexylacetic Acid (13)2-Cyclopropyl-4-Phenylquinoline (12)2-Cyclopropylpyridine (20)2-Cyclopropylpyrimidine (10)2-Iodo-9H-Fluorene (8)2-Methylcyclohexan-1-One (3)2-Phenylcyclopropan-1-Amine (20)3,3-Dimethylcyclohexan-1-One (4)3-Cyclopropylpyridine (28)3-Methylcyclohexan-1-One (9)4-Cyclohexylbenzoic Acid (6)4-Cyclohexylbenzonitrile (10)4-Cyclohexylphenol (7)5-Azaspiro[2.4]Heptane (13)6-Azaspiro[2.5]Octane (10)9,9-Dimethyl-9H-Fluorene (16)Bicyclo[1.1.1]Pentan-1-Ylmethanol (3)Bicyclo[1.1.1]Pentane-1-Carboxylic Acid (6)Bicyclo[2.2.1]Hept-2-Ene (18)Bicyclo[2.2.1]Heptane (14)Bromocyclohexane (7)Cyclobutanamine (90)Cyclobutanecarboxylic Acid (23)Cyclobutanol (46)Cyclobutylmethanol (15)Cycloheptane (12)Cyclohex-3-Ene-1-Carboxylic Acid (7)Cyclohexanamine (59)Cyclohexanecarboxylic Acid (83)Cyclohexanol (70)Cyclohexylmethanol (31)Cyclopentanamine (5)Cyclopentanecarboxylic Acid (26)Cyclopentanol (51)Cyclopropoxybenzene (13)Ethyl 1-Phenylcyclopropane-1-Carboxylate (4)Ethyl 2-Phenylcyclopropane-1-Carboxylate (5)Ethyl Cyclohexanecarboxylate (33)Isopropylcyclohexane (19)Methoxycyclohexane (7)Methyl 1-Phenylcyclopropane-1-Carboxylate (10)Methyl 4-Oxocyclohexane-1-Carboxylate (5)Methyl Bicyclo[1.1.1]Pentane-1-Carboxylate (10)Methyl Cyclobutanecarboxylate (24)Methyl Cyclohexanecarboxylate (45)Methyl Cyclopentanecarboxylate (18)N-Methylcyclohexanamine (7)Naphthalene-1,4-Dione (22)Spiro[3.3]Heptane (11)Tert-Butyl (1-Phenylcyclopropyl)Carbamate (6)Tert-Butyl (2-Phenylcyclopropyl)Carbamate (4)Tert-Butyl Bicyclo[1.1.1]Pentan-1-Ylcarbamate (5)Tert-Butyl Cyclobutylcarbamate (17)Tert-Butyl Cyclohexylcarbamate (9)Tert-Butyl Cyclopentylcarbamate (28)Acyl Chlorides (10)Alcohols (117)Aldehydes (12)Alkenyls (57)Amides (132)Amines (135)Aryls (10)Bromides (31)Carboxylic Acids (65)Chlorides (19)Esters (109)Ethers (32)Fluorinated Building Blocks (56)Hydrazides (5)Hydrazines (11)Iodides (10)Ketones (156)Nitriles (29)Spiroes (19)Sulfamides (8)Sulfonic Acids (4)Sulfonyl Chlorides (8)Trifluoromethyls (19)Ureas (6)Aminobicyclo (24)Aminocyclobutanol (5)Aminocyclobutyl (5)Aminocyclohexane (54)Aminocyclohexanol (21)Aminocyclopentanol (17)Aminocyclopentyl (6)Aminocyclopropyl (4)Azabicyclo (289)Azatricyclo (5)Azetidine (177)Benzylazetidin (9)Bicyclo (59)Bicyclohexyl (6)Bromobicyclo (9)Butylcyclohexyl (9)Butylsulfonyl (6)Chlorocyclopropyl (2)Cyanoazetidine (5)Cyanocyclopropyl (4)Cyclobutanecarbonitrile (2)Cyclobutylacetic (4)Cyclobutylmethyl (4)Cyclohexa (163)Cyclohexane (119)Cyclohexanecarboxylic (19)Cyclohexanediamine (8)Cyclohexanone (92)Cyclohexylacetic (2)Cyclohexylamino (9)Cyclohexylbutanoic (4)Cyclohexylcarbamoyl (5)Cyclohexylethanamine (11)Cyclohexylmethoxy (4)Cyclohexylmethyl (7)Cyclohexyloxy (10)Cyclohexylpropan (75)Cyclohexylpropanoic (3)Cyclopentadienyl (2)Cyclopentane (165)Cyclopentanecarboxylic (7)Cyclopentyl (56)Cyclopentylacetic (3)Cyclopentylamino (1)Cyclopentylmethyl (4)Cyclopentyloxy (15)Cyclopropanamine (32)Cyclopropanecarbonitrile (14)Cyclopropanecarbonyl (6)Cyclopropanecarboxamide (14)Cyclopropanol (4)Cyclopropoxyphenyl (7)Cyclopropyl (356)Cyclopropylacetate (6)Cyclopropylacetic (3)Cyclopropylamino (24)Cyclopropylcarbamoyl (5)Cyclopropylethan (5)Cyclopropylethynyl (1)Cyclopropylmethoxy (32)Cyclopropylmethyl (20)Cyclopropylpropanoic (5)Cyclopropylsulfonyl (6)Diazabicyclo (77)Dicyclohexyl (6)Dicyclohexylphosphino (18)Difluorocyclobutyl (6)Difluorocyclohexyl (6)Dihydroinden (8)Dihydroindeno (5)Dihydropteridin (6)Dimethylbicyclo (5)Dimethylcyclohex (5)Dimethylcyclohexane (14)Dimethylcyclohexanone (7)Dioxathiolane (1)Dioxol (169)Dithiolan (1)Ethylcyclohexyl (4)Ethylsulfonyl (42)Fluoroazetidine (1)Fluorobicyclo (4)Hexahydrocyclohepta (6)Hexahydrocyclopenta (4)Hydroxycyclobutanecarboxylic (4)Hydroxycyclohexanecarboxylic (6)Methanesulfonyl (308)Methoxycyclohexanamine (6)Methylazetidine (30)Methylbicyclo (6)Methylcyclobutanamine (5)Methylcyclobutanecarboxylic (5)Methylcyclohexanamine (11)Methylcyclohexane (8)Methylcyclohexanecarboxylic (5)Methylcyclohexanecarboxylic Acid (4)Methylcyclohexanol (20)Methylcyclohexanone (4)Methylcyclohexyl (31)Methylcyclopentane (2)Methylcyclopropanamine (4)Methylcyclopropane (16)Methylsulfinyl (24)Methylsulfonimidoyl (6)Methylsulphonyl (10)Octahydrocyclopenta (14)Oxabicyclo (40)Oxazepane (13)Oxetanes (229)Oxoazetidine (8)Oxobicyclo (11)Oxocyclobutyl (2)Oxocyclohex (3)Oxocyclohexane (4)Oxocyclohexanecarboxylic (6)Oxocyclohexyl (3)Oxocyclopentane (2)Oxocyclopentyl (5)Pentamethylcyclopentadienyl (11)Pentylcyclohexyl (10)Phenylcyclopropanamine (8)Propylcyclohexyl (15)Tetraazacyclododecane (13)Tetraazacyclotetradecane (7)Tetramethylcyclohexane (4)Tetraoxatridecan (3)Thiazepine (2)Tricyclohexylphosphine (8)Trimethylbicyclo (19)Trimethylcyclohex (20)

Alkenyls (16040)

(1E,4E)-1,5-Diphenylpenta-1,4-Dien-3-One (7)(1E,6E)-1,7-Diphenylhepta-1,6-Diene-3,5-Dione (6)(2,2-Dibromovinyl)Benzene (6)(2-(4-Bromophenyl)Ethene-1,1,2-Triyl)Tribenzene (11)(2-Nitrovinyl)Benzene (28)(Allyloxy)Benzene (17)(E)-5-Benzylidenethiazolidine-2,4-Dione (6)(E)-[3,3'-Biindolinylidene]-2,2'-Dione (5)(E)-N-(3-Oxo-1-Phenyl-3-(Piperidin-1-Yl)Prop-1-En-2-Yl)Benzamide (6)(Z)-3-(Phenyl(Phenylamino)Methylene)Indolin-2-One (5)(Z)-3-Benzylideneindolin-2-One (7)1,2-Diphenylethene (5)1,3,3-Trimethylcyclohex-1-Ene (12)1-Bromo-4-Styrylbenzene (5)1-Methylcyclohex-1-Ene (24)2-Benzalacetophenone (36)2-Methoxycyclohexa-2,5-Diene-1,4-Dione (7)2-Methylcyclohexa-2,5-Diene-1,4-Dione (5)3-(2-Fluorophenyl)Acrylic Acid (17)3-(3-Chlorophenyl)Acrylic Acid (10)3-Methylene-2,3-Dihydro-1H-Inden-1-One (3)3-Methyleneazetidine (8)3-Phenylacrylaldehyde (29)3-Styrylphenol (10)4-(1,2,2-Triphenylvinyl)Benzaldehyde (5)4-(Prop-1-En-2-Yl)Cyclohex-1-Ene (3)5H-Dibenzo[B,F]Azepine (5)Allyl Benzoate (5)Cyclohex-1-En-1-Yl Trifluoromethanesulfonate (3)Cyclohex-1-En-1-Ylboronic Acid (4)Cyclohex-1-Ene-1-Carboxylic Acid (4)Cyclohexa-1,3-Diene (4)Cyclopent-2-En-1-Amine (4)Ethyl Cyclohex-1-Ene-1-Carboxylate (5)Methyl Cinnamate (37)Methyl Cyclohex-3-Ene-1-Carboxylate (3)Methylenecyclobutane (8)Methylenecyclohexane (8)N-Phenylacrylamide (7)Styrene (78)Tert-Butyl-Cyclopent-2-En-1-Ylcarbamate (6)Vinylcyclopropane (8)Acyl Chlorides (7)Alcohols (101)Aldehydes (29)Aliphatic Chain Hydrocarbons (380)Aliphatic Cyclic Hydrocarbons (57)Amides (96)Amines (112)Anhydrides (4)Aryls (277)Benzyl Chlorides (1)Bromides (45)Carboxylic Acid Salts (9)Carboxylic Acids (126)Chlorides (55)Esters (243)Ethers (79)Fluorinated Building Blocks (42)Furans (9)Imidazoles (7)Indoles (4)Indolines (3)Iodides (6)Ketones (84)Nitriles (62)Nitroes (21)Oxetanes (4)Phenols (13)Piperazines (8)Piperidines (18)Pyridines (36)Pyrimidines (10)Pyrrolidines (14)Quinolines (10)Quinuclidines (6)Spiroes (4)Sulfamides (12)Sulfones (12)Tetrahydropyrans (7)Thiophenes (15)Trifluoromethyls (5)Other Aliphatic Heterocycles (19)Other Aromatic Heterocycles (5)Acrylaldehyde (11)Acryloyl (8)Annulene (2)Cyclohexene (86)Cyclooctene (7)Cyclopentene (3)Diacrylamide (6)Diallyl (4)Diazene (21)Divinyl (1)Enamide (6)Enecarbaldehyde (2)Enoyl (7)Methacrylamide (3)Methoxycinnamaldehyde (3)Nitroethylene (37)Tetrahydrocyclopenta (19)

Isopropyl-Phenyl-Boronic Acid/Ester (26)Methylpentan (3)

(3-(Phenylcarbamoyl)Phenyl)Boronic Acid (3)(4-(Phenylcarbamoyl)Phenyl)Boronic Acid (11)(9H-Fluoren-9-Yl)Methyl (3-Phenylpropyl)Carbamate (24)(S)-N-Phenethyl-3-(Pyrrolidin-2-Yl)Propanamide (5)(S)-N-Phenylpiperidine-2-Carboxamide (1)1-(Pyridin-2-Yl-L2-Azaneyl)Ethan-1-One (12)1-Methylindoline-2,3-Dione (8)1-Phenylurea (11)1H-Pyrazole-5-Carboxamide (3)2,2-Dimethyl-1-(Pyridin-2-Yl-L2-Azaneyl)Propan-1-One (7)2-((Tert-Butoxycarbonyl)Amino)Benzoic Acid (11)2-(Trifluoromethyl)Benzamide (6)2-Amino-N-Phenylbenzamide (21)2-Aminobenzamide (30)2-Bromo-N-Phenylacetamide (5)2-Chloro-N-Phenylacetamide (26)2-Chloro-N-Phenylbenzamide (4)2-Chlorobenzamide (16)2-Fluoro-N-Methylbenzamide (12)2-Fluorobenzamide (32)2-Hydroxy-N-Phenylbenzamide (3)2-Hydroxybenzamide (14)2-Iodobenzamide (4)2-Methoxybenzamide (9)3-Benzamidopropanoic Acid (3)3-Bromo-4-Fluorobenzamide (3)3-Fluorobenzamide (26)3-Nitrobenzamide (17)3-Oxo-N-Phenylbutanamide (10)4-Amino-N-Phenylbenzamide (7)4-Benzamidobenzoic Acid (3)4-Fluorobenzamide (19)4-Oxo-4-(Phenylamino)Butanoic Acid (7)Benzoylglycine (15)Benzyl Benzylcarbamate (14)Benzyl Cyclohexylcarbamate (9)Benzyl Phenylcarbamate (15)Ethyl 2-Oxo-2-(Phenylamino)Acetate (8)Isonicotinamide (12)N,N-Diethylbenzamide (17)N,N-Dimethylbenzamide (34)N-((5R,6R)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptan-6-Yl)-3-Phenylisoxazole-4-Carboxamide (1)N-((6R,7R)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-Phenylacetamide (5)N-(2-(1H-Indol-3-Yl)Ethyl)Acetamide (5)N-(2-Benzoylphenyl)-2-Bromoacetamide (3)N-(2-Chlorophenyl)Acetamide (16)N-(2-Iodophenyl)Acetamide (8)N-(2-Nitrophenyl)Acetamide (11)N-(3-Fluorophenyl)Acetamide (14)N-(4-Aminophenyl)Benzamide (2)N-(4-Chlorophenyl)Acetamide (9)N-(4-Chlorophenyl)Benzamide (6)N-(4-Fluorophenyl)Benzamide (3)N-(4-Phenoxyphenyl)Acetamide (4)N-(O-Tolyl)Benzamide (9)N-(P-Tolyl)Benzamide (6)N-(Thiazol-2-Yl)Acetamide (9)N-Isopropylbenzamide (16)N-Methoxy-N-Methylbenzamide (24)N-Methylbenzamide (58)N-Methylpicolinamide (10)N-Phenylacrylamide (7)N-Phenylpivalamide (11)Nicotinamide (61)Phenyl Dimethylcarbamate (5)Phenyl Ethyl(Methyl)Carbamate (5)Picolinamide (26)Piperidine-3-Carboxamide (5)Pyrazine-2-Carboxamide (10)Pyrrolidine-2-Carboxamide (12)Tert-Butyl (1-Phenylethyl)Carbamate (19)Tert-Butyl (4-Fluorophenyl)Carbamate (9)Tert-Butyl Benzylcarbamate (52)Tert-Butyl Methyl(Phenyl)Carbamate (9)Tert-Butyl O-Tolylcarbamate (11)Tert-Butyl Phenethylcarbamate (1)Tert-Butyl-Cyclopent-2-En-1-Ylcarbamate (6)Thiophene-3-Carboxamide (5)Acyl Chlorides (13)Alcohols (364)Aldehydes (56)Aliphatic Chain Hydrocarbons (455)Aliphatic Cyclic Hydrocarbons (132)Alkenyls (96)Alkynyls (30)Amidines (8)Amines (607)Anhydrides (33)Aryls (1172)Azetidines (102)Benzimidazoles (26)Benzisoxazoles (4)Benzofurans (7)Benzothiazoles (23)Benzoxazoles (33)Benzyl Bromides (6)Benzyl Chlorides (8)Bromides (309)Carboxylic Acid Salts (4)Carboxylic Acids (224)Chlorides (371)Epoxides (10)Esters (300)Ethers (251)Fluorinated Building Blocks (235)Furans (30)Guanidines (12)Hydrazides (168)Hydrazines (175)Hydrazones (9)Hydroxylamines (12)Imidazoles (26)Imidazolidines (18)Imidazolines (16)Indazoles (6)Indoles (41)Indolines (73)Iodides (36)Isoquinolines (10)Isoxazoles (16)Ketones (185)Morpholines (95)Nitriles (92)Oxadiazoles (10)Oxazoles (10)Oxazolidines (49)Oxazolines (4)Oxetanes (14)Phenols (41)Phthalazines (6)Piperazines (259)Piperidines (433)Purines (7)Pyrazines (17)Pyrazoles (46)Pyridazines (20)Pyridines (267)Pyrimidines (119)Pyrroles (15)Pyrrolidines (307)Pyrrolines (24)Quinazolines (42)Quinolines (33)Quinoxalines (15)Spiroes (190)Sulfamides (43)Sulfides (40)Sulfonates (15)Sulfones (13)Tetrahydrofurans (19)Tetrahydroisoquinolines (7)Tetrahydropyrans (15)Tetrahydroquinolines (14)Thiadiazoles (11)Thiazoles (40)Thiazolidines (16)Thioesters (25)Thiols (4)Thiophenes (44)Thiophenols (6)Thioureas (61)Triazines (11)Triazoles (8)Trifluoromethyls (74)Ureas (80)Other Aliphatic Heterocycles (102)Other Aromatic Heterocycles (176)Acetamide (639)Acetamido (145)Carboxamide (893)Diacetamide (3)Dicarboxamide (19)Diethylacetamide (4)Dimethylacetamide (9)Dimethylnicotinamide (7)Formamidophenylboronic Acid/Ester (11)Isobutyramide (7)Oxobutanamide (10)Pentanamide (15)Propanamido (5)

Amidines (1559)

Benzimidamide (48)N'-Hydroxybenzimidamide (13)Picolinimidamide (11)Aliphatic Chain Hydrocarbons (21)Amides (8)Amines (6)Aryls (20)Chlorides (9)Ethers (4)Fluorinated Building Blocks (7)Hydrazines (2)Oximes (24)Pyridines (13)Pyrimidines (4)Trifluoromethyls (3)Carbamimidoyl (16)

Amines (137938)

(1-Phenylcyclobutyl)Methanamine (9)(1-Phenylcyclopropyl)Methanamine (12)(1H-Benzo[D]Imidazol-2-Yl)Methanamine (7)(2,3-Dihydrobenzo[B][1,4]Dioxin-2-Yl)Methanamine (3)(2-Aminophenyl)(Phenyl)Methanone (30)(2-Bromophenyl)Methanamine (12)(2-Chlorophenyl)Methanamine (28)(2-Fluorophenyl)Methanamine (49)(3-Chlorophenyl)Methanamine (19)(3-Fluoropyridin-2-Yl)Methanamine (5)(3-Methylpyridin-2-Yl)Methanamine (5)(4-Aminophenyl)(Phenyl)Methanone (4)(4-Fluorophenyl)Methanamine (27)(6-Methylpyridin-2-Yl)Methanamine (6)(Tetrahydrofuran-2-Yl)Methanamine (2)(Tetrahydrofuran-3-Yl)Methanamine (3)1,2,3,4-Tetrahydroisoquinolin-5-Amine (4)1,2,3,4-Tetrahydroisoquinolin-6-Amine (3)1,2,3,4-Tetrahydroisoquinolin-7-Amine (3)1,3,4-Thiadiazol-2-Amine (9)1,3,5-Triazin-2-Amine (3)1-(2,3-Dihydro-1H-Inden-5-Yl)Ethan-1-Amine (3)1-(2-Aminophenyl)Ethan-1-One (29)1-(2-Bromophenyl)Ethan-1-Amine (10)1-(2-Chlorophenyl)-1H-Pyrazole (3)1-(2-Fluorophenyl)Ethan-1-Amine (80)1-(2-Fluorophenyl)Propan-1-Amine (8)1-(3-(Trifluoromethoxy)Phenyl)Ethan-1-Amine (6)1-(3-(Trifluoromethyl)Phenyl)Ethan-1-Amine (25)1-(3-Aminophenyl)Ethan-1-One (18)1-(3-Chlorophenyl)-N-Methylmethanamine (8)1-(4-(Trifluoromethoxy)Phenyl)Ethan-1-Amine (6)1-(Anthracen-9-Yl)Ethan-1-Amine (3)1-(Pyridin-2-Yl)Ethan-1-Amine (15)1-(Pyridin-3-Yl)Ethan-1-Amine (17)1-(Pyridin-4-Yl)Ethan-1-Amine (23)1-Aminoanthracene-9,10-Dione (8)1-Benzyl-N-Methylpiperidin-3-Amine (6)1-Benzylpiperidin-4-Amine (8)1-Methyl-1H-Pyrazol-3-Amine (14)1-Phenyl-1H-Pyrazol-3-Amine (3)1-Phenyl-1H-Pyrazol-5-Amine (4)1-Phenylcyclobutan-1-Amine (5)1-Phenylcyclopropan-1-Amine (26)1-Phenylethan-1-Amine (436)1H-1,2,4-Triazol-3-Amine (6)1H-1,2,4-Triazol-5-Amine (5)1H-Benzo[D]Imidazol-2-Amine (7)1H-Benzo[D]Imidazol-5-Amine (4)1H-Benzo[D]Imidazol-6-Amine (6)1H-Imidazol-2-Amine (6)1H-Indazol-3-Amine (23)1H-Indazol-4-Amine (12)1H-Indazol-5-Amine (3)1H-Indazol-6-Amine (5)1H-Indazol-7-Amine (6)1H-Indol-4-Amine (10)1H-Indol-6-Amine (21)1H-Indol-7-Amine (10)1H-Pyrazol-4-Amine (6)1H-Pyrazol-5-Amine (19)1H-Pyrrol-1-Amine (7)1H-Pyrrolo[2,3-B]Pyridin-6-Amine (4)2,2,2-Trifluoro-1-Phenylethan-1-Amine (48)2,3-Dichloroaniline (18)2,3-Difluoroaniline (34)2,3-Dihydrobenzofuran-3-Amine (11)2,3-Dihydrobenzofuran-5-Amine (3)2,4-Dibromoaniline (18)2,4-Dichloropyrimidin-5-Amine (6)2,4-Difluoroaniline (44)2,5-Difluoroaniline (34)2,6-Dibromoaniline (17)2,6-Dichloroaniline (26)2,6-Difluoroaniline (23)2,6-Diiodoaniline (8)2-((2-Nitrophenyl)Amino)Ethan-1-Ol (5)2-(1H-Benzo[D]Imidazol-2-Yl)Ethan-1-Amine (6)2-(1H-Indol-3-Yl)Ethan-1-Amine (4)2-(Diethylamino)Ethyl Benzoate (3)2-(Methylsulfonyl)Aniline (3)2-(Phenylamino)Benzoic Acid (11)2-(Piperazin-1-Yl)Ethan-1-Amine (8)2-(Piperidin-1-Yl)Ethan-1-Amine (8)2-(Trifluoromethoxy)Aniline (18)2-(Trifluoromethyl)Aniline (58)2-Amino-2-(2-Fluorophenyl)Ethan-1-Ol (7)2-Amino-2-Phenylethan-1-Ol (196)2-Amino-3-Chlorophenol (4)2-Amino-3-Fluorobenzoic Acid (11)2-Amino-6-Bromophenol (3)2-Amino-6-Chlorobenzoic Acid (5)2-Amino-6-Chlorobenzonitrile (3)2-Amino-6-Chlorophenol (5)2-Aminobenzamide (30)2-Aminobenzenesulfonic Acid (9)2-Aminophenol (106)2-Aminopyrimidin-4(3H)-One (11)2-Bromo-3-Chloroaniline (4)2-Bromo-3-Fluoroaniline (13)2-Bromo-3-Methylaniline (6)2-Bromo-4-Methylaniline (14)2-Bromo-6-Methylaniline (11)2-Bromo-N,N-Dimethylaniline (5)2-Bromo-N-Methylaniline (8)2-Chloro-3-Methylaniline (4)2-Chloro-4-Methylaniline (7)2-Chloro-6-Methylaniline (11)2-Chloro-N-Methylaniline (4)2-Chloro-N-Phenylaniline (8)2-Chloroaniline (213)2-Chlorobenzene-1,3-Diamine (3)2-Chlorobenzene-1,4-Diamine (6)2-Chloropyrimidin-4-Amine (22)2-Fluoro-6-Iodoaniline (7)2-Fluoro-N-Phenylaniline (4)2-Fluoroaniline (262)2-Iodo-4-Methylaniline (5)2-Iodo-N,N-Dimethylaniline (3)2-Iodoaniline (87)2-Methoxypyridin-3-Amine (6)2-Methyl-6-Nitroaniline (10)2-Methyl-N-Phenylaniline (7)2-Methylpyridin-4-Amine (7)2-Methylpyrimidin-4-Amine (22)2-Nitro-N-Phenylaniline (3)2-Phenoxyaniline (4)2-Phenylcyclopropan-1-Amine (20)2-Phenylpyrimidin-5-Amine (5)3,4-Dibromoaniline (4)3,4-Dichloroaniline (21)3,4-Difluoroaniline (44)3-(1,3,2-Dioxaborinan-2-Yl)Aniline (3)3-(Benzyloxy)Aniline (12)3-(Methylsulfonyl)Aniline (7)3-(Trifluoromethoxy)Aniline (22)3-(Trifluoromethyl)Aniline (102)3-Aminobenzenesulfonic Acid (6)3-Aminodihydrofuran-2(3H)-One (4)3-Bromo-2-Fluoroaniline (15)3-Bromo-4-Chloroaniline (13)3-Bromo-4-Fluoroaniline (22)3-Bromo-4-Methoxyaniline (7)3-Bromo-4-Methylaniline (14)3-Bromoaniline (187)3-Bromobenzene-1,2-Diamine (11)3-Chloro-2-Iodoaniline (3)3-Chloro-2-Methylaniline (11)3-Chloro-4-Fluoroaniline (18)3-Chloro-4-Iodoaniline (3)3-Chloro-4-Methoxyaniline (6)3-Chloro-4-Methylaniline (12)3-Chlorobenzene-1,2-Diamine (6)3-Chloropyrazin-2-Amine (6)3-Fluoro-2-Methylaniline (9)3-Fluoroaniline (288)3-Iodo-2-Methylaniline (4)3-Iodoaniline (32)3-Methoxypyridin-2-Amine (5)3-Methyl-N-Phenylaniline (4)3-Methylpyridin-2-Amine (7)3-Nitroaniline (98)3-Phenoxyaniline (2)3-Phenyl-1H-Pyrazol-5-Amine (11)3-Phenylisoxazol-5-Amine (8)4,6-Dichloropyrimidin-2-Amine (9)4-(Benzyloxy)Aniline (8)4-(Oxazol-5-Yl)Aniline (3)4-(Pyrrolidin-1-Yl)Aniline (3)4-(Trifluoromethoxy)Aniline (26)4-Amino-2-Chlorobenzonitrile (8)4-Amino-2-Fluorophenol (9)4-Amino-3-Chlorobenzoic Acid (6)4-Amino-3-Chlorophenol (5)4-Amino-N-Phenylbenzenesulfonamide (3)4-Aminopyridazin-3(2H)-One (4)4-Benzylaniline (7)4-Bromo-3-Chloroaniline (21)4-Bromo-3-Fluoroaniline (29)4-Bromo-3-Methylaniline (19)4-Bromo-3-Nitroaniline (8)4-Bromo-N,N-Diphenylaniline (10)4-Bromo-N-Phenylaniline (6)4-Chloro-2-Iodoaniline (9)4-Chloro-3-Fluoroaniline (17)4-Chloro-3-Iodoaniline (3)4-Chloro-3-Methylaniline (11)4-Chloro-N-Phenylaniline (6)4-Chloropyrimidin-2-Amine (23)4-Chloropyrimidin-5-Amine (7)4-Fluoro-N-Phenylaniline (4)4-Fluoroaniline (226)4-Iodo-N,N-Diphenylaniline (3)4-Methoxy-N-Phenylaniline (5)4-Methyl-3-Nitroaniline (8)4-Methylpyrimidin-2-Amine (9)4-Methylthiazol-2-Amine (7)4-Morpholinoaniline (4)4-Nitroaniline (64)4-Phenoxyaniline (6)4-Phenylpyrimidin-2-Amine (15)4-Phenylthiazol-2-Amine (37)5-Bromopyrazin-2-Amine (13)5-Bromothiazol-2-Amine (6)5-Chloropyrazin-2-Amine (9)5-Methoxypyridin-3-Amine (4)5-Methyl-2-Nitroaniline (6)5-Methylpyridin-2-Amine (7)5-Methylpyridin-3-Amine (4)5-Methylthiazol-2-Amine (6)5-Phenylthiophen-2-Amine (5)5H-Dibenzo[B,F]Azepine (5)6-Amino-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)6-Bromopyrazin-2-Amine (5)6-Chloropyrazin-2-Amine (11)6-Chloropyridazin-3-Amine (5)6-Chloropyrimidin-4-Amine (8)6-Methoxypyridin-2-Amine (14)6-Methoxypyridin-3-Amine (8)6-Methylpyridin-2-Amine (46)6-Methylpyridin-3-Amine (5)6-Phenoxypyridin-3-Amine (5)7-Methoxy-N-Phenylquinazolin-4-Amine (12)7H-Purin-2-Amine (6)7H-Purin-6-Amine (9)7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine (5)7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine (3)9H-Purin-6-Amine (3)[1,1'-Biphenyl]-2-Amine (8)[1,1'-Biphenyl]-3-Amine (11)[1,2,4]Triazolo[1,5-A]Pyridin-2-Amine (17)[1,2,4]Triazolo[4,3-A]Pyridin-3-Ylmethanamine (5)Azetidin-3-Amine (4)Azetidin-3-Ylmethanamine (3)Aziridine (9)Benzo[B]Thiophen-2-Amine (5)Benzo[D]Oxazol-2-Amine (16)Benzo[D]Thiazol-2-Amine (30)Benzo[D]Thiazol-5-Amine (3)Benzo[D]Thiazol-6-Amine (3)Benzyl-3-Aminopiperidine-1-Carboxylate (6)Benzyl-3-Aminopyrrolidine-1-Carboxylate (7)Bis(Pyridin-2-Ylmethyl)Amine (6)Chroman-2-Ylmethanamine (3)Chroman-4-Amine (20)Cyclobutanamine (90)Cyclohexanamine (59)Cyclopent-2-En-1-Amine (4)Cyclopentanamine (5)Cyclopropyl(Phenyl)Methanamine (22)Diphenylmethanamine (26)Ethyl 2-Aminobenzoate (23)Ethyl 3-Aminobenzoate (19)Ethyl 4-Aminobenzoate (22)Imidazo[1,2-A]Pyridin-3-Amine (7)Imidazo[1,2-A]Pyridin-8-Amine (7)Isoquinolin-1-Amine (18)Isoquinolin-3-Amine (13)Isoquinolin-4-Amine (16)Isoquinolin-5-Amine (9)Isoquinolin-8-Amine (6)Isoxazol-5-Amine (15)Methyl 2-Amino-2-Phenylacetate (38)Methyl 2-Aminobenzoate (95)Methyl 3-Amino-3-Phenylpropanoate (27)Methyl 3-Aminobenzoate (88)Methyl 4-Aminobenzoate (71)Morpholin-2-Ylmethanamine (8)N,N-Diethylaniline (18)N,N-Dimethyl-2-Phenoxyethan-1-Amine (16)N,N-Dimethylaniline (117)N,N-Dimethylnaphthalen-1-Amine (3)N,N-Dimethylpyridin-2-Amine (10)N,N-Dimethylpyridin-4-Amine (6)N,N-Dimethylpyrimidin-2-Amine (10)N,N-Dimethylpyrrolidin-3-Amine (7)N,N-Diphenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline (6)N,N-Diphenyl-[1,1'-Biphenyl]-4-Amine (8)N-(4-Aminophenyl)Benzamide (2)N-(Furan-2-Ylmethyl)Aniline (5)N-(Prop-2-Yn-1-Yl)-2,3-Dihydro-1H-Inden-1-Amine (3)N-Benzyl-1-Phenylethan-1-Amine (7)N-Benzyl-2-Phenylethan-1-Amine (1)N-Benzylpiperidin-4-Amine (3)N-Cyclopropylpyrimidin-2-Amine (5)N-Methyl-1-Phenylmethanamine (65)N-Methyl-2-Nitroaniline (20)N-Methyl-4-Nitroaniline (5)N-Methylaniline (139)N-Methylcyclohexanamine (7)N-Methylpiperidin-3-Amine (5)N-Methylpyridin-2-Amine (47)N-Methylpyridin-3-Amine (15)N-Methylpyrimidin-2-Amine (10)N-Methylpyrimidin-4-Amine (10)N-Methylpyrrolidin-3-Amine (6)N-Phenyl-3-(Trifluoromethyl)Aniline (3)N-Phenyl-4-(Trifluoromethyl)Aniline (3)N-Phenylnaphthalen-1-Amine (5)N-Phenylpyridin-2-Amine (9)N-Phenylpyrimidin-2-Amine (5)N-Phenylpyrimidin-4-Amine (7)N1,N1-Diphenylbenzene-1,4-Diamine (2)N1-Phenylbenzene-1,4-Diamine (3)N2,N4,N6-Triphenyl-1,3,5-Triazine-2,4,6-Triamine (4)N2,N4-Diphenylpyrimidine-2,4-Diamine (5)Naphthalen-2-Amine (12)O-Benzylhydroxylamine (16)Oxazol-2-Amine (8)Phenylmethanamine (315)Piperidin-2-Ylmethanamine (6)Piperidin-3-Amine (17)Piperidin-3-Ylmethanamine (5)Piperidin-4-Amine (14)Piperidin-4-Ylmethanamine (7)Pyrazin-2-Amine (22)Pyrazin-2-Ylmethanamine (12)Pyridazin-3-Amine (18)Pyridazin-4-Amine (10)Pyridin-2-Amine (29)Pyridin-2-Ylmethanamine (38)Pyridin-3-Amine (21)Pyridin-3-Ylmethanamine (29)Pyridin-4-Amine (22)Pyridin-4-Ylmethanamine (12)Pyridine-2,3-Diamine (5)Pyridine-2,6-Diamine (12)Pyrimidin-2-Ylmethanamine (7)Pyrimidin-4-Amine (29)Pyrimidin-5-Amine (6)Pyrimidine-2,4-Diamine (14)Pyrrolidin-2-Ylmethanamine (12)Pyrrolidin-3-Ylmethanamine (6)Quinazolin-2-Amine (13)Quinazolin-4-Amine (8)Quinoxalin-2-Amine (3)Tetrahydrofuran-3-Amine (6)Thiazol-2-Ylmethanamine (5)Thiazol-5-Amine (6)Thiophen-3-Amine (18)Tri([1,1'-Biphenyl]-4-Yl)Amine (8)Alcohols (287)Aldehydes (29)Aliphatic Chain Hydrocarbons (304)Aliphatic Cyclic Hydrocarbons (135)Alkenyls (112)Alkynyls (19)Amides (607)Amidines (6)Aryls (1256)Azetidines (17)Benzimidazoles (19)Benzisoxazoles (4)Benzodioxans (5)Benzofurans (13)Benzothiazoles (30)Benzothiophenes (6)Benzoxazoles (7)Bromides (216)Carboxylic Acid Salts (4)Carboxylic Acids (178)Chlorides (308)Difluoromethyls (19)Dioxolanes (4)Esters (299)Ethers (400)Fluorinated Building Blocks (282)Furans (22)Hydrazides (8)Hydrazines (26)Hydroxylamines (14)Imidazoles (38)Imidazolines (4)Indazoles (18)Indoles (29)Indolines (9)Iodides (36)Isoquinolines (12)Isoxazoles (25)Ketones (87)Morpholines (54)Nitriles (142)Nitroes (112)Oxadiazoles (16)Oxazoles (16)Oxazolidines (4)Oxetanes (28)Oximes (5)Phenols (26)Piperazines (26)Piperidines (176)Purines (12)Pyrazines (19)Pyrazoles (159)Pyridazines (10)Pyridines (393)Pyrimidines (191)Pyrroles (10)Pyrrolidines (81)Quinazolines (9)Quinolines (79)Quinoxalines (7)Quinuclidines (5)Spiroes (13)Sulfamides (50)Sulfides (41)Sulfonates (6)Sulfones (20)Sulfonic Acids (11)Tetrahydrofurans (7)Tetrahydroisoquinolines (3)Tetrahydropyrans (3)Tetrahydroquinolines (5)Thiadiazoles (24)Thiazoles (102)Thioesters (5)Thiophenes (54)Thiophenols (5)Triazines (13)Triazoles (21)Trifluoromethyls (95)Ureas (6)Other Aliphatic Heterocycles (17)Other Aromatic Heterocycles (129)Amino-Propanol (6)Aminoacetamido (4)Aminoacetyl (2)Aminoadamantan (5)Aminoazepane (10)Aminobutane (23)Aminobutyl (15)Aminoethoxy (18)Aminoethyl (151)Aminohexan (6)Aminohexyl (3)Aminoisonicotinic Acid (12)Aminomethyl (398)Aminooxy (6)Aminopentyl (10)Aminopropanamido (1)Aminopropane (20)Aminopropoxy (2)Aminopyridine (74)Aminotetrahydro (12)Benzylazetidine (4)Bromobenzylamine (6)Bromobenzylcarbamate (28)Butoxycarbonylamino (7)Butylcarbamoyl (5)Carbamothioyl (2)Carbamoyl (112)Chlorobenzylamine (4)Diamino (85)Diaminopteridin (3)Dibutylamino (6)Dichlorobenzylamine (5)Diethylamino (89)Diisopropylamino (1)Dimethylamino (475)Dimethylcarbamoyl (14)Dimethylmethanamine (16)Dipropylamino (1)Ethylamino (37)Fluindamine (32)Hydroxyamino (2)Methoxyimino (2)Methylamino (234)Methylcarbamoyl (18)Propanediamine (6)Propylamino (5)Pyrrolopyridine-Methylamine (6)Silanamine (3)Triamine (25)

Anhydrides (660)

1H,3H-Benzo[De]Isochromene-1,3-Dione (8)Furan-2,5-Dione (8)Aliphatic Chain Hydrocarbons (11)Alkenyls (4)Amides (33)Aryls (14)Benzofurans (13)Bromides (5)Chlorides (8)Esters (81)Ethers (8)Fluorinated Building Blocks (8)Nitroes (5)Oxazolidines (5)Tetrahydrofurans (3)Other Aliphatic Heterocycles (10)Other Aromatic Heterocycles (33)Dianhydride (2)

(6-Phenoxytetrahydro-2H-Pyran-2-Yl)Methanol (16)(8S,9S,14R)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-3H-Cyclopenta[A]Phenanthren-3-One (1)(9H-Fluoren-9-Yl)Methyl (2-(Tritylthio)Ethyl)Carbamate (8)(9H-Fluoren-9-Yl)Methyl Cyclohexylcarbamate (8)(Benzylsulfonyl)Benzene (11)(Cyclopentyloxy)Benzene (12)1,1-Dimethylcyclopropane (5)1,3,4,5-Tetrahydro-2H-Benzo[B]Azepin-2-One (15)1,3-Diphenylurea (24)1-(2-Hydroxyphenyl)-2-Phenylethan-1-One (6)1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One (11)1-([1,1'-Biphenyl]-4-Yl)Ethan-1-One (5)1-(Naphthalen-2-Yl)Ethan-1-One (3)1-Benzyl-4-Chlorobenzene (6)1-Benzyl-4-Fluorobenzene (2)1-Bromonaphthalene (4)1-Chloronaphthalene (24)1-Fluoronaphthalene (23)1-Methoxynaphthalene (18)1-Methyl-4-(Phenylethynyl)Benzene (7)1-Methylnaphthalene (10)1-Naphthaldehyde (23)1-Naphthoic Acid (23)1-Nitronaphthalene (3)10H-Phenothiazine (20)2,2',3,3',5,5',6,6'-Octafluoro-1,1'-Biphenyl (4)2,5-Diphenylthiophene (5)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol (7)2-(Trifluoromethyl)-1,1'-Biphenyl (8)2-Benzylaniline (5)2-Bromo-1,1'-Biphenyl (12)2-Bromonaphthalene (4)2-Chloro-1,1'-Biphenyl (8)2-Chloronaphthalene (6)2-Ethoxynaphthalene (4)2-Fluorocyclopropane-1-Carboxylic Acid (7)2-Hydroxycyclohexa-2,5-Diene-1,4-Dione (3)2-Iodonaphthalene (5)2-Methoxy-1,1'-Biphenyl (7)2-Methoxynaphthalene (22)2-Methoxytetrahydro-2H-Pyran (9)2-Methyl-1,1'-Biphenyl (26)2-Methylnaphthalene (13)2-Naphthaldehyde (12)2-Naphthoic Acid (14)2-Naphthonitrile (15)2-Nitronaphthalene (4)2-Phenoxytetrahydro-2H-Pyran-4-Yl Acetate (6)2-Phenylnaphthalene (12)3,3'-Diphenyl-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthalene (13)3,3-Diphenyl-3H-Benzo[C][1,2]Oxathiole 1,1-Dioxide (19)3-Bromo-1,1'-Biphenyl (12)3-Chloro-1,1'-Biphenyl (12)3-Fluoro-1,1'-Biphenyl (16)3-Methyl-1,1'-Biphenyl (10)3-Methyl-1,1':4',1''-Terphenyl (3)3-Phenethylphenol (5)3-Phenyl-1,2,4,5-Tetrazine (9)3-Styrylphenol (10)4-(Bromomethyl)-1,1'-Biphenyl (13)4-(Phenyldiazenyl)Benzoic Acid (4)4-(Phenylsulfonyl)Morpholine (14)4-(Tert-Butyl)-1,1'-Biphenyl (5)4-Cyclohexylphenol (7)4-Iodo-1,1'-Biphenyl (9)4-Methoxy-1,1'-Biphenyl (4)9H-Xanthene (7)[1,1'-Biphenyl]-2-Amine (8)[1,1'-Biphenyl]-2-Carbonitrile (12)[1,1'-Biphenyl]-2-Carboxylic Acid (24)[1,1'-Biphenyl]-2-Ol (16)[1,1'-Biphenyl]-3-Amine (11)[1,1'-Biphenyl]-3-Carbaldehyde (20)[1,1'-Biphenyl]-3-Carboxylic Acid (40)[1,1'-Biphenyl]-3-Ol (9)[1,1'-Biphenyl]-4-Carbaldehyde (31)[1,1'-Biphenyl]-4-Carbonitrile (27)[1,1'-Biphenyl]-4-Ol (29)[1,1'-Biphenyl]-4-Ylboronic Acid (29)Benzyltriphenylphosphonium (14)Cyclopentylbenzene (28)Cyclopropanecarboxylic Acid (11)Cyclopropyl(Phenyl)Methanamine (22)Cyclopropyl(Phenyl)Methanone (13)Diphenyl Phosphonate (11)Diphenylphosphane (25)Diphenylphosphine Oxide (27)Ethane-1,1-Diyldibenzene (3)Ethene-1,1,2-Triyltribenzene (14)Ethyl Cyclopropanecarboxylate (8)Methyl 1-Naphthoate (7)Methyl 2-Naphthoate (11)Methyl [1,1'-Biphenyl]-4-Carboxylate (7)Methyl Cyclopropanecarboxylate (8)N,1-Diphenylmethanimine (15)N,N-Dimethylnaphthalen-1-Amine (3)N-((5R,6R)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptan-6-Yl)-2-Phenylacetamide (5)N-Benzylbenzamide (21)N-Benzylbenzenesulfonamide (18)N-Cyclopropylbenzamide (14)N-Cyclopropylbenzenesulfonamide (10)N-Phenethylbenzamide (9)N-Phenyl-2-Naphthamide (11)Naphthalen-1-Ol (28)Naphthalen-1-Ylboronic Acid (4)Naphthalen-1-Ylmethanol (8)Naphthalen-2-Amine (12)Naphthalen-2-Ol (25)Naphthalen-2-Ylboronic Acid (8)Naphthalene-1,4-Diol (3)Naphthalene-2-Sulfonic Acid (4)Propane-2,2-Diyldibenzene (17)Tert-Butyl Cyclopropylcarbamate (7)Tetrahydro-2H-Pyran-2-Ol (12)Tetrahydro-2H-Pyran-2-Yl Acetate (12)Tetraphenylmethane (16)Triphenylene (12)Vinylcyclopropane (8)Acyl Chlorides (28)Alcohols (626)Aldehydes (346)Aliphatic Cyclic Hydrocarbons (10)Alkenyls (277)Alkynyls (116)Amides (1172)Amidines (20)Amines (1256)Anhydrides (14)Azetidines (44)Azoes (12)Benzimidazoles (40)Benzofurans (12)Benzothiazoles (10)Benzothiophenes (4)Benzyl Bromides (82)Benzyl Chlorides (53)Bromides (934)Carboxylic Acid Salts (13)Carboxylic Acids (839)Chlorides (1041)Difluoromethyls (43)Dioxolanes (16)Epoxides (25)Esters (876)Ethers (1450)Fluorinated Building Blocks (858)Furans (39)Guanidines (13)Hydrazides (84)Hydrazines (121)Hydrazones (10)Hydroxylamines (8)Imidazoles (50)Imidazolidines (9)Imidazolines (14)Indazoles (7)Indoles (50)Indolines (20)Iodides (86)Isocyanates and Isothiocyanates (8)Isocyanides (2)Isoxazoles (54)Ketones (575)Morpholines (137)Nitriles (348)Nitroes (348)Oxadiazoles (12)Oxazoles (48)Oxazolidines (24)Oxazolines (8)Oxetanes (20)Oximes (24)Phenols (278)Phosphoruses (9)Piperazines (85)Piperidines (304)Purines (4)Pyrans (3)Pyrazines (13)Pyrazoles (121)Pyridazines (15)Pyridines (178)Pyrimidines (77)Pyrroles (30)Pyrrolidines (141)Pyrrolines (14)Quinazolines (7)Quinolines (24)Quinuclidines (2)Spiroes (36)Sulfamides (216)Sulfides (143)Sulfonates (83)Sulfones (118)Sulfonic Acids (22)Sulfonyl Chlorides (57)Sulfoxides (19)Tetrahydrofurans (12)Tetrahydroisoquinolines (3)Tetrahydropyrans (28)Tetrazoles (5)Thiadiazoles (17)Thiazoles (98)Thiazolidines (8)Thioesters (9)Thiols (8)Thiophenes (46)Thiophenols (29)Thioureas (28)Triazines (12)Triazoles (24)Trifluoromethyls (259)Ureas (28)Other Aliphatic Heterocycles (55)Other Aromatic Heterocycles (107)Acetylbenzonitrile (3)Aminobenzyl (4)Benzylamine (21)Benzylamino (47)Benzylhydroxylamine (25)Benzylidene (17)Benzyloxy (1048)Benzylthio (16)Cyanobenzyl (9)Dibenzyl (15)Dibenzylamino (7)Dichlorobenzylidene (7)Difluorobenzyl (17)Dimethoxybenzyl (20)Dimethylbenzonitrile (25)Dimethylbenzyl (6)Dimethylbenzylamine (6)Ethoxybenzyl (8)Fluorobenzyl (129)Fluorobenzylidene (2)Formylbenzonitrile (35)Iodobenzyl (8)Isopropylbenzonitrile (4)Methoxybenzyl (173)Methoxybenzylamine (7)Methoxybenzylidene (6)Methylbenzonitrile (104)Methylbenzyl (73)Methylbenzylamine (8)Methylbenzylidene (1)Nitrobenzyl (30)Nitrobenzylidene (2)Phenoxybenzonitrile (5)Trifluorobenzyl (2)

(E)-1-(Naphthalen-1-Yl)-2-Phenyldiazene (7)1,2-Diphenyldiazene (7)3-(Phenyldiazenyl)Benzoic Acid (7)Aryls (12)

Benzene Compounds (26341)

(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(4-Fluorophenyl)Propanoic Acid (3)(10Ar)-1,2,3,4,4A,9,10,10A-Octahydrophenanthrene (2)(1E,1'E)-N,N'-(Ethane-1,2-Diyl)Bis(1-Phenylmethanimine) (5)(1R,4R)-4-Phenyl-1,1'-Bi(Cyclohexane) (24)(9H-Fluoren-9-Yl)Methyl Benzylcarbamate (22)(9H-Fluoren-9-Yl)Methyl Piperazine-1-Carboxylate (7)(Cyclopentylmethyl)Benzene (5)(R)-3-Benzylpyrrolidine (6)(R)-3-Phenylmorpholine (7)(R)-N-(1,2-Diphenylethyl)Benzenesulfonamide (1)(S)-N-(1,2-Diphenylethyl)Benzenesulfonamide (1)1,1':2',1''-Terphenyl (4)1,1':3',1''-Terphenyl (28)1,1':4',1'':4'',1'''-Quaterphenyl (7)1,1,2,2-Tetra([1,1'-Biphenyl]-4-Yl)Ethene (10)1,1-Dimethyl-1,2,3,4-Tetrahydronaphthalene (10)1,2,3,4-Tetrahydronaphthalen-1-Amine (36)1,2,3,4-Tetrahydronaphthalen-1-Ol (5)1,2,3,4-Tetrahydronaphthalene-1-Carboxylic Acid (3)1,2,3,5,6,7-Hexahydro-S-Indacene (23)1,2,4-Trimethylbenzene (41)1,2-Dihydroacenaphthylene (6)1,2-Dinitrobenzene (6)1,3,5-Tris(Phenylethynyl)Benzene (6)1,3,6,8-Tetraphenylpyrene (10)1,3-Bis(Benzyloxy)Benzene (8)1,3-Dihydro-2H-Inden-2-One (6)1,3-Diphenoxypropane (6)1,3-Diphenyl-1H-Pyrazole (5)1,3-Diphenylpropane (6)1,3-Diphenylpropane-1,3-Dione (3)1,4-Bis(Phenylethynyl)Benzene (7)1,4-Diphenylbuta-1,3-Diyne (9)1-(2,3-Dihydro-1H-Inden-5-Yl)Ethan-1-Amine (3)1-(Anthracen-9-Yl)Ethan-1-Amine (3)1-Benzylazetidine (6)1-Bromopyrene (4)1-Cyclohexyl-4-(Phenylethynyl)Benzene (10)1-Cyclopropylnaphthalene (6)1-Phenyl-1H-Tetrazole (6)1-Phenylnaphthalene (12)1-Trityl-1H-Pyrazole (5)1H-Indene (18)1H-Indene-1,3(2H)-Dione (5)2,2 ', 3,3' - Tetrahydro-1,1 '- Spiro [Indene] (5)2,3,4,5-Tetrahydro-1H-Benzo[C]Azepine (7)2,3-Dihydro-1H-Inden-1-Amine (52)2,3-Dihydro-1H-Inden-1-Ol (13)2,3-Dihydro-1H-Inden-4-Amine (6)2,3-Dihydro-1H-Inden-4-Ol (6)2,3-Dihydro-1H-Indene-1-Carboxylic Acid (5)2,3-Dihydro-1H-Indene-4-Carbonitrile (4)2,4-Diphenyl-1,3,5-Triazine (6)2,5-Diphenyl-1,3,4-Oxadiazole (6)2,7-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-9H-Fluorene (7)2-(2-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (24)2-(2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (21)2-(2-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (29)2-(3-Bromophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (14)2-(3-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (19)2-(3-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (30)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline (17)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde (20)2-(4-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (15)2-(4-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (16)2-Amino-2-(Anthracen-9-Yl)Ethan-1-Ol (4)2-Methyl-2,3-Dihydro-1H-Inden-1-One (9)2-Phenyl-1,3,5-Triazine (6)2-Phenyl-1,3-Dioxane (7)2-Phenyl-2H-1,2,3-Triazole (7)2-Phenylisoindoline-1,3-Dione (7)2H-Benzo[B][1,4]Thiazin-3(4H)-One (6)3,3-Dimethyl-2,3-Dihydro-1H-Inden-1-One (5)3,4-Dihydro-2H-Benzo[B][1,4]Dioxepine (7)3,5,6,7-Tetrahydro-S-Indacen-1(2H)-One (5)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(2-Bromophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(2-Chlorophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(3-(Trifluoromethyl)Phenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(3-Fluorophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(3-Methoxyphenyl)Propanoic Acid (4)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(3-Nitrophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(4-Bromophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(4-Nitrophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(O-Tolyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(P-Tolyl)Propanoic Acid (3)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline (25)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde (19)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoic Acid (12)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol (13)3-Methyl-2,3-Dihydro-1H-Inden-1-One (4)3-Phenyl-1H-Pyrrole (4)3-Phenyloxazolidin-2-One (4)4',5'-Diphenyl-1,1':2',1''-Terphenyl (7)4,4,5,5-Tetramethyl-2-(3-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane (19)4,4,5,5-Tetramethyl-2-(3-Nitrophenyl)-1,3,2-Dioxaborolane (24)4,4,5,5-Tetramethyl-2-(M-Tolyl)-1,3,2-Dioxaborolane (21)4,4,5,5-Tetramethyl-2-(O-Tolyl)-1,3,2-Dioxaborolane (24)4,5-Diphenyloxazole (7)4,7-Diphenylbenzo[C][1,2,5]Thiadiazole (6)4-(4-Cyclopropylnaphthalen-1-Yl)-4H-1,2,4-Triazole (7)4-(Phenylethynyl)-1,1'-Biphenyl (5)4-Bromo-2,3-Dihydro-1H-Inden-1-One (5)4-Bromo-2,3-Dihydro-1H-Indene (10)4-Chloro-2,3-Dihydro-1H-Inden-1-One (8)4-Chloro-2,3-Dihydro-1H-Indene (5)4-Cyclohexyl-1,1'-Biphenyl (18)4-Fluoro-2,3-Dihydro-1H-Inden-1-One (6)4-Fluoro-2,3-Dihydro-1H-Indene (14)4-Methoxy-2,3-Dihydro-1H-Inden-1-One (6)4-Methyl-2,3-Dihydro-1H-Inden-1-One (8)4-Methyl-2,3-Dihydro-1H-Indene (3)4-Phenyl-1,1'-Bi(Cyclohexane) (8)4-Phenyl-4H-1,2,4-Triazole (6)5''-([1,1'-Biphenyl]-4-Yl)-1,1':4',1'':3'',1''':4''',1''''-Quinquephenyl (5)5',5''-Diphenyl-1,1':3',1'':3'',1'''-Quaterphenyl (8)5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthalene (6)5,6,7,8-Tetrahydronaphthalen-2-Ol (5)5-Bromo-1,2,3,4-Tetrahydronaphthalene (6)5-Bromo-2,3-Dihydro-1H-Indene (8)5-Fluoro-2,3-Dihydro-1H-Indene (3)5-Methoxy-1,2,3,4-Tetrahydronaphthalene (3)5-Methoxy-2,3-Dihydro-1H-Indene (2)5-Methyl-3,4-Dihydronaphthalen-1(2H)-One (6)5-Phenyl-1H-Imidazole (6)5-Phenylcyclohexane-1,3-Dione (6)6,7,8,9-Tetrahydro-5H-Benzo[7]Annulen-5-One (6)6-Bromo-1,2,3,4-Tetrahydronaphthalene (9)6-Bromo-2,3-Dihydro-1H-Inden-1-One (8)6-Bromo-3,4-Dihydronaphthalen-1(2H)-One (3)6-Chloro-1,2,3,4-Tetrahydronaphthalene (3)6-Chloro-2,3-Dihydro-1H-Inden-1-One (5)6-Fluoro-1,2,3,4-Tetrahydronaphthalene (6)6-Fluoro-2,3-Dihydro-1H-Inden-1-One (4)6-Methoxy-2,3-Dihydro-1H-Inden-1-One (6)6-Methoxy-3,4-Dihydronaphthalen-1(2H)-One (5)6-Methyl-1,2,3,4-Tetrahydronaphthalene (5)6-Methyl-2,3-Dihydro-1H-Inden-1-One (3)6-Methyl-3,4-Dihydronaphthalen-1(2H)-One (2)7-Bromo-2,3-Dihydro-1H-Inden-1-One (13)7-Chloro-2,3-Dihydro-1H-Inden-1-One (9)7-Fluoro-2,3-Dihydro-1H-Inden-1-One (8)7-Hydroxy-2,3-Dihydro-1H-Inden-1-One (6)7-Methoxy-2,3-Dihydro-1H-Inden-1-One (6)7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One (6)7-Methyl-2,3-Dihydro-1H-Inden-1-One (7)9,10-Bis(Phenylethynyl)Anthracene (5)9,10-Diphenylanthracene (15)9-Methylanthracene (4)9-Phenylxanthylium (7)9H-Fluoren-9-One (17)[1,1'-Binaphthalen]-2-Amine (3)[1,1':4',1''-Terphenyl]-4,4''-Dicarbaldehyde (9)Benzenesulfinic Acid (6)Benzil (17)Benzo-18-Crown-6 (7)Benzo[Lmn][3,8]Phenanthroline-1,3,6,8(2H,7H)-Tetraone (10)Benzyl ((Benzyloxy)Carbonyl)Glycinate (8)Benzyl (4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Carbamate (5)Benzyl (S)-Pyrrolidin-3-Ylcarbamate (7)Benzyl 3-Phenylpropanoate (1)Benzyl Piperidin-4-Ylcarbamate (7)Bicyclo[4.2.0]Octa-1,3,5-Triene (13)Cumene (181)Dibenzyl Phosphonate (6)Diphenylmethanimine (9)Ethane-1,1,2-Triyltribenzene (4)Ethylbenzene (197)Mesitylene (71)Methyl 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate (14)Methyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate (11)N,2-Diphenylacetamide (7)N,N,N-Trimethyl-1-Phenylmethanaminium (6)N,N-Diphenyl-[1,1'-Biphenyl]-4-Amine (8)N-Benzyl-2-Phenylethan-1-Amine (1)N-Benzylcyclopropanamine (6)N-Phenylcinnamamide (16)N1,N1,N4,N4-Tetraphenylbenzene-1,4-Diamine (6)N4,N4,N4',N4'-Tetraphenyl-[1,1'-Biphenyl]-4,4'-Diamine (6)Phenanthrene (26)Phenanthrene-9,10-Dione (8)Phenethyldiphenylphosphane (6)Phenothiazin-5-Ium (6)Phenyl (1R,4R)-[1,1'-Bi(Cyclohexane)]-4-Carboxylate (6)Phenyl 4-Cyclohexylbenzoate (8)Tert-Butyl (2,3-Dihydro-1H-Inden-1-Yl)Carbamate (3)Tert-Butylbenzene (243)Triphenyl Phosphate (6)Acetamidophenyl (5)Acetylbenzoate (7)Acetylphenyl (10)Acetylphenylboronic (3)Aminobenzoyl (3)Aminobiphenyl (3)Aminonaphthalene (14)Aminophenoxy (19)Aminophenyl (222)Anisole (5)Anthracenes (138)Benzaldehyde (1582)Benzamidophenyl (1)Benzenedimethanol (4)Benzenethiol (8)Benzhydrylazetidine (10)Benzhydryloxy (4)Benziodoxol (2)Benzodioxole (9)Benzoquinone (6)Benzoylbenzoate (4)Benzoylphenyl (4)Binaphthalene (123)Biphenyl (1354)Boronophenyl (1)Bromobenzo (104)Bromobenzoyl (5)Bromodibenzo (9)Bromophenoxy (34)Bromophenyl (951)Butoxyphenyl (8)Butylaniline (7)Butylbenzene (16)Butyldiphenylsilyl (7)Butylphenol (18)Butylphenyl (32)Carbamoylphenoxy (11)Carbamoylphenyl (8)Carboxyphenyl (17)Chlorobenzenesulfonyl (23)Chlorobenzoyl (8)Chlorodibenzo (18)Chloronaphthalene (36)Chlorophenethyl (7)Chlorophenoxy (43)Chlorophenylacetate (4)Chlorophenylacetate Acid (9)Chlorophenylboronic (5)Cyclopropylaniline (6)Cyclopropylbenzoate (5)Cyclopropylnaphthalen (10)Cyclopropylphenyl (12)Diaminobenzene (7)Dibenzaldehyde (18)Dibenzene (7)Dibenzimidamide (4)Dibenzo (108)Dibenzoate (9)Dibenzonitrile (11)Dibromobenzene (45)Dibromobenzo (14)Dibromodibenzo (8)Dibromonaphthalene (15)Dibromophenanthrene (3)Dibromophenoxy (2)Dibromophenylboronic (3)Dichlorobenzene (38)Dichlorobenzoyl (4)Dichlorophenoxy (15)Dichlorophenyl (319)Dichlorophenylboronic (5)Didehydrodibenz (2)Diethoxyphenyl (10)Diethylaniline (6)Diethylbenzamide (7)Diethylbenzene (6)Difluorobenzene (57)Difluorobenzo (11)Difluorobenzoyl (9)Difluorophenoxy (9)Difluorophenyl (377)Difluorophenylboronic (11)Dihydroanthracene (1)Dihydrobenzo (187)Dihydrodibenzo (7)Dihydronaphthalene (104)Diiodobenzene (12)Diisopropylaniline (5)Diisopropylbenzamide (8)Diisopropylphenyl (39)Dimesityl (12)Dimethoxyacetophenone (5)Dimethoxyaniline (20)Dimethoxybenzaldehyde (40)Dimethoxybenzamide (6)Dimethoxybenzene (45)Dimethoxybenzo (4)Dimethoxybenzoate (19)Dimethoxybenzohydrazide (3)Dimethoxybenzonitrile (11)Dimethoxybenzoyl (4)Dimethoxybiphenyl (3)Dimethoxynaphthalene (10)Dimethoxyphenol (22)Dimethoxyphenyl (251)Dimethoxyphenylboronic (17)Dimethoxystyryl (4)Dimethylaminophenyl (4)Dimethylanthracene (4)Dimethylbenzaldehyde (27)Dimethylbenzamide (37)Dimethylbenzene (330)Dimethylbenzenesulfonamide (16)Dimethylbenzo (21)Dimethylbenzoate (27)Dimethylbenzoyl (3)Dimethylnaphthalene (6)Dimethylphenol (36)Dimethylphenoxy (13)Dimethylphenylboronic (6)Dimethylphenylhydrazine (3)Dimethylphenylisothiocyanate (4)Dinaphtho (5)Dinitrobenzene (20)Diphenol (30)Diphenylamino (26)Diphenylaniline (8)Diphenylethane (10)Diphenylethanone (5)Diphenylethene (6)Diphenylethyl (4)Diphenylmethyl (5)Diphenylmethylene (6)Diphenylphosphine (199)Diphenylpropane (18)Diphenylsilane (2)Diphenylurea (4)Ethoxyaniline (10)Ethoxybenzaldehyde (9)Ethoxybenzoate (12)Ethoxybenzonitrile (6)Ethoxyphenoxy (7)Ethoxyphenyl (44)Ethoxyphenylboronic (7)Ethylaniline (8)Ethylbenzenesulfonamide (318)Ethylbenzo (7)Ethylbenzoate (9)Ethylphenol (12)Ethylphenyl (39)Ethynylaniline (7)Ethynylbenzaldehyde (17)Ethynylphenyl (35)Fluorobenzeneboronic (24)Fluoronaphthalene (34)Fluorophenoxy (46)Formylbenzoate (39)Formylphenoxy (4)Formylphenyl (40)Formylphenylboronic (9)Hexahydrobenzo (3)Hexylphenyl (3)Homophenylalanine (16)Hydroxybenzenesulfonate (5)Hydroxybenzimidamide (11)Hydroxyisophthalaldehyde (6)Hydroxyphenethyl (2)Hydroxyphenyl (432)Iodobenzo (15)Iodobenzoic (54)Iodobenzoyl (6)Iodobiphenyl (24)Iododibenzo (7)Iodonaphthalene (9)Iodophenoxy (5)Isobutoxyphenyl (15)Isobutylbenzene (5)Isobutylphenyl (9)Isophthalate (8)Isophthalonitrile (4)Isopropoxyaniline (10)Isopropoxybenzaldehyde (7)Isopropoxybenzoate (7)Isopropoxyphenyl (40)Isopropylaniline (18)Isopropylbenzaldehyde (6)Isopropylbenzamide (9)Isopropylbenzenesulfonamide (19)Isopropylbenzoate (8)Isopropylphenyl (58)Mercaptobenzo (20)Methanobenzo (15)Methoxyacetophenone (12)Methoxyaniline (74)Methoxybenzaldehyde (103)Methoxybenzene (1685)Methoxybenzenesulfonamide (6)Methoxybenzenesulfonic (3)Methoxybenzenesulfonyl (13)Methoxybenzimidamide (5)Methoxybenzo (52)Methoxybenzoate (114)Methoxybenzonitrile (67)Methoxybenzoyl (11)Methoxycarbonylphenylboronic (5)Methoxynaphthalene (55)Methoxyphenol (71)Methoxyphenoxy (40)Methoxyphenylacetate (4)Methoxyphenylboronic (24)Methoxyphenylhydrazine (4)Methoxystyryl (12)Methylacetophenone (6)Methylaniline (182)Methylanisole (3)Methylanthracene (5)Methylbenzaldehyde (101)Methylbenzamide (87)Methylbenzamido (3)Methylbenzenesulfinamide (4)Methylbenzenesulfonamide (79)Methylbenzenesulfonic (9)Methylbenzenesulfonyl (4)Methylbenzimidamide (6)Methylbenzoate (193)Methylbenzohydrazide (6)Methylbenzothioamide (6)Methylbenzotrifluoride (5)Methylbenzoyl (23)Methylnaphthalene (34)Methylphenol (107)Methylphenoxy (18)Methylphenyl (524)Methylphenylacetonitrile (44)Methylphenylboronic (24)Methylphenylhydrazine (10)Methylpropiophenone (3)Naphthaldehyde (28)Naphthalene (442)Naphthaleneboronic (15)Naphthalenesulfonic (7)Naphthamide (15)Naphthonitrile (18)Nitrobenzenesulfonyl (8)Nitrobenzo (54)Nitrobenzoyl (12)Nitronaphthalene (23)Nitrophenoxy (43)Nitrophenyl (688)Nitrophenylboronic (14)Nitrotoluene (27)Octylbenzene (11)Paracyclophane (2)Pentafluorobenzene (13)Pentylbenzene (5)Pentylbenzoate (2)Pentylphenol (4)Pentylphenyl (5)Perfluorophenoxy (5)Perfluorophenyl (31)Phenoxyacetate (5)Phenoxyaniline (8)Phenoxybenzaldehyde (4)Phenoxybenzoate (5)Phenoxyethyl (4)Phenoxymethyl (7)Phenoxyphenyl (61)Phenoxypropan (4)Phenylacetamide (34)Phenylacetonitrile (7)Phenylacetyl (1)Phenylacrylamide (3)Phenylalaninol (2)Phenylamino (31)Phenylaniline (19)Phenylanthracene (16)Phenylbenzamide (23)Phenylbenzenesulfonamide (3)Phenylbutanoate (8)Phenylbutoxy (2)Phenylcarbamoyl (5)Phenylcyclohexanone (6)Phenylcyclopropanecarboxylic (6)Phenylcyclopropyl (7)Phenyldiazenyl (4)Phenylene (165)Phenylenediamine (13)Phenylenedimethanamine (5)Phenylethanamine (12)Phenylethane (9)Phenylethanol (8)Phenylethanone (19)Phenylethoxy (2)Phenylethyl (64)Phenylethylisocyanate (1)Phenylhex (3)Phenylimino (1)Phenylisocyanate (9)Phenylisoserine (4)Phenylmethanesulfonyl (2)Phenylmethoxy (4)Phenylmethyl (8)Phenylnaphthalene (6)Phenylpentan (10)Phenylpropanamide (11)Phenylpropyl (17)Phenylpyrazolo (8)Phenylsulfinyl (3)Phenylsulfonyl (88)Phenylthio (23)Phenylthiophene (21)Phenylthiourea (6)Phenylurea (3)Phenylvinyl (9)Phthalate (18)Phthalimide (12)Phthalonitrile (8)Propoxybenzaldehyde (4)Propoxyphenyl (29)Propoxyphenylboronic (79)Propylphenyl (26)Pyrenes (52)Quaternaphthalene (6)Quaterphenyl (15)Styryl (12)Sulfamoylphenyl (3)Sulfophenyl (4)Terephthalaldehyde (11)Terephthalate (13)Terphenyl (238)Tetraaniline (6)Tetrabenzaldehyde (7)Tetrafluorobenzene (16)Tetrahydrobenzo (64)Tetrahydronaphthalene (149)Tetralone (12)Tetramethylbenzene (9)Tetramethylbiphenyl (57)Tetraphenyl (11)Toluenesulfonyl (68)Tolyl (399)Tolylamino (3)Tolylazanediyl (4)Tolylethynyl (3)Tolyloxy (18)Tolylphosphine (8)Tolylthio (3)Trianiline (7)Tribenzaldehyde (5)Tribromobenzene (7)Trichlorobenzene (19)Trichlorophenoxy (3)Trichlorophenylboronic (6)Triethylbenzene (5)Trifluorophenyl (52)Trifluorophenylboronic (154)Triiodobenzene (5)Triisopropylbenzene (9)Triisopropylphenyl (6)Trimethoxybenzene (43)Trimethoxystyryl (5)Trimethylaniline (18)Trimethylbenzene (28)Trimethylphenol (7)Trimethylphenyl (20)Trimethylpropiophenone (4)Triphenylphosphoranylidene (9)Triphenylvinyl (11)Trityl (19)Tritylamino (2)Trityloxy (2)Tritylthio (3)

Benzyl Chlorides (667)

1-(Chloromethyl)-2-Fluorobenzene (8)1-(Chloromethyl)-3-Fluorobenzene (11)Alkenyls (1)Amides (8)Aryls (53)Bromides (5)Chlorides (49)Esters (10)Ethers (7)Fluorinated Building Blocks (2)Dichlorobenzyl (39)

Bromides (52709)

(1-Bromoethyl)Benzene (11)(2,2-Dibromovinyl)Benzene (6)(2-(4-Bromophenyl)Ethene-1,1,2-Triyl)Tribenzene (11)(2-Bromo-6-Fluorophenyl)Methanol (4)(2-Bromoethyl)Benzene (33)(2-Bromophenyl)(Phenyl)Methanone (3)(2-Bromophenyl)Boronic Acid (39)(2-Bromophenyl)Hydrazine (8)(2-Bromophenyl)Methanamine (12)(2-Bromophenyl)Methanol (39)(3-Bromo-2-Fluorophenyl)Boronic Acid (7)(3-Bromo-2-Methoxyphenyl)Boronic Acid (6)(3-Bromophenyl)Boronic Acid (65)(3-Bromopropyl)Benzene (10)(3-Bromopyridin-2-Yl)Methanol (7)(4-Bromophenyl)(Phenyl)Methanone (9)(5-Bromopyridin-2-Yl)Methanamine (5)(5-Bromopyridin-2-Yl)Methanol (5)(Bromoethynyl)Benzene (5)(Dibromomethyl)Benzene (6)1,2,3-Tribromobenzene (4)1,2,4-Tribromobenzene (12)1,2-Dibromo-3-Chlorobenzene (3)1,2-Dibromo-3-Fluorobenzene (8)1,2-Dibromo-3-Methylbenzene (9)1,2-Dibromo-4-Fluorobenzene (11)1,2-Dibromobenzene (62)1,3-Dibromo-2,4-Difluorobenzene (5)1,3-Dibromo-2,4-Dimethylbenzene (3)1,3-Dibromo-2-Chlorobenzene (8)1,3-Dibromo-2-Fluorobenzene (15)1,3-Dibromo-2-Iodobenzene (4)1,3-Dibromo-2-Methoxybenzene (11)1,3-Dibromo-2-Methylbenzene (14)1,3-Dibromo-2-Nitrobenzene (4)1,4-Dibromo-2-Iodobenzene (3)1-(2-Bromophenyl)Ethan-1-Amine (10)1-(2-Bromophenyl)Ethan-1-One (27)1-(5-Bromopyridin-2-Yl)Piperazine (6)1-(Azetidin-1-Yl)-2-Bromoethan-1-One (3)1-(Benzyloxy)-2-Bromobenzene (12)1-(Benzyloxy)-3-Bromobenzene (12)1-(Benzyloxy)-4-Bromobenzene (8)1-(Bromomethyl)-2-Iodobenzene (9)1-(Bromomethyl)-2-Methoxybenzene (14)1-(Bromomethyl)-2-Methylbenzene (14)1-(Bromomethyl)-2-Nitrobenzene (23)1-(Bromomethyl)-3-Methylbenzene (11)1-Benzyl-3-Bromobenzene (7)1-Benzyl-4-Bromo-1H-Pyrazole (5)1-Bromo-2,3-Dichlorobenzene (18)1-Bromo-2,3-Difluorobenzene (67)1-Bromo-2,3-Dimethoxybenzene (8)1-Bromo-2,3-Dimethylbenzene (23)1-Bromo-2,4-Difluorobenzene (59)1-Bromo-2-(Bromomethyl)Benzene (34)1-Bromo-2-(Difluoromethyl)Benzene (5)1-Bromo-2-(Methylsulfonyl)Benzene (4)1-Bromo-2-(Tert-Butyl)Benzene (7)1-Bromo-2-(Trifluoromethoxy)Benzene (22)1-Bromo-2-Chloro-3-Fluorobenzene (20)1-Bromo-2-Chloro-3-Methoxybenzene (6)1-Bromo-2-Chloro-3-Methylbenzene (9)1-Bromo-2-Chloro-4-Nitrobenzene (5)1-Bromo-2-Cyclopropylbenzene (3)1-Bromo-2-Ethoxybenzene (16)1-Bromo-2-Ethylbenzene (13)1-Bromo-2-Fluoro-3-(Trifluoromethyl)Benzene (4)1-Bromo-2-Fluoro-3-Methoxybenzene (7)1-Bromo-2-Fluoro-3-Methylbenzene (11)1-Bromo-2-Fluoro-3-Nitrobenzene (11)1-Bromo-2-Fluoro-4-Nitrobenzene (13)1-Bromo-2-Iodobenzene (65)1-Bromo-2-Isopropylbenzene (10)1-Bromo-2-Phenoxybenzene (3)1-Bromo-3-(Trifluoromethyl)Benzene (100)1-Bromo-3-Chloro-2-Fluorobenzene (9)1-Bromo-3-Chloro-2-Methylbenzene (6)1-Bromo-3-Cyclopropylbenzene (6)1-Bromo-3-Fluoro-2-Iodobenzene (4)1-Bromo-3-Fluoro-2-Methoxybenzene (12)1-Bromo-3-Fluoro-2-Methylbenzene (17)1-Bromo-3-Fluoro-2-Nitrobenzene (10)1-Bromo-3-Iodobenzene (71)1-Bromo-3-Methoxybenzene (186)1-Bromo-3-Methyl-2-Nitrobenzene (3)1-Bromo-3-Nitrobenzene (235)1-Bromo-3-Phenoxybenzene (8)1-Bromo-4-(Phenylsulfonyl)Benzene (7)1-Bromo-4-Chloro-2-Fluorobenzene (21)1-Bromo-4-Fluoro-2-Methoxybenzene (11)1-Bromo-4-Fluoro-2-Methylbenzene (18)1-Bromo-4-Iodobenzene (67)1-Bromo-4-Phenoxybenzene (8)1-Bromo-4-Styrylbenzene (5)1-Bromobicyclo[1.1.1]Pentane (3)1-Bromoisoquinoline (20)1-Bromonaphthalene (4)2,3-Dibromopyridine (21)2,4-Dibromo-1-Chlorobenzene (8)2,4-Dibromo-1-Fluorobenzene (18)2,4-Dibromo-1-Methoxybenzene (6)2,4-Dibromoaniline (18)2,4-Dibromophenol (16)2,4-Dibromopyridine (5)2,4-Dibromothiazole (5)2,5-Dibromopyrazine (4)2,5-Dibromopyridine (26)2,5-Dibromothiazole (5)2,5-Dibromothiophene (18)2,6-Dibromo-3-Fluoropyridine (3)2,6-Dibromoaniline (17)2,6-Dibromobenzaldehyde (4)2,6-Dibromobenzonitrile (4)2,6-Dibromophenol (20)2,6-Dibromopyrazine (9)2,6-Dibromopyridin-4-Amine (3)2,6-Dibromopyridine (28)2-(2-Bromophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (5)2-(2-Bromophenyl)Acetic Acid (23)2-(2-Bromophenyl)Acetonitrile (10)2-(4-Bromophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (8)2-(Bromomethyl)Furan (3)2-(Bromomethyl)Pyridine (27)2-Amino-3-Bromobenzoic Acid (8)2-Amino-3-Bromobenzonitrile (7)2-Amino-3-Bromophenol (3)2-Amino-6-Bromophenol (3)2-Bromo-1,1'-Biphenyl (12)2-Bromo-1,3,4-Thiadiazole (11)2-Bromo-1,3,4-Trifluorobenzene (16)2-Bromo-1,3,4-Trimethylbenzene (4)2-Bromo-1,3-Dichlorobenzene (12)2-Bromo-1,3-Difluorobenzene (43)2-Bromo-1,3-Dimethoxybenzene (7)2-Bromo-1,3-Dimethylbenzene (35)2-Bromo-1,4-Dichlorobenzene (12)2-Bromo-1,4-Difluorobenzene (64)2-Bromo-1,4-Dimethoxybenzene (10)2-Bromo-1,4-Dimethylbenzene (22)2-Bromo-1-Chloro-3-Fluorobenzene (9)2-Bromo-1-Chloro-4-Fluorobenzene (20)2-Bromo-1-Chloro-4-Methylbenzene (6)2-Bromo-1-Chloro-4-Nitrobenzene (9)2-Bromo-1-Fluoro-3-Nitrobenzene (9)2-Bromo-1-Fluoro-4-(Trifluoromethyl)Benzene (4)2-Bromo-1-Fluoro-4-Methoxybenzene (12)2-Bromo-1-Fluoro-4-Methylbenzene (17)2-Bromo-1-Fluoro-4-Nitrobenzene (23)2-Bromo-1-Methoxy-3-Methylbenzene (3)2-Bromo-1-Methoxy-4-Methylbenzene (7)2-Bromo-1-Methyl-4-Nitrobenzene (12)2-Bromo-1H-Benzo[D]Imidazole (4)2-Bromo-1H-Imidazole (13)2-Bromo-1H-Pyrrole (11)2-Bromo-3-(Trifluoromethyl)Pyridine (4)2-Bromo-3-Chloroaniline (4)2-Bromo-3-Chloropyridine (25)2-Bromo-3-Fluoroaniline (13)2-Bromo-3-Fluoropyridine (26)2-Bromo-3-Hydroxybenzaldehyde (4)2-Bromo-3-Methoxybenzaldehyde (4)2-Bromo-3-Methoxypyridine (7)2-Bromo-3-Methylaniline (6)2-Bromo-3-Methylphenol (4)2-Bromo-3-Methylpyrazine (5)2-Bromo-3-Methylpyridine (25)2-Bromo-3-Nitrobenzoic Acid (4)2-Bromo-3-Nitropyridine (5)2-Bromo-4-(Trifluoromethyl)Aniline (9)2-Bromo-4-Chloro-1-Fluorobenzene (16)2-Bromo-4-Chloro-1-Methoxybenzene (7)2-Bromo-4-Chloro-1-Methylbenzene (11)2-Bromo-4-Chloro-1-Nitrobenzene (5)2-Bromo-4-Chloroaniline (15)2-Bromo-4-Chlorophenol (11)2-Bromo-4-Chloropyridine (7)2-Bromo-4-Fluoro-1-Methoxybenzene (12)2-Bromo-4-Fluoro-1-Methylbenzene (21)2-Bromo-4-Fluoro-1-Nitrobenzene (23)2-Bromo-4-Fluoroaniline (28)2-Bromo-4-Fluorobenzaldehyde (7)2-Bromo-4-Fluorobenzoic Acid (8)2-Bromo-4-Fluorobenzonitrile (7)2-Bromo-4-Fluorophenol (10)2-Bromo-4-Methoxy-1-Nitrobenzene (6)2-Bromo-4-Methoxyaniline (6)2-Bromo-4-Methoxybenzaldehyde (8)2-Bromo-4-Methoxybenzoic Acid (4)2-Bromo-4-Methylaniline (14)2-Bromo-4-Methylbenzoic Acid (5)2-Bromo-4-Methylpyridine (6)2-Bromo-4-Methylthiazole (7)2-Bromo-4-Nitroaniline (12)2-Bromo-5-(Trifluoromethyl)Pyridine (6)2-Bromo-5-Chloropyrazine (6)2-Bromo-5-Chloropyridine (22)2-Bromo-5-Fluoroaniline (18)2-Bromo-5-Fluorobenzaldehyde (7)2-Bromo-5-Fluorobenzoic Acid (11)2-Bromo-5-Fluoropyridine (33)2-Bromo-5-Methoxybenzaldehyde (6)2-Bromo-5-Methoxypyridine (11)2-Bromo-5-Methylpyridine (19)2-Bromo-5-Methylthiazole (7)2-Bromo-5-Nitropyridine (11)2-Bromo-6-(Trifluoromethyl)Aniline (5)2-Bromo-6-(Trifluoromethyl)Pyridine (6)2-Bromo-6-Chloroaniline (10)2-Bromo-6-Chlorophenol (5)2-Bromo-6-Chloropyrazine (5)2-Bromo-6-Chloropyridine (23)2-Bromo-6-Fluoroaniline (14)2-Bromo-6-Fluorobenzaldehyde (15)2-Bromo-6-Fluorobenzoic Acid (11)2-Bromo-6-Fluorobenzonitrile (7)2-Bromo-6-Fluorophenol (9)2-Bromo-6-Fluoropyridine (21)2-Bromo-6-Iodoaniline (4)2-Bromo-6-Methoxyaniline (5)2-Bromo-6-Methoxyphenol (5)2-Bromo-6-Methoxypyridine (15)2-Bromo-6-Methylaniline (11)2-Bromo-6-Methylbenzoic Acid (5)2-Bromo-6-Methylphenol (7)2-Bromo-6-Methylpyrazine (5)2-Bromo-6-Methylpyridine (17)2-Bromo-6-Nitroaniline (14)2-Bromo-6-Nitrophenol (9)2-Bromo-6-Phenylpyridine (4)2-Bromo-9,9-Diphenyl-9H-Fluorene (5)2-Bromo-9H-Fluorene (15)2-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (6)2-Bromo-N,N-Dimethylaniline (5)2-Bromo-N-Methylaniline (8)2-Bromo-N-Phenylacetamide (5)2-Bromobenzene-1,3-Diol (7)2-Bromobenzene-1,4-Diol (4)2-Bromobenzenesulfonyl Chloride (8)2-Bromobenzo[D]Thiazole (28)2-Bromodibenzo[B,D]Furan (6)2-Bromofuran (21)2-Bromoimidazo[1,2-A]Pyridine (5)2-Bromonaphthalene (4)2-Bromonicotinic Acid (5)2-Bromooxazole (7)2-Bromopyrazine (15)2-Bromopyridin-3-Amine (10)2-Bromopyridin-3-Ol (7)2-Bromopyridine (10)2-Bromopyridine 1-Oxide (6)2-Bromopyrimidine (22)2-Bromoquinazoline (4)3,4-Dibromoaniline (4)3,4-Dibromophenol (3)3,5-Dibromopyridine (12)3-(Bromomethyl)Pyridine (18)3-Bromo-1,1'-Biphenyl (12)3-Bromo-1,5-Naphthyridine (8)3-Bromo-1-Methyl-1H-Pyrazole (16)3-Bromo-1H-Pyrrole (16)3-Bromo-1H-Pyrrolo[2,3-B]Pyridine (7)3-Bromo-1H-Pyrrolo[3,2-B]Pyridine (6)3-Bromo-2-Chlorobenzaldehyde (4)3-Bromo-2-Chlorobenzoic Acid (7)3-Bromo-2-Chloropyridin-4-Amine (3)3-Bromo-2-Chloropyridine (20)3-Bromo-2-Fluoroaniline (15)3-Bromo-2-Fluorobenzaldehyde (9)3-Bromo-2-Fluorobenzoic Acid (10)3-Bromo-2-Fluorobenzonitrile (10)3-Bromo-2-Fluorophenol (5)3-Bromo-2-Fluoropyridine (21)3-Bromo-2-Hydroxybenzaldehyde (10)3-Bromo-2-Hydroxybenzoic Acid (4)3-Bromo-2-Hydroxybenzonitrile (3)3-Bromo-2-Methoxypyridine (20)3-Bromo-2-Methylpyridine (27)3-Bromo-4-Chloroaniline (13)3-Bromo-4-Chlorobenzoic Acid (6)3-Bromo-4-Chlorophenol (5)3-Bromo-4-Fluoroaniline (22)3-Bromo-4-Fluorobenzaldehyde (7)3-Bromo-4-Fluorobenzamide (3)3-Bromo-4-Fluorobenzoic Acid (10)3-Bromo-4-Fluorophenol (11)3-Bromo-4-Hydroxybenzaldehyde (9)3-Bromo-4-Hydroxybenzoic Acid (3)3-Bromo-4-Methoxyaniline (7)3-Bromo-4-Methoxybenzaldehyde (9)3-Bromo-4-Methoxybenzoic Acid (7)3-Bromo-4-Methylaniline (14)3-Bromo-4-Methylbenzoic Acid (9)3-Bromo-4-Methylpyridine (13)3-Bromo-5'-Phenyl-1,1':3',1''-Terphenyl (4)3-Bromo-5-Chloropyridine (14)3-Bromo-5-Fluoropyridine (18)3-Bromo-5-Methylpyridine (14)3-Bromo-5-Nitropyridine (10)3-Bromoaniline (187)3-Bromoazetidine (3)3-Bromobenzene-1,2-Diamine (11)3-Bromobenzene-1,2-Diol (8)3-Bromobenzo[B]Thiophene (5)3-Bromobenzoic Acid (159)3-Bromobenzonitrile (109)3-Bromofuran (13)3-Bromoimidazo[1,2-A]Pyridine (26)3-Bromoimidazo[1,2-A]Pyrimidine (6)3-Bromoisoquinoline (10)3-Bromoisoxazole (7)3-Bromopicolinic Acid (9)3-Bromopicolinonitrile (13)3-Bromopyrazolo[1,5-A]Pyrimidine (11)3-Bromopyridazine (25)3-Bromopyridin-2-Amine (30)3-Bromopyridin-2-Ol (17)3-Bromopyridine 1-Oxide (8)3-Bromopyrrolidine (6)3-Bromothiophene (6)4-(Bromomethyl)-1,1'-Biphenyl (13)4-(Bromomethyl)Pyridine (8)4-Bromo-1,5-Naphthyridine (5)4-Bromo-1-Methyl-1H-Pyrazole (14)4-Bromo-1-Phenyl-1H-Imidazole (9)4-Bromo-1-Phenyl-1H-Pyrazole (11)4-Bromo-1H-Benzo[D]Imidazole (14)4-Bromo-1H-Indole (25)4-Bromo-1H-Pyrazolo[3,4-B]Pyridine (4)4-Bromo-1H-Pyrrolo[2,3-B]Pyridine (9)4-Bromo-2-Chloro-1-Iodobenzene (4)4-Bromo-2-Chloropyridine (29)4-Bromo-2-Fluoro-1-Iodobenzene (8)4-Bromo-2-Fluoropyridine (4)4-Bromo-2-Iodoaniline (8)4-Bromo-2-Methoxypyridine (4)4-Bromo-3-(Trifluoromethyl)Aniline (7)4-Bromo-3-Chloroaniline (21)4-Bromo-3-Fluoroaniline (29)4-Bromo-3-Methylaniline (19)4-Bromo-3-Methylpyridine (5)4-Bromo-3-Nitroaniline (8)4-Bromo-N,N-Diphenylaniline (10)4-Bromo-N-Phenylaniline (6)4-Bromo-N-Phenylbenzenesulfonamide (23)4-Bromobenzo[C][1,2,5]Thiadiazole (12)4-Bromobenzo[D][1,3]Dioxole (6)4-Bromobenzo[D]Thiazole (9)4-Bromobenzofuran (3)4-Bromoindoline (4)4-Bromoisoindolin-1-One (3)4-Bromoisoquinolin-1(2H)-One (3)4-Bromoisoquinoline (33)4-Bromopyridazine (5)4-Bromopyridine (31)4-Bromopyrimidine (24)4-Bromothiazole (10)5-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)5-Bromo-1-Methyl-1H-Indole (3)5-Bromo-1H-1,2,4-Triazole (6)5-Bromo-1H-Benzo[D][1,2,3]Triazole (5)5-Bromo-1H-Benzo[D]Imidazole (13)5-Bromo-1H-Indazole (12)5-Bromo-1H-Pyrazole (11)5-Bromo-1H-Pyrazolo[3,4-B]Pyridine (11)5-Bromo-1H-Pyrazolo[3,4-C]Pyridine (5)5-Bromo-1H-Pyrrolo[2,3-B]Pyridine (13)5-Bromo-2,3-Dihydro-1H-Indene (8)5-Bromo-2,3-Dihydrobenzofuran (6)5-Bromo-2-Chloro-4-Methylpyridine (5)5-Bromo-2-Chloropyridine (40)5-Bromo-2-Chloropyrimidine (6)5-Bromo-2-Fluoropyridine (22)5-Bromo-2-Methoxypyridine (29)5-Bromo-2-Methylpyridine (23)5-Bromo-2-Methylpyrimidine (5)5-Bromo-2-Phenylpyridine (3)5-Bromo-4-Methylpyridin-2-Amine (5)5-Bromo-6-Chloropyridin-2-Amine (3)5-Bromo-7H-Pyrrolo[2,3-D]Pyrimidine (3)5-Bromobenzo[B]Thiophene (3)5-Bromobenzo[D][1,3]Dioxole (12)5-Bromobenzo[D]Oxazole (3)5-Bromoimidazo[1,2-A]Pyridine (6)5-Bromoindoline (8)5-Bromoisoindolin-1-One (8)5-Bromoisoquinoline (17)5-Bromonicotinaldehyde (12)5-Bromonicotinic Acid (6)5-Bromonicotinonitrile (6)5-Bromopicolinic Acid (11)5-Bromopicolinonitrile (13)5-Bromopyrazin-2-Ol (5)5-Bromopyridin-2-Amine (35)5-Bromopyridin-2-Ol (18)5-Bromopyridin-3-Amine (10)5-Bromopyridin-3-Ol (6)5-Bromoquinoxaline (6)5-Bromothiazole (8)6-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)6-Bromo-1,2,3,4-Tetrahydroquinoline (6)6-Bromo-1-Methyl-1H-Indole (3)6-Bromo-1H-Indazole (22)6-Bromo-1H-Indole (15)6-Bromo-1H-Pyrazolo[4,3-B]Pyridine (4)6-Bromo-1H-Pyrrolo[2,3-B]Pyridine (5)6-Bromo-1H-Pyrrolo[3,2-B]Pyridine (6)6-Bromo-1H-Pyrrolo[3,2-C]Pyridine (5)6-Bromo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (5)6-Bromo-3,4-Dihydroisoquinolin-1(2H)-One (6)6-Bromo-3,4-Dihydroquinolin-2(1H)-One (4)6-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (12)6-Bromo-[1,2,4]Triazolo[4,3-A]Pyridine (8)6-Bromobenzo[B]Thiophene (4)6-Bromobenzo[D]Oxazole (3)6-Bromobenzo[D]Thiazole (7)6-Bromochroman-4-One (6)6-Bromoimidazo[1,2-A]Pyrimidine (5)6-Bromoindoline-2,3-Dione (4)6-Bromoisoindolin-1-One (4)6-Bromoisoquinoline (9)6-Bromonicotinaldehyde (10)6-Bromonicotinic Acid (9)6-Bromonicotinonitrile (7)6-Bromopicolinic Acid (5)6-Bromopyrazolo[1,5-A]Pyrimidine (7)6-Bromopyridin-2-Amine (8)6-Bromopyridin-3-Amine (12)6-Bromopyridin-3-Ol (13)6-Bromoquinazoline (7)6-Bromoquinoxaline (9)7-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)7-Bromo-1H-Indazole (17)7-Bromo-1H-Indole (27)7-Bromo-1H-Pyrrolo[2,3-C]Pyridine (4)7-Bromo-2,3-Dihydrobenzofuran (6)7-Bromo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (7)7-Bromo-3,4-Dihydroisoquinolin-1(2H)-One (6)7-Bromo-3,4-Dihydronaphthalen-1(2H)-One (8)7-Bromobenzo[B]Thiophene (5)7-Bromobenzo[D]Thiazole (8)7-Bromobenzofuran (6)7-Bromochromane (7)7-Bromoindoline (3)7-Bromoisoquinoline (6)8-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (6)8-Bromochromane (6)8-Bromoimidazo[1,2-A]Pyridine (15)8-Bromoisoquinoline (17)8-Bromoquinazoline (8)9-Bromoanthracene (5)Bromocyclohexane (7)Ethyl 2-Bromo-2-Phenylacetate (6)Methyl 2-(2-Bromophenyl)Acetate (8)Methyl 2-Bromo-2-Phenylacetate (7)Methyl 2-Bromo-3-Nitrobenzoate (3)Methyl 2-Bromo-5-Fluorobenzoate (8)Methyl 2-Bromo-6-Fluorobenzoate (7)Methyl 2-Bromo-6-Methylbenzoate (8)Methyl 2-Bromobenzoate (69)Methyl 3-(Bromomethyl)Benzoate (16)Methyl 3-Bromo-4-Chlorobenzoate (6)Methyl 3-Bromo-4-Fluorobenzoate (7)Methyl 3-Bromo-4-Methoxybenzoate (10)Methyl 3-Bromo-4-Methylbenzoate (9)Methyl 3-Bromobenzoate (153)Methyl 3-Bromopicolinate (9)Methyl 4-Amino-3-Bromobenzoate (8)Methyl 5-Amino-2-Bromobenzoate (6)Methyl 6-Bromonicotinate (6)N-(2-Benzoylphenyl)-2-Bromoacetamide (3)Tert-Butyl 2-(Bromomethyl)Morpholine-4-Carboxylate (3)Tert-Butyl 3-Bromo-1H-Indole-1-Carboxylate (9)Tert-Butyl 3-Bromopiperidine-1-Carboxylate (4)Acyl Chlorides (5)Alcohols (147)Aldehydes (78)Aliphatic Chain Hydrocarbons (148)Aliphatic Cyclic Hydrocarbons (31)Alkenyls (45)Alkynyls (11)Amides (309)Amines (216)Anhydrides (5)Aryls (934)Azetidines (7)Benzimidazoles (8)Benzofurans (18)Benzothiazoles (11)Benzothiophenes (4)Benzoxazoles (10)Benzyl Bromides (81)Benzyl Chlorides (5)Carboxylic Acids (176)Chlorides (241)Difluoromethyls (36)Dioxolanes (6)Esters (313)Ethers (328)Fluorinated Building Blocks (304)Furans (13)Imidazoles (16)Indazoles (25)Indoles (35)Indolines (16)Iodides (54)Isoquinolines (11)Isothiazoles (4)Isoxazoles (11)Ketones (168)Morpholines (30)Naphthyridines (4)Nitriles (82)Nitroes (62)Oxadiazoles (4)Oxazoles (12)Oxetanes (9)Phenols (34)Piperazines (8)Piperidines (31)Pyrazines (9)Pyrazoles (38)Pyridazines (10)Pyridines (398)Pyrimidines (71)Pyrroles (5)Pyrrolidines (25)Pyrrolines (6)Quinazolines (13)Quinolines (106)Quinoxalines (9)Spiroes (11)Sulfamides (35)Sulfides (18)Sulfones (31)Sulfonyl Chlorides (17)Tetrahydrofurans (4)Tetrahydropyrans (6)Tetrahydroquinolines (6)Thiazoles (70)Thiophenes (66)Thiophenols (4)Trifluoromethyls (94)Other Aromatic Heterocycles (91)Bromo-Carbazole (1)Bromoacetyl (14)Bromoaniline (2)Bromoanthracene (5)Bromobenzaldehyde (15)Bromobenzamide (7)Bromobenzimidamide (6)Bromobenzyl (31)Bromobut (2)Bromobutoxy (4)Bromobutyl (6)Bromochroman (25)Bromoethoxy (22)Bromoethyl (86)Bromoethynyl (6)Bromohexyl (11)Bromomethyl (758)Bromonicotinaldehyde (5)Bromonicotinamide (5)Bromooctyl (3)Bromopentyl (8)Bromopropane (10)Bromopropoxy (6)Bromopropyl (25)Bromothiochroman (4)Bromovinyl (2)Dibromo (691)Dibromoanthracene (3)Dibromobenzaldehyde (8)Dibromobenzonitrile (8)Dibromomethyl (6)Tetrabromo (10)Tribromo (9)

Carbamates (7462)

Carboxylic Acid Salts (658)

Alcohols (16)Aliphatic Chain Hydrocarbons (58)Alkenyls (9)Amides (4)Amines (4)Aryls (13)Carboxylic Acids (5)Esters (3)Ethers (4)Ketones (4)

Carboxylic Acids (58126)

1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid (19)1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid (12)1,5-Naphthyridine-3-Carboxylic Acid (6)1-((Benzyloxy)Carbonyl)Piperidine-2-Carboxylic Acid (5)1-((Benzyloxy)Carbonyl)Piperidine-3-Carboxylic Acid (3)1-((Benzyloxy)Carbonyl)Pyrrolidine-3-Carboxylic Acid (6)1-Methyl-1H-Indole-2-Carboxylic Acid (8)1-Naphthoic Acid (23)1-Phenyl-1H-Imidazole-4-Carboxylic Acid (5)1-Phenyl-1H-Pyrazole-3-Carboxylic Acid (10)1-Phenyl-1H-Pyrazole-4-Carboxylic Acid (19)1-Phenyl-1H-Pyrazole-5-Carboxylic Acid (3)1-Phenylcyclobutane-1-Carboxylic Acid (16)1-Phenylcyclohexane-1-Carboxylic Acid (6)1-Phenylcyclopropane-1-Carboxylic Acid (23)1H-Benzo[D]Imidazole-2-Carboxylic Acid (7)1H-Benzo[D]Imidazole-4-Carboxylic Acid (6)1H-Benzo[D]Imidazole-5-Carboxylic Acid (4)1H-Imidazole-2-Carboxylic Acid (7)1H-Imidazole-4-Carboxylic Acid (4)1H-Indazole-3-Carboxylic Acid (23)1H-Indazole-4-Carboxylic Acid (9)1H-Indazole-5-Carboxylic Acid (4)1H-Indazole-7-Carboxylic Acid (6)1H-Indole-3-Carboxylic Acid (28)1H-Indole-4-Carboxylic Acid (10)1H-Indole-5-Carboxylic Acid (4)1H-Indole-6-Carboxylic Acid (5)1H-Indole-7-Carboxylic Acid (7)1H-Pyrazole-4-Carboxylic Acid (9)1H-Pyrazole-5-Carboxylic Acid (10)1H-Pyrrole-2-Carboxylic Acid (30)1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid (5)1H-Pyrrolo[2,3-C]Pyridine-2-Carboxylic Acid (4)1H-Pyrrolo[3,2-B]Pyridine-3-Carboxylic Acid (6)2,3-Difluorobenzoic Acid (35)2,3-Dihydrobenzo[B][1,4]Dioxine-2-Carboxylic Acid (3)2,3-Dihydrobenzo[B][1,4]Dioxine-6-Carboxylic Acid (3)2,4-Difluorobenzoic Acid (29)2,5-Dichlorobenzoic Acid (13)2,5-Difluorobenzoic Acid (32)2,6-Dichlorobenzoic Acid (13)2,6-Difluorobenzoic Acid (33)2-(1,3-Dioxoisoindolin-2-Yl)Propanoic Acid (3)2-(1H-Indol-1-Yl)Acetic Acid (5)2-(1H-Indol-3-Yl)Acetic Acid (28)2-(2-Bromophenyl)Acetic Acid (23)2-(2-Chlorophenyl)Acetic Acid (24)2-(2-Fluorophenyl)Acetic Acid (43)2-(2-Hydroxyphenyl)Acetic Acid (8)2-(2-Methoxyphenyl)Acetic Acid (16)2-(2-Methyl-1H-Indol-3-Yl)Acetic Acid (5)2-(2-Nitrophenyl)Acetic Acid (20)2-(2-Oxo-2H-Chromen-4-Yl)Acetic Acid (4)2-(3-Fluorophenyl)Acetic Acid (50)2-(3-Hydroxyphenyl)Acetic Acid (7)2-(3-Methoxyphenyl)Acetic Acid (23)2-(4-Chlorophenoxy)Acetic Acid (3)2-(4-Fluorophenyl)Acetic Acid (30)2-(4-Methoxyphenyl)Acetic Acid (21)2-(4-Nitrophenyl)Acetic Acid (9)2-(Benzofuran-3-Yl)Acetic Acid (3)2-(M-Tolyl)Acetic Acid (16)2-(Morpholin-2-Yl)Acetic Acid (5)2-(O-Tolyl)Acetic Acid (17)2-(P-Tolyl)Acetic Acid (9)2-(Phenylamino)Benzoic Acid (11)2-(Pyridin-3-Yl)Acetic Acid (14)2-(Pyrrolidin-1-Yl)Benzoic Acid (3)2-(Pyrrolidin-2-Yl)Acetic Acid (8)2-(Pyrrolidin-3-Yl)Acetic Acid (6)2-(Thiazol-4-Yl)Acetic Acid (9)2-(Trifluoromethoxy)Benzoic Acid (8)2-(Trifluoromethyl)Benzoic Acid (33)2-Amino-2-(2-Fluorophenyl)Acetic Acid (11)2-Amino-3-Bromobenzoic Acid (8)2-Amino-3-Chlorobenzoic Acid (7)2-Amino-6-Chlorobenzoic Acid (5)2-Benzoylbenzoic Acid (10)2-Bromo-4-Fluorobenzoic Acid (8)2-Bromo-4-Methylbenzoic Acid (5)2-Bromo-6-Fluorobenzoic Acid (11)2-Bromo-6-Methylbenzoic Acid (5)2-Chloro-3-Methoxybenzoic Acid (6)2-Chloro-3-Methylbenzoic Acid (4)2-Chloro-3-Nitrobenzoic Acid (4)2-Chloro-4-Fluorobenzoic Acid (9)2-Chloro-4-Methylbenzoic Acid (3)2-Chloro-6-Fluorobenzoic Acid (8)2-Chlorobenzoic Acid (130)2-Cyclohexylacetic Acid (13)2-Fluoro-4-Methylbenzoic Acid (7)2-Fluoro-5-Methoxybenzoic Acid (9)2-Fluorobenzoic Acid (220)2-Fluorocyclopropane-1-Carboxylic Acid (7)2-Iodobenzoic Acid (47)2-Methoxyisonicotinic Acid (13)2-Methyl-2-Phenylpropanoic Acid (20)2-Methyl-3-Nitrobenzoic Acid (7)2-Naphthoic Acid (14)2-Nitrobenzoic Acid (64)2-Oxo-2-Phenylacetic Acid (17)2-Oxo-2H-Chromene-3-Carboxylic Acid (15)2-Phenoxypropanoic Acid (13)3-(1H-Indol-3-Yl)Propanoic Acid (3)3-(2-Fluorophenyl)Acrylic Acid (17)3-(3-Chlorophenyl)Acrylic Acid (10)3-(3-Chlorophenyl)Propanoic Acid (11)3-(3-Methoxyphenyl)Propanoic Acid (9)3-(Benzyloxy)Benzoic Acid (5)3-(Chlorosulfonyl)Benzoic Acid (15)3-(Methylsulfonyl)Benzoic Acid (6)3-(Phenyldiazenyl)Benzoic Acid (7)3-(Trifluoromethoxy)Benzoic Acid (19)3-(Trifluoromethyl)Benzoic Acid (52)3-Benzamidopropanoic Acid (3)3-Bromo-2-Chlorobenzoic Acid (7)3-Bromo-2-Fluorobenzoic Acid (10)3-Bromo-2-Hydroxybenzoic Acid (4)3-Bromo-4-Chlorobenzoic Acid (6)3-Bromo-4-Fluorobenzoic Acid (10)3-Bromo-4-Hydroxybenzoic Acid (3)3-Bromo-4-Methoxybenzoic Acid (7)3-Bromo-4-Methylbenzoic Acid (9)3-Bromobenzoic Acid (159)3-Chloro-2-Fluorobenzoic Acid (9)3-Chloro-2-Methoxybenzoic Acid (4)3-Chloro-4-Fluorobenzoic Acid (8)3-Chloro-4-Methoxybenzoic Acid (5)3-Chlorobenzoic Acid (144)3-Fluoro-4-Methoxybenzoic Acid (6)3-Fluorobenzoic Acid (206)3-Fluoropicolinic Acid (6)3-Iodobenzoic Acid (54)3-Methoxy-4-Nitrobenzoic Acid (4)3-Methylpicolinic Acid (13)3-Nitrobenzoic Acid (109)3-Phenoxybenzoic Acid (6)3-Phenoxypropanoic Acid (14)4-(1H-Pyrazol-1-Yl)Benzoic Acid (3)4-(Benzyloxy)Benzoic Acid (5)4-(Phenyldiazenyl)Benzoic Acid (4)4-(Trifluoromethyl)Nicotinic Acid (3)4-Amino-3-Chlorobenzoic Acid (6)4-Benzamidobenzoic Acid (3)4-Cyclohexylbenzoic Acid (6)4-Fluoro-3-Iodobenzoic Acid (5)4-Fluorobenzoic Acid (114)4-Methylnicotinic Acid (5)4-Morpholinobenzoic Acid (5)4-Nitrobenzoic Acid (35)4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid (3)4-Oxo-4-(Phenylamino)Butanoic Acid (7)4-Oxo-4-Phenylbutanoic Acid (16)4-Oxopiperidine-2-Carboxylic Acid (3)4-Phenoxybenzoic Acid (4)4-Phenylbutanoic Acid (19)5'-(4-Carboxyphenyl)-[1,1':3',1''-Terphenyl]-4,4''-Dicarboxylic Acid (7)5-Oxotetrahydrofuran-2-Carboxylic Acid (4)5-Phenyl-1H-Pyrazole-3-Carboxylic Acid (15)5-Phenylfuran-2-Carboxylic Acid (6)5-Phenylisoxazole-3-Carboxylic Acid (15)6,6-Dimethylmorpholine-3-Carboxylic Acid (5)6-Methoxypicolinic Acid (9)6-Methylnicotinic Acid (6)6-Methylpicolinic Acid (12)6-Oxopiperidine-2-Carboxylic Acid (3)6-Phenylpicolinic Acid (3)7-Fluoro-1H-Indole-2-Carboxylic Acid (5)[1,1'-Biphenyl]-2-Carboxylic Acid (24)[1,1'-Biphenyl]-3-Carboxylic Acid (40)Azetidine-2-Carboxylic Acid (6)Benzo[B]Thiophene-2-Carboxylic Acid (32)Benzo[D]Thiazole-6-Carboxylic Acid (5)Benzofuran-2-Carboxylic Acid (21)Benzofuran-3-Carboxylic Acid (6)Benzoic Acid (3481)Benzoylglycine (15)Bicyclo[1.1.1]Pentane-1-Carboxylic Acid (6)Chromane-2-Carboxylic Acid (6)Chromane-3-Carboxylic Acid (4)Cyclobutanecarboxylic Acid (23)Cyclohex-1-Ene-1-Carboxylic Acid (4)Cyclohex-3-Ene-1-Carboxylic Acid (7)Cyclohexanecarboxylic Acid (83)Cyclopentanecarboxylic Acid (26)Cyclopropanecarboxylic Acid (11)Ethyl 5-Oxopyrrolidine-2-Carboxylate (3)Furan-2-Carboxylic Acid (30)Furan-3-Carboxylic Acid (11)Imidazo[1,2-A]Pyridine-2-Carboxylic Acid (21)Imidazo[1,2-A]Pyridine-3-Carboxylic Acid (14)Imidazo[1,2-A]Pyridine-5-Carboxylic Acid (3)Imidazo[1,2-A]Pyridine-7-Carboxylic Acid (5)Imidazo[1,2-A]Pyridine-8-Carboxylic Acid (6)Imidazo[1,2-A]Pyrimidine-3-Carboxylic Acid (5)Indoline-2-Carboxylic Acid (3)Isonicotinic Acid (23)Isoquinoline-1-Carboxylic Acid (10)Isoquinoline-3-Carboxylic Acid (7)Isoquinoline-4-Carboxylic Acid (12)Isoquinoline-5-Carboxylic Acid (5)Isoquinoline-6-Carboxylic Acid (3)Isoxazole-3-Carboxylic Acid (8)Isoxazole-5-Carboxylic Acid (7)Methyl Benzofuran-2-Carboxylate (6)Methyl Isoquinoline-3-Carboxylate (3)Morpholine-2-Carboxylic Acid (12)Morpholine-3-Carboxylic Acid (10)Nicotinic Acid (53)Oxazole-4-Carboxylic Acid (4)Picolinic Acid (22)Piperidine-2-Carboxylic Acid (26)Piperidine-3-Carboxylic Acid (14)Piperidine-4-Carboxylic Acid (12)Proline (13)Pyrazine-2-Carboxylic Acid (33)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid (7)Pyridazine-3-Carboxylic Acid (7)Pyridine-2,6-Dicarboxylic Acid (9)Pyrimidine-2-Carboxylic Acid (11)Pyrimidine-4-Carboxylic Acid (17)Pyrimidine-5-Carboxylic Acid (7)Pyrrolidine-3-Carboxylic Acid (14)Tetrahydrofuran-2-Carboxylic Acid (4)Tetrahydrofuran-3-Carboxylic Acid (4)Thiazole-2-Carboxylic Acid (9)Thiazole-4-Carboxylic Acid (5)Thiazole-5-Carboxylic Acid (10)Thiophene-3-Carboxylic Acid (8)Tryptophan (22)Alcohols (162)Aldehydes (18)Aliphatic Chain Hydrocarbons (153)Aliphatic Cyclic Hydrocarbons (65)Alkenyls (126)Alkynyls (13)Amides (224)Amines (178)Aryls (839)Azetidines (17)Benzimidazoles (6)Benzofurans (9)Benzothiazoles (5)Benzoxazoles (4)Bromides (176)Carboxylic Acid Salts (5)Chlorides (172)Difluoromethyls (19)Dioxolanes (4)Esters (73)Ethers (291)Fluorinated Building Blocks (237)Furans (35)Imidazoles (42)Imidazolidines (3)Indazoles (19)Indoles (50)Indolines (16)Iodides (24)Isoquinolines (4)Isoxazoles (18)Ketones (134)Morpholines (34)Naphthyridines (3)Nitriles (45)Nitroes (44)Oxadiazoles (4)Oxazoles (16)Oxetanes (7)Phenols (21)Piperazines (26)Piperidines (89)Pyrans (2)Pyrazines (12)Pyrazoles (71)Pyridazines (10)Pyridines (172)Pyrimidines (46)Pyrroles (28)Pyrrolidines (25)Quinazolines (4)Quinolines (90)Quinoxalines (5)Spiroes (20)Sulfamides (28)Sulfides (57)Sulfones (15)Tetrahydrofurans (7)Tetrahydropyrans (12)Thiazoles (62)Thiazolidines (10)Thioesters (7)Thiophenes (66)Triazoles (10)Trifluoromethyls (71)Ureas (3)Other Aliphatic Heterocycles (12)Other Aromatic Heterocycles (64)Aceticacid (1236)Acetylbenzoic Acid (3)Acrylic (95)Aminobenzoic (6)Aminobutanoic (8)Aminoheptanoic (6)Aminohexanoic (10)Aminonicotinic Acid (4)Aminopentanoic (8)Aminophenylacetic Acid (22)Aminopropanoic (8)Aminoundecanoic Acid (4)Benzenedicarboxylic (6)Benzenedicarboxylic Acid (6)Benzylpropanoic Acid (71)Benzylsuccinic Acid (6)Boronobenzoic (4)Bromobutanoic (5)Bromododecanoate (3)Bromoisonicotinic Acid (4)Bromonicotinic (8)Bromonicotinic Acid (9)Bromophenylacetic Acid (15)Bromovalerate (4)Butanoic (115)Chlorobenzoic (35)Chloromandelic Acid (3)Cyanonicotinic (5)Cyanonicotinic Acid (3)Diacetic (19)Diaminobenzoic (7)Diaminobutanoic (3)Diaminohexanoic (4)Dibenzoic (40)Dibromobenzoic (10)Dibromobenzoic Acid (10)Dibromonicotinic Acid (7)Dicarboxylic (182)Dichlorobenzoic (21)Dichlorobenzoic Acid (21)Dichloroisonicotinic (6)Dichloroisonicotinic Acid (6)Dichlorophenylacetic Acid (4)Dienoate (14)Dienoic (10)Difluorobenzoic (54)Difluorobutanoic (3)Difluoroisonicotinic Acid (7)Difluorophenylacetic (7)Difluorophenylacetic Acid (7)Diiodobenzoic (4)Diisophthalic (17)Diisophthalic Acid (9)Diisopropylbenzoic Acid (4)Dimethoxybenzoic (33)Dimethoxyphenylacetic Acid (3)Dimethylbenzoic (31)Dimethylbutanoic (13)Dimethylpropanoic (5)Diphenylpropanoic (4)Diyldimethanol (17)Enedioic (8)Enoic (127)Ethoxybenzoic (9)Ethylbenzoic (11)Ethylbenzoic Acid (12)Ethynylbenzoic (6)Ethynylbenzoic Acid (5)Fluoroisophthalic Acid (4)Fluorophenylacetic (10)Fluorophenylacetic Acid (11)Fluorophthalic (5)Fluorophthalic Acid (3)Fluoropicolinic (12)Formylbenzoic (22)Formylbenzoic Acid (19)Guanidinopentanoic (8)Heptanoic (6)Hexacarboxylic Acid (5)Hexanoic (25)Hydrazinylbenzoic (6)Hydrazinylbenzoic Acid (5)Hydroxynicotinic (15)Isophthalic (29)Isophthalic Acid (15)Isopropoxybenzoic (8)Isopropoxybenzoic Acid (7)Isopropylbenzoic (13)Isopropylnicotinic Acid (4)Malonate (39)Mercaptobenzoic (6)Mercaptobenzoic Acid (4)Mercaptopropanoic (10)Methoxybenzoic (142)Methoxybutanoic (4)Methoxyisophthalic Acid (5)Methoxyphenylacetic (10)Methoxyphenylacetic Acid (12)Methoxypropanoic (7)Methylbenzoic (174)Methylbutanoic (30)Methylcinnamic Acid (9)Methylhexanoic (8)Methylisophthalic Acid (17)Methylnicotinic (46)Methyloctanoic (6)Methylpentanoic (102)Methylpropanoic (51)Naphthoic (64)Nitrobenzoic (159)Nitroisonicotinic Acid (5)Nitroisophthalic Acid (3)Nitronicotinic (10)Nitropicolinic (11)Octanoic (6)Oxoacetic (22)Oxobutanoic (53)Oxodecanoic (5)Oxododecanoic (9)Oxoheptanoic (5)Oxoheptanoic Acid (4)Oxohexadecanoic (13)Oxohexanoic (10)Oxooctadecanoic (7)Oxopentanoic (35)Oxopropanoic (8)Pentanedioic (17)Pentanoic (27)Phenoxybenzoic (5)Phenylacetic (34)Phenylbutanoic (41)Phenylpentanoic (11)Phenylpropanoic (26)Propanoic (990)Propenoic (6)Succinic (13)Sulfamoylbenzoic (15)Sulfobenzoic (5)Terephthalic (7)Tetraacetic (4)Tetrabenzoic (13)Tetrabenzoic Acid (14)Tetracarboxylic (13)Tribenzoic (15)Tribenzoic Acid (14)Tricarboxylic (18)Trichlorobenzoic (5)Trichlorobenzoic Acid (4)Trifluorobenzoic (12)Trifluorobenzoic Acid (11)Trifluorobutanoic (3)Trifluoromethylbenzoic (5)Trifluoromethylbenzoic Acid (4)Trifluoropentanoic (4)Trifluorophenylacetic Acid (16)Trifluoropropanoic (4)Triiodobenzoic (4)Trimethylbenzoic Acid (4)

Chlorides (77475)

(2,3-Dichlorophenyl)Boronic Acid (11)(2,6-Dichlorophenyl)Boronic Acid (6)(2-Chloroethoxy)Benzene (5)(2-Chlorophenyl)(Phenyl)Methanone (19)(2-Chlorophenyl)Hydrazine (16)(2-Chlorophenyl)Methanamine (28)(2-Chlorophenyl)Methanol (40)(2-Chloropyridin-4-Yl)Boronic Acid (6)(3,4-Dichlorophenyl)Boronic Acid (10)(3-Chloro-4-Fluorophenyl)Boronic Acid (8)(3-Chlorophenyl)(Phenyl)Methanone (19)(3-Chlorophenyl)Boronic Acid (121)(3-Chlorophenyl)Hydrazine (12)(3-Chlorophenyl)Methanamine (19)(3-Chlorophenyl)Methanol (38)(3-Chloropyridin-2-Yl)Methanamine (6)(4-Chlorophenyl)(Phenyl)Methanone (11)(5-Chloropyridin-2-Yl)Methanamine (5)(Chloromethanetriyl)Tribenzene (7)(Chloromethylene)Dibenzene (5)1,2,3,4-Tetrachlorobenzene (8)1,2,4-Trichlorobenzene (26)1,2-Dibromo-3-Chlorobenzene (3)1,2-Dichloro-3-Fluorobenzene (13)1,2-Dichloro-3-Methoxybenzene (7)1,2-Dichloro-3-Methylbenzene (8)1,2-Dichloro-4-Fluorobenzene (15)1,2-Dichloro-4-Methoxybenzene (11)1,2-Dichloro-4-Nitrobenzene (16)1,3-Dibromo-2-Chlorobenzene (8)1,3-Dichloro-2-Fluorobenzene (22)1,3-Dichloro-2-Iodobenzene (5)1,3-Dichloro-2-Methoxybenzene (9)1,3-Dichloro-2-Nitrobenzene (5)1,3-Dichloroisoquinoline (14)1,4-Dichloro-2-Fluorobenzene (11)1,4-Dichloro-2-Methoxybenzene (8)1-(2-Chlorophenyl)Ethan-1-One (40)1-(3-Chlorophenyl)-1H-Pyrazole (3)1-(3-Chlorophenyl)-N-Methylmethanamine (8)1-(3-Chlorophenyl)Ethan-1-One (38)1-(3-Chlorophenyl)Pyrrolidine (3)1-(Benzyloxy)-2-Chlorobenzene (16)1-(Benzyloxy)-3-Chlorobenzene (6)1-(Bromomethyl)-2-Chlorobenzene (28)1-(Bromomethyl)-3-Chlorobenzene (27)1-(Chloromethyl)-2-Methylbenzene (7)1-Benzyl-2-Chlorobenzene (9)1-Benzyl-3-Chlorobenzene (2)1-Benzyl-4-Chlorobenzene (6)1-Bromo-2,3-Dichlorobenzene (18)1-Bromo-2-Chloro-3-Methylbenzene (9)1-Bromo-3-Chloro-2-Fluorobenzene (9)1-Bromo-3-Chloro-2-Methylbenzene (6)1-Bromo-4-Chloro-2-Fluorobenzene (21)1-Chloro-2,3-Difluorobenzene (27)1-Chloro-2,4-Difluorobenzene (35)1-Chloro-2,4-Dimethoxybenzene (7)1-Chloro-2-(Chloromethyl)Benzene (12)1-Chloro-2-(Trifluoromethoxy)Benzene (20)1-Chloro-2-(Trifluoromethyl)Benzene (81)1-Chloro-2-Cyclopropylbenzene (7)1-Chloro-2-Ethoxybenzene (14)1-Chloro-2-Fluoro-3-Iodobenzene (5)1-Chloro-2-Fluoro-4-Nitrobenzene (9)1-Chloro-2-Iodobenzene (65)1-Chloro-2-Isocyanatobenzene (6)1-Chloro-2-Isothiocyanatobenzene (7)1-Chloro-2-Methyl-3-Nitrobenzene (6)1-Chloro-2-Nitrobenzene (138)1-Chloro-2-Phenoxybenzene (9)1-Chloro-2-Propoxybenzene (5)1-Chloro-3,5-Dimethylbenzene (8)1-Chloro-3-(Chloromethyl)Benzene (7)1-Chloro-3-(Trifluoromethoxy)Benzene (18)1-Chloro-3-(Trifluoromethyl)Benzene (101)1-Chloro-3-Fluoro-2-Methylbenzene (10)1-Chloro-3-Fluoro-2-Nitrobenzene (6)1-Chloro-3-Iodo-2-Methylbenzene (3)1-Chloro-3-Iodobenzene (78)1-Chloro-3-Methoxybenzene (125)1-Chloro-3-Nitrobenzene (160)1-Chloro-3-Phenoxybenzene (5)1-Chloro-4-(Trifluoromethoxy)Benzene (8)1-Chloro-4-Iodobenzene (49)1-Chloro-4-Methoxybenzene (98)1-Chloro-4-Phenoxybenzene (13)1-Chloroanthracene-9,10-Dione (6)1-Chloroisoquinoline (20)1-Chloronaphthalene (24)2,3,5-Trichloropyridine (13)2,3,6-Trichloropyridine (16)2,3-Dichloroaniline (18)2,3-Dichlorobenzaldehyde (7)2,3-Dichlorophenol (9)2,3-Dichloropyridine (38)2,4,5-Trichloropyrimidine (6)2,4,6-Trichloropyridine (5)2,4,6-Trichloropyrimidine (14)2,4-Dibromo-1-Chlorobenzene (8)2,4-Dichloro-1-Fluorobenzene (27)2,4-Dichloro-1-Methoxybenzene (18)2,4-Dichloro-1-Nitrobenzene (19)2,4-Dichloro-6-Methylpyridine (8)2,4-Dichloro-6-Methylpyrimidine (7)2,4-Dichlorobenzaldehyde (8)2,4-Dichlorobenzonitrile (4)2,4-Dichloropyridine (50)2,4-Dichloroquinazoline (19)2,4-Dichlorothiazole (4)2,5-Dichlorophenol (7)2,5-Dichloropyrazine (4)2,5-Dichloropyridine (32)2,6-Dichloro-3-Fluoropyridine (10)2,6-Dichloro-3-Methylpyridine (5)2,6-Dichloro-3-Nitropyridine (6)2,6-Dichloro-4-Methylpyridine (5)2,6-Dichloroaniline (26)2,6-Dichlorobenzoic Acid (13)2,6-Dichlorobenzonitrile (8)2,6-Dichloronicotinonitrile (8)2,6-Dichlorophenol (16)2,6-Dichloropyrazine (14)2,6-Dichloropyridin-3-Amine (11)2,6-Dichloropyridine (49)2-(2-Chlorophenyl)Acetic Acid (24)2-(2-Chlorophenyl)Acetonitrile (16)2-(2-Chlorophenyl)Ethan-1-Ol (8)2-(2-Chlorophenyl)Pyridine (3)2-(2-Chlorophenyl)Pyrrolidine (17)2-(3-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (8)2-(3-Chlorophenyl)Acetonitrile (16)2-(4-Chlorophenoxy)Acetic Acid (3)2-(Chloromethyl)-1H-Benzo[D]Imidazole (9)2-(Chloromethyl)-3-Methylpyridine (12)2-(Chloromethyl)Furan (3)2-(Chloromethyl)Pyridine (12)2-(Chloromethyl)Pyridine 1-Oxide (4)2-(Chloromethyl)Pyrimidine (5)2-(Chloromethyl)Thiazole (5)2-Amino-3-Chlorobenzoic Acid (7)2-Amino-3-Chlorobenzonitrile (3)2-Amino-6-Chlorophenol (5)2-Bromo-1,3-Dichlorobenzene (12)2-Bromo-1,4-Dichlorobenzene (12)2-Bromo-1-Chloro-4-Methylbenzene (6)2-Bromo-4-Chloro-1-Iodobenzene (6)2-Bromo-4-Chloro-1-Methoxybenzene (7)2-Bromo-4-Chloro-1-Methylbenzene (11)2-Bromo-4-Chloroaniline (15)2-Bromo-4-Chlorophenol (11)2-Bromo-6-Chloroaniline (10)2-Bromo-6-Chlorophenol (5)2-Chloro-1,1'-Biphenyl (8)2-Chloro-1,3,5-Triazine (10)2-Chloro-1,3-Difluorobenzene (27)2-Chloro-1,3-Dimethoxybenzene (3)2-Chloro-1,3-Dinitrobenzene (2)2-Chloro-1,4-Difluorobenzene (25)2-Chloro-1,4-Dimethoxybenzene (4)2-Chloro-1-Fluoro-4-Nitrobenzene (16)2-Chloro-1-Methyl-3-Nitrobenzene (4)2-Chloro-1-Phenylethan-1-One (20)2-Chloro-1H-Benzo[D]Imidazole (17)2-Chloro-3,6-Dimethylpyridine (4)2-Chloro-3-(Trifluoromethyl)Aniline (3)2-Chloro-3-(Trifluoromethyl)Pyridine (12)2-Chloro-3-Fluoropyridin-4-Amine (3)2-Chloro-3-Hydroxybenzaldehyde (4)2-Chloro-3-Methoxypyridine (12)2-Chloro-3-Methylaniline (4)2-Chloro-3-Methylbenzoic Acid (4)2-Chloro-3-Methylbenzonitrile (5)2-Chloro-3-Methylpyrazine (7)2-Chloro-3-Methylpyridine (17)2-Chloro-3-Nitropyridine (10)2-Chloro-4,6-Dimethylpyridine (7)2-Chloro-4-(Trifluoromethyl)Pyridine (9)2-Chloro-4-Ethoxypyridine (5)2-Chloro-4-Fluoro-1-Nitrobenzene (13)2-Chloro-4-Fluoroaniline (19)2-Chloro-4-Fluoropyridine (10)2-Chloro-4-Methoxypyridine (22)2-Chloro-4-Methyl-1-Nitrobenzene (6)2-Chloro-4-Methylaniline (7)2-Chloro-4-Methylbenzoic Acid (3)2-Chloro-4-Methylpyridine (31)2-Chloro-4-Methylpyrimidine (16)2-Chloro-4-Methylthiazole (5)2-Chloro-4-Phenylpyrimidine (7)2-Chloro-5-(Trifluoromethyl)Pyridine (4)2-Chloro-5-Fluoropyridin-4-Amine (3)2-Chloro-5-Fluoropyridine (16)2-Chloro-5-Methoxyaniline (8)2-Chloro-5-Methylpyridine (11)2-Chloro-5-Methylpyrimidine (5)2-Chloro-5-Methylthiazole (5)2-Chloro-5-Nitropyridine (8)2-Chloro-6-(Trifluoromethyl)Aniline (4)2-Chloro-6-(Trifluoromethyl)Pyridine (16)2-Chloro-6-Fluoroaniline (8)2-Chloro-6-Fluorophenol (5)2-Chloro-6-Fluoropyridine (14)2-Chloro-6-Iodophenol (3)2-Chloro-6-Methoxyaniline (3)2-Chloro-6-Methoxyphenol (4)2-Chloro-6-Methoxypyridine (24)2-Chloro-6-Methyl-3-Nitropyridine (4)2-Chloro-6-Methylaniline (11)2-Chloro-6-Methylnicotinonitrile (10)2-Chloro-6-Methylphenol (5)2-Chloro-6-Methylpyrazine (12)2-Chloro-6-Methylpyridine (49)2-Chloro-6-Nitroaniline (11)2-Chloro-7H-Purine (3)2-Chloro-7H-Pyrrolo[2,3-D]Pyrimidine (13)2-Chloro-9H-Purine (5)2-Chloro-N-Phenylacetamide (26)2-Chloro-N-Phenylaniline (8)2-Chloroaniline (213)2-Chlorobenzamide (16)2-Chlorobenzene-1,3-Diamine (3)2-Chlorobenzene-1,3-Diol (4)2-Chlorobenzene-1,4-Diamine (6)2-Chlorobenzenesulfonyl Chloride (24)2-Chlorobenzenethiol (7)2-Chlorobenzo[D]Oxazole (11)2-Chlorobenzo[D]Thiazole (21)2-Chlorobenzoic Acid (130)2-Chlorobenzonitrile (99)2-Chlorobenzoyl Chloride (13)2-Chlorocyclohexa-2,5-Diene-1,4-Dione (4)2-Chlorofuran (3)2-Chloroisonicotinaldehyde (19)2-Chloroisonicotinic Acid (17)2-Chloroisonicotinonitrile (7)2-Chloronaphthalene (6)2-Chloronicotinic Acid (7)2-Chloronicotinonitrile (9)2-Chlorooxazole (7)2-Chlorophenol (163)2-Chloropyrazine (24)2-Chloropyridin-3-Amine (11)2-Chloropyridin-3-Ol (9)2-Chloropyridin-4-Amine (28)2-Chloropyridine 1-Oxide (10)2-Chloroquinoxaline (39)2-Chlorothiazole (32)2-Chlorothiophene (20)3,4-Dichloroaniline (21)3,5-Dichloropyridine (16)3,6-Dichloropyridazine (20)3-(3-Chlorophenyl)Propanoic Acid (11)3-(Chloromethyl)Pyridine (22)3-Chloro-1,1'-Biphenyl (12)3-Chloro-1-Methyl-1H-Pyrazole (7)3-Chloro-1-Phenylpropan-1-One (10)3-Chloro-1H-Indazole (13)3-Chloro-2-Fluoroaniline (9)3-Chloro-2-Fluorobenzaldehyde (9)3-Chloro-2-Fluorobenzoic Acid (9)3-Chloro-2-Fluorobenzonitrile (7)3-Chloro-2-Fluoropyridine (13)3-Chloro-2-Hydroxybenzaldehyde (5)3-Chloro-2-Methoxypyridine (16)3-Chloro-2-Methylaniline (11)3-Chloro-2-Methylpyridine (4)3-Chloro-2-Nitroaniline (5)3-Chloro-4-(Trifluoromethyl)Aniline (5)3-Chloro-4-Fluoroaniline (18)3-Chloro-4-Fluorobenzoic Acid (8)3-Chloro-4-Hydroxybenzaldehyde (7)3-Chloro-4-Methylaniline (12)3-Chloro-4-Methylpyridazine (7)3-Chloro-4-Nitroaniline (5)3-Chloro-5-Fluoropyridine (10)3-Chloro-5-Methylpyridine (7)3-Chloro-5-Nitropyridine (5)3-Chloro-9H-Carbazole (3)3-Chlorobenzaldehyde (106)3-Chlorobenzene-1,2-Diamine (6)3-Chlorobenzene-1,2-Diol (6)3-Chlorobenzenesulfonyl Chloride (21)3-Chlorobenzo[B]Thiophene (6)3-Chlorobenzoic Acid (144)3-Chlorobenzonitrile (100)3-Chloroimidazo[1,2-A]Pyridine (3)3-Chloroisoquinoline (20)3-Chlorophenol (112)3-Chloropicolinic Acid (9)3-Chloropicolinonitrile (6)3-Chloropyridazine (45)3-Chloropyridin-2-Amine (17)3-Chloropyridin-2-Ol (10)3-Chlorothiophene (17)4,5-Dichloropyrimidine (7)4,6-Dichloro-2-Methylpyrimidine (7)4,6-Dichloropyridin-2-Amine (6)4,6-Dichloropyridin-3-Amine (4)4,6-Dichloropyrimidine (14)4-Chloro-1,5-Naphthyridine (6)4-Chloro-1-Phenylbutan-1-One (8)4-Chloro-1H-Indazole (18)4-Chloro-1H-Indole (21)4-Chloro-1H-Pyrazole (10)4-Chloro-1H-Pyrazolo[3,4-B]Pyridine (5)4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine (5)4-Chloro-1H-Pyrazolo[4,3-C]Pyridine (7)4-Chloro-1H-Pyrrolo[3,2-C]Pyridine (10)4-Chloro-2,6-Dimethylpyridine (4)4-Chloro-2-Methoxypyridine (6)4-Chloro-2-Phenylpyrimidine (5)4-Chloro-3-Fluoroaniline (17)4-Chloro-3-Methylaniline (11)4-Chloro-3-Methylpyridine (7)4-Chloro-5-Methylpyrimidine (8)4-Chloro-N-Phenylaniline (6)4-Chlorobenzene-1,3-Diol (6)4-Chlorobenzenesulfonic Acid (4)4-Chlorobenzenesulfonyl Chloride (12)4-Chlorobenzo[D]Thiazole (7)4-Chloroindoline-2,3-Dione (6)4-Chloroisoquinoline (11)4-Chloronicotinic Acid (4)4-Chloropyridazine (16)4-Chloropyridin-2-Amine (6)4-Chloropyridine (31)4-Chloroquinazoline (39)5,6-Dichloro-1H-Benzo[D]Imidazole (4)5,6-Dichloropyridin-2-Amine (4)5-Bromo-4-Chloropyrimidine (4)5-Chloro-1,2,3,4-Tetrahydroisoquinoline (3)5-Chloro-1H-Imidazole (2)5-Chloro-1H-Indazole (8)5-Chloro-1H-Indole (61)5-Chloro-1H-Indole-2-Carboxylic Acid (6)5-Chloro-1H-Pyrazole (8)5-Chloro-1H-Pyrazolo[4,3-B]Pyridine (6)5-Chloro-1H-Pyrrolo[2,3-B]Pyridine (12)5-Chloro-1H-Pyrrolo[3,2-B]Pyridine (6)5-Chloro-2,3-Dihydrobenzofuran (5)5-Chloro-2-Fluoropyridine (13)5-Chloro-2-Methoxypyridine (10)5-Chloro-2-Methylpyridine (10)5-Chlorobenzo[B]Thiophene (4)5-Chlorobenzo[D]Oxazole (5)5-Chlorobenzo[D]Thiazole (5)5-Chloroimidazo[1,2-A]Pyridine (3)5-Chloroindolin-2-One (3)5-Chloroisoquinoline (6)5-Chloropicolinic Acid (7)5-Chloropicolinonitrile (6)5-Chloropyrazolo[1,5-A]Pyrimidine (24)5-Chloropyridin-2-Amine (26)5-Chloropyridin-2-Ol (15)5-Chloropyridin-3-Amine (7)5-Chloropyrimidine (8)5-Chloroquinazoline (4)6-Chloro-1,2,3,4-Tetrahydroisoquinoline (3)6-Chloro-1,2,3,4-Tetrahydroquinoline (3)6-Chloro-1H-Benzo[D]Imidazole (25)6-Chloro-1H-Indazole (13)6-Chloro-1H-Indole (19)6-Chloro-1H-Pyrazolo[4,3-C]Pyridine (8)6-Chloro-1H-Pyrrolo[2,3-B]Pyridine (13)6-Chloro-1H-Pyrrolo[3,2-C]Pyridine (11)6-Chloro-2,3-Dihydrobenzofuran (3)6-Chloro-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (5)6-Chloro-3-Nitropyridin-2-Amine (4)6-Chloro-5-(Trifluoromethyl)Pyridin-2-Amine (3)6-Chlorobenzo[D]Oxazole (4)6-Chlorobenzo[D]Thiazole (6)6-Chlorochroman-4-One (6)6-Chlorochromane (6)6-Chloroindoline (3)6-Chloroindoline-2,3-Dione (5)6-Chloronicotinaldehyde (24)6-Chloronicotinic Acid (4)6-Chloropicolinic Acid (12)6-Chloropicolinonitrile (9)6-Chloropyridazin-3(2H)-One (5)6-Chloropyridin-2-Amine (21)6-Chloropyridin-2-Ol (9)6-Chloropyridin-3-Amine (4)6-Chloropyridine-3-Sulfonyl Chloride (5)6-Chloroquinoxaline (3)7-Chloro-1,2,3,4-Tetrahydroisoquinoline (5)7-Chloro-1H-Indazole (7)7-Chloro-1H-Indole (29)7-Chloro-1H-Pyrrolo[2,3-C]Pyridine (5)7-Chloro-2,3-Dihydrobenzofuran (3)7-Chloro-3,4-Dihydronaphthalen-1(2H)-One (6)7-Chlorobenzo[D]Thiazole (6)7-Chlorochromane (4)7-Chloroisoquinoline (6)7-Chloropyrazolo[1,5-A]Pyrimidine (8)8-Chlorochromane (5)8-Chloroimidazo[1,2-A]Pyridine (7)8-Chloroisoquinoline (7)8-Chloroquinazoline (5)Ethyl 4,6-Dichloronicotinate (4)Ethyl 5-Chloro-1H-Indole-2-Carboxylate (5)Ethyl 6-Chloropicolinate (7)Ethyl 7-Chloro-1H-Indole-2-Carboxylate (5)Methyl 2,6-Dichlorobenzoate (7)Methyl 2-Chloro-4-Fluorobenzoate (5)Methyl 2-Chloro-6-Fluorobenzoate (7)Methyl 2-Chlorobenzoate (79)Methyl 2-Chloroisonicotinate (11)Methyl 2-Chloronicotinate (6)Methyl 3-Chlorobenzoate (88)Methyl 3-Chloropicolinate (9)Methyl 6-Chloropicolinate (11)N-(2-Chlorophenyl)Acetamide (16)N-(3-Chlorophenyl)Benzenesulfonamide (6)N-(3-Chlorophenyl)Quinazolin-4-Amine (10)N-(4-Chlorophenyl)Acetamide (9)Phenyl Carbonochloridate (5)Pyridine-2-Sulfonyl Chloride (9)Pyridine-3-Sulfonyl Chloride (25)Tert-Butyl (2-Chloropyridin-4-Yl)Carbamate (4)Acyl Chlorides (88)Alcohols (150)Aldehydes (88)Aliphatic Chain Hydrocarbons (137)Aliphatic Cyclic Hydrocarbons (19)Alkenyls (55)Alkynyls (18)Amides (371)Amidines (9)Amines (308)Anhydrides (8)Aryls (1041)Azetidines (10)Benzimidazoles (15)Benzofurans (14)Benzothiazoles (6)Benzoxazoles (11)Benzyl Bromides (6)Benzyl Chlorides (49)Bromides (241)Carboxylic Acids (172)Difluoromethyls (22)Esters (294)Ethers (285)Fluorinated Building Blocks (224)Furans (9)Hydrazides (15)Hydrazines (26)Hydrazones (4)Imidazoles (15)Indazoles (9)Indoles (26)Indolines (14)Iodides (51)Isoquinolines (14)Isoxazoles (19)Ketones (139)Morpholines (24)Nitriles (97)Nitroes (81)Oxazoles (14)Oximes (7)Phenols (26)Piperazines (21)Piperidines (67)Purines (6)Pyrazines (31)Pyrazoles (26)Pyridazines (32)Pyridines (372)Pyrimidines (209)Pyrroles (13)Pyrrolidines (49)Quinazolines (20)Quinolines (110)Quinoxalines (9)Spiroes (3)Sulfamides (50)Sulfides (50)Sulfones (29)Sulfoxides (7)Tetrahydrofurans (3)Tetrahydroisoquinolines (4)Tetrahydropyrans (5)Thiadiazoles (4)Thiazoles (29)Thiophenes (49)Triazines (13)Trifluoromethyls (61)Ureas (7)Other Aliphatic Heterocycles (3)Other Aromatic Heterocycles (147)Chloroacetamide (17)Chloroacetyl (10)Chloroaniline (18)Chlorobenzaldehyde (18)Chlorobenzamide (12)Chlorobutyl (6)Chlorocarbonyl (7)Chloroethoxy (10)Chloroethyl (88)Chloromethyl (477)Chloropicolinaldehyde (8)Chloropicolinamide (5)Chloropropane (13)Chloropropoxy (2)Chloropropyl (23)Dichloride (27)Dichloroaniline (9)Dichloroanthracene (3)Dichlorobenzaldehyde (13)Dichlorobenzamide (8)Dichloroisonicotinaldehyde (4)Dichloromethyl (3)Dichloronicotinaldehyde (6)Dichloronicotinic (6)Dichloronicotinic Acid (5)Dichloropalladium (3)Tetrachloro (2)Trichloro (36)Trichloroacetimidate (5)Trichloroaniline (6)Trichlorobenzaldehyde (4)Trichloromethyl (11)

(2R,3S)-2-((Benzoyloxy)Methyl)Tetrahydrofuran-3-Yl Benzoate (8)(9H-Fluoren-9-Yl)Methyl (3-Phenylpropyl)Carbamate (24)1,3-Dioxoisoindolin-2-Yl 2-Phenylacetate (5)1-Benzyl 2-Methyl Pyrrolidine-1,2-Dicarboxylate (7)1-Benzyl 3-Methyl Piperidine-1,3-Dicarboxylate (3)1-Benzyl 4-(Tert-Butyl) Piperazine-1,4-Dicarboxylate (10)1H-Indol-3-Yl Acetate (4)2,5-Dioxopyrrolidin-1-Yl Benzoate (8)2-((Tert-Butoxycarbonyl)Amino)Benzoic Acid (11)2-(Diethylamino)Ethyl Benzoate (3)2-Ethylhexyl Benzoate (12)2-Hydroxyethyl Benzoate (3)2-Phenoxyacetyl Chloride (3)4-Cyanophenyl Benzoate (11)Allyl Benzoate (5)Azetidin-3-Yl Acetate (3)Benzoic Anhydride (6)Benzyl Acetate (11)Benzyl Benzoate (12)Benzyl Benzylcarbamate (14)Benzyl Cyclohexylcarbamate (9)Benzyl Morpholine-4-Carboxylate (5)Benzyl Phenylcarbamate (15)Benzyl Piperidine-1-Carboxylate (50)Butyl Benzoate (9)Dimethyl Isophthalate (32)Dimethyl Phthalate (14)Dimethyl Pyridine-2,6-Dicarboxylate (7)Ethane-1,2-Diyl Dibenzoate (11)Ethyl 1-Phenyl-1H-Pyrazole-3-Carboxylate (3)Ethyl 1-Phenyl-1H-Pyrazole-4-Carboxylate (13)Ethyl 1-Phenylcyclopropane-1-Carboxylate (4)Ethyl 1H-1,2,4-Triazole-3-Carboxylate (3)Ethyl 1H-Imidazole-2-Carboxylate (6)Ethyl 1H-Pyrazole-4-Carboxylate (11)Ethyl 1H-Pyrrole-2-Carboxylate (24)Ethyl 1H-Pyrrole-3-Carboxylate (8)Ethyl 2-(Imidazo[1,2-A]Pyridin-3-Yl)Acetate (3)Ethyl 2-(Pyridin-2-Yl)Acetate (15)Ethyl 2-Aminobenzoate (23)Ethyl 2-Aminothiazole-4-Carboxylate (6)Ethyl 2-Aminothiazole-5-Carboxylate (5)Ethyl 2-Bromo-2-Phenylacetate (6)Ethyl 2-Fluorobenzoate (37)Ethyl 2-Hydroxybenzoate (18)Ethyl 2-Iodobenzoate (4)Ethyl 2-Methylbenzoate (26)Ethyl 2-Methylnicotinate (6)Ethyl 2-Nitrobenzoate (9)Ethyl 2-Oxo-2-(Phenylamino)Acetate (8)Ethyl 2-Oxo-2-Phenylacetate (18)Ethyl 2-Oxo-2H-Chromene-3-Carboxylate (5)Ethyl 2-Phenoxyacetate (10)Ethyl 2-Phenylacetate (60)Ethyl 2-Phenylcyclopropane-1-Carboxylate (5)Ethyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate (6)Ethyl 3-Aminobenzoate (19)Ethyl 3-Fluorobenzoate (34)Ethyl 3-Hydroxybenzoate (11)Ethyl 3-Iodobenzoate (11)Ethyl 3-Nitrobenzoate (22)Ethyl 3-Oxo-3-Phenylpropanoate (41)Ethyl 3-Phenylpropanoate (17)Ethyl 4-Aminobenzoate (22)Ethyl 4-Chloropyrimidine-5-Carboxylate (5)Ethyl 5-Fluoro-1H-Indole-2-Carboxylate (5)Ethyl 6-Chloro-1H-Indole-2-Carboxylate (5)Ethyl Benzo[B]Thiophene-2-Carboxylate (9)Ethyl Cinnamate (25)Ethyl Cyclohex-1-Ene-1-Carboxylate (5)Ethyl Cyclohexanecarboxylate (33)Ethyl Cyclopropanecarboxylate (8)Ethyl Furan-2-Carboxylate (6)Ethyl Imidazo[1,2-A]Pyridine-2-Carboxylate (26)Ethyl Imidazo[1,2-A]Pyridine-3-Carboxylate (13)Ethyl Isonicotinate (12)Ethyl Isoxazole-3-Carboxylate (8)Ethyl Isoxazole-4-Carboxylate (5)Ethyl Morpholine-2-Carboxylate (4)Ethyl Nicotinate (25)Ethyl Oxazole-4-Carboxylate (8)Ethyl Oxazole-5-Carboxylate (3)Ethyl Oxirane-2-Carboxylate (4)Ethyl Picolinate (41)Ethyl Piperidine-2-Carboxylate (8)Ethyl Piperidine-3-Carboxylate (14)Ethyl Piperidine-4-Carboxylate (10)Ethyl Pyrazine-2-Carboxylate (10)Ethyl Pyridazine-3-Carboxylate (6)Ethyl Pyrimidine-4-Carboxylate (7)Ethyl Pyrimidine-5-Carboxylate (5)Ethyl Quinazoline-2-Carboxylate (4)Ethyl Thiazole-2-Carboxylate (7)Ethyl Thiazole-4-Carboxylate (7)Ethyl Thiazole-5-Carboxylate (7)Ethyl Thiophene-2-Carboxylate (19)Ethyl Thiophene-3-Carboxylate (11)Hexyl Benzoate (4)Isobutyl Benzoate (10)Isopropyl Benzoate (10)Methyl 1-Naphthoate (7)Methyl 1H-Benzo[D]Imidazole-2-Carboxylate (3)Methyl 1H-Imidazole-2-Carboxylate (4)Methyl 1H-Imidazole-5-Carboxylate (8)Methyl 1H-Indazole-4-Carboxylate (10)Methyl 1H-Indazole-5-Carboxylate (3)Methyl 1H-Indazole-6-Carboxylate (9)Methyl 1H-Indazole-7-Carboxylate (8)Methyl 1H-Indole-4-Carboxylate (9)Methyl 1H-Indole-5-Carboxylate (7)Methyl 1H-Indole-6-Carboxylate (9)Methyl 1H-Indole-7-Carboxylate (7)Methyl 1H-Pyrazole-4-Carboxylate (10)Methyl 1H-Pyrrole-2-Carboxylate (30)Methyl 1H-Pyrrole-3-Carboxylate (5)Methyl 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylate (3)Methyl 1H-Pyrrolo[2,3-B]Pyridine-6-Carboxylate (3)Methyl 2,6-Dichlorobenzoate (7)Methyl 2,6-Difluorobenzoate (17)Methyl 2-(1H-Indol-3-Yl)Acetate (3)Methyl 2-(2-Bromophenyl)Acetate (8)Methyl 2-(4-Hydroxyphenyl)Acetate (10)Methyl 2-(Bromomethyl)Benzoate (33)Methyl 2-(Chlorosulfonyl)Benzoate (7)Methyl 2-(Morpholin-3-Yl)Acetate (3)Methyl 2-(Pyridin-2-Yl)Acetate (9)Methyl 2-(Trifluoromethyl)Benzoate (14)Methyl 2-Amino-2-Phenylacetate (38)Methyl 2-Aminobenzoate (95)Methyl 2-Aminothiazole-4-Carboxylate (6)Methyl 2-Bromo-2-Phenylacetate (7)Methyl 2-Bromo-3-Nitrobenzoate (3)Methyl 2-Bromo-5-Fluorobenzoate (8)Methyl 2-Bromo-6-Fluorobenzoate (7)Methyl 2-Bromo-6-Methylbenzoate (8)Methyl 2-Bromobenzoate (69)Methyl 2-Chloro-4-Fluorobenzoate (5)Methyl 2-Chloro-6-Fluorobenzoate (7)Methyl 2-Chlorobenzoate (79)Methyl 2-Cyanobenzoate (22)Methyl 2-Fluorobenzoate (132)Methyl 2-Hydroxybenzoate (74)Methyl 2-Iodobenzoate (28)Methyl 2-Methoxybenzoate (70)Methyl 2-Methyl-2H-Indazole-3-Carboxylate (3)Methyl 2-Methylbenzoate (101)Methyl 2-Naphthoate (11)Methyl 2-Nitrobenzoate (54)Methyl 2-Phenoxyacetate (12)Methyl 2-Phenoxybenzoate (4)Methyl 2-Phenylacetate (114)Methyl 3-(Benzyloxy)Benzoate (5)Methyl 3-(Bromomethyl)Benzoate (16)Methyl 3-(Trifluoromethyl)Benzoate (22)Methyl 3-Amino-3-Phenylpropanoate (27)Methyl 3-Aminobenzoate (88)Methyl 3-Bromo-4-Chlorobenzoate (6)Methyl 3-Bromo-4-Fluorobenzoate (7)Methyl 3-Bromo-4-Methoxybenzoate (10)Methyl 3-Bromo-4-Methylbenzoate (9)Methyl 3-Bromobenzoate (153)Methyl 3-Bromopyrazine-2-Carboxylate (5)Methyl 3-Chlorobenzoate (88)Methyl 3-Cyanobenzoate (29)Methyl 3-Fluorobenzoate (136)Methyl 3-Formylbenzoate (23)Methyl 3-Hydroxybenzoate (57)Methyl 3-Iodo-4-Methylbenzoate (6)Methyl 3-Iodobenzoate (47)Methyl 3-Methoxybenzoate (71)Methyl 3-Methylbenzoate (75)Methyl 3-Nitrobenzoate (109)Methyl 3-Oxo-3-Phenylpropanoate (16)Methyl 3-Phenylpropanoate (28)Methyl 4-Amino-3-Bromobenzoate (8)Methyl 4-Amino-3-Iodobenzoate (7)Methyl 4-Amino-3-Nitrobenzoate (9)Methyl 4-Aminobenzoate (71)Methyl 4-Fluorobenzoate (75)Methyl 4-Nitrobenzoate (29)Methyl 4-Oxocyclohexane-1-Carboxylate (5)Methyl 4-Oxopiperidine-2-Carboxylate (3)Methyl 4-Phenoxybenzoate (3)Methyl 5-Amino-2-Bromobenzoate (6)Methyl 5-Hydroxypicolinate (5)Methyl 5-Oxopyrrolidine-2-Carboxylate (3)Methyl 5-Phenylisoxazole-3-Carboxylate (6)Methyl 6-Bromopyrazine-2-Carboxylate (7)Methyl 6-Chloropyrazine-2-Carboxylate (5)Methyl 6-Methoxynicotinate (4)Methyl [1,1'-Biphenyl]-4-Carboxylate (7)Methyl Azetidine-2-Carboxylate (3)Methyl Benzo[B]Thiophene-2-Carboxylate (27)Methyl Benzo[D]Oxazole-2-Carboxylate (3)Methyl Benzo[D]Thiazole-6-Carboxylate (5)Methyl Bicyclo[1.1.1]Pentane-1-Carboxylate (10)Methyl Cinnamate (37)Methyl Cyclobutanecarboxylate (24)Methyl Cyclohex-3-Ene-1-Carboxylate (3)Methyl Cyclohexanecarboxylate (45)Methyl Cyclopentanecarboxylate (18)Methyl Cyclopropanecarboxylate (8)Methyl Furan-2-Carboxylate (20)Methyl Imidazo[1,2-A]Pyridine-8-Carboxylate (3)Methyl Indoline-6-Carboxylate (3)Methyl Isonicotinate (16)Methyl Isoquinoline-4-Carboxylate (6)Methyl Morpholine-2-Carboxylate (4)Methyl Morpholine-3-Carboxylate (10)Methyl Nicotinate (52)Methyl Oxazole-4-Carboxylate (9)Methyl Piperidine-2-Carboxylate (12)Methyl Piperidine-3-Carboxylate (19)Methyl Prolinate (43)Methyl Pyrazine-2-Carboxylate (19)Methyl Pyridazine-3-Carboxylate (7)Methyl Pyrimidine-2-Carboxylate (10)Methyl Pyrimidine-4-Carboxylate (11)Methyl Pyrimidine-5-Carboxylate (5)Methyl Pyrrolidine-3-Carboxylate (9)Methyl Thiazole-2-Carboxylate (6)Methyl Thiazole-4-Carboxylate (6)Methyl Thiophene-3-Carboxylate (35)Phenyl (1R,4R)-[1,1'-Bi(Cyclohexane)]-4-Carboxylate (6)Phenyl Dimethylcarbamate (5)Phenyl Ethyl(Methyl)Carbamate (5)Propyl Benzoate (11)Tert-Butyl (1-Phenylethyl)Carbamate (19)Tert-Butyl (2,3-Dihydro-1H-Inden-1-Yl)Carbamate (3)Tert-Butyl (2-Phenylcyclopropyl)Carbamate (4)Tert-Butyl (3-Oxocyclohexyl)Carbamate (3)Tert-Butyl (Morpholin-2-Ylmethyl)Carbamate (3)Tert-Butyl (Tetrahydrofuran-3-Yl)Carbamate (4)Tert-Butyl 1H-Benzo[D]Imidazole-1-Carboxylate (3)Tert-Butyl 1H-Imidazole-1-Carboxylate (6)Tert-Butyl 1H-Indazole-1-Carboxylate (29)Tert-Butyl 1H-Indole-1-Carboxylate (18)Tert-Butyl 1H-Pyrrole-1-Carboxylate (8)Tert-Butyl 1H-Pyrrole-2-Carboxylate (3)Tert-Butyl 1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate (9)Tert-Butyl 3,4-Dihydroisoquinoline-2(1H)-Carboxylate (19)Tert-Butyl 3-((Methylsulfonyl)Oxy)Pyrrolidine-1-Carboxylate (5)Tert-Butyl 3-Oxopiperazine-1-Carboxylate (7)Tert-Butyl 4-Phenylpiperidine-1-Carboxylate (16)Tert-Butyl Azetidine-1-Carboxylate (64)Tert-Butyl Benzoate (66)Tert-Butyl Benzylcarbamate (52)Tert-Butyl Bicyclo[1.1.1]Pentan-1-Ylcarbamate (5)Tert-Butyl Cyclopentylcarbamate (28)Tert-Butyl Isoindoline-2-Carboxylate (13)Tert-Butyl Methyl(Phenyl)Carbamate (9)Tert-Butyl Morpholine-4-Carboxylate (23)Tert-Butyl O-Tolylcarbamate (11)Tert-Butyl Phenethylcarbamate (1)Tert-Butyl Piperazine-1-Carboxylate (30)Tert-Butyl Pyrrolidine-1-Carboxylate (21)Acyl Chlorides (22)Alcohols (236)Aldehydes (47)Aliphatic Chain Hydrocarbons (447)Aliphatic Cyclic Hydrocarbons (109)Alkenyls (243)Alkynyls (19)Amides (300)Amines (299)Anhydrides (81)Aryls (876)Azetidines (11)Benzimidazoles (12)Benzofurans (33)Benzothiazoles (5)Benzothiophenes (8)Benzoxazoles (4)Benzyl Bromides (14)Benzyl Chlorides (10)Bromides (313)Carboxylic Acid Salts (3)Carboxylic Acids (73)Chlorides (294)Difluoromethyls (6)Dioxolanes (7)Epoxides (9)Ethers (266)Fluorinated Building Blocks (189)Furans (21)Hydrazines (7)Imidazoles (34)Indazoles (8)Indoles (56)Indolines (9)Iodides (30)Isoquinolines (7)Isoxazoles (11)Ketones (316)Morpholines (31)Nitriles (100)Nitroes (72)Oxazoles (18)Oxazolidines (7)Oxazolines (6)Oxetanes (10)Oximes (5)Phenols (27)Phosphoruses (5)Piperazines (33)Piperidines (67)Pyrans (5)Pyrazines (9)Pyrazoles (29)Pyridazines (11)Pyridines (230)Pyrimidines (63)Pyrroles (21)Pyrrolidines (32)Pyrrolines (2)Quinazolines (5)Quinolines (73)Quinuclidines (3)Spiroes (18)Sulfamides (23)Sulfides (27)Sulfones (16)Tetrahydrofurans (22)Tetrahydropyrans (25)Tetrazoles (5)Thiadiazoles (4)Thiazoles (70)Thiols (9)Thiophenes (69)Triazoles (9)Trifluoromethyls (70)Other Aliphatic Heterocycles (69)Other Aromatic Heterocycles (141)Acetoxymethyl (85)Acetoxyphenyl (1)Acetyloxy (54)Acrylate (118)Acryloyloxy (3)Adipate (17)Aminobenzoate (17)Aminobenzylcarbamate (8)Aminobutanoate (14)Aminocyclobutanecarboxylic Acid (4)Aminocyclohexanecarboxylic (16)Aminocyclohexanecarboxylic Acid (10)Aminocyclopentanecarboxylic (13)Aminoheptanoate (9)Aminohexanoate (6)Aminoisonicotinate (4)Aminoisophthalate (5)Aminonicotinate (7)Aminopentanedioate (15)Aminopentanoate (7)Aminopropanoate (16)Benzoyloxy (14)Benzylcarbamate (8)Bromobenzoate (26)Bromobutanoate (10)Bromodecanoate (20)Bromoisonicotinate (8)Bromoisophthalate (3)Bromonicotinate (13)Bromopropanoate (9)Bromoundecanoate (3)Butoxycarbonyl (1434)Carbamate (1489)Chlorobenzoate (49)Chloroformate (4)Chloropicolinate (30)Chloropropanoate (5)Cyanoacrylate (5)Decanedioate (9)Decanoate (7)Diacetate (49)Diacetoxy (1)Diacrylate (15)Diaminobenzoate (7)Dibromobenzoate (4)Dicarbamate (14)Dichlorobenzoate (24)Dichloroisonicotinate (9)Diethylcarbamodithioate (1)Dimethacrylate (1)Dimethylbutanoate (14)Dimethylcarbamate (3)Dimethylnicotinate (10)Dipropanoate (6)Diyldicarbamate (5)Dodecanoate (11)Enecarboxylate (9)Enoate (115)Ethoxycarbonyl (68)Ethylbutanoate (6)Ethynylbenzoate (7)Ethynylbenzylcarbamate (3)Glutarate (3)Hexanoate (14)Iodoacrylate (6)Iodobutanoate (4)Iodopropanoate (1)Isobutyrate (18)Methacrylate (87)Methacryloyloxy (7)Methoxycarbonyl (168)Methoxyisonicotinate (11)Methoxynicotinate (24)Methoxypropanoate (5)Methylacrylate (13)Methylbutanoate (38)Methylmalonate (6)Methylnicotinate (57)Methylpentanoate (17)Methylpropanoate (45)Nitropicolinate (13)Nonanedioate (4)Oxoacetate (21)Oxobutanoate (55)Oxoheptanoate (8)Oxohexanoate (14)Oxopentanoate (30)Oxopropanoate (39)Pentanoate (13)Phenylacrylate (5)Phenylpropanoate (30)Propanoate (265)Propylpentanoate (5)Succinate (22)Sulfamoylbenzoate (6)Tetraacetate (7)Tetradecanoate (10)Tosylcarbamate (4)Tosyloxy (12)Triacetate (12)Vinylbenzoate (3)Vinylcyclopropanecarboxylic Acid (3)

(1S,4Ar,7Ar)-1-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-1,4A,5,7A-Tetrahydrocyclopenta[C]Pyran (3)(2,2,2-Trifluoroethoxy)Benzene (18)(2-(Benzyloxy)Phenyl)Boronic Acid (23)(2-(Phenoxymethyl)Phenyl)Boronic Acid (3)(2-Chloro-3-Methoxyphenyl)Boronic Acid (5)(2-Chloroethoxy)Benzene (5)(2-Methoxyethoxy)Benzene (32)(3-(Benzyloxy)Phenyl)Boronic Acid (9)(3-(Phenoxymethyl)Phenyl)Boronic Acid (3)(3-Chloro-2-Methoxyphenyl)Boronic Acid (4)(3-Phenoxyphenyl)Methanol (3)(4-(Benzyloxy)Phenyl)Boronic Acid (26)(4-(Phenoxymethyl)Phenyl)Boronic Acid (6)(4-Methoxyphenyl)(Phenyl)Methanone (7)(9H-Fluoren-9-Yl)Methyl (2-(Benzyloxy)Ethyl)Carbamate (6)(9H-Fluoren-9-Yl)Methyl (4-Methoxybenzyl)Carbamate (7)(Allyloxy)Benzene (17)(Ethoxymethyl)Benzene (7)(Hexyloxy)Benzene (7)(Methoxymethyl)Benzene (30)(Prop-2-Yn-1-Yloxy)Benzene (12)(R)-2-Phenoxytetrahydro-2H-Pyran (7)(S)-7-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-7,8,9,10-Tetrahydrotetracene-5,12-Dione (5)1,2-Bis(Benzyloxy)Benzene (11)1,2-Dichloro-3-Methoxybenzene (7)1,2-Dichloro-4-Methoxybenzene (11)1,2-Difluoro-3-Methoxybenzene (28)1,2-Difluoro-4-Methoxybenzene (19)1,2-Dimethoxybenzene (223)1,2-Diphenoxyethane (11)1,3-Bis(Benzyloxy)Benzene (8)1,3-Dibromo-2-Methoxybenzene (11)1,3-Dichloro-2-Methoxybenzene (9)1,3-Diiodo-2-Phenoxybenzene (1)1,3-Dimethoxybenzene (238)1,3-Diphenoxybenzene (8)1,4-Dichloro-2-Methoxybenzene (8)1,4-Dimethoxybenzene (65)1-(2-Methoxyphenyl)Ethan-1-One (34)1-(3-(Benzyloxy)Phenyl)Ethan-1-One (3)1-(3-Methoxyphenyl)Ethan-1-One (37)1-(4-(Benzyloxy)Phenyl)Ethan-1-One (4)1-(4-Methoxybenzyl)-1H-Pyrazole (5)1-(Benzyloxy)-2-Bromobenzene (12)1-(Benzyloxy)-2-Chlorobenzene (16)1-(Benzyloxy)-2-Fluorobenzene (10)1-(Benzyloxy)-2-Methoxybenzene (19)1-(Benzyloxy)-2-Methylbenzene (12)1-(Benzyloxy)-2-Nitrobenzene (3)1-(Benzyloxy)-3-Bromobenzene (12)1-(Benzyloxy)-3-Chlorobenzene (6)1-(Benzyloxy)-3-Fluorobenzene (14)1-(Benzyloxy)-3-Methylbenzene (8)1-(Benzyloxy)-3-Nitrobenzene (10)1-(Benzyloxy)-4-Bromobenzene (8)1-(Benzyloxy)-4-Iodobenzene (3)1-(Bromomethyl)-2-Methoxybenzene (14)1-(Bromomethyl)-3-Methoxybenzene (19)1-(Difluoromethoxy)-2-Fluorobenzene (11)1-Benzyl-4-Methoxybenzene (6)1-Bromo-2,3-Dimethoxybenzene (8)1-Bromo-2-Chloro-3-Methoxybenzene (6)1-Bromo-2-Ethoxybenzene (16)1-Bromo-2-Fluoro-3-Methoxybenzene (7)1-Bromo-2-Phenoxybenzene (3)1-Bromo-3-Methoxybenzene (186)1-Bromo-3-Phenoxybenzene (8)1-Bromo-4-Phenoxybenzene (8)1-Chloro-2,4-Dimethoxybenzene (7)1-Chloro-2-Ethoxybenzene (14)1-Chloro-2-Phenoxybenzene (9)1-Chloro-2-Propoxybenzene (5)1-Chloro-3-Fluoro-2-Methoxybenzene (4)1-Chloro-3-Methoxybenzene (125)1-Chloro-3-Phenoxybenzene (5)1-Chloro-4-Methoxybenzene (98)1-Chloro-4-Phenoxybenzene (13)1-Cyclopropyl-3-(4-(Quinolin-4-Yloxy)Phenyl)Urea (6)1-Ethoxy-2,3-Difluorobenzene (9)1-Ethoxy-2-Fluorobenzene (37)1-Ethoxy-3-Nitrobenzene (7)1-Fluoro-2-(Trifluoromethoxy)Benzene (20)1-Fluoro-2-Isopropoxybenzene (18)1-Fluoro-2-Phenoxybenzene (11)1-Fluoro-3-Methoxybenzene (213)1-Fluoro-3-Phenoxybenzene (8)1-Fluoro-4-(Trifluoromethoxy)Benzene (14)1-Fluoro-4-Methoxybenzene (125)1-Fluoro-4-Phenoxybenzene (8)1-Iodo-2-Methoxybenzene (50)1-Iodo-3-Methoxybenzene (48)1-Iodo-4-Methoxybenzene (34)1-Iodo-4-Phenoxybenzene (4)1-Methoxy-2-(Trifluoromethyl)Benzene (21)1-Methoxy-3-(Trifluoromethoxy)Benzene (9)1-Methoxy-3-(Trifluoromethyl)Benzene (40)1-Methoxy-3-Nitrobenzene (108)1-Methoxy-4-(Phenoxymethyl)Benzene (3)1-Methoxy-4-(Trifluoromethyl)Benzene (18)1-Methoxy-4-Nitrobenzene (90)1-Methoxynaphthalene (18)1-Methyl-3-Phenoxybenzene (9)1-Nitro-2-Phenoxybenzene (4)1-Nitro-4-Phenoxybenzene (5)1-Phenoxy-3-(Trifluoromethyl)Benzene (2)1-Phenoxy-4-(Trifluoromethyl)Benzene (2)1-Phenyl-3-(4-(Pyridin-4-Yloxy)Phenyl)Urea (8)2,3,5,6,8,9,11,12-Octahydrobenzo[B][1,4,7,10,13]Pentaoxacyclopentadecine (8)2,3-Dimethoxypyridine (7)2,4,6-Triphenoxy-1,3,5-Triazine (4)2,4-Dibromo-1-Methoxybenzene (6)2,4-Dichloro-1-Methoxybenzene (18)2,4-Difluoro-1-Methoxybenzene (25)2,4-Dimethoxy-1-Nitrobenzene (5)2,4-Dimethoxypyrimidine (13)2,6-Dimethoxypyridine (11)2-(2-Methoxyphenyl)Acetic Acid (16)2-(3-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (5)2-(3-Methoxyphenyl)Acetic Acid (23)2-(4-(Benzyloxy)Phenyl)Acetonitrile (3)2-(4-Methoxyphenyl)Acetic Acid (21)2-(Benzyloxy)Benzaldehyde (13)2-(Benzyloxy)Naphthalene (5)2-(Benzyloxy)Phenol (5)2-(Methoxymethyl)Morpholine (4)2-(Methoxymethyl)Pyrrolidine (6)2-(Phenoxymethyl)Oxirane (11)2-(Phenoxymethyl)Pyridine (5)2-(Phenoxymethyl)Tetrahydro-2H-Pyran (5)2-Bromo-1,3-Dimethoxybenzene (7)2-Bromo-1,4-Dimethoxybenzene (10)2-Bromo-1-Fluoro-4-Methoxybenzene (12)2-Bromo-1-Methoxy-3-Methylbenzene (3)2-Bromo-1-Methoxy-4-Methylbenzene (7)2-Bromo-3-Methoxypyrazine (5)2-Bromo-4-Methoxy-1-Nitrobenzene (6)2-Bromo-4-Methoxyaniline (6)2-Bromo-4-Methoxybenzaldehyde (8)2-Bromo-4-Methoxybenzoic Acid (4)2-Bromo-5-Methoxybenzaldehyde (6)2-Bromo-6-Methoxyaniline (5)2-Bromo-6-Methoxyphenol (5)2-Chloro-1,3-Dimethoxybenzene (3)2-Chloro-1,4-Dimethoxybenzene (4)2-Chloro-3-Methoxybenzaldehyde (7)2-Chloro-3-Methoxybenzoic Acid (6)2-Chloro-4-Fluoro-1-Methoxybenzene (10)2-Chloro-4-Methoxypyrimidine (14)2-Chloro-5-Methoxyaniline (8)2-Chloro-6-Methoxyaniline (3)2-Chloro-6-Methoxyphenol (4)2-Ethoxynaphthalene (4)2-Ethoxypyridine (20)2-Ethoxypyrimidine (7)2-Fluoro-1,3-Dimethoxybenzene (8)2-Fluoro-1-Methoxy-4-Nitrobenzene (8)2-Fluoro-4-Methoxyaniline (6)2-Fluoro-5-Methoxybenzoic Acid (9)2-Fluoro-5-Methoxypyridine (4)2-Fluoro-6-Methoxypyridine (6)2-Isopropoxypyridine (16)2-Methoxy-1,1'-Biphenyl (7)2-Methoxy-1,3,5-Triazine (10)2-Methoxy-4-Methylpyridine (5)2-Methoxy-5-Methylpyridine (5)2-Methoxy-6-Methylpyridine (14)2-Methoxy-6-Nitrophenol (5)2-Methoxybenzamide (9)2-Methoxybenzenesulfonyl Chloride (15)2-Methoxynaphthalene (22)2-Methoxyphenol (196)2-Methoxypyrazine (45)2-Methoxypyridine (434)2-Methoxypyrimidin-4-Amine (6)2-Methoxypyrimidine (59)2-Methoxythiophene (7)2-Methyl-N-Phenylaniline (7)2-Phenoxyacetonitrile (11)2-Phenoxyaniline (4)2-Phenoxybenzonitrile (5)2-Phenoxyethan-1-Ol (14)2-Phenoxypropanoic Acid (13)2-Phenoxypyrimidine (8)2-Phenoxytetrahydro-2H-Pyran (6)2-Phenoxythiazole (5)2-Propoxypyridine (9)3,5-Dimethoxypyridine (4)3-(3-Methoxyphenyl)Propanoic Acid (9)3-(Benzyloxy)Aniline (12)3-(Benzyloxy)Benzaldehyde (13)3-(Benzyloxy)Benzoic Acid (5)3-(Benzyloxy)Phenol (5)3-(Methoxymethyl)Morpholine (4)3-Chloro-2-Methoxybenzoic Acid (4)3-Chloro-4-Methoxyaniline (6)3-Chloro-4-Methoxybenzaldehyde (7)3-Chloro-4-Methoxybenzoic Acid (5)3-Ethoxypyridine (12)3-Fluoro-2-Methoxypyridine (14)3-Fluoro-4-Methoxybenzoic Acid (6)3-Methoxypiperidine (7)3-Methoxypyridazine (17)3-Methoxypyridine (51)3-Methoxythiophene (9)3-Phenoxyaniline (2)3-Phenoxybenzaldehyde (6)3-Phenoxybenzoic Acid (6)3-Phenoxybenzonitrile (5)3-Phenoxypropanoic Acid (14)3-Phenoxypyrrolidine (5)4-(3-Phenoxypropyl)Morpholine (7)4-(Benzyloxy)Aniline (8)4-(Benzyloxy)Benzaldehyde (23)4-(Benzyloxy)Benzoic Acid (5)4-(Benzyloxy)Phenol (2)4-(Difluoromethoxy)Aniline (6)4-(Dimethoxymethyl)Pyrimidine (5)4-(Phenylethynyl)Phenol (7)4-Chloro-2-Methoxypyrimidine (12)4-Chloro-5-Methoxypyrimidine (7)4-Chloro-6-Methoxypyrimidine (5)4-Ethoxypyridine (7)4-Ethoxypyrimidine (6)4-Methoxy-1,1'-Biphenyl (4)4-Methoxy-1H-Indazole (7)4-Methoxy-1H-Indole (11)4-Methoxy-2-Methylpyrimidine (8)4-Methoxy-N-Phenylaniline (5)4-Methoxy-N-Phenylbenzenesulfonamide (3)4-Methoxybenzenesulfonamide (5)4-Methoxypyridazine (8)4-Methoxypyridine (136)4-Methoxypyrimidin-2-Amine (6)4-Methoxypyrimidine (102)4-Phenoxyaniline (6)4-Phenoxybenzaldehyde (12)4-Phenoxybenzoic Acid (4)4-Phenoxypyridine (7)4-Phenoxypyrimidine (5)4-Phenoxyquinoline (5)4-Phenoxytetrahydro-2H-Pyran (5)5-(Benzyloxy)Pyrimidine (5)5-Fluoro-2-Methoxypyridine (15)5-Methoxy-1H-Benzo[D]Imidazole (2)5-Methoxy-1H-Indazole (4)5-Methoxy-1H-Indole (11)5-Methoxy-2-Methyl-1H-Indole (4)5-Methoxy-2-Nitroaniline (7)5-Methoxyindoline (4)5-Methoxyisobenzofuran-1(3H)-One (5)5-Methoxyisoquinoline (6)6-Methoxy-1,2,3,4-Tetrahydroisoquinoline (3)6-Methoxy-1H-Indazole (14)6-Methoxy-1H-Indole (12)6-Methoxy-1H-Pyrrolo[2,3-B]Pyridine (3)6-Methoxy-3,4-Dihydroisoquinolin-1(2H)-One (3)6-Methoxybenzo[D]Thiazole (6)6-Methoxybenzofuran (4)6-Methoxychromane (5)6-Methoxyisoindolin-1-One (3)6-Methoxyquinoxaline (6)7-(Benzyloxy)Quinoline (6)7-Methoxy-1,2,3,4-Tetrahydroisoquinoline (6)7-Methoxy-1H-Indazole (5)7-Methoxy-1H-Indole (8)7-Methoxy-3,4-Dihydroquinolin-2(1H)-One (3)7-Methoxyisoquinoline (5)8-Methoxyisoquinoline (7)8-Methoxyquinazoline (3)Butoxybenzene (51)Ethoxybenzene (283)Ethyl 2-Phenoxyacetate (10)Isobutoxybenzene (22)Isopropoxybenzene (84)Methoxycyclohexane (7)Methyl 2-Methoxybenzoate (70)Methyl 2-Phenoxyacetate (12)Methyl 2-Phenoxybenzoate (4)Methyl 3-(Benzyloxy)Benzoate (5)Methyl 3-Methoxybenzoate (71)Methyl 4-Phenoxybenzoate (3)N,N-Dimethyl-2-Phenoxyethan-1-Amine (16)N-(2-Phenoxyphenyl)Methanesulfonamide (3)N-(4-Phenoxyphenyl)Acetamide (4)N-Phenyl-N-(4-(Quinolin-4-Yloxy)Phenyl)Cyclopropane-1,1-Dicarboxamide (5)Phenethoxybenzene (23)Propoxybenzene (63)Tert-Butoxybenzene (12)Tert-Butyl 3-Methoxypyrrolidine-1-Carboxylate (6)Tert-Butyl 4-Phenoxypiperidine-1-Carboxylate (12)Tert-Butyl 5-Methoxy-1H-Indole-1-Carboxylate (6)Alcohols (224)Aldehydes (130)Aliphatic Chain Hydrocarbons (199)Aliphatic Cyclic Hydrocarbons (32)Alkenyls (79)Alkynyls (29)Amides (251)Amidines (4)Amines (400)Anhydrides (8)Aryls (1450)Azetidines (18)Benzimidazoles (17)Benzofurans (2)Benzothiazoles (15)Benzoxazoles (6)Benzyl Bromides (6)Benzyl Chlorides (7)Bromides (328)Carboxylic Acid Salts (4)Carboxylic Acids (291)Chlorides (285)Difluoromethyls (64)Epoxides (13)Esters (266)Fluorinated Building Blocks (233)Furans (10)Hydrazides (23)Hydrazines (40)Imidazoles (6)Indazoles (9)Indoles (54)Indolines (5)Iodides (32)Isoquinolines (8)Isoxazoles (12)Ketones (159)Morpholines (17)Nitriles (103)Nitroes (83)Oxazoles (4)Oxetanes (6)Phenols (44)Piperazines (26)Piperidines (81)Pyrans (5)Pyrazines (19)Pyrazoles (39)Pyridazines (7)Pyridines (238)Pyrimidines (113)Pyrrolidines (56)Quinazolines (17)Quinolines (81)Quinuclidines (2)Sulfamides (22)Sulfides (29)Sulfonates (4)Sulfones (12)Sulfonyl Chlorides (19)Sulfoxides (5)Tetrahydrofurans (1)Tetrahydropyrans (24)Thiadiazoles (7)Thiazoles (16)Thiophenes (5)Thiophenols (7)Triazoles (5)Trifluoromethyls (107)Other Aliphatic Heterocycles (5)Other Aromatic Heterocycles (47)Butoxy-Phenyl-Boronic Acid/Ester (68)Diethoxy (14)Diethoxyethyl (9)Diethoxymethyl (8)Dimethoxyethyl (8)Dimethoxypropane (11)Dioxane (154)Dioxepine (7)Disulfide (38)Methoxyphenylboronic-Acid (32)

Fluorinated Building Blocks (98813)

(2,3-Difluorophenyl)Boronic Acid (33)(2,6-Difluorophenyl)Boronic Acid (28)(2-Chloro-6-Fluorophenyl)Boronic Acid (9)(2-Fluorobenzyl)Hydrazine (6)(2-Fluorophenyl)(Phenyl)Methanone (15)(2-Fluorophenyl)Boronic Acid (229)(2-Fluorophenyl)Hydrazine (22)(2-Fluorophenyl)Methanamine (49)(2-Fluorophenyl)Methanol (60)(3-Fluorophenyl)(Phenyl)Methanone (5)(3-Fluorophenyl)Boronic Acid (169)(3-Fluorophenyl)Methanol (58)(4-Fluorophenyl)(Phenyl)Methanone (8)(4-Fluorophenyl)Boronic Acid (93)(4-Fluorophenyl)Methanamine (27)(4-Fluorophenyl)Methanol (29)1,1-Difluorocyclobutane (14)1,1-Difluorocyclohexane (18)1,2,3,4,5-Pentafluorobenzene (45)1,2,3,4-Tetrafluorobenzene (68)1,2,3-Trifluorobenzene (144)1,2,4-Trifluorobenzene (197)1,2-Dibromo-3-Fluorobenzene (8)1,2-Dibromo-4-Fluorobenzene (11)1,2-Dichloro-3-Fluorobenzene (13)1,2-Dichloro-4-Fluorobenzene (15)1,2-Difluoro-3-Iodobenzene (13)1,2-Difluoro-3-Methoxybenzene (28)1,2-Difluoro-3-Methylbenzene (23)1,2-Difluoro-3-Nitrobenzene (23)1,2-Difluoro-4-Methoxybenzene (19)1,2-Difluoro-4-Nitrobenzene (43)1,2-Difluorobenzene (631)1,3-Dibromo-2,4-Difluorobenzene (5)1,3-Dibromo-2-Fluorobenzene (15)1,3-Dichloro-2-Fluorobenzene (22)1,3-Difluoro-2-Iodobenzene (12)1,3-Difluoro-2-Methylbenzene (18)1,3-Difluoro-2-Nitrobenzene (16)1,4-Dichloro-2-Fluorobenzene (11)1,4-Difluoro-2-Iodobenzene (8)1,4-Difluoro-2-Nitrobenzene (28)1,4-Difluorobenzene (343)1-(2-Fluorophenyl)Ethan-1-Amine (80)1-(2-Fluorophenyl)Ethan-1-One (58)1-(2-Fluorophenyl)Propan-1-Amine (8)1-(3-Fluorophenyl)Ethan-1-One (63)1-(4-Fluorophenyl)Ethan-1-One (36)1-(Benzyloxy)-2-Fluorobenzene (10)1-(Benzyloxy)-3-Fluorobenzene (14)1-(Bromomethyl)-2-Fluorobenzene (50)1-(Bromomethyl)-3-Fluorobenzene (47)1-(Chloromethyl)-2-Fluorobenzene (8)1-(Chloromethyl)-3-Fluorobenzene (11)1-Benzyl-4-Fluorobenzene (2)1-Bromo-2,3-Difluorobenzene (67)1-Bromo-2,4-Difluorobenzene (59)1-Bromo-2-Chloro-3-Fluorobenzene (20)1-Bromo-2-Fluoro-3-Methylbenzene (11)1-Bromo-3-Fluoro-2-Methoxybenzene (12)1-Bromo-3-Fluoro-2-Methylbenzene (17)1-Bromo-3-Fluoro-2-Nitrobenzene (10)1-Bromo-4-Fluoro-2-Methoxybenzene (11)1-Bromo-4-Fluoro-2-Methylbenzene (18)1-Chloro-2,3-Difluorobenzene (27)1-Chloro-2,4-Difluorobenzene (35)1-Chloro-3-Fluoro-2-Methoxybenzene (4)1-Chloro-3-Fluoro-2-Methylbenzene (10)1-Cyclohexyl-2-Fluorobenzene (4)1-Ethoxy-2,3-Difluorobenzene (9)1-Ethoxy-2-Fluorobenzene (37)1-Ethynyl-2-Fluorobenzene (10)1-Fluoro-2,3-Dimethylbenzene (8)1-Fluoro-2-(Methylsulfonyl)Benzene (5)1-Fluoro-2-Iodo-4-Methylbenzene (3)1-Fluoro-2-Iodobenzene (102)1-Fluoro-2-Isopropoxybenzene (18)1-Fluoro-2-Methylbenzene (255)1-Fluoro-2-Phenoxybenzene (11)1-Fluoro-3,5-Dimethylbenzene (12)1-Fluoro-3-(Methylsulfonyl)Benzene (10)1-Fluoro-3-Iodo-2-Methylbenzene (3)1-Fluoro-3-Iodobenzene (94)1-Fluoro-3-Methoxybenzene (213)1-Fluoro-3-Methylbenzene (254)1-Fluoro-3-Nitrobenzene (216)1-Fluoro-3-Phenoxybenzene (8)1-Fluoro-4-Iodobenzene (65)1-Fluoro-4-Methoxybenzene (125)1-Fluoro-4-Methylbenzene (140)1-Fluoro-4-Phenoxybenzene (8)1-Fluorobicyclo[1.1.1]Pentane (4)1-Fluoronaphthalene (23)2'-Fluoro-1,1':4',1''-Terphenyl (6)2,2',3,3',5,5',6,6'-Octafluoro-1,1'-Biphenyl (4)2,3-Difluoroaniline (34)2,3-Difluorobenzaldehyde (18)2,3-Difluorobenzoic Acid (35)2,3-Difluorobenzonitrile (29)2,3-Difluorophenol (36)2,3-Difluoropyridine (13)2,4-Dibromo-1-Fluorobenzene (18)2,4-Dichloro-1-Fluorobenzene (27)2,4-Difluoro-1-Iodobenzene (14)2,4-Difluoro-1-Methoxybenzene (25)2,4-Difluoro-1-Nitrobenzene (46)2,4-Difluoroaniline (44)2,4-Difluorobenzaldehyde (19)2,4-Difluorobenzoic Acid (29)2,4-Difluorobenzonitrile (21)2,4-Difluorophenol (21)2,5-Difluoroaniline (34)2,5-Difluorobenzoic Acid (32)2,5-Difluoropyridine (8)2,6-Difluoroaniline (23)2,6-Difluorobenzaldehyde (25)2,6-Difluorobenzoic Acid (33)2,6-Difluorobenzonitrile (28)2,6-Difluorophenol (23)2,6-Difluoropyridine (29)2-(2-Fluorophenyl)Acetic Acid (43)2-(2-Fluorophenyl)Acetonitrile (30)2-(2-Fluorophenyl)Pyrrolidine (16)2-(3-Fluorophenyl)Acetic Acid (50)2-(3-Fluorophenyl)Pyrrolidine (5)2-(4-Fluorophenyl)-1H-Indole (4)2-(4-Fluorophenyl)Acetic Acid (30)2-(Bromomethyl)-1,3-Difluorobenzene (12)2-Amino-2-(2-Fluorophenyl)Acetic Acid (11)2-Amino-3-Fluorobenzoic Acid (11)2-Bromo-1,3,4-Trifluorobenzene (16)2-Bromo-1,3-Difluorobenzene (43)2-Bromo-1,4-Difluorobenzene (64)2-Bromo-1-Chloro-3-Fluorobenzene (9)2-Bromo-1-Chloro-4-Fluorobenzene (20)2-Bromo-1-Fluoro-4-Methylbenzene (17)2-Bromo-4-Chloro-1-Fluorobenzene (16)2-Bromo-4-Fluoro-1-Methoxybenzene (12)2-Bromo-4-Fluoro-1-Methylbenzene (21)2-Bromo-4-Fluoroaniline (28)2-Bromo-4-Fluorobenzaldehyde (7)2-Bromo-4-Fluorobenzonitrile (7)2-Bromo-4-Fluorophenol (10)2-Bromo-5-Fluoroaniline (18)2-Bromo-5-Fluorobenzaldehyde (7)2-Bromo-5-Fluorobenzoic Acid (11)2-Bromo-6-Fluoroaniline (14)2-Bromo-6-Fluorophenol (9)2-Chloro-1,3-Difluorobenzene (27)2-Chloro-1,4-Difluorobenzene (25)2-Chloro-3-Fluoropyridine (20)2-Chloro-4-Fluoro-1-Methoxybenzene (10)2-Chloro-4-Fluoroaniline (19)2-Chloro-4-Fluorobenzaldehyde (10)2-Chloro-4-Fluorobenzoic Acid (9)2-Chloro-4-Fluorobenzonitrile (9)2-Chloro-4-Fluorophenol (9)2-Chloro-5-Fluoropyrimidine (6)2-Chloro-6-Fluoroaniline (8)2-Chloro-6-Fluorobenzoic Acid (8)2-Chloro-6-Fluorobenzonitrile (5)2-Chloro-6-Fluorophenol (5)2-Fluoro-1,3-Dimethoxybenzene (8)2-Fluoro-1,3-Dimethylbenzene (14)2-Fluoro-1-Iodo-4-Methylbenzene (5)2-Fluoro-3-Methylbenzaldehyde (8)2-Fluoro-3-Methylpyridine (14)2-Fluoro-4-Methoxyaniline (6)2-Fluoro-4-Methyl-1-Nitrobenzene (13)2-Fluoro-4-Methylbenzoic Acid (7)2-Fluoro-4-Methylpyridine (6)2-Fluoro-5-Methylpyridine (6)2-Fluoro-6-Methylpyridine (20)2-Fluoro-N-Methylbenzamide (12)2-Fluoro-N-Phenylaniline (4)2-Fluoro-N-Phenylbenzenesulfonamide (6)2-Fluoroaniline (262)2-Fluorobenzaldehyde (175)2-Fluorobenzamide (32)2-Fluorobenzenesulfonamide (12)2-Fluorobenzenesulfonyl Chloride (31)2-Fluorobenzoic Acid (220)2-Fluoropyridine (15)2-Fluoropyrimidine (9)3,3-Difluoropiperidine (29)3,3-Difluoropyrrolidine (29)3,4-Difluoroaniline (44)3,4-Difluorophenol (19)3,5-Difluoropyridine (12)3-Chloro-2-Fluoroaniline (9)3-Fluoro-1,1'-Biphenyl (16)3-Fluoro-2-Iodoaniline (8)3-Fluoro-2-Methylaniline (9)3-Fluoro-2-Methylpyridine (15)3-Fluoro-4-Nitroaniline (7)3-Fluoroaniline (288)3-Fluorobenzaldehyde (137)3-Fluorobenzamide (26)3-Fluorobenzenesulfonyl Chloride (22)3-Fluorobenzoic Acid (206)3-Fluorophenol (177)3-Fluoropiperidine (26)3-Fluoropyridin-2-Amine (12)3-Fluoropyridin-4-Amine (4)3-Fluorothiophene (6)4,4-Difluoropiperidine (5)4-(2-Fluorophenyl)Morpholine (8)4-(4-Fluorophenyl)Thiazole (9)4-Chloro-5-Fluoro-2-Methylpyrimidine (5)4-Fluoro-1-Methyl-2-Nitrobenzene (12)4-Fluoro-1H-Indazole (22)4-Fluoro-1H-Indole (24)4-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (6)4-Fluoro-2-Iodoaniline (7)4-Fluoro-2-Nitroaniline (14)4-Fluoroaniline (226)4-Fluorobenzaldehyde (78)4-Fluorobenzamide (19)4-Fluorobenzenesulfonyl Chloride (26)4-Fluorobenzo[D]Thiazole (6)4-Fluorobenzoic Acid (114)4-Fluorobenzonitrile (89)4-Fluoroisoquinoline (6)4-Fluorophenol (111)4-Fluoropyrimidine (8)5-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)5-Fluoro-1H-Benzo[D][1,2,3]Triazole (4)5-Fluoro-1H-Benzo[D]Imidazole (12)5-Fluoro-1H-Indole (48)5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (9)5-Fluoro-2,3-Dihydro-1H-Indene (3)5-Fluoro-2,3-Dihydrobenzofuran (5)5-Fluoro-2-Methylpyridine (8)5-Fluoro-3,4-Dihydronaphthalen-1(2H)-One (5)5-Fluorochromane (6)5-Fluoroindoline (3)5-Fluoroisoindolin-1-One (3)5-Fluoropyridin-2-Amine (15)5-Fluoropyrimidine (11)6-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)6-Fluoro-1,2,3,4-Tetrahydroquinoline (3)6-Fluoro-1H-Indazole (15)6-Fluoro-1H-Indole (17)6-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (3)6-Fluorobenzo[D]Thiazole (5)6-Fluorochromane (6)6-Fluoropyridin-2-Amine (8)6-Fluoropyridin-3-Amine (4)7-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)7-Fluoro-1,2,3,4-Tetrahydroquinoline (3)7-Fluoro-1H-Indazole (12)7-Fluoro-1H-Indole (24)7-Fluorobenzo[D]Thiazole (9)7-Fluoroindoline-2,3-Dione (6)7-Fluoroisoquinoline (3)8-Fluoro-3,4-Dihydronaphthalen-1(2H)-One (5)8-Fluorochromane (5)8-Fluoroimidazo[1,2-A]Pyridine (3)8-Fluoroisoquinoline (10)8-Fluoroquinazoline (4)Benzenesulfonyl Fluoride (50)Ethyl 2-Fluorobenzoate (37)Ethyl 3-Fluorobenzoate (34)Fluorobenzene (9773)Methyl 2,6-Difluorobenzoate (17)Methyl 2-Fluorobenzoate (132)Methyl 3-Fluorobenzoate (136)Methyl 4-Fluorobenzoate (75)Methyl 6-Fluoronicotinate (4)N-(3-Fluorophenyl)Acetamide (14)N-(4-Fluorophenyl)Benzamide (3)Pentafluoro(Phenyl)-L6-Sulfane (19)Phenyl Trifluoromethanesulfonate (27)Tert-Butyl (4-Fluorophenyl)Carbamate (9)Trifluoro(Phenyl)Borate (80)Alcohols (168)Aldehydes (79)Aliphatic Chain Hydrocarbons (167)Aliphatic Cyclic Hydrocarbons (56)Alkenyls (42)Alkynyls (6)Amides (235)Amidines (7)Amines (282)Anhydrides (8)Aryls (858)Azetidines (20)Benzimidazoles (14)Benzisoxazoles (4)Benzofurans (11)Benzothiazoles (7)Benzothiophenes (5)Benzoxazoles (5)Benzyl Bromides (2)Benzyl Chlorides (2)Bromides (304)Carboxylic Acids (237)Chlorides (224)Difluoromethyls (124)Esters (189)Ethers (233)Furans (4)Hydrazides (6)Hydrazines (12)Imidazoles (25)Indazoles (10)Indoles (37)Indolines (11)Iodides (52)Isoquinolines (7)Isoxazoles (12)Ketones (147)Morpholines (17)Naphthyridines (4)Nitriles (76)Nitroes (75)Oxazoles (5)Oxazolidines (1)Oxetanes (5)Phenols (28)Phosphoruses (5)Piperazines (22)Piperidines (95)Pyrazines (8)Pyrazoles (52)Pyridazines (4)Pyridines (296)Pyrimidines (38)Pyrroles (8)Pyrrolidines (38)Quinazolines (5)Quinolines (50)Quinoxalines (5)Spiroes (9)Sulfamides (26)Sulfides (21)Sulfonates (23)Sulfones (13)Tetrahydropyrans (8)Tetrahydroquinolines (6)Thiazoles (9)Thioesters (4)Thiophenes (18)Thiophenols (4)Trifluoromethyls (496)Other Aliphatic Heterocycles (5)Other Aromatic Heterocycles (46)Dichlorofluorobenzene (21)Difluoro (890)Difluoroaniline (37)Difluorobenzaldehyde (33)Difluorobenzamide (6)Difluorobenzenesulfonamide (5)Difluorobenzoate (59)Difluoroethyl (26)Difluoromethoxy (196)Difluoropropan (7)Fluindamine (32)Fluoroacetanilide (5)Fluoroacetophenone (8)Fluoroaniline (65)Fluoroanisole (9)Fluorobenzaldehyde (69)Fluorobenzamide (28)Fluorobenzenesulfonamide (7)Fluorobenzenethiol (6)Fluorobenzylamine (10)Fluorobromobenzene (3)Fluorocinnamic (10)Fluorocinnamic Acid (9)Fluorocyclopropanecarboxylic (9)Fluoroethoxy (4)Fluoroethyl (8)Fluoroindan (3)Fluoroisonicotinaldehyde (7)Fluoroisonicotinate (8)Fluoroisonicotinic (13)Fluoroisonicotinic Acid (13)Fluoromethyl (15)Fluoronicotinaldehyde (20)Fluoronicotinamide (3)Fluoronicotinic (19)Fluoronicotinic Acid (15)Fluorophenylisocyanate (3)Fluoropropan (15)Fluorostyryl (7)Fluorosulfonyl (12)Hexafluoro (8)Hexafluoropropan (3)Nonafluoro (2)Nonafluorohexyl (1)Octafluoro (2)Pentafluoro (4)Pentafluorobenzoate (4)Tetrafluoro (12)Tetrafluoroaniline (7)Tetrafluoroethoxy (3)Trifluoro (269)Trifluoroacetamide (8)Trifluoroacetyl (12)Trifluoroaniline (11)Trifluorobenzaldehyde (9)Trifluorobenzoate (14)Trifluorobut (36)Trifluoroethan (2)Trifluoroethanamine (23)Trifluoroethanol (6)Trifluoroethoxy (59)Trifluoroethyl (61)Trifluoromethanesulfonyl (22)Trifluoromethoxy (475)Trifluoromethylthio (5)Trifluoropropane (35)Trifluoropropanoate (5)Trifluoropropyl (9)

Guanidines (763)

Aliphatic Chain Hydrocarbons (18)Amides (12)Aryls (13)Nitriles (4)Biguanide (2)

Hydrazines (6227)

Hydrazones (1737)

1-Benzylidene-2-Phenylhydrazine (4)Amides (9)Aryls (10)Chlorides (4)

Hydroxylamines (627)

N-Hydroxybenzamide (8)Aliphatic Chain Hydrocarbons (11)Amides (12)Amines (14)Aryls (8)

Iodides (14113)

(2-Iodophenyl)(Phenyl)Methanone (4)(2-Iodophenyl)Methanol (12)(3-Iodophenyl)Boronic Acid (5)(3-Iodophenyl)Methanol (13)1,2-Benziodoxol-3-(1H)-One (6)1,2-Difluoro-3-Iodobenzene (13)1,2-Diiodobenzene (10)1,3-Dibromo-2-Iodobenzene (4)1,3-Dichloro-2-Iodobenzene (5)1,3-Difluoro-2-Iodobenzene (12)1,3-Diiodo-2-Phenoxybenzene (1)1,3-Diiodobenzene (50)1,4-Dibromo-2-Iodobenzene (3)1,4-Difluoro-2-Iodobenzene (8)1-(2-Iodophenyl)Ethan-1-One (4)1-(3-Iodophenyl)Ethan-1-One (7)1-(Benzyloxy)-4-Iodobenzene (3)1-(Bromomethyl)-2-Iodobenzene (9)1-Benzyl-4-Iodo-1H-Pyrazole (5)1-Bromo-2-Iodobenzene (65)1-Bromo-3-Fluoro-2-Iodobenzene (4)1-Bromo-3-Iodobenzene (71)1-Bromo-4-Iodobenzene (67)1-Chloro-2-Fluoro-3-Iodobenzene (5)1-Chloro-2-Iodobenzene (65)1-Chloro-3-Iodo-2-Methylbenzene (3)1-Chloro-3-Iodobenzene (78)1-Chloro-4-Iodobenzene (49)1-Ethyl-2-Iodobenzene (6)1-Fluoro-2-Iodo-4-Methylbenzene (3)1-Fluoro-2-Iodobenzene (102)1-Fluoro-3-Iodo-2-Methylbenzene (3)1-Fluoro-3-Iodobenzene (94)1-Fluoro-4-Iodobenzene (65)1-Iodo-2,3-Dimethylbenzene (8)1-Iodo-2,4-Dimethylbenzene (9)1-Iodo-2-(Trifluoromethoxy)Benzene (6)1-Iodo-2-(Trifluoromethyl)Benzene (13)1-Iodo-2-Isopropylbenzene (4)1-Iodo-2-Methoxybenzene (50)1-Iodo-2-Methylbenzene (91)1-Iodo-2-Nitrobenzene (36)1-Iodo-3-(Trifluoromethoxy)Benzene (6)1-Iodo-3-(Trifluoromethyl)Benzene (30)1-Iodo-3-Methoxybenzene (48)1-Iodo-3-Methylbenzene (60)1-Iodo-3-Nitrobenzene (45)1-Iodo-4-Methoxybenzene (34)1-Iodo-4-Phenoxybenzene (4)2,4-Difluoro-1-Iodobenzene (14)2,6-Dichloro-4-Iodopyridine (4)2,6-Diiodoaniline (8)2,6-Diiodophenol (9)2-Bromo-3-Iodopyridine (6)2-Bromo-4-Chloro-1-Iodobenzene (6)2-Bromo-6-Iodoaniline (4)2-Bromo-6-Iodopyridine (5)2-Chloro-3-Iodopyridin-4-Amine (3)2-Chloro-3-Iodopyridine (13)2-Chloro-4-Iodopyridine (19)2-Chloro-5-Iodopyridine (18)2-Chloro-6-Iodophenol (3)2-Chloro-6-Iodopyridine (9)2-Fluoro-1-Iodo-4-Methylbenzene (5)2-Fluoro-3-Iodopyridine (8)2-Fluoro-6-Iodoaniline (7)2-Hydroxy-3-Iodobenzaldehyde (3)2-Iodo-1,3-Dimethylbenzene (15)2-Iodo-1,4-Dimethylbenzene (5)2-Iodo-1-Methyl-4-Nitrobenzene (3)2-Iodo-4-Methylaniline (5)2-Iodo-6-Methylpyridine (5)2-Iodo-6-Nitroaniline (3)2-Iodo-9H-Fluorene (8)2-Iodo-N,N-Dimethylaniline (3)2-Iodoaniline (87)2-Iodobenzaldehyde (17)2-Iodobenzamide (4)2-Iodobenzene-1,3-Diol (3)2-Iodobenzoic Acid (47)2-Iodobenzonitrile (26)2-Iodonaphthalene (5)2-Iodophenol (53)2-Iodopyrazine (25)2-Iodopyridine (27)2-Iodopyrimidine (8)2-Iodothiophene (14)3-Chloro-2-Iodoaniline (3)3-Chloro-4-Iodoaniline (3)3-Fluoro-2-Iodoaniline (8)3-Iodo-1-Methyl-1H-Pyrazole (6)3-Iodo-1H-Pyrrolo[2,3-B]Pyridine (11)3-Iodo-1H-Pyrrolo[3,2-B]Pyridine (6)3-Iodo-2-Methylaniline (4)3-Iodoaniline (32)3-Iodobenzaldehyde (28)3-Iodobenzoic Acid (54)3-Iodobenzonitrile (27)3-Iodoimidazo[1,2-A]Pyridine (10)3-Iodophenol (21)3-Iodopyridazine (5)3-Iodopyridin-2-Amine (12)3-Iodopyridin-2-Ol (4)3-Iodopyridin-4-Amine (6)3-Iodopyridin-4-Ol (4)3-Iodopyridine (37)3-Iodotetrahydrofuran (3)4-Bromo-2-Chloro-1-Iodobenzene (4)4-Bromo-2-Fluoro-1-Iodobenzene (8)4-Bromo-2-Iodoaniline (8)4-Chloro-2-Iodoaniline (9)4-Chloro-3-Iodoaniline (3)4-Chloro-5-Iodopyrimidine (6)4-Fluoro-2-Iodoaniline (7)4-Fluoro-3-Iodobenzoic Acid (5)4-Iodo-1,1'-Biphenyl (9)4-Iodo-1H-Pyrazole (9)4-Iodo-N,N-Diphenylaniline (3)4-Iodopyridine (17)4-Iodopyrimidine (9)5-Bromo-2-Iodopyridine (5)5-Iodo-1H-Imidazole (4)5-Iodo-1H-Pyrazole (4)5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine (4)5-Iodopyridin-2-Amine (17)5-Iodopyridin-2-Ol (8)5-Iodopyrimidine (5)6-Chloro-5-Iodopyridin-2-Amine (3)Ethyl 2-Iodobenzoate (4)Ethyl 3-Iodobenzoate (11)Methyl 2-Iodobenzoate (28)Methyl 3-Iodo-4-Methylbenzoate (6)Methyl 3-Iodobenzoate (47)Methyl 4-Amino-3-Iodobenzoate (7)N-(2-Iodophenyl)Acetamide (8)Phenyl(O-Tolyl)Iodonium (14)Tert-Butyl 3-Iodo-1H-Indole-1-Carboxylate (7)Alcohols (16)Aliphatic Chain Hydrocarbons (36)Aliphatic Cyclic Hydrocarbons (10)Alkenyls (6)Amides (36)Amines (36)Aryls (86)Benzofurans (4)Bromides (54)Carboxylic Acids (24)Chlorides (51)Esters (30)Ethers (32)Fluorinated Building Blocks (52)Imidazoles (12)Indazoles (12)Indoles (10)Ketones (10)Nitriles (10)Nitroes (6)Oxetanes (6)Phenols (9)Piperidines (4)Pyrazoles (17)Pyridines (78)Pyrimidines (15)Quinolines (12)Tetrahydropyrans (4)Thiazoles (4)Thiophenes (3)Trifluoromethyls (14)Other Aromatic Heterocycles (28)Diiodo (18)Diiodobenzoate (5)Iodoaniline (60)Iodoanisole (5)Iodobenzaldehyde (38)Iodobenzamide (6)Iodoethoxy (6)Iodoethyl (5)Iodomethyl (26)Iodonicotinaldehyde (6)Iodonicotinic (14)Iodopropyl (4)

Isocyanates and Isothiocyanates (240)

(Isothiocyanatomethyl)Benzene (6)1-Chloro-2-Isocyanatobenzene (6)1-Chloro-2-Isothiocyanatobenzene (7)Isocyanatobenzene (47)Isothiocyanatobenzene (39)Aryls (8)Isocyanate (31)

Isocyanides (68)

Aryls (2)Isocyanato (7)Isocyanide (1)Isothiocyanato (5)

Ketones (39548)

(1E,4E)-1,5-Diphenylpenta-1,4-Dien-3-One (7)(1E,6E)-1,7-Diphenylhepta-1,6-Diene-3,5-Dione (6)(2-Aminophenyl)(Phenyl)Methanone (30)(2-Bromophenyl)(Phenyl)Methanone (3)(2-Chlorophenyl)(Phenyl)Methanone (19)(2-Fluorophenyl)(Phenyl)Methanone (15)(2-Hydroxyphenyl)(Phenyl)Methanone (23)(2-Iodophenyl)(Phenyl)Methanone (4)(3-Chlorophenyl)(Phenyl)Methanone (19)(3-Fluorophenyl)(Phenyl)Methanone (5)(3-Nitrophenyl)(Phenyl)Methanone (5)(4-Aminophenyl)(Phenyl)Methanone (4)(4-Bromophenyl)(Phenyl)Methanone (9)(4-Chlorophenyl)(Phenyl)Methanone (11)(4-Fluorophenyl)(Phenyl)Methanone (8)(4-Hydroxyphenyl)(Phenyl)Methanone (3)(4-Methoxyphenyl)(Phenyl)Methanone (7)(4-Nitrophenyl)(Phenyl)Methanone (3)(R)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-8-One (8)1,3-Dioxoisoindolin-2-Yl 2-Phenylacetate (5)1,3-Diphenylpropan-1-One (9)1,4-Diazepan-5-One (9)1,4-Dihydroisoquinolin-3(2H)-One (5)1-(1H-Indazol-1-Yl)Ethan-1-One (7)1-(1H-Indol-1-Yl)Ethan-1-One (9)1-(2-(Trifluoromethyl)Phenyl)Ethan-1-One (9)1-(2-Aminophenyl)Ethan-1-One (29)1-(2-Bromophenyl)Ethan-1-One (27)1-(2-Chlorophenyl)Ethan-1-One (40)1-(2-Fluorophenyl)Ethan-1-One (58)1-(2-Hydroxyphenyl)-2-Phenylethan-1-One (6)1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One (11)1-(2-Hydroxyphenyl)Ethan-1-One (72)1-(2-Iodophenyl)Ethan-1-One (4)1-(2-Methoxyphenyl)Ethan-1-One (34)1-(2-Nitrophenyl)Ethan-1-One (24)1-(3-(Benzyloxy)Phenyl)Ethan-1-One (3)1-(3-Aminophenyl)Ethan-1-One (18)1-(3-Chlorophenyl)Ethan-1-One (38)1-(3-Fluorophenyl)Ethan-1-One (63)1-(3-Hydroxyphenyl)Ethan-1-One (19)1-(3-Iodophenyl)Ethan-1-One (7)1-(3-Methoxy-2-Nitrophenyl)Ethan-1-One (4)1-(3-Methoxyphenyl)Ethan-1-One (37)1-(3-Nitrophenyl)Ethan-1-One (25)1-(3-Nitrophenyl)Propan-1-One (4)1-(4-(Benzyloxy)Phenyl)Ethan-1-One (4)1-(4-Fluorophenyl)Ethan-1-One (36)1-([1,1'-Biphenyl]-4-Yl)Ethan-1-One (5)1-(Benzofuran-2-Yl)Ethan-1-One (3)1-(Imidazo[1,2-A]Pyridin-3-Yl)Ethan-1-One (3)1-(M-Tolyl)Ethan-1-One (37)1-(Naphthalen-2-Yl)Ethan-1-One (3)1-(O-Tolyl)Ethan-1-One (26)1-(Piperidin-1-Yl)Ethan-1-One (13)1-(Pyrazin-2-Yl)Ethan-1-One (5)1-(Pyridin-2-Yl)Ethan-1-One (36)1-(Pyridin-3-Yl)Ethan-1-One (29)1-(Pyridin-4-Yl)Ethan-1-One (14)1-(Pyrimidin-2-Yl)Ethan-1-One (5)1-(Pyrimidin-4-Yl)Ethan-1-One (6)1-(Pyrrolidin-1-Yl)Ethan-1-One (9)1-(Thiazol-2-Yl)Ethan-1-One (9)1-(Thiophen-2-Yl)Ethan-1-One (17)1-Aminoanthracene-9,10-Dione (8)1-Benzylindoline-2,3-Dione (5)1-Benzylpiperidin-3-One (5)1-Chloroanthracene-9,10-Dione (6)1-Hydroxyanthracene-9,10-Dione (12)1-Methylpiperazin-2-One (6)1-Methylpyrrolidin-2-One (13)1-Phenylbutan-1-One (13)1-Phenylpentan-1-One (11)1-Phenylpiperidin-2-One (8)1-Phenylpropan-2-One (36)2,2,2-Trifluoro-1-Phenylethan-1-One (51)2,2-Dimethyl-1-Phenylpropan-1-One (8)2,2-Dimethyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)2,3,4,9-Tetrahydro-1H-Carbazol-1-One (7)2,3-Dihydrofuran-3-One (9)2,3-Dihydropyridin-2-One (5)2,5-Dichlorobenzoic Acid (13)2-Amino-1-(Pyrrolidin-1-Yl)Ethan-1-One (5)2-Benzalacetophenone (36)2-Benzoylbenzoic Acid (10)2-Chloro-1-Phenylethan-1-One (20)2-Chlorocyclohexa-2,5-Diene-1,4-Dione (4)2-Chloroquinazolin-4(3H)-One (4)2-Hydroxy-1,2-Diphenylethan-1-One (3)2-Hydroxy-1-Phenylethan-1-One (8)2-Hydroxycyclohexa-2,5-Diene-1,4-Dione (3)2-Hydroxyquinolin-4(1H)-One (3)2-Methoxycyclohexa-2,5-Diene-1,4-Dione (7)2-Methyl-1-Phenylpropan-1-One (20)2-Methyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One (6)2-Methylcyclohexa-2,5-Diene-1,4-Dione (5)2-Methylcyclohexan-1-One (3)2-Methylisoindolin-1-One (7)2-Methylisoindoline-1,3-Dione (5)2-Methylpyridazin-3(2H)-One (7)2-Oxo-2-Phenylacetaldehyde (12)2-Oxo-2-Phenylacetic Acid (17)3,3-Difluoropiperidin-4-One (3)3,3-Dimethylcyclohexan-1-One (4)3,3-Dimethylpiperidin-4-One (3)3,4-Dihydroquinoxalin-2(1H)-One (7)3-Acetyl-2H-Chromen-2-One (3)3-Aminopyrrolidin-2-One (5)3-Bromo-1H-Pyrrole-2,5-Dione (3)3-Chloro-1-Phenylpropan-1-One (10)3-Fluoropiperidin-4-One (3)3-Hydroxy-2-Phenyl-4H-Chromen-4-One (20)3-Hydroxypyrrolidin-2-One (4)3-Methylcyclohexan-1-One (9)3-Methylene-2,3-Dihydro-1H-Inden-1-One (3)3-Methylpiperazin-2-One (7)3-Methylpyrimidin-4(3H)-One (6)3-Oxo-3-Phenylpropanenitrile (21)3-Oxo-N-Phenylbutanamide (10)3-Phenyl-1-(Pyrrolidin-1-Yl)Propan-1-One (1)3-Phenyl-2-Thioxoimidazolidin-4-One (6)3-Phenylacrylaldehyde (29)3-Phenylimidazolidine-2,4-Dione (4)4,4,4-Trifluoro-1-Phenylbutane-1,3-Dione (10)4-(1,2,2-Triphenylvinyl)Benzaldehyde (5)4-(Hydroxymethyl)Pyrrolidin-2-One (4)4-Benzylmorpholin-3-One (6)4-Bromoisoindolin-1-One (3)4-Bromopyridazin-3(2H)-One (3)4-Chloro-1-Phenylbutan-1-One (8)4-Chloropyridazin-3(2H)-One (4)4-Fluoroindoline-2,3-Dione (3)4-Hydroxy-2H-Chromen-2-One (10)4-Hydroxydihydrofuran-2(3H)-One (14)4-Hydroxypiperidin-2-One (3)4-Hydroxypyrrolidin-2-One (7)4-Methyl-2H-Chromen-2-One (27)4-Methylisobenzofuran-1(3H)-One (3)4-Oxo-4-Phenylbutanoic Acid (16)4-Phenylbutan-2-One (15)4-Phenylcyclohexan-1-One (11)4-Phenylmorpholin-3-One (6)5,6-Dihydrobenzo[D]Thiazol-7(4H)-One (5)5-(Aminomethyl)Pyrrolidin-2-One (3)5-(Hydroxymethyl)Pyrrolidin-2-One (7)5-Bromoisoindolin-1-One (8)5-Bromoisoindoline-1,3-Dione (3)5-Bromopyrimidin-4(3H)-One (3)5-Chloroisoindoline-1,3-Dione (3)5-Chloropyrimidin-4(3H)-One (4)5-Chloropyrimidine-2,4(1H,3H)-Dione (3)5-Fluoro-3,4-Dihydronaphthalen-1(2H)-One (5)5-Fluorochroman-4-One (3)5-Fluoroindolin-2-One (4)5-Fluoroisoindolin-1-One (3)5-Fluoropyrimidin-4(3H)-One (3)5-Fluoropyrimidine-2,4(1H,3H)-Dione (3)5-Hydroxy-2-Phenyl-4H-Chromen-4-One (35)5-Hydroxypiperidin-2-One (3)5-Methoxy-2-Phenyl-4H-Chromen-4-One (9)5-Methyl-3,4-Dihydronaphthalen-1(2H)-One (6)5-Methylindolin-2-One (3)5-Oxopyrrolidine-2-Carboxylic Acid (4)6-Bromoisoindolin-1-One (4)6-Fluorochroman-4-One (5)6-Fluoroindoline-2,3-Dione (3)6-Fluoroisobenzofuran-1(3H)-One (3)6-Hydroxy-2,3-Dihydro-1H-Inden-1-One (3)6-Methoxy-2,3-Dihydro-1H-Inden-1-One (6)6-Methoxy-3,4-Dihydronaphthalen-1(2H)-One (5)6-Methoxyisoindolin-1-One (3)6-Methyl-2,3-Dihydro-1H-Inden-1-One (3)7,8-Dihydroquinolin-5(6H)-One (5)7-(Diethylamino)-2H-Chromen-2-One (9)7-Bromo-3,4-Dihydronaphthalen-1(2H)-One (8)7-Bromochroman-4-One (4)7-Bromoindoline-2,3-Dione (3)7-Bromoquinazolin-4(3H)-One (4)7-Chloro-3,4-Dihydronaphthalen-1(2H)-One (6)7-Fluorochroman-4-One (5)7-Fluoroindolin-2-One (3)7-Fluoroquinazolin-4(3H)-One (4)7-Hydroxy-2H-Chromen-2-One (23)7-Methoxy-2H-Chromen-2-One (12)7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One (6)7-Methoxychroman-4-One (3)7-Methylindoline-2,3-Dione (7)8-Bromochroman-4-One (4)8-Fluoro-3,4-Dihydronaphthalen-1(2H)-One (5)8-Fluoroisoquinolin-1(2H)-One (3)8-Methylchroman-4-One (4)Acetophenone (1110)Azepan-2-One (18)Benzo[Cd]Indol-2(1H)-One (5)Benzofuran-2(3H)-One (7)Chroman-2-One (5)Cyclobutanone (24)Cyclohex-2-En-1-One (27)Cyclohexane-1,3-Dione (12)Cyclopent-2-En-1-One (21)Cyclopentane-1,3-Dione (6)Dihydro-2H-Pyran-2,6(3H)-Dione (5)Dihydrofuran-2,5-Dione (12)Dihydrofuran-3(2H)-One (8)Dihydrothiophen-3(2H)-One (4)Ethene-1,1-Diyldibenzene (10)Ethyl 2-Oxo-2-Phenylacetate (18)Ethyl 3-Oxo-3-Phenylpropanoate (41)Furan-2(5H)-One (26)Isoquinolin-1-Ol (9)Methyl 3-Oxo-3-Phenylpropanoate (16)Morpholin-3-One (3)Phenyl(3-(Trifluoromethyl)Phenyl)Methanone (3)Phenyl(M-Tolyl)Methanone (3)Phenyl(P-Tolyl)Methanone (4)Phenyl(Pyridin-3-Yl)Methanone (9)Phenyl(Thiophen-2-Yl)Methanone (6)Piperidine-2,4-Dione (5)Propiophenone (55)Pyrimidine-4,6(1H,5H)-Dione (3)Tert-Butyl (2-Oxopiperidin-3-Yl)Carbamate (4)Tert-Butyl (2-Oxopyrrolidin-3-Yl)Carbamate (3)Tert-Butyl (3-Oxocyclohexyl)Carbamate (3)Tert-Butyl (5-Oxopyrrolidin-3-Yl)Carbamate (3)Tert-Butyl (6-Oxopiperidin-3-Yl)Carbamate (3)Tert-Butyl 2-Oxopiperidine-1-Carboxylate (3)Tert-Butyl 2-Oxopyrrolidine-1-Carboxylate (15)Tert-Butyl 4-Oxopiperidine-1-Carboxylate (14)Tetrahydropyrimidin-2(1H)-One (6)Alcohols (62)Aldehydes (19)Aliphatic Chain Hydrocarbons (182)Aliphatic Cyclic Hydrocarbons (156)Alkenyls (84)Alkynyls (8)Amides (185)Amines (87)Aryls (575)Azetidines (16)Benzofurans (10)Bromides (168)Carboxylic Acid Salts (4)Carboxylic Acids (134)Chlorides (139)Difluoromethyls (1)Dioxolanes (5)Epoxides (4)Esters (316)Ethers (159)Fluorinated Building Blocks (147)Furans (10)Imidazoles (7)Indoles (15)Indolines (11)Iodides (10)Morpholines (8)Naphthyridines (4)Nitriles (57)Nitroes (28)Phenols (33)Piperidines (66)Pyrans (7)Pyrazoles (13)Pyridazines (4)Pyridines (98)Pyrimidines (8)Pyrroles (16)Pyrrolidines (23)Quinolines (50)Spiroes (47)Sulfamides (4)Sulfides (18)Sulfones (9)Sulfonic Acids (4)Tetrahydrofurans (6)Tetrahydropyrans (7)Thiazoles (19)Thiophenes (42)Trifluoromethyls (41)Other Aliphatic Heterocycles (59)Other Aromatic Heterocycles (130)Acetylacetonate (26)Bromoethanone (4)Butanedione (6)Butanone (10)Carbonyl-Phenyl-Boronic Acid/Ester (176)Chloroethanone (1)Chromen-One (1)Dicarbonyl (2)Dichloroacetophenone (5)Dienone (2)Diethanone (3)Dione (1760)Dioxobutanoate (2)Enone (21)Ethanone (986)Heptanedionato (7)Hydroxyethanone (3)Methyl-Pyrazolone (85)Oxoacetaldehyde (4)Oxoazepane (3)Oxochroman (5)Oxotetrahydro (11)Pyrimidinone (2)Tetraone (46)Trifluoroacetophenone (9)Trifluoroethanone (14)

Mercaptopropanoate (10)

Nitrates and Nitrites (1)

Nitriles (28599)

1-Phenyl-1H-Pyrazole-4-Carbonitrile (17)1-Phenylcyclobutane-1-Carbonitrile (7)1-Phenylcyclopropane-1-Carbonitrile (19)1H-Imidazole-4-Carbonitrile (2)1H-Indazole-3-Carbonitrile (9)1H-Indole-2-Carbonitrile (9)1H-Indole-3-Carbonitrile (17)1H-Indole-5-Carbonitrile (5)1H-Indole-6-Carbonitrile (4)1H-Indole-7-Carbonitrile (6)1H-Pyrazole-4-Carbonitrile (5)1H-Pyrrole-2-Carbonitrile (7)1H-Pyrrole-3-Carbonitrile (9)2,3-Difluorobenzonitrile (29)2,4-Dichlorobenzonitrile (4)2,4-Difluorobenzonitrile (21)2,6-Dibromobenzonitrile (4)2,6-Dichlorobenzonitrile (8)2,6-Difluorobenzonitrile (28)2-(1,3,2-Dioxaborinan-2-Yl)Benzonitrile (4)2-(2-Bromophenyl)Acetonitrile (10)2-(2-Chlorophenyl)Acetonitrile (16)2-(2-Fluorophenyl)Acetonitrile (30)2-(3-Chlorophenyl)Acetonitrile (16)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile (14)2-(4-(Benzyloxy)Phenyl)Acetonitrile (3)2-(Bromomethyl)Benzonitrile (14)2-(Pyridin-2-Yl)Acetonitrile (8)2-(Pyridin-3-Yl)Acetonitrile (6)2-(Trifluoromethoxy)Benzonitrile (7)2-(Trifluoromethyl)Benzonitrile (35)2-Amino-3-Bromobenzonitrile (7)2-Amino-3-Chlorobenzonitrile (3)2-Amino-6-Chlorobenzonitrile (3)2-Aminonicotinonitrile (6)2-Bromo-6-Fluorobenzonitrile (7)2-Chloro-3-Methylbenzonitrile (5)2-Chloro-4-Fluorobenzonitrile (9)2-Chloro-6-Fluorobenzonitrile (5)2-Chloro-N-Methylaniline (4)2-Chlorobenzonitrile (99)2-Hydroxybenzonitrile (45)2-Iodobenzonitrile (26)2-Naphthonitrile (15)2-Nitrobenzonitrile (37)2-Oxo-2H-Chromene-3-Carbonitrile (4)2-Phenoxyacetonitrile (11)2-Phenoxybenzonitrile (5)2-Phenylacetonitrile (172)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile (25)3-(Trifluoromethoxy)Benzonitrile (11)3-(Trifluoromethyl)Benzonitrile (47)3-Bromo-2-Fluorobenzonitrile (10)3-Bromo-2-Hydroxybenzonitrile (3)3-Bromobenzonitrile (109)3-Chloro-2-Fluorobenzonitrile (7)3-Chlorobenzonitrile (100)3-Chloropyrazine-2-Carbonitrile (6)3-Fluoropicolinonitrile (5)3-Hydroxybenzonitrile (40)3-Iodobenzonitrile (27)3-Nitrobenzonitrile (59)3-Oxo-3-Phenylpropanenitrile (21)3-Phenoxybenzonitrile (5)4-Amino-2-Chlorobenzonitrile (8)4-Chloropyrimidine-5-Carbonitrile (6)4-Cyanophenyl Benzoate (11)4-Cyclohexylbenzonitrile (10)4-Fluorobenzonitrile (89)4-Nitrobenzonitrile (25)5-Fluoropicolinonitrile (5)6-Methylnicotinonitrile (7)6-Methylpicolinonitrile (10)[1,1'-Biphenyl]-2-Carbonitrile (12)[1,1'-Biphenyl]-4-Carbonitrile (27)Benzo[B]Thiophene-2-Carbonitrile (3)Benzo[D]Thiazole-2-Carbonitrile (11)Benzonitrile (1374)Furan-2-Carbonitrile (8)Imidazo[1,2-A]Pyridine-6-Carbonitrile (3)Isonicotinonitrile (16)Isoquinoline-1-Carbonitrile (7)Methyl 2-Cyanobenzoate (22)Methyl 3-Cyanobenzoate (29)Morpholine-2-Carbonitrile (4)Nicotinonitrile (82)Pyrazine-2-Carbonitrile (15)Pyrimidine-2-Carbonitrile (14)Pyrimidine-4-Carbonitrile (9)Pyrimidine-5-Carbonitrile (6)Pyrrolidine-2-Carbonitrile (9)Pyrrolidine-3-Carbonitrile (6)Thiazole-5-Carbonitrile (7)Thiophene-2-Carbonitrile (23)Thiophene-3-Carbonitrile (13)Alcohols (44)Aldehydes (12)Aliphatic Chain Hydrocarbons (92)Aliphatic Cyclic Hydrocarbons (29)Alkenyls (62)Amides (92)Amines (142)Aryls (348)Azetidines (5)Benzyl Bromides (5)Bromides (82)Carboxylic Acids (45)Chlorides (97)Esters (100)Ethers (103)Fluorinated Building Blocks (76)Furans (7)Guanidines (4)Hydrazines (5)Indazoles (7)Indoles (29)Indolines (5)Iodides (10)Isoquinolines (4)Ketones (57)Morpholines (5)Nitroes (26)Oxazoles (6)Phenols (5)Piperazines (14)Piperidines (54)Pyrazoles (39)Pyridazines (5)Pyridines (126)Pyrimidines (15)Pyrroles (6)Pyrrolidines (11)Quinolines (19)Spiroes (2)Sulfamides (4)Sulfides (13)Sulfones (9)Sulfonyl Chlorides (5)Tetrahydropyrans (9)Thiazoles (7)Thiophenes (15)Trifluoromethyls (13)Other Aromatic Heterocycles (31)Acetonitrile (249)Acrylonitrile (8)Aminobutanenitrile (5)Aminocyclohexanecarbonitrile (6)Bromobenzonitrile (15)Bromonicotinonitrile (9)Bromophenylacetonitrile (2)Butanenitrile (2)Chlorobenzonitrile (26)Chloroisonicotinonitrile (4)Chloronicotinonitrile (40)Cyanide (428)Cyanoacetamide (4)Cyanoacetate (14)Cyanobenzaldehyde (4)Cyanobenzoate (27)Cyanobenzoic (20)Cyanoethyl (15)Cyanoisonicotinate (4)Cyanomethyl (42)Cyanonicotinate (8)Cyanophenoxy (8)Cyanophenyl (58)Cyanophenylboronic (5)Cyanopropan (4)Diacetonitrile (1)Diaminobenzonitrile (8)Dibromoisonicotinonitrile (3)Dicarbonitrile (45)Dichlorobenzonitrile (12)Dichloroisonicotinonitrile (4)Difluorobenzonitrile (41)Fluorobenzonitrile (85)Fluoroisonicotinonitrile (5)Fluoronicotinonitrile (14)Fluorophenylacetonitrile (8)Fluoropicolinonitrile (13)Formylnicotinonitrile (5)Hydrazinylbenzonitrile (6)Iodobenzonitrile (44)Iodonicotinonitrile (8)Malononitrile (41)Methoxyisonicotinonitrile (7)Methoxynicotinonitrile (17)Methylnicotinonitrile (57)Methylpropanenitrile (9)Nitropicolinonitrile (10)Oxopropanenitrile (8)Phenylacrylonitrile (20)Propanenitrile (41)Pyrazino-Nitrile (50)Tetrafluorobenzonitrile (5)Thiocyanatoaniline (3)Tricarbonitrile (5)Trifluorobenzonitrile (7)Trifluoromethylbenzonitrile (5)

Nitroes (23886)

(2-Nitrophenyl)Boronic Acid (13)(2-Nitrophenyl)Methanol (29)(2-Nitrovinyl)Benzene (28)(3-Nitrophenyl)(Phenyl)Methanone (5)(3-Nitrophenyl)Boronic Acid (32)(3-Nitrophenyl)Methanol (31)(4-Nitrophenyl)(Phenyl)Methanone (3)(4-Nitrophenyl)Methanol (17)1,2-Dichloro-4-Nitrobenzene (16)1,2-Difluoro-3-Nitrobenzene (23)1,2-Difluoro-4-Nitrobenzene (43)1,2-Dimethyl-3-Nitrobenzene (6)1,2-Dinitrobenzene (6)1,3-Dibromo-2-Nitrobenzene (4)1,3-Dichloro-2-Nitrobenzene (5)1,3-Difluoro-2-Nitrobenzene (16)1,3-Dimethyl-2-Nitrobenzene (9)1,3-Dinitrobenzene (31)1,4-Difluoro-2-Nitrobenzene (28)1,4-Dimethyl-2-Nitrobenzene (10)1-(2-Nitrophenyl)Ethan-1-One (24)1-(3-Methoxy-2-Nitrophenyl)Ethan-1-One (4)1-(3-Nitrophenyl)Ethan-1-One (25)1-(3-Nitrophenyl)Propan-1-One (4)1-(Benzyloxy)-2-Nitrobenzene (3)1-(Benzyloxy)-3-Nitrobenzene (10)1-(Bromomethyl)-2-Nitrobenzene (23)1-(Methylsulfonyl)-3-Nitrobenzene (7)1-(Tert-Butyl)-2-Nitrobenzene (4)1-(Tert-Butyl)-3-Nitrobenzene (7)1-Bromo-2-Chloro-4-Nitrobenzene (5)1-Bromo-2-Fluoro-3-Nitrobenzene (11)1-Bromo-2-Fluoro-4-Nitrobenzene (13)1-Bromo-3-Methyl-2-Nitrobenzene (3)1-Bromo-3-Nitrobenzene (235)1-Chloro-2-Fluoro-4-Nitrobenzene (9)1-Chloro-2-Methyl-3-Nitrobenzene (6)1-Chloro-2-Nitrobenzene (138)1-Chloro-3-Fluoro-2-Nitrobenzene (6)1-Chloro-3-Nitrobenzene (160)1-Ethoxy-3-Nitrobenzene (7)1-Fluoro-3-Nitrobenzene (216)1-Iodo-2-Nitrobenzene (36)1-Iodo-3-Nitrobenzene (45)1-Methoxy-3-Nitrobenzene (108)1-Methoxy-4-Nitrobenzene (90)1-Methyl-2-Nitrobenzene (175)1-Methyl-3-Nitrobenzene (147)1-Methyl-4-Nitrobenzene (82)1-Nitro-2-(Trifluoromethoxy)Benzene (8)1-Nitro-2-(Trifluoromethyl)Benzene (32)1-Nitro-2-Phenoxybenzene (4)1-Nitro-3-(Trifluoromethoxy)Benzene (9)1-Nitro-3-(Trifluoromethyl)Benzene (82)1-Nitro-4-Phenoxybenzene (5)1-Nitronaphthalene (3)2,4-Dichloro-1-Nitrobenzene (19)2,4-Difluoro-1-Nitrobenzene (46)2,4-Dimethoxy-1-Nitrobenzene (5)2,4-Dimethyl-1-Nitrobenzene (15)2-((2-Nitrophenyl)Amino)Ethan-1-Ol (5)2-(2-Nitrophenyl)Acetic Acid (20)2-(4-Nitrophenyl)Acetic Acid (9)2-Bromo-1-Chloro-4-Nitrobenzene (9)2-Bromo-1-Fluoro-3-Nitrobenzene (9)2-Bromo-1-Fluoro-4-Nitrobenzene (23)2-Bromo-1-Methyl-4-Nitrobenzene (12)2-Bromo-3-Nitrobenzoic Acid (4)2-Bromo-4-Chloro-1-Nitrobenzene (5)2-Bromo-4-Fluoro-1-Nitrobenzene (23)2-Bromo-4-Nitroaniline (12)2-Bromo-6-Nitroaniline (14)2-Bromo-6-Nitrophenol (9)2-Chloro-1,3-Dinitrobenzene (2)2-Chloro-1-Fluoro-4-Nitrobenzene (16)2-Chloro-1-Methyl-3-Nitrobenzene (4)2-Chloro-3-Nitrobenzoic Acid (4)2-Chloro-4-Fluoro-1-Nitrobenzene (13)2-Chloro-4-Methyl-1-Nitrobenzene (6)2-Chloro-4-Nitrophenol (5)2-Chloro-5-Nitropyrimidine (5)2-Chloro-6-Nitroaniline (11)2-Chloro-6-Nitrophenol (7)2-Fluoro-1-Methoxy-4-Nitrobenzene (8)2-Fluoro-4-Methyl-1-Nitrobenzene (13)2-Iodo-1-Methyl-4-Nitrobenzene (3)2-Iodo-6-Nitroaniline (3)2-Methoxy-5-Nitropyridine (8)2-Methoxy-6-Nitrophenol (5)2-Methyl-3-Nitrobenzoic Acid (7)2-Methyl-3-Nitropyridine (9)2-Methyl-6-Nitroaniline (10)2-Nitro-1H-Pyrrole (5)2-Nitro-N-Phenylaniline (3)2-Nitrobenzaldehyde (53)2-Nitrobenzoic Acid (64)2-Nitrobenzonitrile (37)2-Nitrofuran (9)2-Nitronaphthalene (4)2-Nitropyridine (40)2-Nitrothiophene (20)3-Chloro-2-Nitroaniline (5)3-Chloro-4-Nitroaniline (5)3-Fluoro-4-Nitroaniline (7)3-Methoxy-2-Nitrobenzaldehyde (3)3-Methoxy-4-Nitrobenzoic Acid (4)3-Methyl-5-Nitropyridine (4)3-Nitroaniline (98)3-Nitrobenzaldehyde (49)3-Nitrobenzamide (17)3-Nitrobenzene-1,2-Diol (6)3-Nitrobenzenesulfonamide (8)3-Nitrobenzoic Acid (109)3-Nitrobenzonitrile (59)3-Nitrophenol (72)3-Nitropyridin-2-Ol (11)3-Nitropyridin-4-Amine (5)3-Nitropyridine (54)3-Nitrothiophene (6)4,4,5,5-Tetramethyl-2-(2-Nitrophenyl)-1,3,2-Dioxaborolane (5)4-Fluoro-1-Methyl-2-Nitrobenzene (12)4-Fluoro-2-Nitroaniline (14)4-Hydroxy-3-Nitrobenzaldehyde (5)4-Methyl-3-Nitroaniline (8)4-Methyl-3-Nitropyridine (8)4-Nitro-1H-Indazole (10)4-Nitro-1H-Indole (6)4-Nitro-1H-Pyrazole (8)4-Nitroaniline (64)4-Nitrobenzaldehyde (18)4-Nitrobenzene-1,3-Diol (5)4-Nitrobenzoic Acid (35)4-Nitrobenzonitrile (25)4-Nitrophenol (67)4-Nitropyridine (11)5-(4-Nitrophenyl)Oxazole (3)5-Methoxy-2-Nitroaniline (7)5-Methyl-2-Nitroaniline (6)5-Nitro-1H-Indazole (5)5-Nitro-1H-Indole (6)5-Nitro-1H-Pyrazole (9)5-Nitro-1H-Pyrazolo[3,4-B]Pyridine (3)5-Nitro-2,3-Dihydrobenzofuran (3)5-Nitrobenzo[D][1,3]Dioxole (4)5-Nitrobenzo[D]Thiazole (3)5-Nitroisoquinoline (7)5-Nitronicotinic Acid (5)5-Nitropyridin-2-Amine (6)6-Nitro-1,2,3,4-Tetrahydroisoquinoline (3)6-Nitro-1H-Indazole (9)6-Nitro-1H-Indole (8)6-Nitrobenzo[D]Thiazole (3)7-Nitro-1,2,3,4-Tetrahydroisoquinoline (3)7-Nitro-1H-Indazole (11)7-Nitro-1H-Indole (11)Ethyl 2-Nitrobenzoate (9)Ethyl 3-Nitrobenzoate (22)Ethyl Cinnamate (25)Methyl 2-Nitrobenzoate (54)Methyl 3-Nitrobenzoate (109)Methyl 4-Amino-3-Nitrobenzoate (9)Methyl 4-Nitrobenzoate (29)N-(2-Nitrophenyl)Acetamide (11)N-Methyl-2-Nitroaniline (20)N-Methyl-4-Nitroaniline (5)Nitrobenzene (2273)Alcohols (42)Aldehydes (22)Aliphatic Chain Hydrocarbons (7)Alkenyls (21)Amines (112)Anhydrides (5)Aryls (348)Benzofurans (5)Benzothiazoles (5)Benzoxazoles (5)Bromides (62)Carboxylic Acids (44)Chlorides (81)Epoxides (5)Esters (72)Ethers (83)Fluorinated Building Blocks (75)Furans (8)Imidazoles (13)Indazoles (7)Indoles (10)Indolines (9)Iodides (6)Ketones (28)Morpholines (12)Nitriles (26)Oxazoles (4)Phenols (12)Piperazines (6)Piperidines (13)Pyrazoles (28)Pyridines (61)Pyrimidines (13)Pyrroles (8)Pyrrolidines (12)Quinazolines (4)Quinolines (19)Quinoxalines (7)Sulfamides (7)Sulfides (12)Sulfonates (6)Thiazoles (8)Thiophenes (7)Trifluoromethyls (5)Other Aromatic Heterocycles (22)Difluoronitrobenzene (9)Dinitro (7)Dinitroaniline (5)Nitroacetophenone (7)Nitroaniline (207)Nitrobenzaldehyde (100)Nitrobenzamide (35)Nitrobenzenesulfonamide (26)Nitrobenzonitrile (105)Nitrobenzotrifluoride (16)Nitroisophthalate (4)

Amidines (24)Amines (5)Aryls (24)Chlorides (7)Esters (5)Piperidines (5)Pyridines (11)

1,2,3,4-Tetrahydroisoquinolin-5-Ol (3)1,2,3,4-Tetrahydroisoquinolin-6-Ol (6)1-(2-Hydroxyphenyl)Ethan-1-One (72)1-(3-Hydroxyphenyl)Ethan-1-One (19)1-Hydroxyanthracene-9,10-Dione (12)2,3-Dichlorophenol (9)2,3-Difluorophenol (36)2,4-Dibromophenol (16)2,4-Difluorophenol (21)2,5-Dichlorophenol (7)2,6-Dibromophenol (20)2,6-Dichlorophenol (16)2,6-Difluorophenol (23)2,6-Diiodophenol (9)2,6-Dimethylphenol (19)2-(2-Hydroxyphenyl)Acetic Acid (8)2-(3-Hydroxyphenyl)Acetic Acid (7)2-(Benzyloxy)Phenol (5)2-(Difluoromethoxy)Phenol (5)2-(Tert-Butyl)Phenol (54)2-(Trifluoromethoxy)Phenol (8)2-(Trifluoromethyl)Phenol (23)2-Amino-3-Bromophenol (3)2-Amino-3-Chlorophenol (4)2-Aminophenol (106)2-Benzylphenol (8)2-Bromo-3-Methylphenol (4)2-Bromo-6-Methylphenol (7)2-Bromobenzene-1,3-Diol (7)2-Bromobenzene-1,4-Diol (4)2-Chloro-4-Fluorophenol (9)2-Chloro-4-Nitrophenol (5)2-Chloro-6-Methylphenol (5)2-Chloro-6-Nitrophenol (7)2-Chlorobenzene-1,3-Diol (4)2-Chlorophenol (163)2-Ethylphenol (10)2-Hydroxy-N-Phenylbenzamide (3)2-Hydroxybenzamide (14)2-Hydroxybenzonitrile (45)2-Iodobenzene-1,3-Diol (3)2-Iodophenol (53)2-Isopropylphenol (28)2-Methoxyphenol (196)3,4-Dibromophenol (3)3,4-Difluorophenol (19)3-(Benzyloxy)Phenol (5)3-(Trifluoromethoxy)Phenol (12)3-(Trifluoromethyl)Phenol (43)3-Bromo-2-Fluorophenol (5)3-Bromo-4-Chlorophenol (5)3-Bromo-4-Fluorophenol (11)3-Bromobenzene-1,2-Diol (8)3-Chloro-4-Hydroxybenzaldehyde (7)3-Chlorobenzene-1,2-Diol (6)3-Chlorophenol (112)3-Fluorophenol (177)3-Hydroxybenzonitrile (40)3-Iodophenol (21)3-Nitrobenzene-1,2-Diol (6)3-Nitrophenol (72)4-(Benzyloxy)Phenol (2)4-(Trifluoromethyl)Phenol (18)4-Amino-2-Fluorophenol (9)4-Amino-3-Chlorophenol (5)4-Benzylphenol (14)4-Chlorobenzene-1,3-Diol (6)4-Fluorophenol (111)4-Hydroxybenzenesulfonic Acid (5)4-Nitrobenzene-1,3-Diol (5)4-Nitrophenol (67)6-Hydroxy-2,3-Dihydro-1H-Inden-1-One (3)Ethyl 2-Hydroxybenzoate (18)Ethyl 3-Hydroxybenzoate (11)M-Cresol (144)Methyl 2-(4-Hydroxyphenyl)Acetate (10)Methyl 2-Hydroxybenzoate (74)Methyl 3-Hydroxybenzoate (57)O-Cresol (163)P-Cresol (71)Pyrocatechol (125)Resorcinol (145)Aminophenol (9)Bromophenol (13)Chlorophenol (27)Dibromophenol (9)Dichlorophenol (17)Difluorophenol (36)Dihydroxybenzaldehyde (16)Dihydroxybenzamide (6)Dihydroxybenzoate (14)Dihydroxybenzoic (17)Dihydroxybenzonitrile (6)Dihydroxyphenyl (90)Dihydroxystyryl (4)Diiodophenol (6)Fluorophenol (73)Hydroxyacetophenone (16)Hydroxybenzaldehyde (88)Hydroxybenzamide (24)Hydroxybenzenesulfonic (4)Hydroxybenzenesulfonic Acid (3)Hydroxybenzoate (111)Hydroxybenzohydrazide (4)Hydroxybenzoic (87)Hydroxybenzonitrile (60)Hydroxybenzoyl (1)Hydroxyphenoxy (7)Hydroxyphenylacetic (6)Hydroxyphenylacetic Acid (6)Hydroxyphenylboronic (8)Hydroxypropiophenone (3)Iodophenol (42)Nitrophenol (134)Tetrafluorophenol (10)Trifluorophenol (5)Trihydroxybenzaldehyde (5)Trihydroxybenzoate (12)Trihydroxybenzoic (5)Trihydroxybenzoic Acid (4)Trihydroxyphenyl (10)

Phosphoruses (831)

1,1,1-Trifluoro-N-(4-Oxido-2,6-Diphenyldinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Yl)Methanesulfonamide (16)Diethyl Benzylphosphonate (17)Dimethyl(Phenyl)Phosphine Oxide (20)Ethyltriphenylphosphonium (2)Methyltriphenylphosphonium (2)Phenyl Phosphate (3)Phenylphosphonic Acid (6)Aryls (9)Esters (5)Fluorinated Building Blocks (5)Diethoxyphosphoryl (5)Diisopropylphosphoramidite (4)Dimethoxyphosphoryl (4)Dimethylphosphine (28)Dioxaphosphepine (146)Diphosphonic (9)Phosphorothioate (1)

Polycyclic Aromatic Hydrocarbons (1)

Protective Groups (21)

Saturated Aliphatic Fused Rings (4)

(8Ar,12Br,14Br)-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Icosahydropicene (4)

Silicon Compounds (448)

1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine (8)Tert-Butyldimethyl(Phenoxy)Silane (17)Tetraphenylsilane (7)Trimethoxy(Phenyl)Silane (6)Trimethyl(Phenyl)Silane (22)Trimethyl(Phenylethynyl)Silane (23)Butyldimethylsilyl (95)Butyldimethylsilyloxy (8)Dimethylsilane (16)Dimethylsilyl (4)Tetramethyldisiloxane (3)Triethoxysilyl (13)Triisopropylsilyl (22)Trimethoxysilane (19)Trimethylsilane (155)

Sulfamides (10232)

2-Fluoro-N-Phenylbenzenesulfonamide (6)2-Fluorobenzenesulfonamide (12)2-Methylbenzenesulfonamide (8)3-Nitrobenzenesulfonamide (8)4-Amino-N-Phenylbenzenesulfonamide (3)4-Bromo-N-Phenylbenzenesulfonamide (23)4-Chloro-N-Phenylbenzenesulfonamide (4)4-Methoxy-N-Phenylbenzenesulfonamide (3)4-Methoxybenzenesulfonamide (5)4-Methyl-N-Phenylbenzenesulfonamide (13)N,N-Diethylbenzenesulfonamide (8)N,N-Dimethylbenzenesulfonamide (23)N-(2-Phenoxyphenyl)Methanesulfonamide (3)N-(3-Chlorophenyl)Benzenesulfonamide (6)N-(O-Tolyl)Benzenesulfonamide (4)N-(Tert-Butyl)Benzenesulfonamide (14)N-Ethylbenzenesulfonamide (8)N-Isopropylbenzenesulfonamide (8)N-Methyl-N-(4-Phenylpyrimidin-2-Yl)Methanesulfonamide (7)N-Methylbenzenesulfonamide (15)N-Phenylbenzenesulfonamide (81)N-Phenylmethanesulfonamide (37)Phenylmethanesulfonamide (13)Pyridine-2-Sulfonamide (6)Alcohols (27)Aldehydes (6)Aliphatic Chain Hydrocarbons (37)Aliphatic Cyclic Hydrocarbons (8)Alkenyls (12)Amides (43)Amines (50)Aryls (216)Azetidines (5)Benzothiazoles (6)Benzyl Bromides (3)Bromides (35)Carboxylic Acids (28)Chlorides (50)Esters (23)Ethers (22)Fluorinated Building Blocks (26)Hydrazines (4)Imidazoles (7)Indoles (6)Ketones (4)Morpholines (11)Nitriles (4)Nitroes (7)Piperazines (12)Piperidines (24)Pyrazoles (4)Pyridines (19)Pyrimidines (1)Pyrrolidines (10)Sulfonates (6)Thiadiazoles (4)Thiophenes (16)Trifluoromethyls (5)Ureas (3)Other Aliphatic Heterocycles (11)Other Aromatic Heterocycles (17)Dimethylsulfamoyl (5)Methanesulfonamide (49)Methylmethanesulfonamide (3)Methylsulfonamido (4)Sulfinamide (55)

Sulfides (10154)

(S)-2-(Phenylthio)Tetrahydro-2H-Pyran (5)1,2-Diphenyldisulfane (18)2-((Pyridin-2-Ylmethyl)Thio)-1H-Benzo[D]Imidazole (7)2-(Methylthio)Benzo[D]Thiazole (6)2-(Methylthio)Pyridine (5)2-(Methylthio)Pyrimidin-4-Amine (10)2-(Methylthio)Pyrimidine (19)2-(Methylthio)Thiazole (5)2-(Propylthio)Pyrimidine (5)4,6-Dichloro-2-(Methylthio)Pyrimidine (9)4-Chloro-2-(Methylthio)Pyrimidine (29)4-Methyl-2-(Methylthio)Pyrimidine (7)5-Bromo-2-(Methylthio)Pyrimidine (6)Benzyl(Phenyl)Sulfane (5)Ethyl(Phenyl)Sulfane (8)Pentafluoro(Phenyl)-L6-Sulfane (19)Phenyl(Trifluoromethyl)Sulfane (23)Alcohols (27)Aldehydes (8)Aliphatic Chain Hydrocarbons (28)Amides (40)Amines (41)Aryls (143)Benzimidazoles (7)Bromides (18)Carboxylic Acids (57)Chlorides (50)Esters (27)Ethers (29)Fluorinated Building Blocks (21)Furans (6)Ketones (18)Nitriles (13)Nitroes (12)Phenols (3)Pyridines (18)Pyrimidines (53)Pyrrolidines (7)Tetrahydropyrans (3)Thiadiazoles (7)Thiazoles (8)Thiophenes (4)Triazoles (3)Other Aliphatic Heterocycles (8)Other Aromatic Heterocycles (8)Methylthio (424)

Sulfonates (1153)

4-Methylbenzenesulfonate (8)Aliphatic Chain Hydrocarbons (4)Amides (15)Amines (6)Aryls (83)Dioxolanes (4)Epoxides (7)Ethers (4)Fluorinated Building Blocks (23)Nitroes (6)Oxetanes (5)Piperidines (10)Pyrrolidines (4)Sulfamides (6)Trifluoromethyls (14)

Sulfones (3920)

(4-(Methylsulfonyl)Phenyl)Boronic Acid (6)(Ethylsulfonyl)Benzene (8)1-(Methylsulfonyl)-3-Nitrobenzene (7)1-(Methylsulfonyl)Piperazine (5)1-(Methylsulfonyl)Piperidine (5)1-(Phenylsulfonyl)-1H-1,2,4-Triazole (6)1-(Phenylsulfonyl)-1H-Imidazole (5)1-(Phenylsulfonyl)Azetidine (7)1-Bromo-2-(Methylsulfonyl)Benzene (4)1-Bromo-4-(Phenylsulfonyl)Benzene (7)1-Fluoro-2-(Methylsulfonyl)Benzene (5)1-Fluoro-3-(Methylsulfonyl)Benzene (10)1-Methyl-3-(Methylsulfonyl)Benzene (5)2-(Methylsulfonyl)Aniline (3)2-(Methylsulfonyl)Pyridine (11)2-(Methylsulfonyl)Pyrimidine (25)3-(Methylsulfonyl)Aniline (7)3-(Methylsulfonyl)Benzoic Acid (6)3-(Methylsulfonyl)Pyridine (5)Benzenesulfonyl Fluoride (50)Tetrahydro-2H-Thiopyran 1,1-Dioxide (8)Tetrahydrothiophene 1,1-Dioxide (13)Alcohols (7)Aliphatic Chain Hydrocarbons (18)Alkenyls (12)Amides (13)Amines (20)Aryls (118)Bromides (31)Carboxylic Acids (15)Chlorides (29)Esters (16)Ethers (12)Fluorinated Building Blocks (13)Ketones (9)Nitriles (9)Phenols (5)Piperazines (1)Piperidines (6)Pyridines (14)Pyrimidines (7)Thiomorpholines (8)Thiophenes (4)Other Aliphatic Heterocycles (9)Other Aromatic Heterocycles (5)

Sulfonic Acids (1259)

2-Aminobenzenesulfonic Acid (9)2-Methylbenzenesulfonic Acid (8)3-Aminobenzenesulfonic Acid (6)4-Chlorobenzenesulfonic Acid (4)4-Hydroxybenzenesulfonic Acid (5)Naphthalene-2-Sulfonic Acid (4)Pyridine-3-Sulfonic Acid (6)Aliphatic Cyclic Hydrocarbons (4)Amines (11)Aryls (22)Ketones (4)Aminobenzenesulfonic (4)Bromobenzenesulfonic Acid (4)Disulfonic (9)Ethanesulfonic (3)Methanesulfonic (2)Methylbenzenesulfonate (142)Propanesulfonic Acid (2)

Sulfonyl Hydrazides (25)

Benzenesulfonohydrazide (12)

Sulfoxides (334)

(Methylsulfinyl)Benzene (7)Aryls (19)Chlorides (7)Ethers (5)

Thioesters (624)

Aliphatic Chain Hydrocarbons (4)Amides (25)Amines (5)Aryls (9)Benzothiazoles (12)Carboxylic Acids (7)Fluorinated Building Blocks (4)Thiazolidines (8)

1H-Benzo[D]Imidazole-2-Thiol (10)2-Chlorobenzenethiol (7)2-Mercaptoquinazolin-4(3H)-One (3)Benzo[D]Oxazole-2-Thiol (6)Benzo[D]Thiazole-2-Thiol (11)Phenylmethanethiol (16)Pyridine-2-Thiol (8)Pyrimidine-2-Thiol (6)Alcohols (5)Aliphatic Chain Hydrocarbons (27)Amides (4)Aryls (8)Esters (9)Dithiole (9)Ethanethioate (9)Methanethiol (6)

Thiophenols (3052)

Amides (6)Amines (5)Aryls (29)Bromides (4)Ethers (7)Fluorinated Building Blocks (4)Pyridines (6)Pyrimidines (4)Thiadiazoles (6)Thiazoles (4)Triazoles (8)

Thioureas (1119)

1,3-Diphenylthiourea (8)1-Phenylthiourea (33)Aliphatic Chain Hydrocarbons (19)Amides (61)Aryls (28)Hydrazides (11)Hydrazines (8)Pyridines (4)Carbamimidothioate (4)

Trifluoromethyls (28901)

(2,2,2-Trifluoroethoxy)Benzene (18)(2-(Trifluoromethoxy)Phenyl)Boronic Acid (5)(2-(Trifluoromethyl)Phenyl)Boronic Acid (20)(2-(Trifluoromethyl)Phenyl)Methanol (10)(2-Fluoro-3-(Trifluoromethyl)Phenyl)Boronic Acid (6)(3-(Trifluoromethoxy)Phenyl)Boronic Acid (9)(3-(Trifluoromethoxy)Phenyl)Methanol (4)(3-(Trifluoromethyl)Phenyl)Boronic Acid (41)(3-(Trifluoromethyl)Phenyl)Methanol (22)(4-(Trifluoromethyl)Phenyl)Boronic Acid (23)(Perfluoropropane-2,2-Diyl)Dibenzene (7)(Trifluoromethyl)Benzene (1314)1,3-Bis(Trifluoromethyl)Benzene (70)1-(2-(Trifluoromethyl)Phenyl)Ethan-1-One (9)1-(3-(Trifluoromethoxy)Phenyl)Ethan-1-Amine (6)1-(3-(Trifluoromethyl)Phenyl)Ethan-1-Amine (25)1-(4-(Trifluoromethoxy)Phenyl)Ethan-1-Amine (6)1-(Bromomethyl)-2-(Trifluoromethyl)Benzene (13)1-(Bromomethyl)-3-(Trifluoromethyl)Benzene (17)1-Bromo-2-(Trifluoromethoxy)Benzene (22)1-Bromo-2-Fluoro-3-(Trifluoromethyl)Benzene (4)1-Bromo-3-(Trifluoromethyl)Benzene (100)1-Chloro-2-(Trifluoromethoxy)Benzene (20)1-Chloro-2-(Trifluoromethyl)Benzene (81)1-Chloro-3-(Trifluoromethoxy)Benzene (18)1-Chloro-3-(Trifluoromethyl)Benzene (101)1-Chloro-4-(Trifluoromethoxy)Benzene (8)1-Fluoro-2-(Trifluoromethoxy)Benzene (20)1-Fluoro-2-(Trifluoromethyl)Benzene (125)1-Fluoro-3-(Trifluoromethyl)Benzene (98)1-Fluoro-4-(Trifluoromethoxy)Benzene (14)1-Fluoro-4-(Trifluoromethyl)Benzene (53)1-Iodo-2-(Trifluoromethyl)Benzene (13)1-Iodo-3-(Trifluoromethyl)Benzene (30)1-Methoxy-2-(Trifluoromethyl)Benzene (21)1-Methoxy-3-(Trifluoromethoxy)Benzene (9)1-Methoxy-3-(Trifluoromethyl)Benzene (40)1-Methoxy-4-(Trifluoromethyl)Benzene (18)1-Methyl-2-(Trifluoromethoxy)Benzene (5)1-Methyl-2-(Trifluoromethyl)Benzene (43)1-Methyl-3-(Trifluoromethyl)Benzene (22)1-Nitro-2-(Trifluoromethoxy)Benzene (8)1-Nitro-2-(Trifluoromethyl)Benzene (32)1-Nitro-3-(Trifluoromethoxy)Benzene (9)1-Nitro-3-(Trifluoromethyl)Benzene (82)1-Phenoxy-3-(Trifluoromethyl)Benzene (2)1-Phenoxy-4-(Trifluoromethyl)Benzene (2)1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazole (5)2,2,2-Trifluoro-1-Phenylethan-1-Amine (48)2,2,2-Trifluoro-1-Phenylethan-1-Ol (27)2,2,2-Trifluoro-1-Phenylethan-1-One (51)2-(2,2,2-Trifluoroethoxy)Pyridine (8)2-(Trifluoromethoxy)Aniline (18)2-(Trifluoromethoxy)Benzaldehyde (7)2-(Trifluoromethoxy)Benzoic Acid (8)2-(Trifluoromethoxy)Benzonitrile (7)2-(Trifluoromethoxy)Phenol (8)2-(Trifluoromethoxy)Pyridine (6)2-(Trifluoromethyl)-1,1'-Biphenyl (8)2-(Trifluoromethyl)Aniline (58)2-(Trifluoromethyl)Benzaldehyde (27)2-(Trifluoromethyl)Benzamide (6)2-(Trifluoromethyl)Benzoic Acid (33)2-(Trifluoromethyl)Benzonitrile (35)2-(Trifluoromethyl)Phenol (23)2-(Trifluoromethyl)Pyrazine (6)2-(Trifluoromethyl)Pyridine (6)2-(Trifluoromethyl)Pyrimidine (27)2-(Trifluoromethyl)Quinazoline (4)2-(Trifluoromethyl)Thiazole (11)2-(Trifluoromethyl)Thiophene (10)2-Bromo-1-Fluoro-4-(Trifluoromethyl)Benzene (4)2-Bromo-4-(Trifluoromethyl)Aniline (9)2-Bromo-6-(Trifluoromethyl)Aniline (5)2-Chloro-3-(Trifluoromethyl)Aniline (3)2-Chloro-4-(Trifluoromethyl)Pyrimidine (6)2-Chloro-6-(Trifluoromethyl)Aniline (4)2-Methoxy-3-(Trifluoromethyl)Pyridine (6)2-Methoxy-5-(Trifluoromethyl)Pyridine (4)2-Phenoxy-5-(Trifluoromethyl)Pyridine (7)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Pyridine (3)3-(Trifluoromethoxy)Aniline (22)3-(Trifluoromethoxy)Benzaldehyde (10)3-(Trifluoromethoxy)Benzoic Acid (19)3-(Trifluoromethoxy)Benzonitrile (11)3-(Trifluoromethoxy)Phenol (12)3-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine (3)3-(Trifluoromethyl)Aniline (102)3-(Trifluoromethyl)Benzaldehyde (31)3-(Trifluoromethyl)Benzenesulfonyl Chloride (13)3-(Trifluoromethyl)Benzoic Acid (52)3-(Trifluoromethyl)Benzonitrile (47)3-(Trifluoromethyl)Phenol (43)3-(Trifluoromethyl)Pyridazine (3)3-(Trifluoromethyl)Pyridin-2-Ol (5)3-(Trifluoromethyl)Pyridine (51)3-Chloro-4-(Trifluoromethyl)Aniline (5)4,4,4-Trifluoro-1-Phenylbutane-1,3-Dione (10)4,4,5,5-Tetramethyl-2-(2-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane (5)4,4,5,5-Tetramethyl-2-(3-(Trifluoromethoxy)Phenyl)-1,3,2-Dioxaborolane (5)4-(Trifluoromethoxy)Aniline (26)4-(Trifluoromethyl)-2H-Chromen-2-One (7)4-(Trifluoromethyl)Phenol (18)4-(Trifluoromethyl)Pyridine (14)4-(Trifluoromethyl)Pyrimidin-2-Amine (6)4-(Trifluoromethyl)Pyrimidine (12)4-(Trifluoromethyl)Thiazole (7)4-Bromo-3-(Trifluoromethyl)Aniline (7)5-(Trifluoromethyl)Pyridin-2-Amine (5)5-(Trifluoromethyl)Pyridin-2-Ol (8)6-(Trifluoromethyl)-1H-Indazole (6)6-(Trifluoromethyl)-1H-Indole (5)6-(Trifluoromethyl)Pyridin-2-Amine (11)6-(Trifluoromethyl)Pyridin-3-Amine (5)Methyl 2-(Trifluoromethyl)Benzoate (14)Methyl 3-(Trifluoromethyl)Benzoate (22)N-Phenyl-4-(Trifluoromethyl)Aniline (3)Phenyl(3-(Trifluoromethyl)Phenyl)Methanone (3)Phenyl(Trifluoromethyl)Sulfane (23)Alcohols (71)Aldehydes (10)Aliphatic Chain Hydrocarbons (67)Aliphatic Cyclic Hydrocarbons (19)Alkenyls (5)Amides (74)Amidines (3)Amines (95)Aryls (259)Bromides (94)Carboxylic Acids (71)Chlorides (61)Esters (70)Ethers (107)Fluorinated Building Blocks (496)Hydrazines (4)Imidazoles (12)Indoles (5)Iodides (14)Ketones (41)Morpholines (5)Nitriles (13)Nitroes (5)Phenols (2)Piperazines (7)Piperidines (8)Pyrazines (5)Pyrazoles (26)Pyridines (39)Pyrimidines (6)Pyrroles (4)Pyrrolidines (4)Quinolines (7)Sulfamides (5)Sulfonates (14)Thiophenes (1)Other Aromatic Heterocycles (18)Trifluoromethyl-Picolinamide (7)Trifluoromethylaniline (3)Trifluoromethylphenol (16)

Alcohols (5)Aliphatic Chain Hydrocarbons (28)Aliphatic Cyclic Hydrocarbons (6)Amides (80)Amines (6)Aryls (28)Carboxylic Acids (3)Chlorides (7)Hydrazides (7)Hydrazines (4)Morpholines (4)Piperazines (5)Pyrrolidines (2)Sulfamides (3)

Other Function Groups (2)

Organocatalysts

Chiral Hydrogen-Bonding Organocatalysts (76)

Chiral Phosphoric Acids (190)

4-Hydroxy-2,6-Diphenyldinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepine 4-Oxide (20)

Chiral Squaramides Organocatalysts (14)

Chiral Thiourea Catalyst (36)

Cinchona Alkaloids (32)

MacMillan Imidazolidinone Organocatalysts (11)

Proline-Based Organocatalysts (51)

Other Organocatalysts (47)

Organometallic Reagents

Organoborons (34434)

(1-(Tert-Butoxycarbonyl)-1H-Indol-2-Yl)Boronic Acid (17)(1-Phenyl-1H-Pyrazol-4-Yl)Boronic Acid (4)(1H-Indazol-4-Yl)Boronic Acid (3)(1H-Indazol-6-Yl)Boronic Acid (4)(1H-Indol-2-Yl)Boronic Acid (3)(2,3-Dichlorophenyl)Boronic Acid (11)(2,3-Difluorophenyl)Boronic Acid (33)(2,6-Dichlorophenyl)Boronic Acid (6)(2,6-Difluorophenyl)Boronic Acid (28)(2-(Phenoxymethyl)Phenyl)Boronic Acid (3)(2-(Trifluoromethoxy)Phenyl)Boronic Acid (5)(2-(Trifluoromethyl)Phenyl)Boronic Acid (20)(2-Bromophenyl)Boronic Acid (39)(2-Chloro-3-Methoxyphenyl)Boronic Acid (5)(2-Chloro-6-Fluorophenyl)Boronic Acid (9)(2-Fluoro-3-(Trifluoromethyl)Phenyl)Boronic Acid (6)(2-Fluorophenyl)Boronic Acid (229)(2-Nitrophenyl)Boronic Acid (13)(3,4-Dichlorophenyl)Boronic Acid (10)(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol (7)(3-(Benzyloxy)Phenyl)Boronic Acid (9)(3-(Phenoxymethyl)Phenyl)Boronic Acid (3)(3-(Phenylcarbamoyl)Phenyl)Boronic Acid (3)(3-(Trifluoromethoxy)Phenyl)Boronic Acid (9)(3-(Trifluoromethyl)Phenyl)Boronic Acid (41)(3-Bromo-2-Fluorophenyl)Boronic Acid (7)(3-Bromo-2-Methoxyphenyl)Boronic Acid (6)(3-Bromophenyl)Boronic Acid (65)(3-Chloro-2-Methoxyphenyl)Boronic Acid (4)(3-Chloro-4-Fluorophenyl)Boronic Acid (8)(3-Chlorophenyl)Boronic Acid (121)(3-Fluorophenyl)Boronic Acid (169)(3-Iodophenyl)Boronic Acid (5)(3-Nitrophenyl)Boronic Acid (32)(4-(Benzyloxy)Phenyl)Boronic Acid (26)(4-(Methylsulfonyl)Phenyl)Boronic Acid (6)(4-(Phenoxymethyl)Phenyl)Boronic Acid (6)(4-(Phenylcarbamoyl)Phenyl)Boronic Acid (11)(4-(Trifluoromethyl)Phenyl)Boronic Acid (23)(4-Cyclohexylphenyl)Boronic Acid (7)(4-Fluorophenyl)Boronic Acid (93)(5-(Trifluoromethyl)Pyridin-3-Yl)Boronic Acid (4)(6-Phenoxypyridin-3-Yl)Boronic Acid (5)(9H-Fluoren-2-Yl)Boronic Acid (6)(E)-4,4,5,5-Tetramethyl-2-Styryl-1,3,2-Dioxaborolane (16)1,3,2-Dioxaborinane (6)1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperazine (6)1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole (6)2,7-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-9H-Fluorene (7)2-(1,3,2-Dioxaborinan-2-Yl)Benzonitrile (4)2-(1,3,2-Dioxaborolan-2-Yl)-1-Methyl-1H-Indole (6)2-(2-(Bromomethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (9)2-(2-Bromophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (5)2-(3-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (8)2-(3-Cyclopropylphenyl)-1,3,2-Dioxaborolane (5)2-(3-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (5)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile (14)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol (7)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)2-(4-(Benzyloxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (10)2-(4-Bromophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (8)2-(4-Cyclopropylphenyl)-1,3,2-Dioxaborolane (8)2-(4-Fluorophenyl)-1,3,2-Dioxaborinane (5)2-([1,1'-Biphenyl]-4-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (10)2-(Cyclohex-1-En-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (16)2-(Furan-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (6)2-(M-Tolyl)-1,3,2-Dioxaborinane (4)2-Benzyl-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (12)2-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (4)2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (14)2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (3)3-(1,3,2-Dioxaborinan-2-Yl)Aniline (3)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile (25)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (74)3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)4,4,5,5-Tetramethyl-2-(2-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane (5)4,4,5,5-Tetramethyl-2-(2-Nitrophenyl)-1,3,2-Dioxaborolane (5)4,4,5,5-Tetramethyl-2-(3-(Trifluoromethoxy)Phenyl)-1,3,2-Dioxaborolane (5)4,4,5,5-Tetramethyl-2-(Naphthalen-1-Yl)-1,3,2-Dioxaborolane (19)4,4,5,5-Tetramethyl-2-(Naphthalen-2-Yl)-1,3,2-Dioxaborolane (12)4,4,5,5-Tetramethyl-2-(Thiophen-2-Yl)-1,3,2-Dioxaborolane (23)4,4,5,5-Tetramethyl-2-(Thiophen-3-Yl)-1,3,2-Dioxaborolane (10)4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine (11)4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole (4)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indoline (5)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile (4)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine (9)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine (27)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole (7)[1,1'-Biphenyl]-4-Ylboronic Acid (29)Benzo[B]Thiophen-2-Ylboronic Acid (5)Benzofuran-2-Ylboronic Acid (8)Benzyl (4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Carbamate (5)Cyclohex-1-En-1-Ylboronic Acid (4)Ethyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate (6)Isoquinolin-4-Ylboronic Acid (3)Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinate (4)N,N-Diphenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline (6)Naphthalen-1-Ylboronic Acid (4)Naphthalen-2-Ylboronic Acid (8)Phenylboronic Acid (1287)Pyridin-2-Ylboronic Acid (9)Pyridin-3-Ylboronic Acid (49)Pyridin-4-Ylboronic Acid (21)Pyrimidin-5-Ylboronic Acid (9)Tert-Butyl 2-(1,3,2-Dioxaborolan-2-Yl)-1H-Indole-1-Carboxylate (6)Tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-1-Carboxylate (3)Tetraphenylborate (8)Thiophen-2-Ylboronic Acid (20)Fluorene-Phenyl-Boronic Acid/Ester (4)Hydroxymethyl-Phenyl-Boronic-Acid (32)Methoxyphenylboronic-Acid (32)Phenyl-Naphthalene-Boronic Acid/Ester (9)

Organosilicons (74)

Phase-Transfer Catalysts

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Specialty Synthesis

Ionic Liquids (634)

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Materials Science

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Inhibitors/Agonists

ADC Linker (371)

Angiogenesis (2326)

ALK (117)Bcr-Abl (121)BTK (190)EGFR (558)FAK (73)FGFR (192)FLT3 (173)HER2 (44)HIF (191)JAK (357)PDGFR (176)Src (201)Syk (64)VDA (3)VEGFR (402)

Antibody-Drug Conjugate/ADC Related (744)

ADC Linker (371)ADC Toxins (205)Payload-Linker Conjugate (184)

Apelin signaling pathway (1591)

Akt (514)AMPK (208)Apelin Receptor (23)cAMP (66)MLCK (11)NOS (450)Phospholipase (180)PI3K (580)PKA (149)PKC (260)β-arrestin (33)

Autophagy (1107)

ATG4B (4)ATTECs (6)AUTACs (11)Autophagy (999)Beclin1 (2)FKBP (37)LC3 (28)LRRK2 (43)Lysosome (1)mitoNEET (1)Mitophagy (78)PPT (1)SPHK (41)TFEB (1)ULK (24)

Calcium Signaling Pathway (1387)

AChR (603)ATPase (146)Calcineurin (9)Calcium Channel (555)CaMK (94)CRAC Channel (17)Na+/Ca2+ Exchanger (19)Orai1 (2)Phospholipase (180)PKC (260)TRP Channel (259)

cAMP Signaling Pathway (761)

Adenylyl Cyclase (1)cAMP (66)CD73 (30)CREB (6)Epac (9)GSK-3 (219)HCN Channel (17)PDE (567)PKA (149)

Endoplasmic Reticulum Stress (1416)

ASK (2)IRE1 (39)JNK (224)PDI (6)PERK (114)ROS (1081)

Ferroptosis Signaling Pathway (175)

ABC Transporter (23)ACC (32)GPx (77)GTPCH (1)SCD (31)SLC (7)VDAC (6)

FOXO Signaling Pathway (2639)

Akt (514)AMPK (208)CRM1 (19)EGFR (558)ERK (445)FOXO (13)Insulin Receptor (59)JNK (224)MDM2 (217)MEK (156)PDK-1 (26)PI3K (580)Ras (410)SOS (17)STAT (327)TGF-beta/Smad (375)TGF-β Receptor (26)β-catenin (134)

GPCR/G Protein Pathway (5312)

5-HT Receptor (576)Adenosine Receptor (264)Adenylate Cyclase (36)Adenylyl Cyclase (1)Adiponectin Receptor (6)Adrenergic Receptor (383)Amylin receptor (1)Angiotensin Receptor (115)Apelin Receptor (23)Bombesin Receptor (12)Bradykinin Receptor (22)cAMP (66)Cannabinoid Receptor (103)CaSR (26)CCR (125)CGRP Receptor (21)Chemerin Receptor (6)Cholecystokinin Receptor (81)CRF Receptor (32)CXCR (147)Dopamine Receptor (293)Endothelin Receptor (63)Epac (9)Free Fatty Acid Receptor (81)G protein (3)G protein-coupled Bile Acid Receptor 1 (24)GHSR (29)GLP Receptor (42)Glucagon Receptor (92)GNRH Receptor (28)GPCR (319)GPCR19 (2)GPR109A (1)GPR119 (24)GPR139 (6)GPR171 (2)GPR183 (3)GPR24 (18)GPR35 (17)GPR40 (7)GPR52 (6)GPR55 (6)GPR6 (4)GPR68 (2)GPR84 (13)GPR88 (10)Guanylate Cyclase (40)HCAR (12)Histamine Receptor (354)ICMT (61)Kisspeptin Receptor (2)LHCGR (40)LPA Receptor (30)LPL Receptor (169)Mas-related G-protein-coupled Receptor (MRGPR) (24)Melanocortin Receptor (43)mGluR (285)Motilin Receptor (4)MRGPR (13)Neuropeptide Y receptor (38)Neurotensin Receptor (21)NMUR (3)NPFF receptor (4)Opioid Receptor (116)OXTR (20)P2Y Receptor (122)PACAP Receptor (4)PAFR (89)PAR (62)Prostaglandin Receptor (506)Ras (410)RGS (6)RXFP Receptor (15)S1P Receptor (6)Sigma Receptor (68)SOS (17)SRPK (49)SSTR (45)SUCNR1 (6)TAAR (12)TSH Receptor (20)Urotensin Receptor (9)Vasopressin Receptor (37)β-arrestin (33)

Hedgehog (Hh) (1297)

BMI-1 (10)c-Myc (87)Casein Kinase (160)CDK (689)Cytoplasmic dynein (1)Gli (8)GSK-3 (219)PKA (149)Smo (47)ULK (24)

Lats kinase (3)MAP4K (48)MST (6)TEAD (10)YAP (51)

Immunology/Inflammation (4843)

AIM2 (6)AP-1 (40)Arginase (28)Calcineurin (9)CCR (125)CD19 (3)CD2 (1)CD20 (10)CD22 (4)CD276/B7-H3 (5)CD28 (12)CD28-B7 (1)CD3 (6)CD38 (14)CD47 (12)CD6 (1)CD73 (30)CD74 (3)CD80 (1)cGAS (20)Complement C3 (1)COX (643)CRTH2 (9)CTLA-4 (6)CXCR (147)Cyclophilin (6)CYPA (2)FAP (24)FKBP (37)FLAP (24)FPR (24)Galectin (17)Glucocorticoid Receptor (73)Glycoprotein VI (7)GM-CSF (4)Histamine Receptor (354)HMGB (1)IFNAR (60)IKZF_Family (2)IL (157)IL Receptor (197)Immunology & Inflammation Related (404)IRAK (84)IRF3 (1)LAG-3 (7)LanC-like protein (1)Legumain (3)Leukotriene C4 Synthase (1)LTA4H (3)LTR (160)MALT1 (28)Mast Cell (2)Mesothelin (2)MIF (22)Mucin (12)MyD88 (23)NADPH Oxidase (56)NFAT (25)NLR (142)NO Synthesis (6)NOS (450)NOT (4)Nrf2 (218)PD-1/PD-L1 (156)PG Synthase (61)PSMA (27)Pyroptosis (36)ROS (1081)Ros1 (48)S100A9 (1)Scavenger receptor (6)SIK (18)SOD (58)SPHK (41)STING (129)TENT (1)Thrombopoietin Receptor (14)Tim3 (8)TLR (260)TRAF (1)TSPO (5)VISTA (4)XBP1 (1)

Insulin Receptor/IGF-1 Receptor Signaling (2024)

Akt (514)Bcl-2 (234)CREB (6)ERK (445)FOXO (13)GLUT (54)GSK-3 (219)IGF-1R (101)Insulin Receptor (59)MEK (156)mTOR (325)PI3K (580)PKM2 (8)PTEN (18)Raf (150)Ras (410)RSK (41)SOS (17)

JAK-STAT-Signaling Pathway (1233)

EGFR (558)JAK (357)Pim (83)STAT (327)

Metabolic Enzyme (5882)

11β-HSD (40)15-PGDH (4)2OG Oxygenase (1)3-PGDH (1)3MST (2)6PGD (3)ACAT (131)ACC (32)ACMSD (2)Aconitate hydratase (2)ACS (6)Adenosine Deaminase (25)Adenosylhomocysteinase (12)ADP-ribosyltransferase (1)AhR (87)AKR (18)ALDH (55)Aldose Reductase (87)Aminopeptidase (70)Antifolate (78)AO (3)APOA (1)ApoE (2)Arginase (28)Asparagine synthetase (1)ATF/CREB proteins (2)ATP Citrate Lyase (8)ATP synthase (33)BDK (1)Beta-glucuronidase (27)Carbonic Anhydrase (185)Carboxylesterase (46)Carboxypeptidase (23)Cathepsin (147)Ceramidase (23)CETP (20)Cholesterol Transporter (2)CPA (7)CPSI (4)Creatine kinase (1)Cryptochrome (7)CSE (4)CYP51 (5)D-amino acid oxidase (3)D6D (1)Decarboxylase (15)Dehydrogenase (385)DGAT (66)DGK (19)DMT1 (1)Dopamine β-hydroxylase (9)E-NTPDase (15)Elastase (48)Enolase (7)Enteropeptidase (7)ERAP (4)FABP (13)Factor Xa (77)Farnesyl Transferase (47)FAS (72)FBPase (6)Ferroptosis (249)FOXO (13)FPR (24)FTO (23)Fumarate hydratase (3)FVII (4)FXR (107)G0/G1 switch protein 2 (2)GABA Transaminase (2)Galactosidases (6)GCN (3)GCS (7)GGTase (7)Glucokinase (62)Glucosidase (172)GLUT (54)Glutaminase C (2)Glutathione Reductase (6)Glyoxalase (15)GOAT (1)GPx (77)GSNOR (3)GST (38)Heme Oxygenase (HO) (5)Hexokinase (11)HMGCR (69)HPSE (4)Hydrolase (14)Hydroxylase (41)IDH (48)IDO (86)Ketohexokinase (7)LDL (29)LDLR (23)Lipase (142)Lipoxygenase (212)LOX (8)LRH-1 (5)LXR (41)MAGL (43)MASTL (4)MDH (3)MetAP (23)MGAT (7)Mineralocorticoid Receptor (13)Mitochondrial Electron Transport Chain (4)Mitochondrial Metabolism (214)MPC (5)NAMPT (39)Neprilysin (35)NNMT (12)NPP (2)NPR (15)NQO (3)OGT (12)OPA1 (1)P448 (1)P450 (526)PAI-1 (47)PARG (13)PDE (567)PDHK (19)PEPCK (5)PGAM1 (2)PGC-1α (12)PHGDH (6)Phospholipase (180)Phosphorylase (28)PI5P4K (14)PKM1 (3)PKM2 (8)Procollagen C Proteinase (2)Proprotein convertases (7)Pyruvate Kinase (39)QR (29)RAR/RXR (132)RBP (5)REV-ERB (12)ROR (92)SCD (31)sEH (54)SGK (19)SHMT (8)Sialyltransferase (4)Sphingosine acyltransferase (1)SQOR (2)Steroid Sulfatase (13)TDO (3)TGH (1)Thioredoxin (24)Thrombin (110)Thymidylate Synthase (52)Transferase (272)Transketolase (10)TrxR (18)Trypanothione reductase (1)UGT (15)VD/VDR (63)Xanthine Oxidase (85)αKGD (2)

Necroptosis signaling pathway (772)

Caspase (465)MLKL (5)Necroptosis (65)RIP Kinase (109)TNF Receptor (336)TNF-alpha (80)

Neuronal Signaling (6031)

5-HT Receptor (576)AAK1 (21)AChE (61)AChR (603)Adenosine Kinase (9)Adrenergic Receptor (383)AMPAR (57)Amylin receptor (1)Amyloid-β (308)Calcium Channel (555)CaMK (94)Cannabinoid Receptor (103)CGRP Receptor (21)Cholecystokinin Receptor (81)Cholinesterase (393)CHT (1)COMT (25)DAT (36)Dopamine Receptor (293)Endorphin (1)Enkephalinase (5)FAAH (72)GABA Receptor (313)Glucosylceramide Synthase (21)GluR (582)GPR119 (24)GPR139 (6)GPR24 (18)GPR55 (6)Histamine Receptor (354)Huntingtin (10)Imidazoline Receptor (25)Kainate receptor (5)MAO (308)Melanocortin Receptor (43)mGluR (285)MT Receptor (18)NET (6)Neuropeptide Y receptor (38)Neurotensin Receptor (21)NGF (3)NK Receptor (99)NMDA (1)NMDAR (126)Notch (46)Nurr1 (10)OLIG2 (2)Opioid Receptor (116)OX Receptor (50)P2X Receptor (99)Proprotein convertases (7)PSD-95 (2)QC (7)RAGE (6)REST (1)Ryanodine Receptor-1 (1)S100β (4)Secretase (196)SERT (65)Sigma Receptor (68)SMS (5)SSRIs (5)Substance P (3)TAAR (12)Tau Protein (57)Trk Receptor (109)TRP Channel (259)TTR (11)α-synuclein (36)

NF-κB Signaling Pathway (1144)

IKK (101)MALT1 (28)NF-κB (882)Nrf2 (218)Pirin (4)RANKL (12)RANKL/RANK (12)RIP Kinase (109)TAK1 (4)

Notch Signaling Pathway (1219)

ERK (445)Gli (8)MRCK (2)Notch (46)p53 (126)ROCK (124)TGF-beta/Smad (375)β-catenin (134)

p53 Signaling Pathway (1183)

AMPK (208)ATM/ATR (92)Bcl-2 (234)Caspase (465)Chk (78)MDM2 (217)mTOR (325)p21 (5)p53 (126)

Phospholipase D signaling pathway (2606)

APC (12)EGFR (558)Frizzled (2)GPCR (319)GSK-3 (219)HIF (191)IL Receptor (197)mTOR (325)NF-κB (882)Phospholipase (180)Raf (150)Ras (410)SOS (17)Wnt (206)β-catenin (134)

PI3K/AKT/mTOR Pathway (1727)

Akt (514)AMPK (208)ATM/ATR (92)DNA-PK (66)FOXO (13)GSK-3 (219)MELK (10)mTOR (325)PDK (38)PDK-1 (26)PI3K (580)PI4K (39)PIKfyve (17)PIN1 (17)PTEN (18)RSK (41)

Protease (1165)

ADAMTS (7)Aspartic Protease (2)Cysteine Protease (129)Dipeptidase 1 (4)DP-IV (1)DPP (32)DPP2 (2)DPP4 (68)Glutaminase (47)MMP (305)NEP (6)PE (2)Proteasome (231)Ser/Thr Protease (245)Serine Protease (5)SPP (1)Tyrosinase (203)

Pyroptosis (1790)

Caspase (465)Cathepsin (147)IL (157)MyD88 (23)NF-κB (882)TLR (260)

RAS signaling pathway (3378)

Akt (514)c-Myc (87)CDK (689)EGFR (558)ERK (445)MEK (156)mTOR (325)NF-κB (882)PAK (40)PDK (38)PI3K (580)PKC (260)PKD (18)Raf (150)Ras (410)RasGAP (2)SHP2 (64)YAP (51)

TGF-beta/Smad (647)

Bcr-Abl (121)PKC (260)ROCK (124)TGF-beta/Smad (375)TGF-β Receptor (26)

Toll-like Receptor (TLR) Pathway (1023)

CREB (6)IKK (101)IRAK (84)IRF3 (1)JNK (224)MyD88 (23)p38 MAPK (452)TAK1 (4)TLR (260)

Ubiquitin (574)

DUB (106)E1/E2/E3 Enzyme (210)FBXO (3)NAE (9)p97 (22)Proteasome (231)SUMO (10)USP30 (1)

VEGF signaling pathway (2044)

Akt (514)ERK (445)FAK (73)JNK (224)NOS (450)p38 MAPK (452)PAK (40)PKC (260)SHP2 (64)Src (201)VEGFR (402)

Vitamin D Related/Nuclear Receptor (1060)

Androgen Receptor (165)Glucocorticoid Receptor (73)LXR (41)Mineralocorticoid Receptor (13)PPAR (418)Progesterone Receptor (23)RAR/RXR (132)REV-ERB (12)ROR (92)Thyroid Hormone Receptor (66)VD/VDR (63)

Other Inhibitors/Agonists (6822)

20-HETE (2)AIMP2-DX2 (3)Amino Acids and Amino Acid Derivatives (112)Aminoacyl-tRNA Synthetase (32)Analgetic (38)Anesthetic (25)Anti-inflammation (32)Anti-Thyroid Agent (1)Anti-tumor (7)Anti-ulcer (17)Anticoagulant (3)Antispasmodic Agent (10)ASGPR (10)Bcat (12)c-RET (82)Cancer Stem Cells (2)CAR (9)Cardiac transcription factor (2)CBFβ-SMMHC (1)CD20 (10)CD73 (30)CerK (1)CHC (1)Chelating Agent (46)Choleretic (2)Choline Kinase (9)CNT (1)CRTH2 (9)CSE (4)CSN5/Jab1 (1)DcpS (1)Decarboxylase (15)Dehydrogenase (385)Diabetes (16)Diuretic (15)Drug Metabolite (597)DUE-B (1)E2F (3)ECE (2)ELOVL6 (1)Endogenous Metabolite (3311)ERO1 (5)Factor VIII (1)FAP (24)FATP (4)Fer/FerT (2)FPP synthase (1)Fucosyltransferase (4)Fungicide (64)G protein (3)Galectin (17)Galectin-3 (11)GBF1 (1)GCase (8)Glucocorticoid Receptor (73)GRK (31)GTPCH (1)Herbicide (56)HIPK2 (3)Histidine kinase (6)HMG-CoA (1)HNF4α (2)HPPD (5)HRGP (1)Hydroxylase (41)IMP1 (1)Importin β (2)Insecticide (71)ITPKA (2)LAT1 (5)LDL (29)Lipase (142)Lipocalin-2 (1)LYTACs (11)MALAT1 (2)MITF (3)MLKL (5)Molecular Glues (104)MPO (8)MTTP (13)Muscle Relaxant (12)MYOF (3)Neuroprotection/neurogenic Agent (4)NMD (1)NT (6)Nur77 (11)O-GlcNAcase (17)OPN4 (1)OSBP (2)OSBPL (1)OSC (2)Osteoclasts/Bone/Osteogenesis (22)OxPhos (47)PAM complex (1)PANK (5)PAX2 (1)PBR (4)PC-TP (1)PCA1 (1)PCSK9 (39)PDX1 (1)PEPT (1)PFKFB3 (7)Phosphatase (428)Phosphorylase (28)Photosensitizer (43)PIN1 (17)PKG (26)Platelet (46)PME-1 (2)PMO/MNA (4)PNP (1)PREP (36)Protein Synthesis (6)PXR (9)Quorum Sensing (60)RasGAP (2)Rev-ErbA (3)RPE65 (3)RUNX (12)SAP (1)SARM1 NADase (1)SMARC (9)SQS (7)SREBP (6)SRPK (49)Sweetener (5)Tgase (7)Thioredoxin (24)TIR1 (4)TNIK (8)TNK (5)TNNI3K (2)UGT1A1 (2)Urease (11)vanin (4)VDA (3)Vitamin (141)VPS (6)XOR (1)α-amylase (18)Others (2691)

Inhibitory Monoclonal Antibody

Human Inhibitory Monoclonal Antibody (549)

ADAM9/monoclonal antibody (1)Adrenomedullin/monoclonal antibody (1)ALK/monoclonal antibody (1)AMHRII/monoclonal antibody (1)Amyloid Alpha/monoclonal antibody (1)Amyloid-β/monoclonal antibody (6)Ang2/monoclonal antibody (1)ANGPTL3/monoclonal antibody (1)Antifolate/monoclonal antibody (1)APRIL/monoclonal antibody (1)ASCT2/monoclonal antibody (1)AXL/monoclonal antibody (2)B7-H4/monoclonal antibody (1)BST2/monoclonal antibody (1)BTLA/monoclonal antibody (1)BTN1A1/monoclonal antibody (1)c-FMS/monoclonal antibody (6)c-Kit/monoclonal antibody (1)c-Met/HGFR/monoclonal antibody (3)C1q/monoclonal antibody (1)C1s/monoclonal antibody (1)C5AR/monoclonal antibody (1)CA Ⅸ/monoclonal antibody (1)CA-125/monoclonal antibody (1)CCL2/monoclonal antibody (1)CCL20/monoclonal antibody (1)CCL5/monoclonal antibody (1)CCR/monoclonal antibody (3)CD105/monoclonal antibody (1)CD11/monoclonal antibody (2)CD123/monoclonal antibody (2)CD137/monoclonal antibody (1)CD138/monoclonal antibody (1)CD14/monoclonal antibody (1)CD163/monoclonal antibody (1)CD166/monoclonal antibody (1)CD19/monoclonal antibody (5)CD2/monoclonal antibody (1)CD20/monoclonal antibody (7)CD22/monoclonal antibody (3)CD23/monoclonal antibody (1)CD248/monoclonal antibody (1)CD25/monoclonal antibody (3)CD276/B7-H3/monoclonal antibody (4)CD27L/monoclonal antibody (1)CD28/monoclonal antibody (3)CD3/monoclonal antibody (3)CD33/monoclonal antibody (2)CD37/monoclonal antibody (3)CD38/monoclonal antibody (3)CD39/monoclonal antibody (1)CD4/monoclonal antibody (5)CD40/monoclonal antibody (8)CD40L/monoclonal antibody (4)CD44v6/monoclonal antibody (1)CD45/monoclonal antibody (1)CD46/monoclonal antibody (1)CD47/monoclonal antibody (5)CD52/monoclonal antibody (2)CD56/monoclonal antibody (1)CD6/monoclonal antibody (1)CD62p/monoclonal antibody (2)CD7/monoclonal antibody (1)CD70/monoclonal antibody (1)CD73/monoclonal antibody (2)CD74/monoclonal antibody (1)CD79b/monoclonal antibody (2)CD80/monoclonal antibody (1)CD98/monoclonal antibody (2)CDH6/monoclonal antibody (1)Cdiff Toxin A/monoclonal antibody (1)CEA/monoclonal antibody (1)CEACAM1/monoclonal antibody (1)CEACAM5 /monoclonal antibody (1)CEACAM6/monoclonal antibody (1)CGRP Receptor/monoclonal antibody (4)CLDN18.2/monoclonal antibody (1)CLDN6/monoclonal antibody (2)CLEC4C/monoclonal antibody (1)clusterin/monoclonal antibody (1)Complement C3/monoclonal antibody (1)Complement System/monoclonal antibody (8)CTGF/monoclonal antibody (1)CTLA-4/monoclonal antibody (5)CX3CL1/monoclonal antibody (1)CXCL10/monoclonal antibody (1)CXCR/monoclonal antibody (2)DKK1/monoclonal antibody (2)DLL3/monoclonal antibody (1)DLL4/monoclonal antibody (1)DPEP3/monoclonal antibody (1)DPP4/monoclonal antibody (1)EGFR/monoclonal antibody (9)EpCAM/monoclonal antibody (2)EphA3/monoclonal antibody (1)ErbB/monoclonal antibody (4)Factor XI/monoclonal antibody (2)Factor XII/monoclonal antibody (1)FAP/monoclonal antibody (1)FcRn/monoclonal antibody (3)FGF23/monoclonal antibody (1)FGFR/monoclonal antibody (4)Filovirus/monoclonal antibody (7)FLT3/monoclonal antibody (1)FRα/monoclonal antibody (1)FZD/monoclonal antibody (1)FZD10/monoclonal antibody (1)GCGR/monoclonal antibody (2)GD2/monoclonal antibody (2)GD3/monoclonal antibody (1)GDF-15/monoclonal antibody (2)GFRA3/monoclonal antibody (1)GFRAL/monoclonal antibody (1)glycoprotein (GP) IIb/IIIa/monoclonal antibody (1)Glycoprotein VI/monoclonal antibody (1)GM-CSF/monoclonal antibody (3)GPA33/monoclonal antibody (1)GPC3/monoclonal antibody (1)GPNMB/monoclonal antibody (1)GPRC5D/monoclonal antibody (1)Gremlin-1/monoclonal antibody (1)GUCY2C/monoclonal antibody (1)HBEGF/monoclonal antibody (1)Hepcidin/monoclonal antibody (1)HER2/monoclonal antibody (5)HFE2/monoclonal antibody (1)HGF/monoclonal antibody (2)Histone H1/monoclonal antibody (1)HTRA1/monoclonal antibody (1)ICAM-1/monoclonal antibody (1)ICOS/monoclonal antibody (4)ICOSL/monoclonal antibody (1)IFNAR/monoclonal antibody (5)IgE/monoclonal antibody (3)IGF-1R/monoclonal antibody (5)IL-12/monoclonal antibody (1)IL-13/monoclonal antibody (5)IL-13Ra1/monoclonal antibody (1)IL-15/monoclonal antibody (1)IL-17a/monoclonal antibody (5)IL-17c/monoclonal antibody (1)IL-17R/monoclonal antibody (1)IL-18/monoclonal antibody (1)IL-1a/monoclonal antibody (1)IL-1R1/monoclonal antibody (1)IL-1RL1/monoclonal antibody (2)IL-1β/monoclonal antibody (2)IL-20/monoclonal antibody (1)IL-21/monoclonal antibody (1)IL-22/monoclonal antibody (1)IL-22Ra/monoclonal antibody (1)IL-23/monoclonal antibody (5)IL-31Ra/monoclonal antibody (1)IL-33/monoclonal antibody (2)IL-36R/monoclonal antibody (1)IL-3Rβ/monoclonal antibody (1)IL-4/monoclonal antibody (1)IL-4Ra/monoclonal antibody (3)IL-5/monoclonal antibody (2)IL-5Rα/monoclonal antibody (1)IL-6/monoclonal antibody (7)IL-6R/monoclonal antibody (1)IL-6Ra/monoclonal antibody (1)IL-7Ra/monoclonal antibody (1)IL-8/monoclonal antibody (1)IL-9/monoclonal antibody (1)IL1RAP/monoclonal antibody (1)IL22RA1 /monoclonal antibody (1)ILDR2/monoclonal antibody (1)ILT7/monoclonal antibody (1)Influenza Virus/monoclonal antibody (1)Integrin/monoclonal antibody (9)KIR/monoclonal antibody (1)KIR3DL2 /monoclonal antibody (1)Klotho β/monoclonal antibody (1)L-selectin/monoclonal antibody (1)LAG-3/monoclonal antibody (3)LDLR/monoclonal antibody (1)LEPR/monoclonal antibody (1)LIF/monoclonal antibody (1)LILRB2/monoclonal antibody (1)LINGO-1/monoclonal antibody (1)LIV-1/monoclonal antibody (1)LOXL2/monoclonal antibody (1)LRRC15/monoclonal antibody (1)LT α/monoclonal antibody (1)LYPD3/monoclonal antibody (1)MAdCAM-1/monoclonal antibody (1)MASP-2/monoclonal antibody (1)MCAM/monoclonal antibody (1)Mesothelin/monoclonal antibody (2)MIF/monoclonal antibody (1)MMP/monoclonal antibody (1)MUC16/monoclonal antibody (1)MUC5AC/monoclonal antibody (1)Mucin/monoclonal antibody (2)NaPi2b /monoclonal antibody (2)Nectin-4/monoclonal antibody (1)NeuGcGM3/monoclonal antibody (1)Neuropilin-1/monoclonal antibody (1)Neurotensin Receptor/monoclonal antibody (1)NGF/monoclonal antibody (4)NKG2A/monoclonal antibody (1)NKG2D /monoclonal antibody (1)Notch/monoclonal antibody (1)NOTCH3/monoclonal antibody (1)OSMR/monoclonal antibody (1)Osteopontin/monoclonal antibody (1)OX40/monoclonal antibody (5)OX40L /monoclonal antibody (2)P-cadherin/monoclonal antibody (1)PAC1/monoclonal antibody (1)PAR/monoclonal antibody (1)PCSK9/monoclonal antibody (4)PD-1/PD-L1/monoclonal antibody (31)PDGFR/monoclonal antibody (3)Phosphatidylserine/monoclonal antibody (1)Phosphorylcholine/monoclonal antibody (1)PRLR/monoclonal antibody (1)Prolactin Receptor/monoclonal antibody (1)Protective antigen/monoclonal antibody (1)PSMA/monoclonal antibody (1)PTK/monoclonal antibody (1)PVR/monoclonal antibody (1)PVRIG/monoclonal antibody (1)Rabies virus/monoclonal antibody (2)RAGE/monoclonal antibody (1)RANKL /monoclonal antibody (1)RG1/monoclonal antibody (1)RGMα/monoclonal antibody (1)RHD/monoclonal antibody (2)RON/monoclonal antibody (1)ROR/monoclonal antibody (1)ROR2/monoclonal antibody (1)RSPO3/monoclonal antibody (1)RSV/monoclonal antibody (4)RTN4/monoclonal antibody (1)SAA1/monoclonal antibody (1)SAP/monoclonal antibody (1)SARS-CoV/monoclonal antibody (11)Sclerostin/monoclonal antibody (2)SEMA4D/monoclonal antibody (1)Sialyl-Lewis A/monoclonal antibody (1)Siglec-15/monoclonal antibody (1)Siglec-4a/monoclonal antibody (1)SIRPα/monoclonal antibody (1)SLAMF7/monoclonal antibody (1)SLC40A1/monoclonal antibody (1)SLITRK6/monoclonal antibody (1)SpA/monoclonal antibody (1)sphingosine-1-phosphate/monoclonal antibody (1)STAB1/monoclonal antibody (1)STEAP1/monoclonal antibody (1)TAG-72/monoclonal antibody (1)Tau Protein/monoclonal antibody (2)TBFbR2/monoclonal antibody (1)TCR/monoclonal antibody (1)Tenascin-C/monoclonal antibody (1)TFPI/monoclonal antibody (1)TGF-beta/monoclonal antibody (3)TGM2/monoclonal antibody (1)Tie-2/monoclonal antibody (1)TIGIT/monoclonal antibody (5)Tim3/monoclonal antibody (3)Tissue Factor/monoclonal antibody (1)TLR/monoclonal antibody (2)TNF Receptor/monoclonal antibody (15)TNF-alpha/monoclonal antibody (5)TNF/monoclonal antibody (1)TREM2/monoclonal antibody (2)TROP2/monoclonal antibody (2)TSHR/monoclonal antibody (1)TSLP/monoclonal antibody (1)TWEAK/monoclonal antibody (1)TYRP1/monoclonal antibody (1)uPAR/monoclonal antibody (1)VAP-1/monoclonal antibody (1)VEGF/monoclonal antibody (1)VEGFC/monoclonal antibody (1)VEGFR/monoclonal antibody (5)VEGI/monoclonal antibody (2)Vimentin/monoclonal antibody (2)VISTA/monoclonal antibody (1)α-Synuclein/monoclonal antibody (2)α-toxin /monoclonal antibody (2)

Recombinant Protein

CD Antigens (645)

B Cell CD Proteins (138)Dendritic Cell CD Proteins (226)Endothelial cell CD Proteins (179)Epithelial cell CD Proteins (216)Erythrocyte CD Proteins (45)Macrophage CD Proteins (317)Monocyte CD Proteins (134)NK Cell CD Proteins (176)Platelet CD Proteins (90)Stem Cell CD Proteins (165)T Cell CD Proteins (159)

Complement System (24)

Complement Component 1 (1)Complement Component 3 (2)Complement Component 5 (2)Complement Component 8 (1)Complement Receptor/Recombinant Protein (3)Complement Regulatory Proteins (13)Mannose-binding Protein (2)

Cytokines and Growth Factors (672)

Angiopoietins (14)Chemokine & Receptors (54)CSF & Receptors (35)EGF Superfamily (25)Ephrin/Eph Family (24)FGF Family (10)HGF & Receptors (4)IGF family (13)Interferon & Receptors (24)Interleukin & Receptors (208)Neurotrophic Factors (52)PDGFs & PDGFRs (4)Peptide Hormone & Neuropeptides (29)TGF-beta Superfamily (57)TNF Superfamily (145)VEGF & VEGFR (3)Other Cytokines and Growth Factors (12)

Enzymes & Regulators (244)

Carbonic Anhydrase Proteins (2)Carboxypeptidase Proteins (5)Caspase Proteins (1)Cathepsin Proteins (5)Cyclin-Dependent Kinase Inhibitor Proteins (2)Cystatin Family (12)Hydrolases (EC 3) (50)Isomerases (EC 5) (4)Lyases (EC 4) (9)Matrix Metalloproteinases (3)Oxidoreductases (EC 1) (18)Phosphatase/Recombinant Protein (6)Protease Inhibitors (42)Protein Tyrosine Kinases (79)Serine/Threonine Kinase Proteins (17)Transferases (EC 2) (15)

Fc Receptors (33)

Fc alpha RI/CD89 (1)Fc Receptor-like Proteins (2)Fc-epsilon Receptor (1)Fc-gamma Receptor (8)FcRn (5)Immunoglobulin Fc Region (16)

Immune Checkpoint Proteins (276)

Butyrophilins (24)Inhibitory Checkpoint Molecules (167)Stimulatory Immune Checkpoint Molecules (120)

Receptor Proteins (383)

Cell Adhesion Molecules (CAMs) (114)Cytokine Receptors (51)G-Protein-Coupled Receptors (GPCRs) (32)Killer-Cell Immunoglobulin-like Receptors (4)Leukocyte Immunoglobin-like Receptors (23)Notch family (6)Nuclear Receptor Superfamily (1)Pattern Recognition Receptors (18)Receptor Serine/Threonine Kinases (16)Receptor Tyrosine Kinases (81)Receptor Tyrosine Phosphatase (2)Siglec/Recombinant Protein (36)

Ubiquitin Related Proteins (5)

Deubiquitinase (2)Ubiquitin Enzymes/Recombinant Protein (2)Ubiquitin/UBLs (1)

Viral Proteins (1)

HIV Proteins (1)

Animal Modeling Reagents

Circulatory System Disease Models (11)

Cardiomyopathy Model (1)Heart Disease Correlation Model (2)Heart Failure Model (1)Hyperlipidemia Model (1)Hypertension Model (3)Thrombolysis Model (2)Vascular Inflammation Model (1)

Digestive System Disease Models (16)

Gallstone Model (1)Gastrointestinal Disease Model (7)Liver Disease Model (5)Pancreatic Disease Model (3)

Endocrine System Disease Models (12)

Aging Model (1)Diabetes Model (4)Hyperuricemia Model (8)

Immune and Inflammatory Disease Models (29)

Arthritis Model (2)Cystitis Model (1)Dermatitis Model (1)Ear Edema Model (1)Encephalomyelitis Model (2)Foot Edema Model (2)Gastrointestinal Inflammation and Ulcer Model (7)Gouty Arthritis Model (1)Liver Inflammation Model (2)Myocarditis Model (2)Nephritis Model (1)Pancreatitis Model (5)Psoriasis Model (3)Systemic Lupus Erythematosus Model (2)

Nervous System Disease Models (8)

Alzheimers Disease Model (2)Epilepsy Model (2)Neuropathic Pain Model (1)Parkinsons Disease Model (3)Schizophrenia Model (1)

Otorhinolaryngological Disease Models (4)

Cataract Model (1)Gingival Hyperplasia Model (2)Optic Neuropathy Model (1)Other Otorhinolaryngological Disease Model (1)

Respiratory System Disease Models (1)

Pulmonary Fibrosis Model (1)

Skin Disease Models (1)

Atopic Dermatitis Model (1)

Tumor Models (9)

Breast Tumor Model (2)Colon Tumor Model (1)Esophageal Tumor Model (1)Kidney Tumor Model (1)Liver Tumor Model (1)Lung Tumor Model (2)Skin Tumor Model (2)Uterine Fibroid Model (1)

Urinary System Disease Models (20)

Aging Model (1)Chronic Kidney Disease Model (2)Diabetes Model (4)Hyperuricemia Model (8)Kidney Stone Model (2)Nephrotoxicity Model (1)Renal Injury Model (5)Other Urinary System Disease Model (3)

Biochemical Reagents

Amino Acids (1413)

Amino Acid Amide (20)Biologically Modified Amino Acid (27)C-protective Amino Acid (218)N-protective Amino Acid (982)Non-protein Amino Acid (132)Protein Amino Acid (64)Side Chain Protected Amino Acid (39)

Bioconjugation Reagents (406)

Biotin Linkers (378)GalNAc Linkers (28)

Biological Buffers (2732)

Good's Buffer (23)Other Buffers (19)Others (2691)

Cross-Linking Agents (56)

Amino-amino Crosslinker (13)Amino-sulfhydryl Crosslinker (15)Photoreactive Crosslinker (18)Sulfhydryl-carbonyl Crosslinker (1)Sulfhydryl-sulfhydryl Crosslinker (4)Other Reactive Crosslinkers (5)

Denaturants (2)

Surface Active Agent (2)

Detergents (18)

Amphoteric Surfactant (4)Anionic Surfactant (3)Cationic Surfactant (2)Nonionic Surfactant (6)Sulfonated Betaine (3)

Aliphatic Acyl (233)Glycerol Lipid (15)Glycolipid (1)LNP Research (62)Sphingolipid (3)

Polypeptides (32)

Dipeptide and Tripeptide (31)Oligopeptide (1)

Steroids (2755)

Bile Acid (49)Cholestane (3)Estrogen (1)Plant Sterol (11)Steroidal Glycoside (2)Other Steroids (2)Others (2691)

Sugar and Derivatives (135)

Sugar (119)Sugar Alcohol (17)

Sweeteners (For Research Experiments) (19)

Artificial sweetener (7)Natural sweetener (12)

Cancer Stem Cells (4015)

Cathepsin (147)CXCR (147)Hedgehog (52)IL (157)IL Receptor (197)Integrin (222)MIF (22)MMP (305)NF-κB (882)NOS (450)Notch (46)PDGFR (176)PPAR (418)STAT (327)TGF-beta/Smad (375)VEGFR (402)Wnt (206)YAP (51)

Cervical cancer (2217)

Akt (514)Bcl-2 (234)Caspase (465)EGFR (558)IGF-1R (101)Insulin Receptor (59)mTOR (325)NF-κB (882)p53 (126)PI3K (580)VEGF & VEGFR (3)

Colorectal Cancer (2049)

Akt (514)CTLA-4 (6)EGFR (558)ERK (445)HER2 (44)MEK (156)mTOR (325)PD-1/PD-L1 (156)PI3K (580)Raf (150)Ras (410)VEGF (2)VEGFR (402)

Leukaemia (1448)

Bcl-2 (234)CD47 (12)CTLA-4 (6)Epigenetic Reader Domain (556)FLT3 (173)Galectin (17)Histone Methyltransferase (402)IDH (48)p53 (126)PD-1/PD-L1 (156)PTEN (18)Ras (410)RUNX (12)Smo (47)STAT (327)TET (12)Tim3 (8)VISTA (4)

Non-Small Cell Lung Cancer (1494)

ALK (117)c-Met/HGFR (173)EGFR (558)ErbB (9)ErbB2/HER2 (6)ErbB3/HER3 (5)ERK (445)FGFR (192)MEK (156)p53 (126)Raf (150)Ras (410)Ros1 (48)Trk Receptor (109)

Tumor Growth, Proliferation and Apoptosis (3375)

Akt (514)Aurora Kinase (129)Bcl-2 (234)c-Met/HGFR (173)c-Myc (87)EGFR (558)ERK (445)HER2 (44)MEK (156)MLKL (5)mTOR (325)p53 (126)PI3K (580)PTEN (18)Raf (150)Ras (410)ROR (92)Telomerase (30)

Cell Analysis (2)

Cell Proliferation and Cytotoxicity (2)

Cell Apoptosis/Death Detection (1374)

Apoptosis Inducer (1362)Apoptosis Inhibitor (2)Iron death Inhibitor (10)

Cell Culture (288)

Additive and Auxiliary Reagent (102)Cell Assay Reagents (9)Cell Staining (2)Organoid Culture Additive (77)Stem Cell Induction (117)

Enzyme Inhibitors (204)

Acetaldehyde Dehydrogenase Inhibitor (2)Acyltransferase Inhibitor (5)Alkaline Phosphatase Inhibitor (1)Angiotensin Converting Enzyme Inhibitor (3)ATP Enzyme Inhibitor (8)Calcineurin Inhibitor (1)Carbonic Acid Dehydratase Inhibitor (2)Caspase Inhibitor (2)Cyclooxygenase (COX) Inhibitor (53)DNA Topoisomerase II Inhibitor (11)Hypoxia Inducible Factor (HIF) Inhibitor (3)Inosine Monophosphate (IMP) Dehydrogenase Inhibitor (10)Leukotriene A4 Hydrolase Inhibitor (3)Lipoxygenase Inhibitor (11)Monoamine Oxidase Inhibitor (4)NADH Peroxidase Inhibitor (2)Pancreatic Lipase Inhibitor (2)Phosphodiesterase Inhibitor (19)Protease Inhibitor (14)Reverse Transcriptase Inhibitor (16)Starch Glucosidase Inhibitor (3)Thromboxane Synthase Inhibitor (3)Topoisomerase I Inhibitor (8)Tyrosine / EGF Receptor Protein Kinase Inhibitor (30)

Enzyme Preparation (71)

Cyclooxygenase (COX) (53)E3 Ubiquitin Ligase (1)Hydrolase (14)Nitric Oxide Metabolism (3)

Enzyme Substrates (5)

Peroxidase Substrate (2)β-Galactosidase Substrate (1)β-Glucuronidase Substrate (2)

Fluorescent Probe / Staining

Cell Biology Fluorescent Dyes (157)

Apoptosis Dyes (5)BODIPY (21)Cytoplasm Dyes (5)Cytotoxicity Analysis Dyes (11)Endocytosis and pinocytosis Dyes (5)Endoplasmic Reticulum Dyes (1)Exosome Dyes (4)Fluorescent Probes (15)Fluorescent Tracers (13)Lipid Droplet Dyes (4)Lysosome Dyes (5)Membrane Dyes (5)Mitochondrial Dyes (9)NOS Dyes (8)Nucleic Acid Dyes (1)Nucleus Dyes (11)PH Indicators (19)ROS Dyes (28)

Fluorescence Labeling Reagents (2937)

Anthocyanine (1)Boron Dipyrrole Methylene (2)Coumarin (9)Danacyl (2)Fluoressin (8)Fluorogenic Substrates (2)Nitrobenzoxadiazole (NBD) (2)Pyrene (6)Other Fluorescence Labeling Reagents (217)Others (2691)

Fluorescent Dyes (2944)

Acridine Dye (9)Cancer Analysis Dyes (9)Coumarine Dye (57)Cyanine Dye (34)Neuroscience Analysis Dyes (35)Protein (3)Other Fluorescent Dyes (120)Others (2691)

Molecular Biology

Extraction and Analysis Of Nucleic Acid (8)

Hybridization Reagent (4)Probe (4)

Gene Cloning (17)

Nucleic Acid Electrophoresis (4)

Electrophoretic Buffer (3)Gelatin (1)

Nucleosides & Nucleotides (250)

Nucleoside (43)Nucleotides and Derivatives (80)Phosphoramidite Monomers (91)Riboses (29)Universal Linker Phosphoramidites (8)

Natural Products

Acanthaceae (21)

Adhatoda (5)Andrographis (9)Justicia (4)Phlogacanthus (2)Strobilanthes (1)

Adiantaceae (2)

Alariaceae (78)

Acanthopanax (5)Aralia (8)Diplopanax (3)Eleutherococcus (3)Hedera (4)Oplopanax (1)Panax (53)Undaria (1)

Alismataceae (3)

Amaranthaceae (7)

Achyranthes (3)Celosia (3)Cyathula (1)

Amaryllidaceae (25)

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Chemical Structure| 1997302-16-5

Chemical Structure| 1997302-16-5

Structure of 1997302-16-5

Chemical Structure| 1997302-16-5

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Product Details of [ 1997302-16-5 ]

CAS No. :	1997302-16-5
Formula :	C₂₈H₄₀N₄O₅S
M.W :	544.71
SMILES Code :	O=C(OC(C)(C)C)N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)C[C@@H](O)C1)=O
English Name :	tert-Butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
MDL No. :	MFCD30748173

Safety of [ 1997302-16-5 ]

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Application In Synthesis of [ 1997302-16-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1997302-16-5 ]

[ 1997302-16-5 ] Synthesis Path-Downstream 1~14

1
[ 847728-89-6 ]
[ 1997302-16-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 18 h / 90 °C / Inert atmosphere 2: hydrogenchloride / methanol / 3 h / 20 °C 3: HATU; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 3 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere 2: dichloromethane / 0.5 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
	Multi-step reaction with 5 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 12 h / 90 °C 2: hydrogenchloride / methanol; 1,4-dioxane / 12 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere 4: hydrogenchloride / methanol; 1,4-dioxane / 12 h / 20 °C 5: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

	Multi-step reaction with 5 steps 1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 2 h / 120 °C 2: hydrogenchloride / methanol / 2 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C 4: hydrogenchloride / methanol / 2 h / 20 °C 5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C
	Multi-step reaction with 3 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 12 h / 90 °C 2: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C 3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 18 h / 90 °C 2: hydrogenchloride / water; 1,4-dioxane / 3 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere 2: hydrogenchloride / water; methanol / 3 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 5 steps 1: palladium diacetate; potassium acetate / dimethyl amine / 12 h / 90 °C 2: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C 3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere 4: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C 5: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 5 steps 1: potassium acetate; palladium diacetate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane / 25 °C / Inert atmosphere 3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere 4: hydrogenchloride / 1,4-dioxane / 16 h / 25 °C / Inert atmosphere 5: triethylamine; HATU / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 7 h / 90 °C / Inert atmosphere 2: hydrogenchloride / water; 1,4-dioxane / 5 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Cooling with ice
	Multi-step reaction with 3 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere 2: hydrogenchloride / water; methanol / 3 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 5 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 2 h / 120 °C / Inert atmosphere 2: hydrogenchloride / methanol / 2 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C 4: hydrogenchloride / methanol / 2 h / 20 °C 5: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C
	Multi-step reaction with 5 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere 2: hydrogenchloride / ethyl acetate / 12 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C 4: methanol; hydrogenchloride / ethyl acetate / 20 °C 5: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
	Multi-step reaction with 3 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 4 h / 130 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1.1: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 2.2: 20 °C 3.1: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 3.2: 20 °C
	Multi-step reaction with 5 steps 1: potassium acetate; palladium diacetate / N,N-dimethyl-formamide / 120 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 16 h / 20 °C 3: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 16 h / 20 °C 4: dichloromethane / 18 h / 20 °C 5: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C
	Multi-step reaction with 3 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 18 h / 90 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1: palladium diacetate; potassium acetate / 90 °C 2: hydrogenchloride / methanol 3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 12 h / 20 °C
	Multi-step reaction with 5 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 16 h / 90 °C 2: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 25 °C 3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C 4: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 25 °C 5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C
	Multi-step reaction with 5 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 12 h / 90 °C 2: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C 4: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 5 steps 1.1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 4 h / 130 °C / Inert atmosphere 2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 18 h / 0 - 20 °C 3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide; dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 4.1: hydrogenchloride / 1,4-dioxane / 18 h / 0 - 20 °C 5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere 5.2: 18 h / 20 °C / Inert atmosphere
	Multi-step reaction with 5 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 12 h / 90 °C 2: hydrogenchloride / ethyl acetate / 12 h / 20 °C 3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere 4: hydrogenchloride / ethyl acetate / 12 h / 20 °C 5: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 5 steps 1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 18 h / 150 °C 2: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 20 °C 4: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 5: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 20 °C
	Multi-step reaction with 5 steps 1: potassium acetate; palladium diacetate / N,N-dimethyl-formamide / 3 h / 16 - 90 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane / 1 h / 16 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 16 °C 4: hydrogenchloride / 1,4-dioxane / 1 h / 16 °C 5: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 16 - 20 °C
	Multi-step reaction with 3 steps 1: potassium acetate; palladium diacetate / 12 h / 95 °C / Inert atmosphere 2: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 0 - 20 °C 3: 1-methyl-1H-imidazole / acetonitrile / 3 h / 20 °C
	Multi-step reaction with 3 steps 1: palladium diacetate; potassium acetate / 18 h / 90 °C 2: hydrogenchloride / methanol; water / 3 h / 25 - 30 °C 3: TFFH; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 30 °C
	Multi-step reaction with 3 steps 1.1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 150 °C 2.1: trifluoroacetic acid / dichloromethane / 1 h / Cooling with ice 2.2: 3 h / 20 °C 3.1: trifluoroacetic acid / 1 h / Cooling with ice 3.2: 3 h / 20 °C

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2
[ 630421-46-4 ]
[ 1948273-01-5 ]
[ 1997302-16-5 ]

Yield	Reaction Conditions	Operation in experiment
79%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; for 20h;	66.4 Step 4: 7er/-butyl N-GG1 S)- l -ri2S.4R)-4-hvdroxy-2-rin S)- l -r4-(4-methylthiazol-5- yl iphenyllethyllcarba oyllpyrrolidine- 1 -carbonyl] -2.2-dim ethyl -propyl] carbarn ate. To a mixture of (2S,4R)-l-[(2S)-2-(tert-butoxycarbonylamino)-3,3-dimethyl- butanoyl]-4-hydroxy-pyrrolidine-2-carboxylic acid (27.3 g, 79.2 mmol), (1 S)-l-[4-(4- methylthiazol-5-yl)phenyl]ethanamine hydrochloride (20.2 g, 79.2 mmol) and HATU (45.2 g, 119 mmol) in DCM (775 mL) at 0 °C, was slowly added DIEA (68.0 mL, 396 mmol) and the mixture was stirred for 20 h. The mixture was then diluted with 5% citric acid (500 mL) and the layers were separated. The organic layer was washed with 1M NaOH (2 x 300 mL) and brine (300 mL) then dried (Na2S04), filtered and concentrated under reduced pressure. The resulting solid was dissolved into minimal amount of MeOH and then water was added until precipitation is observed. The resulting solid were filtered, washed with ether (400 mL) and then dried in a vacuum oven at 60 °C to afford the title compound as a solid (34 g, 79%). MS (ESI) [M+H]+ 545.3.
74.2%	With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 0 - 20℃; for 2h;	4 Step 4: Preparation of (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride (7) HATU (1.6 g, 4.2 mmol) was added to a stirred solution of compound 6 (1.21 g, 3.5 mmol), compound 3 (0.9 g, 3.5 mmol), and DIPEA (1.36 g, 10.5 mmol) in anhydrous THF (15 mL) at 0° C. The resulting mixture was allowed to warm up to ambient temperature and continued to stir for 2 h. TLC showed reaction complete. THF was removed by concentration. To the residue was added water (15 mL) and the resulting mixture was stirred for 4 h. The resulting mixture was filtered. The solid was collected and dried in oven at 50° C. to give a white solid. This solid was taken into methanol (10 mL) and activated carbon (150 mg) was added. The resulting mixture was heated at 80° C. and stirred for 1 h. The mixture was filtered while it was hot. Water (5 mL) was added to the filtrate at 80° C. The resulting mixture was cooled to ambient temperature and continued to stir for 18 h. The suspension was filtered. The solid was collected and dried in oven at 50° C. to afford tert-butyl-{(S)-1-[(2S,4R)-4-hydroxy]-2-[(S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethylcarbamoyl]pyrrolidin-1-yl}-3,3-dimethyl-1-oxobutan-2-yl-carbamate (1.41 g, 74.2%) as white solid. 1H NMR (400 MHz, CDCl3): δ 1.05 (s, 9H), 1.42 (s, 9H), 1.47 (d, J=7.2 Hz, 3H), 2.04-2.10 (m, 1H), 2.53 (s, 3H), 2.58-2.64 (m, 1H), 3.23 (s, 1H), 3.58 (dd, J=11.2 Hz, 3.2 Hz, 1H), 4.11 (d, J=11.6 Hz, 1H), 4.22 (d, J=9.2 Hz, 1H), 4.51 (br, 1H), 4.79 (t, J=8.0 Hz, 1H), 5.04-5.11 (m, 1H), 5.22 (d, J=8.8 Hz, 1H), 7.36-7.42 (m, 4H), 7.61 (d, J=7.6 Hz 1H), 8.68 (s, 1H). This solid (1.04 g, 1.9 mmol) was dissolved in 4N hydrogen chloride in methanol (3.0 mL) and the mixture was stirred at ambient temperature for 3 h. TLC showed reaction complete. The reaction mixture was concentrated to remove all volatiles under reduced pressure to give a light yellow solid.The solid was added to TBME (5 mL) and the resulting mixture was stirred at ambient temperature for 4 h. The reaction mixture was filtered and the solid was collected and dried in oven at 50° C. to afford compound 7 (0.92 g, 100%). 1H NMR (400 MHz, DMSO-d6): δ 1.03 (s, 9H), 1.38 (d, J=7.2 Hz, 3H), 1.72-1.79 (m, 1H), 2.09-2.14 (m, 1H), 2.49 (s, 3H), 3.48-3.52 (m, 1H), 3.75-3.79 (m, 1H), 3.88-3.90 (m, 1H), 4.31 (br, 1H), 4.56 (t, J=8.4 Hz, 1H), 4.89-4.95 (m, 1H), 7.41 (d, J=8.4 Hz, 2H), 7.47 (d, J=8.4 Hz, 2H), 8.20 (br, 3H), 8.67 (d, J=7.6 Hz, 1H), 9.22 (s, 1H); 13C NMR (400 MHz, DMSO-d6): δ 170.7, 167.1, 153.0, 146.5, 145.7, 132.5, 129.4, 129.3, 126.9, 69.4, 59.3, 58.5, 56.9, 48.3, 38.4, 34.8, 26.6, 23.0, 15.7; LC-MS [M+1]+: 445.6
74.2%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 0 - 20℃; for 2h;	4 Step 4: Preparation of (25,4R)-l-[(25)-2-amino-3,3-dimethylbutanoyl]-4- hydroxy-N-[(15)-l-[4-(4-methyl-l,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride (7) HATU (1.6 g, 4.2 mmol) was added to a stirred solution of intermediate compound 6 (1.21 g, 3.5 mmol), intermediate compound 3 (0.9 g, 3.5 mmol), and DIPEA (1.36 g, 10.5 mmol) in anhydrous THF (15 mL) at 0°C. The resulting mixture was allowed to warm up to ambient temperature and continued to stir for 2 hours. TLC showed reaction complete. THF was removed by concentration. To the residue was added water (15 mL) and the resulting mixture was stirred for 4 hours. The resulting mixture was filtered. The solid was collected and dried in oven at 50°C to give a white solid. This solid was taken into methanol (10 mL) and activated carbon (150 mg) was added. The resulting mixture was heated at 80°C and stirred for 1 hour. The mixture was filtered while it was hot. Water (5 mL) was added to the filtrate at 80°C. The resulting mixture was cooled to ambient temperature and continued to stir for 18 hours. The suspension was filtered. The solid was collected and dried in oven at 50°C to afford tert-butyl-{ (S)-l-[(2S,4R)-4- hydroxy] -2- [ (S)- 1 -(4-(4-methylthiazol-5-yl)phenyl)ethylcarbamoyl]pyrrolidin- 1 -yl } -3 ,3- dimethyl- l-oxobutan-2-yl-carbamate (1.41 g, 74.2%) as white solid. 1H NMR (400 MHz, CDC13): δ 1.05 (s, 9H), 1.42 (s, 9H), 1.47 (d, = 7.2 Hz, 3H), 2.04-2.10 (m, 1H), 2.53 (s, 3H), 2.58-2.64 (m, 1H), 3.23 (s, 1H), 3.58 (dd, = 11.2 Hz, 3.2 Hz, 1H), 4.11 (d, = 11.6 Hz, 1H), 4.22 (d, = 9.2 Hz, 1H), 4.51 (br, 1H), 4.79 (t, = 8.0 Hz, 1H), 5.04-5.11 (m, 1H), 5.22 (d, = 8.8 Hz, 1H), 7.36-7.42 (m, 4H), 7.61 (d, = 7.6 Hz 1H), 8.68 (s, 1H). This solid (1.04 g, 1.9 mmol) was dissolved in 4N hydrogen chloride in methanol (3.0 mL) and the mixture was stirred at ambient temperature for 3 hours. TLC showed reaction complete. The reaction mixture was concentrated to remove all volatiles under reduced pressure to give a light yellow solid. The solid was added to TBME (5 mL) and the resulting mixture was stirred at ambient temperature for 4 h. The reaction mixture was filtered and the solid was collected and dried in oven at 50°C to afford intermediate compound 7 (0.92 g, 100%). 1H NMR (400 MHz, DMSO-d6): δ 1.03 (s, 9H), 1.38 (d, = 7.2 Hz, 3H), 1.72- 1.79 (m, 1H), 2.09-2.14 (m, 1H), 2.49 (s, 3H), 3.48-3.52 (m, 1H), 3.75- 3.79 (m, 1H), 3.88-3.90 (m, 1H), 4.31 (br, 1H), 4.56 (t, = 8.4 Hz, 1H), 4.89-4.95 (m, 1H), 7.41 (d, = 8.4 Hz, 2H), 7.47 (d, = 8.4 Hz, 2H), 8.20 (br, 3H), 8.67 (d, = 7.6 Hz, 1H), 9.22 (s, 1H); 13C NMR (400 MHz, DMSO-d6): δ 170.7, 167.1 , 153.0, 146.5, 145.7, 132.5, 129.4, 129.3, 126.9, 69.4, 59.3, 58.5, 56.9, 48.3, 38.4, 34.8, 26.6, 23.0, 15.7; LC-MS [M+l]+: 445.6

74.2%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 0 - 20℃; for 2h;	4 Step 4: Preparation of (2S,4R)-1-[(S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl]-pyrrolidine-2-carboxamide hydrochloride (ULM-2) HATU (1.6 g, 4.2 mmol) was added to a stirred solution containing (2S,4R)-1-{(S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutanoyl}-4-hydroxypyrrolidine-2-carboxylic acid (1.21 g, 3.5 mmol), (S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethanamine hydrochloride (0.9 g, 3.5 mmol), and DIPEA (1.36 g, 10.5 mmol) in anhydrous THF (15 mL) at 0° C. The resulting mixture was allowed to warm up to ambient temperature and continued to stir for 2 hours. TLC showed reaction completed. THF was removed by concentration. To the residue was added water (15 mL) and the resulting mixture was stirred for 4 hours. The resulting mixture was filtered. The solid was collected and dried in oven at 50° C. to give a white solid. This solid was taken into methanol (10 mL) and activated carbon (150 mg) was added. The resulting mixture was heated at 80° C. and stirred for 1 h. The mixture was filtered while it was hot. Water (5 mL) was added to the filtrate at 80° C. The resulting mixture was cooled to ambient temperature and continued to stir for 18 hours. The suspension was filtered. The solid was collected and dried in oven at 50° C. to afford tert-butyl-{(S)-1-[(2S,4R)-4-hydroxy]-2-[(S)-1-(4-(4-methylthiazol-5-yl)phenyl)-ethylcarbamoyl]pyrrolidin-1-yl}-3,3-dimethyl-1-oxobutan-2-yl-carbamate (1.41 g, 74.2%) as a white solid. 1H NMR (400 MHz, CDCl3): δ 1.05 (s, 9H), 1.42 (s, 9H), 1.47 (d, J=7.2 Hz, 3H), 2.04-2.10 (m, 1H), 2.53 (s, 3H), 2.58-2.64 (m, 1H), 3.23 (s, 1H), 3.58 (dd, J=11.2 Hz, 3.2 Hz, 1H), 4.11 (d, J=11.6 Hz, 1H), 4.22 (d, J=9.2 Hz, 1H), 4.51 (br, 1H), 4.79 (t, J=8.0 Hz, 1H), 5.04-5.11 (m, 1H), 5.22 (d, J=8.8 Hz, 1H), 7.36-7.42 (m, 4H), 7.61 (d, J=7.6 Hz 1H), 8.68 (s, 1H).
74.2%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 0 - 20℃; for 2h;	4 Step 4: Preparation of (2S,4R)- -[fV)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[fV)-l - (4-(4-methylthiazol-5-yl)phenyl)ethyl]-pyrrolidine-2-carboxamide hydrochloride (ULM-2) HATU (1.6 g, 4.2 mmol) was added to a stirred solution containing (2S, 4R)- - (S)-2- [(/er/-butoxycarbonyl)amino]-3,3-dimethylbutanoyl}-4-hydroxypyrrolidine-2-carboxylic acid (1.21 g, 3.5 mmol), (A)-l-(4-(4-methylthiazol-5-yl)phenyl)ethanamine hydrochloride (0.9 g, 3.5 mmol), and DIPEA (1.36 g, 10.5 mmol) in anhydrous THF (15 mL) at 0°C. The resulting mixture was allowed to warm up to ambient temperature and continued to stir for 2 hours. TLC showed reaction completed. THF was removed by concentration. To the residue was added water (15 mL) and the resulting mixture was stirred for 4 hours. The resulting mixture was filtered. The solid was collected and dried in oven at 50°C to give a white solid. This solid was taken into methanol (10 mL) and activated carbon (150 mg) was added. The resulting mixture was heated at 80°C and stirred for lh. The mixture was filtered while it was hot. Water (5 mL) was added to the filtrate at 80°C. The resulting mixture was cooled to ambient temperature and continued to stir for 18 hours. The suspension was filtered. The solid was collected and dried in oven at 50°C to afford tert- butyl - {( S )- 1 -[(2S, -/A)-4-hydroxy]-2-[(k)- 1 -(4-(4-methylthiazol-5-yl)phenyl)-ethylcarbamoyl]pyrrolidin- l-yl}-3,3-dimethyl-l-oxobutan-2-yl-carbamate (1.41 g, 74.2%) as a white solid. NMR (400 MHz, CDCh): d 1.05 (s, 9H), 1.42 (s, 9H), 1.47 (d, J= 7.2 Hz, 3H), 2.04-2.10 (m, 1H), 2.53 (s, 3H), 2.58-2.64 (m, 1H), 3.23 (s, 1H), 3.58 (dd, 7= 1 1.2 Hz, 3.2 Hz, 1H),4.11 (d, J= 11.6 Hz, 1H), 4.22 (d, 7= 9.2 Hz, 1H), 4.51 (br, 1H), 4.79 (t, 7= 8.0 Hz, 1H), 5.04-5.11 (m, 1H), 5.22 (d, 7= 8.8 Hz, 1H), 7.36-7.42 (m, 4H), 7.61 (d, 7= 7.6 Hz 1H), 8.68 (s, 1H).
74.2%	With N-ethyl-N,N-diisopropylamine; TFFH In tetrahydrofuran at 0 - 30℃; for 2h;	1 Synthesis of compound 17: Tetramethyl chlorouronium hexafluorophosphate (1.6 g, 4.2 mmol), compound 16 (1.21 g, 3.5 mmol), compound 14 (0.9 g, 3.5 mmol) and N,N-diisopropylethylamine (1.36 g, 10.5 mmol) were dissolved in anhydrous tetrahydrofuran (15 ml) at 0°C. After the addition was completed, the system was heated to room temperature and stirred for 2 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure. Water (15 ml) was added to the concentrate and stirred for 4 hours, then filtered. The solid part was collected and placed in a 50°C oven to dry to obtain compound 17 (white solid, 1.41 g, yield 74.2%).
71%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 0 - 20℃; for 5h; Inert atmosphere;	Tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (AQ) The titled compound can be prepared according to the process described by Raina K. et al. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 7124-7129. Under nitrogen atmosphere, to a stirred solution of (2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylic acid (AP) (1.40 g, 4.06 mmol), (S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethan-1-amine hydrochloride (AM) (1.04 g, 4.06 mmol), and DIPEA (2.12 mL, 1.57 g, 12.19 mmol) in dry THF (20 mL) was added HATU (1.85 g, 4.88 mmol) at 0° C. The resulting mixture was allowed to warm to rt and stirred for 5 h. The organic solvent was removed under vacuo. Water (15 mL) was added to the residue, and the resulting mixture was stirred for 1 h and then was filtered. The solid was collected, dried in an oven at 50° C., and purified by flash column chromatography on SiO2 (DCM/Acetone, 75:25) to give the titled product as a white solid (1.57 g, 71% yield). 1H NMR (400 MHz, CDCl3): δ 8.70 (s, 1H), 7.62 (d, J=7.6 Hz, 1H), 7.45-7.37 (m, 4H), 5.23 (d, J=8.8 Hz, 1H), 5.14-5.02 (m, 1H), 4.82 (t, J=7.9 Hz, 1H), 4.53 (s, 1H), 4.22 (d, J=9.0 Hz, 1H), 4.17 (d, J=11.1 Hz, 1H), 3.58 (d, J=8.6 Hz, 1H), 2.83 (bs, 1H), 2.70-2.59 (m, 1H), 2.55 (s, 3H), 2.14-2.01 (m, 1H), 1.48 (d, J=7.0 Hz, 3H), 1.44 (s, 9H), 1.07 (s, 9H); 13C NMR (101 MHz, CDCl3): δ 173.04, 169.45, 156.57, 150.29, 148.52, 143.14, 131.60, 130.91, 129.60 (2C), 126.43 (2C), 80.57, 70.09, 59.01, 58.10, 56.43, 48.89, 35.07, 34.68, 28.30 (3C), 26.47 (3C), 22.30, 16.10.
33%	With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In dichloromethane at 20℃; for 16h;
36.9 g	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Cooling with ice;	5.5-6 (5-6) t-Butyl {(2S) -1-[(2S, 4R) -4-hydroxy-2-({(1S) -1-[4-(4-methyl-1,3-thiazole-) 5-Il) Phenyl] Ethyl} Carbamoyl) Pyrrolidine-1-yl] -3,3-Dimethyl-1-oxobutan-2-yl} Carbamate (Reference Example Compound 5-6) Reference Example Compound 5-3 (20.5 g),Reference Example Compound 5-5 (27.8 g),N, N-dimethylformamide (350 mL)N, N-diisopropylethylamine (42.2 mL) and HATU (36.8 g) were added to the mixture under ice-cooling, and the mixture was stirred overnight at room temperature. Water was added to the reaction solution, the mixture was extracted with ethyl acetate, the organic layer was washed successively with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The obtained residue was dissolved in chloroform, hexane was added, and the precipitated solid was coylected by filtration to give the title compound (36.9 g) as a colorless solid.
5.9 g	With triethylamine; HATU In dichloromethane at 0℃; for 20h; Inert atmosphere;
71 %	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	Tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5- yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (L). Under nitrogen atmosphere, to a stirred solution of (2S,4R)-1-((S)-2-((tert- butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylic acid (K) (1.40 g, 4.06 mmol), (S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethan-1-amine hydrochloride (H) (1.04 g, 4.06 mmol), and DIPEA (2.12 mL, 1.57 g, 12.19 mmol) in dry THF (20 mL) is added HATU (1.85 g, 4.88 mmol) at 0 °C. The resulting mixture is allowed to warm to rt and stirred for 5 h. The organic solvent is removed under vacuo. Water (15 mL) is added to the residue, and the resulting mixture is stirred for 1 h and is then filtered. The solid is collected, dried in an oven at 50 °C, and purified by flash column chromatography on SiO2(DCM/Acetone, 75:25) to give the titled product as a white solid (1.57 g, 71% yield).1H NMR (400 MHz, CDCl3): δ 8.70 (s, 1H), 7.62 (d, J = 7.6 Hz, 1H), 7.45- 7.37 (m, 4H), 5.23 (d, J = 8.8 Hz, 1H), 5.14- 5.02 (m, 1H), 4.82 (t, J = 7.9 Hz, 1H), 4.53 (s, 1H), 4.22 (d, J = 9.0 Hz, 1H), 4.17 (d, J = 11.1 Hz, 1H), 3.58 (d, J = 8.6 Hz, 1H), 2.83 (bs, 1H), 2.70- 2.59 (m, 1H), 2.55 (s, 3H), 2.14-2.01 (m, 1H), 1.48 (d, J = 7.0 Hz, 3H), 1.44 (s, 9H), 1.07 (s, 9H);13C NMR (101 MHz, CDCl3): δ 173.04, 169.45, 156.57, 150.29, 148.52, 143.14, 131.60, 130.91, 129.60 (2C), 126.43 (2C), 80.57, 70.09, 59.01, 58.10, 56.43, 48.89, 35.07, 34.68, 28.30 (3C), 26.47 (3C), 22.30, 16.10
71 %	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	Tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5- yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (L). Under nitrogen atmosphere, to a stirred solution of (2S,4R)-1-((S)-2-((tert- butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylic acid (K) (1.40 g, 4.06 mmol), (S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethan-1-amine hydrochloride (H) (1.04 g, 4.06 mmol), and DIPEA (2.12 mL, 1.57 g, 12.19 mmol) in dry THF (20 mL) is added HATU (1.85 g, 4.88 mmol) at 0 °C. The resulting mixture is allowed to warm to rt and stirred for 5 h. The organic solvent is removed under vacuo. Water (15 mL) is added to the residue, and the resulting mixture is stirred for 1 h and is then filtered. The solid is collected, dried in an oven at 50 °C, and purified by flash column chromatography on SiO2(DCM/Acetone, 75:25) to give the titled product as a white solid (1.57 g, 71% yield).1H NMR (400 MHz, CDCl3): δ 8.70 (s, 1H), 7.62 (d, J = 7.6 Hz, 1H), 7.45- 7.37 (m, 4H), 5.23 (d, J = 8.8 Hz, 1H), 5.14- 5.02 (m, 1H), 4.82 (t, J = 7.9 Hz, 1H), 4.53 (s, 1H), 4.22 (d, J = 9.0 Hz, 1H), 4.17 (d, J = 11.1 Hz, 1H), 3.58 (d, J = 8.6 Hz, 1H), 2.83 (bs, 1H), 2.70- 2.59 (m, 1H), 2.55 (s, 3H), 2.14-2.01 (m, 1H), 1.48 (d, J = 7.0 Hz, 3H), 1.44 (s, 9H), 1.07 (s, 9H);13C NMR (101 MHz, CDCl3): δ 173.04, 169.45, 156.57, 150.29, 148.52, 143.14, 131.60, 130.91, 129.60 (2C), 126.43 (2C), 80.57, 70.09, 59.01, 58.10, 56.43, 48.89, 35.07, 34.68, 28.30 (3C), 26.47 (3C), 22.30, 16.10
	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate at 20℃;	General Procedure for the amide condensation (A): General procedure: To a stirredsolution of carboxylic acid containing intermediate (1.2 eq.) in DCM wasadded HATU (1.2 eq.), DIPEA (6 eq.), and amino-containing intermediate(1.2 eq.), and the reaction mixture was stirred at room temperaturefor 12 h. The reaction solution was diluted with water, extracted with DCM three times, washed with brine, dried over Na2SO4, filtered, and concentrated. The residue obtained was purified with column chromatography.
71 %	With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	Tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl) ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (L). The titled compound can be prepared according to the process described by Raina K. et al., Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 7124-7129.[00154] Under nitrogen atmosphere, to a stirred solution of (2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylic acid (K) (1.40 g, 4.06 mmol), (S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethan-1-amine hydrochloride (H) (1.04 g, 4.06 mmol), and DIPEA (2.12 mL, 1.57 g, 12.19 mmol) in dry THF (20 mL) is added HATU (1.85 g, 4.88 mmol) at 0 °C. The resulting mixture is allowed to warm to rt and stirred for 5 h. The organic solvent is removed under vacuo. Water (15 mL) is added to the residue, and the resulting mixture is stirred for 1 h and is then filtered. The solid is collected, dried in an oven at 50 °C, and purified by flash column chromatography on SiO2 (DCM/Acetone, 75:25) to give the titled product as a white solid (1.57 g, 71% yield).1H NMR (400 MHz, CDCl3): δ 8.70 (s, 1H), 7.62 (d, J = 7.6 Hz, 1H), 7.45- 7.37 (m, 4H), 5.23 (d, J = 8.8 Hz, 1H), 5.14- 5.02 (m, 1H), 4.82 (t, J = 7.9 Hz, 1H), 4.53 (s, 1H), 4.22 (d, J = 9.0 Hz, 1H), 4.17 (d, J = 11.1 Hz, 1H), 3.58 (d, J = 8.6 Hz, 1H), 2.83 (bs, 1H), 2.70- 2.59 (m, 1H), 2.55 (s, 3H), 2.14-2.01 (m, 1H), 1.48 (d, J = 7.0 Hz, 3H), 1.44 (s, 9H), 1.07 (s, 9H);13C NMR (101 MHz, CDCl3): δ 173.04, 169.45, 156.57, 150.29, 148.52, 143.14, 131.60, 130.91, 129.60 (2C), 126.43 (2C), 80.57, 70.09, 59.01, 58.10, 56.43, 48.89, 35.07, 34.68, 28.30 (3C), 26.47 (3C), 22.30, 16.10.
71 %	With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	Tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl) ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (L). The titled compound can be prepared according to the process described by Raina K. et al., Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 7124-7129.[00154] Under nitrogen atmosphere, to a stirred solution of (2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxylic acid (K) (1.40 g, 4.06 mmol), (S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethan-1-amine hydrochloride (H) (1.04 g, 4.06 mmol), and DIPEA (2.12 mL, 1.57 g, 12.19 mmol) in dry THF (20 mL) is added HATU (1.85 g, 4.88 mmol) at 0 °C. The resulting mixture is allowed to warm to rt and stirred for 5 h. The organic solvent is removed under vacuo. Water (15 mL) is added to the residue, and the resulting mixture is stirred for 1 h and is then filtered. The solid is collected, dried in an oven at 50 °C, and purified by flash column chromatography on SiO2 (DCM/Acetone, 75:25) to give the titled product as a white solid (1.57 g, 71% yield).1H NMR (400 MHz, CDCl3): δ 8.70 (s, 1H), 7.62 (d, J = 7.6 Hz, 1H), 7.45- 7.37 (m, 4H), 5.23 (d, J = 8.8 Hz, 1H), 5.14- 5.02 (m, 1H), 4.82 (t, J = 7.9 Hz, 1H), 4.53 (s, 1H), 4.22 (d, J = 9.0 Hz, 1H), 4.17 (d, J = 11.1 Hz, 1H), 3.58 (d, J = 8.6 Hz, 1H), 2.83 (bs, 1H), 2.70- 2.59 (m, 1H), 2.55 (s, 3H), 2.14-2.01 (m, 1H), 1.48 (d, J = 7.0 Hz, 3H), 1.44 (s, 9H), 1.07 (s, 9H);13C NMR (101 MHz, CDCl3): δ 173.04, 169.45, 156.57, 150.29, 148.52, 143.14, 131.60, 130.91, 129.60 (2C), 126.43 (2C), 80.57, 70.09, 59.01, 58.10, 56.43, 48.89, 35.07, 34.68, 28.30 (3C), 26.47 (3C), 22.30, 16.10.
79 %	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃;	7 Synthesis of tert-butyl N-[(1S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4- methylthiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidine-1-carbonyl]-2,2-dimethyl- propyl]carbamate(HB7n) methyl- butanoyl]-4-hydroxy-pyrrolidine-2-carboxylic acid (HB7m) (27.3 g, 79.2 mmol), (1S)-1-[4-(4- methylthiazol-5-yl)phenyl]ethanamine hydrochloride (HB7h) (20.2 g, 79.2 mmol), and HATU (45.2 g, 119 mmol) in DCM (775 mL) at 0 °C was slowly added DIEA (68.0 mL, 396 mmol), and the mixture was stirred for 20 h. The mixture was then diluted with 5% citric acid (500 mL) and the layers were separated. The organic layer was washed with 1 M NaOH (2 x 300 mL) and brine (300 mL) and then dried (Na2SO4), filtered, and concentrated under reduced pressure. The resulting solid was dissolved into a minimal amount of MeOH and then water was added until precipitation was observed. The resulting solids were filtered, washed with ether (400 mL), and then dried in a vacuum oven at 60 °C to afford the title compound HB7n as a solid (34 g, 79%). MS (ESI) [M+H]+ 545.3.
79 %	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃;	7 Synthesis of tert-butyl N-[(1S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4- methylthiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidine-1-carbonyl]-2,2-dimethyl- propyl]carbamate(HB7n) methyl- butanoyl]-4-hydroxy-pyrrolidine-2-carboxylic acid (HB7m) (27.3 g, 79.2 mmol), (1S)-1-[4-(4- methylthiazol-5-yl)phenyl]ethanamine hydrochloride (HB7h) (20.2 g, 79.2 mmol), and HATU (45.2 g, 119 mmol) in DCM (775 mL) at 0 °C was slowly added DIEA (68.0 mL, 396 mmol), and the mixture was stirred for 20 h. The mixture was then diluted with 5% citric acid (500 mL) and the layers were separated. The organic layer was washed with 1 M NaOH (2 x 300 mL) and brine (300 mL) and then dried (Na2SO4), filtered, and concentrated under reduced pressure. The resulting solid was dissolved into a minimal amount of MeOH and then water was added until precipitation was observed. The resulting solids were filtered, washed with ether (400 mL), and then dried in a vacuum oven at 60 °C to afford the title compound HB7n as a solid (34 g, 79%). MS (ESI) [M+H]+ 545.3.

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Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 0 - 20 °C 2: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 20 °C 3: HATU; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere 2: lithium hydroxide hydrate; water / tetrahydrofuran / 18 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 2: lithium hydroxide / water; tetrahydrofuran / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere 2: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Cooling with ice 2: lithium hydroxide; water / tetrahydrofuran / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Cooling with ice
	Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C 1.2: 20 °C 2.1: water; lithium hydroxide hydrate / tetrahydrofuran / 18 h / 20 °C 3.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 16 h / 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere 2: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 3 steps 1: HATU; triethylamine / dichloromethane / 18 h / 0 - 25 °C 2: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 25 °C / Inert atmosphere 3: HATU; triethylamine / dichloromethane / 20 h / 0 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 0 °C 1.2: 18 h / 20 °C / Inert atmosphere 2.1: 10% Pd/C; hydrogen / ethanol / 18 h / 760.05 Torr 3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 12 h / 20 °C 2: lithium hydroxide; water / tetrahydrofuran 3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 12 h / 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere 2: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 0 - 20 °C 3: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1: TFFH; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 25 - 30 °C / Inert atmosphere; Enzymatic reaction 2: lithium hydroxide monohydrate / water; tetrahydrofuran / 18 h / 25 - 30 °C 3: TFFH; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 30 °C

References: [1]Current Patent Assignee: ARVINAS OPERATIONS - US2018/72711, 2018, A1.
[2]Current Patent Assignee: ARVINAS OPERATIONS - WO2018/140809, 2018, A1.
[3]Han, Xin; Wang, Chao; Qin, Chong; Xiang, Weiguo; Fernandez-Salas, Ester; Yang, Chao-Yie; Wang, Mi; Zhao, Lijie; Xu, Tianfeng; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng [Journal of Medicinal Chemistry, 2019, vol. 62, # 2, p. 941 - 964].
[4]Current Patent Assignee: ARVINAS - US2018/125821, 2018, A1.
[5]Current Patent Assignee: MITSUBISHI TANABE PHARMA - WO2020/9176, 2020, A1.
[6]Current Patent Assignee: JOHNSON JOHNSON CHINA INVESTMENT - WO2021/18118, 2021, A1.
[7]Current Patent Assignee: ARVINAS OPERATIONS - WO2021/11913, 2021, A1.
[8]Current Patent Assignee: AMGEN - WO2021/142247, 2021, A1.
[9]Keuler, Tim; König, Beate; Bückreiß, Nico; Kraft, Fabian B.; König, Philipp; Schäker-Hübner, Linda; Steinebach, Christian; Bendas, Gerd; Gütschow, Michael; Hansen, Finn K. [Chemical Communications, 2022, vol. 58, # 79, p. 11087 - 11090].
[10]Cai, Maohua; Ma, Furong; Hu, Can; Li, Haobin; Cao, Fei; Li, Yulong; Dong, Jinyun; Qin, Jiang-Jiang [Bioorganic and Medicinal Chemistry, 2023, vol. 90].
[11]Current Patent Assignee: DBD THERAPEUTICS - WO2023/39602, 2023, A1.
[12]Current Patent Assignee: INSTITUTE OF BASIC MEDICAL AND ONCOLOGY CHINESE ACADEMY OF SCIENCES - CN115894439, 2024, B.

4
[ 40216-83-9 ]
[ 1997302-16-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 0 - 20 °C 2: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 20 °C 3: HATU; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 2: lithium hydroxide / water; tetrahydrofuran / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C 2: lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 0 - 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere 2: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Cooling with ice 2: lithium hydroxide; water / tetrahydrofuran / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Cooling with ice
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere 2: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 0 - 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

References: [1]Current Patent Assignee: ARVINAS OPERATIONS - US2018/72711, 2018, A1.
[2]Han, Xin; Wang, Chao; Qin, Chong; Xiang, Weiguo; Fernandez-Salas, Ester; Yang, Chao-Yie; Wang, Mi; Zhao, Lijie; Xu, Tianfeng; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng [Journal of Medicinal Chemistry, 2019, vol. 62, # 2, p. 941 - 964].
[3]Current Patent Assignee: DBD THERAPEUTICS - US2020/239430, 2020, A1.
[4]Current Patent Assignee: ARVINAS - US2018/125821, 2018, A1.
[5]Current Patent Assignee: MITSUBISHI TANABE PHARMA - WO2020/9176, 2020, A1.
[6]Current Patent Assignee: DBD THERAPEUTICS - WO2023/39601, 2023, A1.

5
[ 630421-45-3 ]
[ 1997302-16-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 20 °C 2: HATU; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 2 steps 1: lithium hydroxide hydrate; water / tetrahydrofuran / 18 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 2 steps 1: lithium hydroxide / water; tetrahydrofuran / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

	Multi-step reaction with 2 steps 1: methanol; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 48 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 h / 0 °C
	Multi-step reaction with 2 steps 1: lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 2 steps 1: lithium hydroxide; water / tetrahydrofuran / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Cooling with ice
	Multi-step reaction with 2 steps 1: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 2 steps 1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 25 °C / Inert atmosphere 2: HATU; triethylamine / dichloromethane / 20 h / 0 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: lithium hydroxide; water / tetrahydrofuran 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 12 h / 20 °C
	Multi-step reaction with 2 steps 1: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: lithium hydroxide hydrate; methanol / tetrahydrofuran / 48 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 h / 0 °C
	Multi-step reaction with 2 steps 1: lithium hydroxide monohydrate / water; tetrahydrofuran / 18 h / 25 - 30 °C 2: TFFH; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 30 °C

References: [1]Current Patent Assignee: ARVINAS OPERATIONS - US2018/72711, 2018, A1.
[2]Current Patent Assignee: ARVINAS OPERATIONS - WO2018/140809, 2018, A1.
[3]Han, Xin; Wang, Chao; Qin, Chong; Xiang, Weiguo; Fernandez-Salas, Ester; Yang, Chao-Yie; Wang, Mi; Zhao, Lijie; Xu, Tianfeng; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng [Journal of Medicinal Chemistry, 2019, vol. 62, # 2, p. 941 - 964].
[4]Current Patent Assignee: NURIX THERAPEUTICS - WO2020/81450, 2020, A1.
[5]Current Patent Assignee: DBD THERAPEUTICS - US2020/239430, 2020, A1.
[6]Current Patent Assignee: ARVINAS - US2018/125821, 2018, A1.
[7]Current Patent Assignee: MITSUBISHI TANABE PHARMA - WO2020/9176, 2020, A1.
[8]Current Patent Assignee: ARVINAS OPERATIONS - WO2021/11913, 2021, A1.
[9]Current Patent Assignee: AMGEN - WO2021/142247, 2021, A1.
[10]Current Patent Assignee: DBD THERAPEUTICS - WO2023/39601, 2023, A1.
[11]Cai, Maohua; Ma, Furong; Hu, Can; Li, Haobin; Cao, Fei; Li, Yulong; Dong, Jinyun; Qin, Jiang-Jiang [Bioorganic and Medicinal Chemistry, 2023, vol. 90].
[12]Current Patent Assignee: DBD THERAPEUTICS - WO2023/39602, 2023, A1.
[13]Current Patent Assignee: NURIX THERAPEUTICS - WO2023/69514, 2023, A2.
[14]Current Patent Assignee: INSTITUTE OF BASIC MEDICAL AND ONCOLOGY CHINESE ACADEMY OF SCIENCES - CN115894439, 2024, B.

6
[ 1997302-16-5 ]
[ 1948273-03-7 ]

Yield	Reaction Conditions	Operation in experiment
100%	With hydrogenchloride In methanol at 20℃; for 3h;	4 Step 4: Preparation of (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride (7) HATU (1.6 g, 4.2 mmol) was added to a stirred solution of compound 6 (1.21 g, 3.5 mmol), compound 3 (0.9 g, 3.5 mmol), and DIPEA (1.36 g, 10.5 mmol) in anhydrous THF (15 mL) at 0° C. The resulting mixture was allowed to warm up to ambient temperature and continued to stir for 2 h. TLC showed reaction complete. THF was removed by concentration. To the residue was added water (15 mL) and the resulting mixture was stirred for 4 h. The resulting mixture was filtered. The solid was collected and dried in oven at 50° C. to give a white solid. This solid was taken into methanol (10 mL) and activated carbon (150 mg) was added. The resulting mixture was heated at 80° C. and stirred for 1 h. The mixture was filtered while it was hot. Water (5 mL) was added to the filtrate at 80° C. The resulting mixture was cooled to ambient temperature and continued to stir for 18 h. The suspension was filtered. The solid was collected and dried in oven at 50° C. to afford tert-butyl-{(S)-1-[(2S,4R)-4-hydroxy]-2-[(S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethylcarbamoyl]pyrrolidin-1-yl}-3,3-dimethyl-1-oxobutan-2-yl-carbamate (1.41 g, 74.2%) as white solid. 1H NMR (400 MHz, CDCl3): δ 1.05 (s, 9H), 1.42 (s, 9H), 1.47 (d, J=7.2 Hz, 3H), 2.04-2.10 (m, 1H), 2.53 (s, 3H), 2.58-2.64 (m, 1H), 3.23 (s, 1H), 3.58 (dd, J=11.2 Hz, 3.2 Hz, 1H), 4.11 (d, J=11.6 Hz, 1H), 4.22 (d, J=9.2 Hz, 1H), 4.51 (br, 1H), 4.79 (t, J=8.0 Hz, 1H), 5.04-5.11 (m, 1H), 5.22 (d, J=8.8 Hz, 1H), 7.36-7.42 (m, 4H), 7.61 (d, J=7.6 Hz 1H), 8.68 (s, 1H). This solid (1.04 g, 1.9 mmol) was dissolved in 4N hydrogen chloride in methanol (3.0 mL) and the mixture was stirred at ambient temperature for 3 h. TLC showed reaction complete. The reaction mixture was concentrated to remove all volatiles under reduced pressure to give a light yellow solid.The solid was added to TBME (5 mL) and the resulting mixture was stirred at ambient temperature for 4 h. The reaction mixture was filtered and the solid was collected and dried in oven at 50° C. to afford compound 7 (0.92 g, 100%). 1H NMR (400 MHz, DMSO-d6): δ 1.03 (s, 9H), 1.38 (d, J=7.2 Hz, 3H), 1.72-1.79 (m, 1H), 2.09-2.14 (m, 1H), 2.49 (s, 3H), 3.48-3.52 (m, 1H), 3.75-3.79 (m, 1H), 3.88-3.90 (m, 1H), 4.31 (br, 1H), 4.56 (t, J=8.4 Hz, 1H), 4.89-4.95 (m, 1H), 7.41 (d, J=8.4 Hz, 2H), 7.47 (d, J=8.4 Hz, 2H), 8.20 (br, 3H), 8.67 (d, J=7.6 Hz, 1H), 9.22 (s, 1H); 13C NMR (400 MHz, DMSO-d6): δ 170.7, 167.1, 153.0, 146.5, 145.7, 132.5, 129.4, 129.3, 126.9, 69.4, 59.3, 58.5, 56.9, 48.3, 38.4, 34.8, 26.6, 23.0, 15.7; LC-MS [M+1]+: 445.6
100%	With hydrogenchloride In methanol at 20℃; for 3h;	4 Step 4: Preparation of (25,4R)-l-[(25)-2-amino-3,3-dimethylbutanoyl]-4- hydroxy-N-[(15)-l-[4-(4-methyl-l,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride (7) HATU (1.6 g, 4.2 mmol) was added to a stirred solution of intermediate compound 6 (1.21 g, 3.5 mmol), intermediate compound 3 (0.9 g, 3.5 mmol), and DIPEA (1.36 g, 10.5 mmol) in anhydrous THF (15 mL) at 0°C. The resulting mixture was allowed to warm up to ambient temperature and continued to stir for 2 hours. TLC showed reaction complete. THF was removed by concentration. To the residue was added water (15 mL) and the resulting mixture was stirred for 4 hours. The resulting mixture was filtered. The solid was collected and dried in oven at 50°C to give a white solid. This solid was taken into methanol (10 mL) and activated carbon (150 mg) was added. The resulting mixture was heated at 80°C and stirred for 1 hour. The mixture was filtered while it was hot. Water (5 mL) was added to the filtrate at 80°C. The resulting mixture was cooled to ambient temperature and continued to stir for 18 hours. The suspension was filtered. The solid was collected and dried in oven at 50°C to afford tert-butyl-{ (S)-l-[(2S,4R)-4- hydroxy] -2- [ (S)- 1 -(4-(4-methylthiazol-5-yl)phenyl)ethylcarbamoyl]pyrrolidin- 1 -yl } -3 ,3- dimethyl- l-oxobutan-2-yl-carbamate (1.41 g, 74.2%) as white solid. 1H NMR (400 MHz, CDC13): δ 1.05 (s, 9H), 1.42 (s, 9H), 1.47 (d, = 7.2 Hz, 3H), 2.04-2.10 (m, 1H), 2.53 (s, 3H), 2.58-2.64 (m, 1H), 3.23 (s, 1H), 3.58 (dd, = 11.2 Hz, 3.2 Hz, 1H), 4.11 (d, = 11.6 Hz, 1H), 4.22 (d, = 9.2 Hz, 1H), 4.51 (br, 1H), 4.79 (t, = 8.0 Hz, 1H), 5.04-5.11 (m, 1H), 5.22 (d, = 8.8 Hz, 1H), 7.36-7.42 (m, 4H), 7.61 (d, = 7.6 Hz 1H), 8.68 (s, 1H). This solid (1.04 g, 1.9 mmol) was dissolved in 4N hydrogen chloride in methanol (3.0 mL) and the mixture was stirred at ambient temperature for 3 hours. TLC showed reaction complete. The reaction mixture was concentrated to remove all volatiles under reduced pressure to give a light yellow solid. The solid was added to TBME (5 mL) and the resulting mixture was stirred at ambient temperature for 4 h. The reaction mixture was filtered and the solid was collected and dried in oven at 50°C to afford intermediate compound 7 (0.92 g, 100%). 1H NMR (400 MHz, DMSO-d6): δ 1.03 (s, 9H), 1.38 (d, = 7.2 Hz, 3H), 1.72- 1.79 (m, 1H), 2.09-2.14 (m, 1H), 2.49 (s, 3H), 3.48-3.52 (m, 1H), 3.75- 3.79 (m, 1H), 3.88-3.90 (m, 1H), 4.31 (br, 1H), 4.56 (t, = 8.4 Hz, 1H), 4.89-4.95 (m, 1H), 7.41 (d, = 8.4 Hz, 2H), 7.47 (d, = 8.4 Hz, 2H), 8.20 (br, 3H), 8.67 (d, = 7.6 Hz, 1H), 9.22 (s, 1H); 13C NMR (400 MHz, DMSO-d6): δ 170.7, 167.1 , 153.0, 146.5, 145.7, 132.5, 129.4, 129.3, 126.9, 69.4, 59.3, 58.5, 56.9, 48.3, 38.4, 34.8, 26.6, 23.0, 15.7; LC-MS [M+l]+: 445.6
100%	With hydrogenchloride In methanol; water at 20℃; for 3h;	4 Step 4: Preparation of (2S,4R)-1-[(S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl]-pyrrolidine-2-carboxamide hydrochloride (ULM-2) HATU (1.6 g, 4.2 mmol) was added to a stirred solution containing (2S,4R)-1-{(S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutanoyl}-4-hydroxypyrrolidine-2-carboxylic acid (1.21 g, 3.5 mmol), (S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethanamine hydrochloride (0.9 g, 3.5 mmol), and DIPEA (1.36 g, 10.5 mmol) in anhydrous THF (15 mL) at 0° C. The resulting mixture was allowed to warm up to ambient temperature and continued to stir for 2 hours. TLC showed reaction completed. THF was removed by concentration. To the residue was added water (15 mL) and the resulting mixture was stirred for 4 hours. The resulting mixture was filtered. The solid was collected and dried in oven at 50° C. to give a white solid. This solid was taken into methanol (10 mL) and activated carbon (150 mg) was added. The resulting mixture was heated at 80° C. and stirred for 1 h. The mixture was filtered while it was hot. Water (5 mL) was added to the filtrate at 80° C. The resulting mixture was cooled to ambient temperature and continued to stir for 18 hours. The suspension was filtered. The solid was collected and dried in oven at 50° C. to afford tert-butyl-{(S)-1-[(2S,4R)-4-hydroxy]-2-[(S)-1-(4-(4-methylthiazol-5-yl)phenyl)-ethylcarbamoyl]pyrrolidin-1-yl}-3,3-dimethyl-1-oxobutan-2-yl-carbamate (1.41 g, 74.2%) as a white solid.1H NMR (400 MHz, CDCl3): δ 1.05 (s, 9H), 1.42 (s, 9H), 1.47 (d, J=7.2 Hz, 3H), 2.04-2.10 (m, 1H), 2.53 (s, 3H), 2.58-2.64 (m, 1H), 3.23 (s, 1H), 3.58 (dd, J=11.2 Hz, 3.2 Hz, 1H), 4.11 (d, J=11.6 Hz, 1H), 4.22 (d, J=9.2 Hz, 1H), 4.51 (br, 1H), 4.79 (t, J=8.0 Hz, 1H), 5.04-5.11 (m, 1H), 5.22 (d, J=8.8 Hz, 1H), 7.36-7.42 (m, 4H), 7.61 (d, J=7.6 Hz 1H), 8.68 (s, 1H). This solid (1.04 g, 1.9 mmol) was dissolved in 4N hydrogen chloride in methanol (3.0 mL) and the mixture was stirred at ambient temperature for 3 hours. TLC showed reaction complete. The reaction mixture was concentrated to remove all volatiles under reduced pressure to give a light yellow solid. The solid was added to TBME (5 mL) and the resulting mixture was stirred at ambient temperature for 4 hours. The reaction mixture was filtered and the solid was collected and dried in oven at 50° C. to afford the title compound (0.92 g, 100%). 1H NMR (400 MHz, DMSO-d6): δ 1.03 (s, 9H), 1.38 (d, J=7.2 Hz, 3H), 1.72-1.79 (m, 1H), 2.09-2.14 (m, 1H), 2.49 (s, 3H), 3.48-3.52 (m, 1H), 3.75-3.79 (m, 1H), 3.88-3.90 (m, 1H), 4.31 (br, 1H), 4.56 (t, J=8.4 Hz, 1H), 4.89-4.95 (m, 1H), 7.41 (d, J=8.4 Hz, 2H), 7.47 (d, J=8.4 Hz, 2H), 8.20 (br, 3H), 8.67 (d, J=7.6 Hz, 1H), 9.22 (s, 1H); 13C NMR (400 MHz, DMSO-d6): δ 170.7, 167.1, 153.0, 146.5, 145.7, 132.5, 129.4, 129.3, 126.9, 69.4, 59.3, 58.5, 56.9, 48.3, 38.4, 34.8, 26.6, 23.0, 15.7; LC-MS [M+1]+: 445.6.

100%	With hydrogenchloride In methanol; water at 20℃; for 3h;	4 This solid (1.04 g, 1.9 mmol) was dissolved in 4N hydrogen chloride in methanol (3.0 mL) and the mixture was stirred at ambient temperature for 3 hours. TLC showed reaction complete. The reaction mixture was concentrated to remove all volatiles under reduced pressure to give a light yellow solid. The solid was added to TBME (5 mL) and the resulting mixture was stirred at ambient temperature for 4 hours. The reaction mixture was filtered and the solid was collected and dried in oven at 50°C to afford the title compound (0.92 g, 100%). NMR (400 MHz, DMSO-d6): d 1.03 (s, 9H), 1.38 (d, J= 7.2 Hz, 3H), 1.72-1.79 (m,1H), 2.09-2.14 (m, 1H), 2.49 (s, 3H), 3.48-3.52 (m, 1H), 3.75-3.79 (m, 1H), 3.88-3.90 (m, 1H), 4.31 (br, 1H), 4.56 (t, J= 8.4 Hz, 1H), 4.89-4.95 (m, 1H), 7.41 (d, J= 8.4 Hz, 2H), 7.47 (d, J= 8.4 Hz, 2H), 8.20 (br, 3H), 8.67 (d, J= 7.6 Hz, 1H), 9.22 (s, 1H);13C NMR (400 MHz, DMSO-d6): d170.7, 167.1, 153.0, 146.5, 145.7, 132.5, 129.4, 129.3, 126.9, 69.4, 59.3, 58.5, 56.9, 48.3, 38.4, 34.8, 26.6, 23.0, 15.7; LC-MS [M+l]+: 445.6
99%	With hydrogenchloride In 1,4-dioxane; water at 20℃; for 3h;	(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide Hydrochloride (E3LB-3) The titled compound can be prepared according to the process described by Raina K. et al. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 7124-7129. A solution of 4N HCl in dioxane (6.0 mL) was added to tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (AQ) (1.55 g, 2.85 mmol) and the mixture was stirred at rt for 3 h. The solvent was evaporated to dryness and the crude residue was triturated with DEE, filtered off, and dried in an oven at 50° C. to give the titled compound as a white solid (1.36 g, 99% yield). 1H NMR (400 MHz, DMSO-d6): δ 9.11 (s, 1H), 8.62 (d, J=7.8 Hz, 1H), 8.16 (s, 3H), 7.50-7.34 (m, 4H), 6.83 (s, 1H), 4.91 (q, J=7.2 Hz, 1H), 4.55 (t, J=8.4 Hz, 1H), 4.31 (s, 1H), 3.89 (d, J=5.3 Hz, 1H), 3.75 (d, J=10.8 Hz, 1H), 3.50 (dd, J=3.7, 10.9 Hz, 1H), 2.47 (s, 3H), 2.21-1.65 (m, 2H), 1.38 (d, J=7.0 Hz, 3H), 1.03 (s, 9H); 13C NMR (101 MHz, DMSO-d6): δ 170.68, 167.08, 151.52, 147.47, 145.31, 131.96, 129.84, 129.32 (2C), 126.85 (2C), 69.35, 59.30, 58.51, 56.94, 48.24, 38.39, 34.85, 26.53 (3C), 22.97, 16.14.
99.98%	With hydrogenchloride; methanol In ethyl acetate	1.1.3 The ((S)-1-((2S,4R)-4-hydroxy-2-((S)-1-(4-methylthiazole-5-yl)phenyl)carbamoyl)pyrrolidine-1-yl)-3,3-dimethyl-1-oxobutane-2-yl) carbamic acid tert-butyl ester (compound C-11) (17.94g, 33mmol) in methanol (36mL) solution was slowly added to the solution of hydrogen chloride in ethyl acetate (2M, 66mL, 132mmol) and the reaction was stirred overnight. Concentrated reaction solution, methyl tert-butyl ether (180mL), beat overnight, filtered, dried filter cake, to give a bright yellow solid product ((S)-1-((2S,4R)-4-hydroxy-2-((S)-1-(4-(4-methylthiazole-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-yl)-3,3-dimethyl-1-oxobutane-2-yl) amine hydrochloride (Compound C) (15.84g, yield 99.98%).
98%	With hydrogenchloride In 1,4-dioxane at 25℃; for 16h; Inert atmosphere;	6 Step 6: (2S, 4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4- methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride (Intermediate N). To a stirred mixture of tert-butyl N-[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3- thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate (49.0 g, 90.0 mmol) in MeOH (100 mL) and dioxane (400 mL) was added a solution of HCl (gas) in 1,4-dioxane (4 M, 200 mL) dropwise at 25 °C under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 25 °C under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. This resulted in the title compound as a light yellow solid (50.0 g, 98%): 1H NMR (400 MHz, CD3OD) d 10.10 (s, 1H), 7.66-7.57 (d, J = 8.4 Hz, 2H), 7.55 (d, J = 8.4 Hz, 2H), 5.03 (q, J = 7.0 Hz, 1H), 4.73 (dd, J = 9.5, 7.7 Hz, 1H), 4.53-4.46 (m, 1H), 4.11 (s, 1H), 3.90 (dt, J = 11.3, 1.6 Hz, 1H), 3.7-3.64 (m, 1H), 3.71-3.60 (m, 1H), 2.65 (s, 3H), 2.35 (ddt, J = 13.3, 7.7, 1.8 Hz, 1H), 1.94 (ddd, J = 13.5, 9.5, 4.2 Hz, 1H), 1.54 (d, J = 7.0 Hz, 3H), 1.16 (s, 9H); LC/MS (ESI, m/z): [(M + H)]+ = 445.20.
97%	With hydrogenchloride In 1,4-dioxane at 0 - 20℃; for 16h;	Step-g: Synthesis of (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride (17g) To a stirred solution of tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-ethylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (5.0 g, 9.19 mmol) in l,4-dioxane (25 mL) at 0 °C was added 4M HCl in l,4-dioxane (25 mL). The reaction mixture was stirred at RT for 16 h. Solvents from the reaction mixture was evaporated under reduced pressure and the residue was washed with diethyl ether to afford the title compound (4.5 g, 97 %). 1H NMR (400 MHz, DMSO-d6) d 9.60 (s, 1H), 8.58 (d, / = 7.2 Hz, 1H), 8.12 (s, 3H), 7.44 (d, / = 8.4 Hz, 2H), 7.38 (d, / = 8.4 Hz, 2H), 4.92 (d, / = 7.0 Hz, 1H), 4.54 (t, / = 8.4 Hz, 1H), 4.30 (s, 1H), 3.89-3.88 (m, 1H), 3.75-3.72 (m, 1H), 3.51-3.48 (m, 2H), 2.46 (s, 3H), 2.12-2.08 (m, 1H), 1.80-1.75 (m, 1H), l.38(d, / = 6.8 Hz, 3H), 1.05 (s, 9H); LC-MS: m/z 445.3 (M+l)+.
92%	With hydrogenchloride In 1,4-dioxane; dichloromethane at 0 - 20℃; for 0.25h;	66.5 Step 5: (2S.4R)- 1 -r(2S)-2-amino-3.3-dimethyl-butanoyl1-4-hvdroxy-N-r( l S)- l -G4- (4-methylthiazol-5-vnphenyl1ethyl1pyrrolidine-2-carboxamide hydrochloride. To a solution of /er/-butyl N-[(l S)-l-[(2S,4R)-4-hydroxy-2-[[(l S)-l-[4-(4- methylthiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidine-l-carbonyl]-2,2-dimethyl- propyl]carbamate (34.0 g, 62.0 mmol) in DCM (200 mL) at 0 °C, was added an HC1 solution (4M in dioxane, 200 mL, 800 mmol) and the mixture was warmed to rt and stirred for 15 min. The mixture was diluted with MeOH (150 mL) and the mixture was stirred for 30 min. The volatiles were evaporated under reduced pressure and coevaporated with PhMe (2 x 100 mL) to afford the title compound as a solid (30.6 g, 92%, contains 9% PhMe by weight). 'H NMR (500 MHz, DMSO) d 9.04 (s, 1H), 8.59 (d, J = 7.8 Hz, 1H), 8.09 (d, J = 4.3 Hz, 3H), 7.47 - 7.43 (m, 2H), 7.42 - 7.37 (m, 2H), 4.93 (p, J = 7.0 Hz, 1H), 4.55 (t, J = 8.4 Hz, 1H), 4.33 (br s, 1H), 3.91 (q, J = 5.7 Hz, 1H), 3.73 (d, J = 10.6 Hz, 1H), 3.50 (dd, J = 10.9, 3.9 Hz, 1H), 2.70 (s, 1H), 2.47 (s, 3H), 2.12 (dd, J = 12.9, 7.7 Hz, 1H), 1.81 - 1.72 (m, 1H), 1.39 (d, J = 7.0 Hz, 3H), 1.03 (s, 9H). MS (ESI) [M+H]+ 445.2.
3.5 g	With hydrogenchloride In methanol at 20℃; for 2h;	7 Step 7: Preparation of (2S,4R)-l-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N- ((S)-l-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride Into a lOO-mL round-bottom flask, was placed a solution of tert-butyl N-[(2S)-l- [(2S,4R)-4-hydroxy-2-[[(lS)-l-[4-(4-methyl-l,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin- l-yl]-3, 3-dimethyl- l-oxobutan-2-yl]carbamate (4.0 g, 7.34 mmol, 1.00 equiv) in methanol (30 mL), then hydrogen chloride (gas) was bubbled into the reaction mixture for 2 hours at room temperature. The resulting mixture was concentrated under vacuum. This resulted in 3.5 g of (2S ,4R)- 1 - [(2S )-2-amino-3 ,3 -dimethylbutanoyl] -4-hydroxy-N- [( 1 S )- 1 - [4-(4-methyl- 1 ,3 -thiazol- 5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride as a yellow solid. LC/MS (ESI) m/z : 445.05 [M+l] +; 1H-NMR (400MHz, DMSO-ifc) d 8.99 (s, 1 H), 8.57-8.55 (d, J = 7.8 Hz, 1 H), 8.01 (b, 3 H), 7.46-7.43 (d, J = 8.4 Hz, 2 H), 7.39-7.37 (d, J = 8.4 Hz, 2 H), 4.98-4.90 (m, 1 H), 4.57-4.51 (m, 1 H), 4.34 (b, 1 H), 3.94-3.92 (m, 1 H), 3.69-3.66 (m, 1 H), 3.53-3.49 (m, 1 H), 2.52 (s, 3 H), 2.10-2.07 (m, 1 H), 1.83-1.81 (m, 1 H), 1.40-1.30 (m, 3 H), 1.03 (s, 9 H).
3.5 g	With hydrogenchloride In methanol at 20℃; for 2h;	7 Step 7: Preparation of (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N- ((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride Into a 100-mL round-bottom flask, was placed a solution of tert-butyl N-[(2S)-1- [(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin- 1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate (4.0 g, 7.34 mmol, 1.00 equiv) in methanol (30 mL), then hydrogen chloride (gas) was bubbled into the reaction mixture for 2 h at room temperature. The resulting mixture was concentrated under vacuum. This resulted in 3.5 g of (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol- 5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride as a yellow solid. LC/MS (ESI) m/z: 445.05 [M+1] +; 1H-NMR (400MHz, DMSO-d6) d 8.99 (s, 1 H), 8.57-8.55 (d, J = 7.8 Hz, 1 H), 8.01 (b, 3 H), 7.46-7.43 (d, J = 8.4 Hz, 2 H), 7.39-7.37 (d, J = 8.4 Hz, 2 H), 4.98-4.90 (m, 1 H), 4.57-4.51 (m, 1 H), 4.34 (b, 1 H), 3.94-3.92 (m, 1 H), 3.69-3.66 (m, 1 H), 3.53-3.49 (m, 1 H), 2.52 (s, 3 H), 2.10-2.07 (m, 1 H), 1.83-1.81 (m, 1 H), 1.40-1.30 (m, 3 H), 1.03 (s, 9 H).
30 g	With hydrogenchloride In 1,4-dioxane; chloroform; water at 20℃; Cooling with ice;	5.5-7 (5-7) (2S, 4R) -1-[(2S) -2-amino-3,3-dimethylbutanoyl] -4-hydroxy-N-{(1S) -1-[4-(4-(4-(4-(4-) Methyl-1,3-thiazole-5-yl) phenyl] ethyl} pyrrolidine-2-carboxamide hydrochloride (Reference Example Compound 5) In a mixture of Reference Example Compound 5-6 (34.8 g), chloroform (160 mL), 1,4-dioxane (500 mL), a 4M hydrogen chloride / dioxane solution was added dropwise under ice-cooling, and the mixture was stirred overnight at room temperature.After concentrating the reaction solution, acetonitrile was added and concentrated to give the title compound (30.0 g) as a pale yellow solid.
	With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 2h;
3.5 g	With hydrogenchloride In methanol at 20℃; for 2h;	7 Step 7: Preparation of (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride Into a 100-mL round-bottom flask, was placed a solution of tert-butyl N-[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate (4.0 g, 7.34 mmol, 1.00 equiv) in methanol (30 mL), then hydrogen chloride (gas) was bubbled into the reaction mixture for 2 hours at room temperature. The resulting mixture was concentrated under vacuum. This resulted in 3.5 g of (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride as a yellow solid. LC/MS (ESI) m/z: 445.05 [M+1] +; 1H-NMR (400MHz, DMSO-d6) δ 8.99 (s, 1H), 8.57-8.55 (d, J = 7.8 Hz, 1H), 8.01 (b, 3 H), 7.46-7.43 (d, J = 8.4 Hz, 2 H), 7.39-7.37 (d, J = 8.4 Hz, 2 H), 4.98-4.90 (m, 1H), 4.57-4.51 (m, 1H), 4.34 (b, 1H), 3.94-3.92 (m, 1H), 3.69-3.66 (m, 1H), 3.53-3.49 (m, 1H), 2.52 (s, 3 H), 2.10-2.07 (m, 1H), 1.83-1.81 (m, 1H), 1.40-1.30 (m, 3 H), 1.03 (s, 9 H).
99 %	With hydrogenchloride In 1,4-dioxane at 20℃;	(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4- methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride (E3LB-1) A solution of 4N HCl in dioxane (6.0 mL) is added to tert-butyl ((S)-1-((2S,4R)-4- hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3- dimethyl-1-oxobutan-2-yl)carbamate (L) (1.55 g, 2.85 mmol) and the mixture is stirred at rt for 3 h. The solvent is evaporated to dryness and the crude residue is triturated with DEE, filtered off, and dried in an oven at 50 °C to give the titled compound as a white solid (1.36 g, 99% yield).1H NMR (400 MHz, DMSO-d6): δ 9.11 (s, 1H), 8.62 (d, J = 7.8 Hz, 1H), 8.16 (s, 3H), 7.50-7.34 (m, 4H), 6.83 (s, 1H), 4.91 (q, J = 7.2 Hz, 1H), 4.55 (t, J = 8.4 Hz, 1H), 4.31 (s, 1H), 3.89 (d, J = 5.3 Hz, 1H), 3.75 (d, J = 10.8 Hz, 1H), 3.50 (dd, J = 3.7, 10.9 Hz, 1H), 2.47 (s, 3H), 2.21-1.65 (m, 2H), 1.38 (d, J = 7.0 Hz, 3H), 1.03 (s, 9H);13C NMR (101 MHz, DMSO-d6): δ 170.68, 167.08, 151.52, 147.47, 145.31, 131.96, 129.84, 129.32 (2C), 126.85 (2C), 69.35, 59.30, 58.51, 56.94, 48.24, 38.39, 34.85, 26.53 (3C), 22.97, 16.14
99 %	With hydrogenchloride In 1,4-dioxane at 20℃;	(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4- methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride (E3LB-1) A solution of 4N HCl in dioxane (6.0 mL) is added to tert-butyl ((S)-1-((2S,4R)-4- hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3- dimethyl-1-oxobutan-2-yl)carbamate (L) (1.55 g, 2.85 mmol) and the mixture is stirred at rt for 3 h. The solvent is evaporated to dryness and the crude residue is triturated with DEE, filtered off, and dried in an oven at 50 °C to give the titled compound as a white solid (1.36 g, 99% yield).1H NMR (400 MHz, DMSO-d6): δ 9.11 (s, 1H), 8.62 (d, J = 7.8 Hz, 1H), 8.16 (s, 3H), 7.50-7.34 (m, 4H), 6.83 (s, 1H), 4.91 (q, J = 7.2 Hz, 1H), 4.55 (t, J = 8.4 Hz, 1H), 4.31 (s, 1H), 3.89 (d, J = 5.3 Hz, 1H), 3.75 (d, J = 10.8 Hz, 1H), 3.50 (dd, J = 3.7, 10.9 Hz, 1H), 2.47 (s, 3H), 2.21-1.65 (m, 2H), 1.38 (d, J = 7.0 Hz, 3H), 1.03 (s, 9H);13C NMR (101 MHz, DMSO-d6): δ 170.68, 167.08, 151.52, 147.47, 145.31, 131.96, 129.84, 129.32 (2C), 126.85 (2C), 69.35, 59.30, 58.51, 56.94, 48.24, 38.39, 34.85, 26.53 (3C), 22.97, 16.14
99 %	With hydrogenchloride In 1,4-dioxane at 20℃;	(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride (E3LB-1). The titled compound can be prepared according to the process described by Raina K. et al., Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 7124-7129.[00157] A solution of 4N HCl in dioxane (6.0 mL) is added to tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (L) (1.55 g, 2.85 mmol) and the mixture is stirred at rt for 3 h. The solvent is evaporated to dryness and the crude residue is triturated with DEE, filtered off, and dried in an oven at 50 °C to give the titled compound as a white solid (1.36 g, 99% yield).1H NMR (400 MHz, DMSO-d6): δ 9.11 (s, 1H), 8.62 (d, J = 7.8 Hz, 1H), 8.16 (s, 3H), 7.50-7.34 (m, 4H), 6.83 (s, 1H), 4.91 (q, J = 7.2 Hz, 1H), 4.55 (t, J = 8.4 Hz, 1H), 4.31 (s, 1H), 3.89 (d, J = 5.3 Hz, 1H), 3.75 (d, J = 10.8 Hz, 1H), 3.50 (dd, J = 3.7, 10.9 Hz, 1H), 2.47 (s, 3H), 2.21-1.65 (m,2H), 1.38 (d, J = 7.0 Hz, 3H), 1.03 (s, 9H);13C NMR (101 MHz, DMSO-d6): δ 170.68, 167.08, 151.52, 147.47, 145.31, 131.96, 129.84, 129.32 (2C), 126.85 (2C), 69.35, 59.30, 58.51, 56.94, 48.24, 38.39, 34.85, 26.53 (3C), 22.97, 16.14.
99 %	With hydrogenchloride In 1,4-dioxane at 20℃;	(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride (E3LB-1). The titled compound can be prepared according to the process described by Raina K. et al., Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 7124-7129.[00157] A solution of 4N HCl in dioxane (6.0 mL) is added to tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (L) (1.55 g, 2.85 mmol) and the mixture is stirred at rt for 3 h. The solvent is evaporated to dryness and the crude residue is triturated with DEE, filtered off, and dried in an oven at 50 °C to give the titled compound as a white solid (1.36 g, 99% yield).1H NMR (400 MHz, DMSO-d6): δ 9.11 (s, 1H), 8.62 (d, J = 7.8 Hz, 1H), 8.16 (s, 3H), 7.50-7.34 (m, 4H), 6.83 (s, 1H), 4.91 (q, J = 7.2 Hz, 1H), 4.55 (t, J = 8.4 Hz, 1H), 4.31 (s, 1H), 3.89 (d, J = 5.3 Hz, 1H), 3.75 (d, J = 10.8 Hz, 1H), 3.50 (dd, J = 3.7, 10.9 Hz, 1H), 2.47 (s, 3H), 2.21-1.65 (m,2H), 1.38 (d, J = 7.0 Hz, 3H), 1.03 (s, 9H);13C NMR (101 MHz, DMSO-d6): δ 170.68, 167.08, 151.52, 147.47, 145.31, 131.96, 129.84, 129.32 (2C), 126.85 (2C), 69.35, 59.30, 58.51, 56.94, 48.24, 38.39, 34.85, 26.53 (3C), 22.97, 16.14.
	With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃;	7 Synthesis of (2S,4R)-1-[(2S)-2-amino-3,3-dimethyl-butanoyl]-4-hydroxy-N-[(1S)- 1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;hydrochloride (HB7) )-1-[4-(4- methylthiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidine-1-carbonyl]-2,2-dimethyl- propyl]carbamate (HB7h) (34.0 g, 62.0 mmol) in DCM (200 mL) at 0 °C was added an HCl solution (4 M in dioxane, 200 mL, 800 mmol) and the mixture was warmed to rt and then stirred for 15 min. The mixture was then diluted with MeOH (150 mL) and the mixture was further stirred for 30 min. The volatiles were evaporated under reduced pressure and coevaporated with PhMe (2 x 100 mL) to afford the title compound HB7 as a solid (30.6 g, 92%, contained 9% PhMe by weight).1H NMR (500 MHz, DMSO-d6) δ 9.04 (s, 1H), 8.59 (d, J = 7.8 Hz, 1H), 8.09 (d, J = 4.3 Hz, 3H), 7.47 - 7.43 (m, 2H), 7.42 - 7.37 (m, 2H), 4.93 (p, J = 7.0 Hz, 1H), 4.55 (t, J = 8.4 Hz, 1H), 4.33 (br s, 1H), 3.91 (q, J = 5.7 Hz, 1H), 3.73 (d, J = 10.6 Hz, 1H), 3.50 (dd, J = 10.9, 3.9 Hz, 1H), 2.70 (s, 1H), 2.47 (s, 3H), 2.12 (dd, J = 12.9, 7.7 Hz, 1H), 1.81 - 1.72 (m, 1H), 1.39 (d, J = 7.0 Hz, 3H), 1.03 (s, 9H). MS (ESI) [M+H]+ 445.2
	With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃;	7 Synthesis of (2S,4R)-1-[(2S)-2-amino-3,3-dimethyl-butanoyl]-4-hydroxy-N-[(1S)- 1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;hydrochloride (HB7) )-1-[4-(4- methylthiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidine-1-carbonyl]-2,2-dimethyl- propyl]carbamate (HB7h) (34.0 g, 62.0 mmol) in DCM (200 mL) at 0 °C was added an HCl solution (4 M in dioxane, 200 mL, 800 mmol) and the mixture was warmed to rt and then stirred for 15 min. The mixture was then diluted with MeOH (150 mL) and the mixture was further stirred for 30 min. The volatiles were evaporated under reduced pressure and coevaporated with PhMe (2 x 100 mL) to afford the title compound HB7 as a solid (30.6 g, 92%, contained 9% PhMe by weight).1H NMR (500 MHz, DMSO-d6) δ 9.04 (s, 1H), 8.59 (d, J = 7.8 Hz, 1H), 8.09 (d, J = 4.3 Hz, 3H), 7.47 - 7.43 (m, 2H), 7.42 - 7.37 (m, 2H), 4.93 (p, J = 7.0 Hz, 1H), 4.55 (t, J = 8.4 Hz, 1H), 4.33 (br s, 1H), 3.91 (q, J = 5.7 Hz, 1H), 3.73 (d, J = 10.6 Hz, 1H), 3.50 (dd, J = 10.9, 3.9 Hz, 1H), 2.70 (s, 1H), 2.47 (s, 3H), 2.12 (dd, J = 12.9, 7.7 Hz, 1H), 1.81 - 1.72 (m, 1H), 1.39 (d, J = 7.0 Hz, 3H), 1.03 (s, 9H). MS (ESI) [M+H]+ 445.2
60 %	With hydrogenchloride In 1,4-dioxane; methanol; dichloromethane at 0 - 20℃;	4.6.7. (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamidehydrochloride (17) To a solution of 54 in a mixture of dry DCM (6.0 mL) and dry MeOH(2.0 mL), 4.0 N HCl in dioxane (4.7 mL) was added dropwise at 0 C forover 30 min. The mixture was stirred at room temperature overnight.Then, the reaction mixture was concentrated, water (50 mL) was added,and the solution was extracted with DCM (20 mL x 3). The aqueousphase was then transferred to a beaker, and solid NaHCO3 (2.5 g) wasadded to the solution to adjust the pH to 8. Then, the aqueous phase wasextracted with DCM (30 mL x 3); the reunited organic phase was washedwith brine (20 mL), dried over Na2SO4 and concentrated in vacuo. Theresulting beige foam was dissolved in dioxane (20 mL), and 4.0 N HCl indioxane (3.0 mL) was added dropwise for over 30 min at 0 C. Theresulting mixture was concentrated in vacuo and dissolved in MeOH (7.0mL). The solution was added dropwise to EA (60.0 mL) over 2 h. Theprecipitated solid was filtered and dried in vacuo to give a 0.664 g beigesolid (two-step yield 68 %; and overall yield 60 %). 1H NMR (400 MHz,DMSO-d6) 9.08 (s, 1H), 8.61 (d, J = 7.6 Hz, 1H), 8.16 (bs, 3H), 7.42 (dd,J = 25.4, 8.1 Hz, 4H), 4.99-4.85 (m, 1H), 4.58-4.51 (m, 1H), 4.34-4.27(m, 1H), 3.92-3.84 (m, 1H), 3.79-3.70 (m, 1H), 3.55-3.44 (m, 1H), 2.46(s, 3H), 2.16-2.06 (m, 1H), 1.81-1.69 (m, 1H), 1.38 (d, J = 6.9 Hz, 3H),1.02 (s, 9H). 13C NMR (101 MHz, DMSO-d6) δ 170.68, 167.08, 152.32,147.62, 145.27, 131.88, 129.91, 129.32 (2C), 126.84 (2C), 69.35,60.22, 59.30, 58.51, 56.94, 48.24, 34.85, 26.54 (3C), 22.97, 16.20.HRMS (ESI) m/z [M + H]+ calcd for C23H32N4O3S 445.22679, found445.2275. UPLC retention time: 3.211 min.
60 %	With hydrogenchloride In 1,4-dioxane; methanol; dichloromethane at 0 - 20℃;	4.6.7. (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamidehydrochloride (17) To a solution of 54 in a mixture of dry DCM (6.0 mL) and dry MeOH(2.0 mL), 4.0 N HCl in dioxane (4.7 mL) was added dropwise at 0 C forover 30 min. The mixture was stirred at room temperature overnight.Then, the reaction mixture was concentrated, water (50 mL) was added,and the solution was extracted with DCM (20 mL x 3). The aqueousphase was then transferred to a beaker, and solid NaHCO3 (2.5 g) wasadded to the solution to adjust the pH to 8. Then, the aqueous phase wasextracted with DCM (30 mL x 3); the reunited organic phase was washedwith brine (20 mL), dried over Na2SO4 and concentrated in vacuo. Theresulting beige foam was dissolved in dioxane (20 mL), and 4.0 N HCl indioxane (3.0 mL) was added dropwise for over 30 min at 0 C. Theresulting mixture was concentrated in vacuo and dissolved in MeOH (7.0mL). The solution was added dropwise to EA (60.0 mL) over 2 h. Theprecipitated solid was filtered and dried in vacuo to give a 0.664 g beigesolid (two-step yield 68 %; and overall yield 60 %). 1H NMR (400 MHz,DMSO-d6) 9.08 (s, 1H), 8.61 (d, J = 7.6 Hz, 1H), 8.16 (bs, 3H), 7.42 (dd,J = 25.4, 8.1 Hz, 4H), 4.99-4.85 (m, 1H), 4.58-4.51 (m, 1H), 4.34-4.27(m, 1H), 3.92-3.84 (m, 1H), 3.79-3.70 (m, 1H), 3.55-3.44 (m, 1H), 2.46(s, 3H), 2.16-2.06 (m, 1H), 1.81-1.69 (m, 1H), 1.38 (d, J = 6.9 Hz, 3H),1.02 (s, 9H). 13C NMR (101 MHz, DMSO-d6) δ 170.68, 167.08, 152.32,147.62, 145.27, 131.88, 129.91, 129.32 (2C), 126.84 (2C), 69.35,60.22, 59.30, 58.51, 56.94, 48.24, 34.85, 26.54 (3C), 22.97, 16.20.HRMS (ESI) m/z [M + H]+ calcd for C23H32N4O3S 445.22679, found445.2275. UPLC retention time: 3.211 min.
8.12 g	With hydrogenchloride In methanol at 4℃;
	With hydrogenchloride In 1,4-dioxane; water at 20℃;

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7
[ 1973408-97-7 ]
[ 1997302-16-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: hydrogenchloride / methanol / 3 h / 20 °C 2: HATU; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 2 steps 1: dichloromethane / 0.5 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
	Multi-step reaction with 4 steps 1: hydrogenchloride / methanol; 1,4-dioxane / 12 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere 3: hydrogenchloride / methanol; 1,4-dioxane / 12 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

	Multi-step reaction with 4 steps 1: hydrogenchloride / methanol / 2 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C 3: hydrogenchloride / methanol / 2 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C
	Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: hydrogenchloride / water; 1,4-dioxane / 3 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: hydrogenchloride / water; methanol / 3 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 4 steps 1: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C 2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C 4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 4 steps 1: hydrogenchloride / 1,4-dioxane / 25 °C / Inert atmosphere 2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane / 16 h / 25 °C / Inert atmosphere 4: triethylamine; HATU / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: hydrogenchloride / water; 1,4-dioxane / 5 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Cooling with ice
	Multi-step reaction with 2 steps 1: hydrogenchloride / water; methanol / 3 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 4 steps 1: hydrogenchloride / methanol / 2 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C 3: hydrogenchloride / methanol / 2 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C
	Multi-step reaction with 4 steps 1: hydrogenchloride / ethyl acetate / 12 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C 3: methanol; hydrogenchloride / ethyl acetate / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
	Multi-step reaction with 2 steps 1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1.1: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 1.2: 20 °C 2.1: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 2.2: 20 °C
	Multi-step reaction with 4 steps 1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 16 h / 20 °C 3: dichloromethane / 18 h / 20 °C 4: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C
	Multi-step reaction with 2 steps 1: hydrogenchloride / methanol 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 12 h / 20 °C
	Multi-step reaction with 4 steps 1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 25 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C 3: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 25 °C 4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C
	Multi-step reaction with 2 steps 1.1: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C / Inert atmosphere 1.2: 12 h / 0 - 20 °C / Inert atmosphere 2.1: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C / Inert atmosphere 2.2: 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 4 steps 1: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C 3: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 4 steps 1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 18 h / 0 - 20 °C 2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide; dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: hydrogenchloride / 1,4-dioxane / 18 h / 0 - 20 °C 4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere 4.2: 18 h / 20 °C / Inert atmosphere
	Multi-step reaction with 4 steps 1: hydrogenchloride / ethyl acetate / 12 h / 20 °C 2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere 3: hydrogenchloride / ethyl acetate / 12 h / 20 °C 4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 4 steps 1: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 20 °C 3: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 20 °C
	Multi-step reaction with 4 steps 1: hydrogenchloride / 1,4-dioxane / 1 h / 16 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 16 °C 3: hydrogenchloride / 1,4-dioxane / 1 h / 16 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 16 - 20 °C
	Multi-step reaction with 2 steps 1: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 0 - 20 °C 2: 1-methyl-1H-imidazole / acetonitrile / 3 h / 20 °C
	Multi-step reaction with 2 steps 1.1: trifluoroacetic acid / dichloromethane / 1 h / Cooling with ice 1.2: 3 h / 20 °C 2.1: trifluoroacetic acid / 1 h / Cooling with ice 2.2: 3 h / 20 °C

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[10]Current Patent Assignee: MITSUBISHI TANABE PHARMA - WO2020/9176, 2020, A1.
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[14]Keuler, Tim; König, Beate; Bückreiß, Nico; Kraft, Fabian B.; König, Philipp; Schäker-Hübner, Linda; Steinebach, Christian; Bendas, Gerd; Gütschow, Michael; Hansen, Finn K. [Chemical Communications, 2022, vol. 58, # 79, p. 11087 - 11090].
[15]Wang, Chao; Zheng, Cangxin; Wang, Han; Shui, Sufang; Jin, Hongwei; Liu, Guoquan; Xu, Fengrong; Liu, Zhenming; Zhang, Liangren; Sun, Dan; Xu, Ping [European Journal of Medicinal Chemistry, 2023, vol. 247].
[16]Current Patent Assignee: HINOVA PHARMACEUTICALS - WO2023/280237, 2023, A1.
[17]Cai, Maohua; Ma, Furong; Hu, Can; Li, Haobin; Cao, Fei; Li, Yulong; Dong, Jinyun; Qin, Jiang-Jiang [Bioorganic and Medicinal Chemistry, 2023, vol. 90].
[18]Current Patent Assignee: SHANGHAI QILU PHARMACEUTICAL RES AND DEVELOPMENT CENTRE - WO2023/143249, 2023, A1.
[19]Du, Wenhao; Huang, Yuting; Chen, Xiaoai; Deng, Yue; Sun, Yaoliang; Yang, Hong; Shi, Qiongyu; Wu, Feifei; Liu, Guobin; Huang, He; Ding, Jian; Huang, Xun; Xu, Shilin [Cell Chemical Biology, 2024, vol. 31, # 1, p. 177 - 17,183].
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[26]Current Patent Assignee: WUHAN UNIVERSITY - CN120247870, 2025, A.

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[ 27298-97-1 ]
[ 1997302-16-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / water; ethyl acetate / 2 h / 5 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 18 h / 90 °C / Inert atmosphere 3: hydrogenchloride / methanol / 3 h / 20 °C 4: HATU; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / water; ethyl acetate / 1 h / 20 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere 3: dichloromethane / 0.5 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
	Multi-step reaction with 6 steps 1: sodium hydrogencarbonate / water; ethyl acetate / 2 h 2: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 12 h / 90 °C 3: hydrogenchloride / methanol; 1,4-dioxane / 12 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere 5: hydrogenchloride / methanol; 1,4-dioxane / 12 h / 20 °C 6: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

	Multi-step reaction with 6 steps 1: triethylamine / dichloromethane / 2 h / 20 °C 2: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 2 h / 120 °C 3: hydrogenchloride / methanol / 2 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C 5: hydrogenchloride / methanol / 2 h / 20 °C 6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C
	Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / ethyl acetate; water / 2 h / 20 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 12 h / 90 °C 3: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C 4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / ethyl acetate; water / 2 h / 5 - 20 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 18 h / 90 °C 3: hydrogenchloride / water; 1,4-dioxane / 3 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / water; ethyl acetate / 2 h / 5 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere 3: hydrogenchloride / water; methanol / 3 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 6 steps 1: sodium hydrogencarbonate / water; ethyl acetate / 2 h 2: palladium diacetate; potassium acetate / dimethyl amine / 12 h / 90 °C 3: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C 4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere 5: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C 6: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / ethyl acetate; water / 20 °C / Cooling with ice 2: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 7 h / 90 °C / Inert atmosphere 3: hydrogenchloride / water; 1,4-dioxane / 5 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Cooling with ice
	Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / water; ethyl acetate / 2 h / 5 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere 3: hydrogenchloride / water; methanol / 3 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 2 h / 0 - 20 °C
	Multi-step reaction with 6 steps 1: triethylamine / dichloromethane / 2 h / 20 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 2 h / 120 °C / Inert atmosphere 3: hydrogenchloride / methanol / 2 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C 5: hydrogenchloride / methanol / 2 h / 20 °C 6: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C
	Multi-step reaction with 6 steps 1: triethylamine / dichloromethane / 12 h / 20 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere 3: hydrogenchloride / ethyl acetate / 12 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C 5: methanol; hydrogenchloride / ethyl acetate / 20 °C 6: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
	Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / ethyl acetate; water / 2 h / 0 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 4 h / 130 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
	Multi-step reaction with 4 steps 1.1: sodium hydrogencarbonate / ethyl acetate; water / 1 h / 20 °C 2.1: palladium diacetate; potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere 3.1: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 3.2: 20 °C 4.1: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 4.2: 20 °C
	Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / ethyl acetate; water / 2 h / 5 - 20 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 18 h / 90 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / water; ethyl acetate 2: palladium diacetate; potassium acetate / 90 °C 3: hydrogenchloride / methanol 4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 12 h / 20 °C
	Multi-step reaction with 6 steps 1: sodium hydrogencarbonate / water; ethyl acetate / 1 h / 25 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 16 h / 90 °C 3: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 25 °C 4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C 5: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 25 °C 6: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C
	Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 2 h / 20 °C / Cooling with ice 1.2: 12 h / 90 °C / Inert atmosphere 2.1: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C / Inert atmosphere 2.2: 12 h / 0 - 20 °C / Inert atmosphere 3.1: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C / Inert atmosphere 3.2: 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 6 steps 1: triethylamine / dichloromethane / 2 h / 20 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 12 h / 90 °C 3: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C 5: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 6 steps 1.1: sodium hydrogencarbonate / water / 18 h / 20 °C 2.1: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 4 h / 130 °C / Inert atmosphere 3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 18 h / 0 - 20 °C 4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide; dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 5.1: hydrogenchloride / 1,4-dioxane / 18 h / 0 - 20 °C 6.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere 6.2: 18 h / 20 °C / Inert atmosphere
	Multi-step reaction with 6 steps 1: sodium hydrogencarbonate / water; ethyl acetate / 2 h / 20 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 12 h / 90 °C 3: hydrogenchloride / ethyl acetate / 12 h / 20 °C 4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere 5: hydrogenchloride / ethyl acetate / 12 h / 20 °C 6: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 6 steps 1: triethylamine / dichloromethane / 2 h / 20 °C 2: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 18 h / 150 °C 3: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 20 °C 5: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 6: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 20 °C
	Multi-step reaction with 5 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 18 h / -10 - 20 °C 2: potassium carbonate; Trimethylacetic acid; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / N,N-dimethyl acetamide / 125 °C 3: hydrogenchloride / methanol / 2 h / 4 °C 4: sodium hydroxide / methanol; dichloromethane; water / 4 °C / pH 12.5 - 13 5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / -10 - 20 °C
	Multi-step reaction with 4 steps 1: sodium hydrogencarbonate; ethanol / water / 2 h / 25 - 30 °C 2: palladium diacetate; potassium acetate / 18 h / 90 °C 3: hydrogenchloride / methanol; water / 3 h / 25 - 30 °C 4: TFFH; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 30 °C
	Multi-step reaction with 4 steps 1.1: sodium hydrogencarbonate / water; ethyl acetate / 3 h / 20 °C / Cooling with ice 2.1: palladium diacetate; potassium acetate / N,N-dimethyl acetamide / 150 °C 3.1: trifluoroacetic acid / dichloromethane / 1 h / Cooling with ice 3.2: 3 h / 20 °C 4.1: trifluoroacetic acid / 1 h / Cooling with ice 4.2: 3 h / 20 °C

References: [1]Current Patent Assignee: ARVINAS OPERATIONS - US2018/72711, 2018, A1.
[2]Han, Xin; Wang, Chao; Qin, Chong; Xiang, Weiguo; Fernandez-Salas, Ester; Yang, Chao-Yie; Wang, Mi; Zhao, Lijie; Xu, Tianfeng; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng [Journal of Medicinal Chemistry, 2019, vol. 62, # 2, p. 941 - 964].
[3]Hu, Jiantao; Hu, Biao; Wang, Mingliang; Xu, Fuming; Miao, Bukeyan; Yang, Chao-Yie; Wang, Mi; Liu, Zhaomin; Hayes, Daniel F.; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng [Journal of Medicinal Chemistry, 2019, vol. 62, # 3, p. 1420 - 1442].
[4]Current Patent Assignee: YALE UNIVERSITY - WO2019/195609, 2019, A2.
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[6]Current Patent Assignee: DBD THERAPEUTICS - US2020/239430, 2020, A1.
[7]Current Patent Assignee: ARVINAS - US2018/125821, 2018, A1.
[8]Current Patent Assignee: UNIVERSITY OF MICHIGAN - WO2020/142227, 2020, A1.
[9]Current Patent Assignee: MITSUBISHI TANABE PHARMA - WO2020/9176, 2020, A1.
[10]Current Patent Assignee: ARVINAS OPERATIONS - WO2021/11913, 2021, A1.
[11]Current Patent Assignee: YALE UNIVERSITY - WO2021/207172, 2021, A1.
[12]Current Patent Assignee: JIANGSU YAHONG MEDITECH - WO2022/161166, 2022, A1.
[13]Keuler, Tim; König, Beate; Bückreiß, Nico; Kraft, Fabian B.; König, Philipp; Schäker-Hübner, Linda; Steinebach, Christian; Bendas, Gerd; Gütschow, Michael; Hansen, Finn K. [Chemical Communications, 2022, vol. 58, # 79, p. 11087 - 11090].
[14]Wang, Chao; Zheng, Cangxin; Wang, Han; Shui, Sufang; Jin, Hongwei; Liu, Guoquan; Xu, Fengrong; Liu, Zhenming; Zhang, Liangren; Sun, Dan; Xu, Ping [European Journal of Medicinal Chemistry, 2023, vol. 247].
[15]Current Patent Assignee: DBD THERAPEUTICS - WO2023/39601, 2023, A1.
[16]Cai, Maohua; Ma, Furong; Hu, Can; Li, Haobin; Cao, Fei; Li, Yulong; Dong, Jinyun; Qin, Jiang-Jiang [Bioorganic and Medicinal Chemistry, 2023, vol. 90].
[17]Current Patent Assignee: SHANGHAI QILU PHARMACEUTICAL RES AND DEVELOPMENT CENTRE - WO2023/143249, 2023, A1.
[18]Du, Wenhao; Huang, Yuting; Chen, Xiaoai; Deng, Yue; Sun, Yaoliang; Yang, Hong; Shi, Qiongyu; Wu, Feifei; Liu, Guobin; Huang, He; Ding, Jian; Huang, Xun; Xu, Shilin [Cell Chemical Biology, 2024, vol. 31, # 1, p. 177 - 17,183].
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[20]Desantis, Jenny; Bazzacco, Alessandro; Eleuteri, Michela; Tuci, Sara; Bianconi, Elisa; Macchiarulo, Antonio; Mercorelli, Beatrice; Loregian, Arianna; Goracci, Laura [European Journal of Medicinal Chemistry, 2024, vol. 268].
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[22]Xin, Lilan; Wang, Chao; Cheng, Yan; Wang, Hongli; Guo, Xinyi; Deng, Xiaofei; Deng, Xiangping; Xie, Baohua; Hu, Hankun; Min, Chang; Dong, Chune; Zhou, Hai-Bing [Journal of Medicinal Chemistry, 2024, vol. 67, # 11, p. 8913 - 8931].
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[24]Current Patent Assignee: INSTITUTE OF BASIC MEDICAL AND ONCOLOGY CHINESE ACADEMY OF SCIENCES - CN115894439, 2024, B.
[25]Current Patent Assignee: WUHAN UNIVERSITY - CN120247870, 2025, A.

9
[ 1997302-16-5 ]
[ 1948273-02-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	With hydrogenchloride In methanol; water at 25 - 30℃; for 3h;	1 Synthesis of compound 18: Compound 17 (1.04 g, 1.9 mmol) was dissolved in 4N HCl methanol solution (3.0 ml), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure to obtain a light yellow solid. The solid was added to tert-butyl methyl ether (5 ml), and the resulting mixture was stirred at ambient temperature for 4 hours. The mixture was filtered, the solid part was collected, and dried in a 50°C oven to obtain compound 18 (white solid, 0.92 g, yield 100%).
98%	With trifluoroacetic acid In dichloromethane at 25 - 30℃;
	With trifluoroacetic acid In dichloromethane at 20℃;

	With hydrogenchloride In 1,4-dioxane; methanol at 20℃; for 12h;
	With hydrogenchloride In 1,4-dioxane; methanol at 20℃; for 12h;	1 (2S,4R)- 1 -((S)-2-Amino-3 ,3-dimethylbutanoyl)-4-hydroxy-N-((S)- 1 -(4-(4- methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide (58) The solid material (57) obtained as described above was dissolved in 4N HC1 in dioxane (4 mL, 16 mmol) and MeOH (4.0 mL) and the mixture was stirred at ambient temperature for 12 h. The mixture was then concentrated and the residue was dried under vacuum to afford the crude product, which was purified by reversed-phase preparative HPLC to afford the pure final compound (58) as an off-white solid. UPLC-MS (ESI+) calc for C23H33N4O3S [M+l]+: 445.23, found 445.44.
	With trifluoroacetic acid In dichloromethane at 20℃; for 1h;
	With trifluoroacetic acid In dichloromethane at 20℃;
96 %	With trifluoroacetic acid In dichloromethane at 20℃;	4.1.5. (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide (V5) To a solution of V4 (0.41 g, 0.95 mmol) in CH2Cl2 (20 mL) was addedTFA (10 mL) and stirred at room temperature for 30 min. The resultingsolution was added saturated NaHCO3 solution adjusting pH to alkalescence,followed by extraction. Then the organic phase was washedwith brine and dried with Na2SO4 successively, followed by concentrationto give the crude product. The compound was purified by dryloadedsilica gel chromatography (CH2Cl2/MeOH30/1) to give a=yellowish white solid V5 (0.35 g, 96%).1HNMR (400 MHz, CDCl3)8.69 (s, 1H, Ar-Ha), 7.76 (d, J7.5 Hz, 1H, NH), 7.37-7.42 (m, 4H,=Ar-H × 4), 5.05-5.12 (m, 1H, CH), 4.79 (t, J = 7.6, CH), 4.51 (brs, 1H,×=CH), 3.60-3.76 (m, 2H, CH2), 3.38 (s, 1H, CH), 2.54 (s, 3H, CH3),2.05-2.49 (m, 2H, CH2), 1.50 (d, J = 6.9 Hz, 3H, CH3), 1.02 (s, 9H, CH3=13C3);NMR (100 MHz, CDCl3) 174.36, 170.01, 150.24, 148.46,×143.37, 131.60, 130.80, 129.53, 126.39, 70.02, 60.46, 58.58, 56.39,48.89, 36.06, 35.66, 26.19, 22.32, 16.09.
96 %	With trifluoroacetic acid In dichloromethane at 20℃;	4.1.5. (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide (V5) To a solution of V4 (0.41 g, 0.95 mmol) in CH2Cl2 (20 mL) was addedTFA (10 mL) and stirred at room temperature for 30 min. The resultingsolution was added saturated NaHCO3 solution adjusting pH to alkalescence,followed by extraction. Then the organic phase was washedwith brine and dried with Na2SO4 successively, followed by concentrationto give the crude product. The compound was purified by dryloadedsilica gel chromatography (CH2Cl2/MeOH30/1) to give a=yellowish white solid V5 (0.35 g, 96%).1HNMR (400 MHz, CDCl3)8.69 (s, 1H, Ar-Ha), 7.76 (d, J7.5 Hz, 1H, NH), 7.37-7.42 (m, 4H,=Ar-H × 4), 5.05-5.12 (m, 1H, CH), 4.79 (t, J = 7.6, CH), 4.51 (brs, 1H,×=CH), 3.60-3.76 (m, 2H, CH2), 3.38 (s, 1H, CH), 2.54 (s, 3H, CH3),2.05-2.49 (m, 2H, CH2), 1.50 (d, J = 6.9 Hz, 3H, CH3), 1.02 (s, 9H, CH3=13C3);NMR (100 MHz, CDCl3) 174.36, 170.01, 150.24, 148.46,×143.37, 131.60, 130.80, 129.53, 126.39, 70.02, 60.46, 58.58, 56.39,48.89, 36.06, 35.66, 26.19, 22.32, 16.09.
	With hydrogenchloride In methanol
196 mg	With hydrogenchloride In 1,4-dioxane; dichloromethane at 25℃;	G Step G: Add 1,4-dioxane solution (4 M, 2 ml) of hydrochloric acid to a mixture of compound INT-5-6 (240 mg, 0.4 mmol) and dichloromethane (2 ml). Stirring the mixture at 25 degrees Celsius for 1 h, LCMS monitoring shows that the raw material disappears. The mixture was removed from the solvent to obtain 196 mg of intermediate INT-5.
	With trifluoroacetic acid In dichloromethane at 20℃; Inert atmosphere;
	With hydrogenchloride In 1,4-dioxane; methanol at 20℃; Inert atmosphere;
	With trifluoroacetic acid In dichloromethane at 20℃;
87 %	With trifluoroacetic acid In dichloromethane at 20℃;
50.8 %	With hydrogenchloride In ethyl acetate at 20℃;	4.1.21. (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4 methylthiazol-5-yl) phenyl) ethyl) pyrrolidine-2-carboxamide(P14) The solid material (P13) obtained above was dissolved in 2 M HCl inEA (25 mL, 50 mmol) and the mixture was stirred at ambient temperaturefor 12 h. The mixture was then concentrated and the residue wasdried under vacuum to afford crude compound, which was purified bysilica gel flash column chromatography (DCM: MeOH 30:1) to afford thedesired compound (P14, 3.90 g, 50.8 %).
50.8 %	With hydrogenchloride In ethyl acetate at 20℃;	4.1.21. (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4 methylthiazol-5-yl) phenyl) ethyl) pyrrolidine-2-carboxamide(P14) The solid material (P13) obtained above was dissolved in 2 M HCl inEA (25 mL, 50 mmol) and the mixture was stirred at ambient temperaturefor 12 h. The mixture was then concentrated and the residue wasdried under vacuum to afford crude compound, which was purified bysilica gel flash column chromatography (DCM: MeOH 30:1) to afford thedesired compound (P14, 3.90 g, 50.8 %).
	With hydrogenchloride; methanol In 1,4-dioxane; dichloromethane at 20℃; Inert atmosphere;
57 %	With trifluoroacetic acid In dichloromethane at 20℃;
	Multi-step reaction with 2 steps 1: hydrogenchloride / methanol / 2 h / 4 °C 2: sodium hydroxide / methanol; dichloromethane; water / 4 °C / pH 12.5 - 13
96 %	With hydrogenchloride In 1,4-dioxane at 16℃;	6.g Synthesis of Int. 29 Into a 40 mL vial were added tert-butyl N-[(2S)-1-[(2S,4R)-4-hydroxy-2-[(1S)-1-[4-(4- methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl}pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan- 2-yl]carbamate (500 mg, 0.918 mmol, 1 equiv), 1,4-dioxane (1 mL) and HCl in 1,4-dioxane (4 mL, 4 M). The mixture was stirred for 1 h at 16 °C and concentrated under reduced pressure. This afforded (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N- [(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide (400 mg, 96% yield) as an off-white solid. LCMS: (ES, m/z): [M+H]+ = 445 (LCMS condition: Column: HALO 90A C18; Mobile phase A: water/0.1%FA; Mobile phase B: ACN/0.1%FA; Flow rate: 1.2 mL/min; RT: 0.561 min)
73.17 %	With hydrogenchloride In ethyl acetate at 20℃;	Step 2: Dissolve 9-a (500 mg, 0.942 mmol) in EA (20 mL) and HCl/ethyl acetate solution (2 mol/L, 20 mL), react overnight at room temperature, and TLC monitors the reaction completely. The reaction solution was spun dry, water (5mL) and EA (5mL) were added, pH = 6-7 was adjusted with saturated sodium bicarbonate solution, the liquid was divided, ethyl acetate (20mL×3) was added to extract the aqueous phase, the organic phase was combined, anhydrous sodium sulfate was dried and concentrated, and the intermediate 9 (300mg, yellow solid) was obtained, and the yield was 73.17%.
	With trifluoroacetic acid In dichloromethane at 20℃; for 2h;	General procedure: To a solution of compound 7 (65 mg, 0.09 mmol) in dry DCM (4 mL) was added TFA (1 mL), and the reaction mixture was stirred at room temperature for 2 h. After that, the reaction solution was adjusted to neutral by DIPEA and concentrated to afford compound 8 without further purification. The synthetic methods for compounds 12 and 15 were similar to that for 8.
	With trifluoroacetic acid In dichloromethane at 20℃; for 2h;
	With trifluoroacetic acid In dichloromethane at 25℃; for 1h;
	With trifluoroacetic acid In dichloromethane at 20℃; Inert atmosphere;	General Procedure for the Preparation of 2a-2e, 3a-3e and 3bN (3e was Used as an Example) In a 20 mL vial with a magnetic stirring bar, RL2(272 mg, 0.6 mmol), methanol (2 mL), sodium hydroxidesolution (2.0 N) (2 mL) was sequentially added. The reactionmixture was stirred at room temperature, until the startingmaterial RL2 disappeared, as indicated by TLC. The mixturewas adjusted to pH 7.0 with HCI (2.0 N) (2 mL) andconcentrated in high vacuum. Boc-VHL was synthesizedbased on previously published procedures.44 In a 20 mL vialwith a magnetic stirring bar, Boc-VHL (327 mg, 0.6 mmol) was dissolved in mixture solvent (6 mL, 50% (vol/vol)trifluoroacetic acid in dichloromethane) and stirred at roomtemperature until the starting material disappeared, as indicatedby TLC. The mixture was concentrated in highvacuum. This Boc deprotected intermediate was dissolved in3 mL of dimethylformamide and transfer to the vial containedhydrolyzed RL2, a magnetic stirring bar, N,N-diisopropylethylamine(0.43 mL, 2.4 mmol) (Adjust to pH 7.0),(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyAOP) (376 mg, 0.72 mmol) weresequentially added. The reaction mixture was stirred at roomtemperature, until the starting material disappeared, as indicatedby TLC. The mixture was partitioned between ethylacetate and a saturated solution of sodium carbonate; theorganic layer was washed with brine, dried over Na2SO4,and concentrated in vacuum. The residue was purified bycolumn chromatography on silica to provide intermediateRL2-VHL (379 mg, yield of 73%). Following the sameprocedure, S5 (15 mg, 0.023 mmol) was hydrolyzed; intermediateRL2-VHL (20 mg, 0.023 mmol) was deprotectedthe Boc; then amide coupling by PyAOP (13 mg, 0.025mmol) afford Boc-3e (20 mg, yield of 63%). In a 20 mL vialwith a magnetic stirring bar, Boc-3e (20 mg, 0.0145 mmol)was dissolved in mixture solvent (2 mL, 50% (vol/vol)trifluoroacetic acid in dichloromethane) and stirred at roomtemperature until the starting material disappeared, as indicatedby TLC. The mixture was concentrated in highvacuum. The residue was redissolved in acetonitrile (2 mL),IN HCI methanol solution (44 uL, 0.044 mmol) was added,white solid precipitation was observed. The solvent wasremoved by high vacuum, 3e (19 mg, 0.0145 mmol) wasobtained in x. HCl salts form
7.55 g	With trifluoroacetic acid In dichloromethane for 0.5h; Cooling with ice;	Further, step S10 can be specifically selected as follows: Take a 50 mL single-necked flask and add DCM, then add the raw material Boc-VHL (400 mg, 0.73 mmol) obtained in reaction (9), and slowly add TFA (335 mg, 2.94 mmol) dropwise under ice bath conditions. After the addition is complete, continue stirring for 0.5 h. Monitor the reaction by TLC. After the raw material disappears, remove DCM and TFA from the system by rotary evaporation, and dissolve the residue in an appropriate amount of DCM. Adjust the pH to alkaline using ammonia water, extract with DCM, dry and remove DCM by rotary evaporation to obtain white solid VHL (7.55 g, 14.02 mmol).
	With trifluoroacetic acid In dichloromethane at 20℃; for 2h;

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[26]Current Patent Assignee: WARF - US2025/222120, 2025, A1 Location in patent: Paragraph 0070; 0078; 0091.
[27]Current Patent Assignee: WUHAN UNIVERSITY - CN120247870, 2025, A Location in patent: Paragraph 0054-0056.
[28]Wittenburg, Sophie; Zuleeg, Maximilian R.; Peter, Kirsten; Lemnitzer, Patricia; Voget, Rabea; Bricelj, Aleša; Gobec, Martina; Dierlamm, Nele; Braun, Michael B.; Geiger, Thomas M.; Heim, Christopher; Stakemeier, Alicia; Wagner, Karl G.; Nowak, Radosław P.; Hartmann, Marcus D.; Sosič, Izidor; Gütschow, Michael; Krönke, Jan; Steinebach, Christian [Journal of Medicinal Chemistry, 2025, vol. 68, # 15, p. 15711 - 15737].

10
[ 1948273-00-4 ]
[ 1997302-16-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride / methanol; 1,4-dioxane / 12 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C 3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dimethyl sulfoxide / 24 h / 20 °C 2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 2.2: 24 h / 20 °C

	Multi-step reaction with 3 steps 1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 16 h / 20 °C 2: dichloromethane / 18 h / 20 °C 3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C
	Multi-step reaction with 3 steps 1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C 2: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 25 °C 3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 3 steps 1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride / ethyl acetate / 12 h / 20 °C 3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 20 °C 2: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 16 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 16 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 16 - 20 °C

References: [1]Hu, Jiantao; Hu, Biao; Wang, Mingliang; Xu, Fuming; Miao, Bukeyan; Yang, Chao-Yie; Wang, Mi; Liu, Zhaomin; Hayes, Daniel F.; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng [Journal of Medicinal Chemistry, 2019, vol. 62, # 3, p. 1420 - 1442].
[2]Current Patent Assignee: UNIVERSITY OF MICHIGAN - WO2020/142227, 2020, A1.
[3]Xu, Chenxi; Meng, Fanye; Park, Kwang-Su; Storey, Aaron J.; Gong, Weida; Tsai, Yi-Hsuan; Gibson, Elisa; Byrum, Stephanie D.; Li, Dongxu; Edmondson, Rick D.; Mackintosh, Samuel G.; Vedadi, Masoud; Cai, Ling; Tackett, Alan J.; Kaniskan, H. Ümit; Jin, Jian; Wang, Gang Greg [Cell Chemical Biology, 2022, vol. 29, # 3, p. 386 - 9,397].
[4]Current Patent Assignee: HINOVA PHARMACEUTICALS - WO2023/280237, 2023, A1.
[5]Current Patent Assignee: SHANGHAI QILU PHARMACEUTICAL RES AND DEVELOPMENT CENTRE - WO2023/143249, 2023, A1.
[6]Wang, Xiaohua; Xin, Lilan; Deng, Xiaofei; Dong, Chune; Hu, Guoyuan; Zhou, Hai-Bing [European Journal of Medicinal Chemistry, 2024, vol. 267].
[7]Yao, Xiaoxuan; Mao, Jianping; Zhang, Haoyu; Xiao, Yi; Wang, Yongjun; Liu, Hongzhuo [European Journal of Medicinal Chemistry, 2024, vol. 272].
[8]Xin, Lilan; Wang, Chao; Cheng, Yan; Wang, Hongli; Guo, Xinyi; Deng, Xiaofei; Deng, Xiangping; Xie, Baohua; Hu, Hankun; Min, Chang; Dong, Chune; Zhou, Hai-Bing [Journal of Medicinal Chemistry, 2024, vol. 67, # 11, p. 8913 - 8931].
[9]Current Patent Assignee: KESMALEA THERAPEUTICS LTD - WO2024/175905, 2024, A1.

11
[ 62965-35-9 ]
[ 2086301-12-2 ]
[ 1997302-16-5 ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere;
1.31 g	With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere;	1 tert- Butyl ((S)-l-((2S,4R)-4-hydroxy-2-(((S)-l-(4-(4-methylthiazol-5- yl)phenyl)ethyl)carb-amoyl)pyrrolidin- 1 -yl)-3 ,3 -dimethyl- 1 -oxobutan-2-yl)carbamate (57) This solid (56), obtained as described above was dissolved in 4N HC1 in dioxane (0327) (25 mL, 100 mmol) and MeOH (25 mL) and the mixture was stirred at ambient temperature for 12 h. The mixture was then concentrated and the residue was dried under vacuum to afford an intermediate, which was used in next step without further purification. UPLC-MS (ESL) calc, for C17H22N3O2S [M+l]+: 332.14, found 332.11. HATU (1.37 g, 3.6 mmol, 1.2 eq) was added to a solution of this intermediate (994 mg, 3.0 mmol, 1.0 eq), (S)-2-((/er/-butoxycarbonyl)amino)-3,3-dimethylbutanoic acid (694 mg, 3.0 mmol, 1.0 eq), and DIPEA (1.57 mL, 9.0 mmol, 3.0 eq) in DMF (10 mL) at 0 °C under N2. The mixture was stirred at ambient temperature for 12 h when TLC showed that the reaction was complete. The reaction mixture was quenched with H2O (100 mL) and extracted with EtOAc (75mLx2). The combined organic layer was washed with brine (100 mL) and dried over Na2S04. The organic solution was filtered and concentrated. The residue was purified by silica gel flash column chromatography with hexane :EtO Ac then DCM: MeOH to afford the desired compound (57) as a white solid (1.31 g, 80% yield). NMR (CDCI3, 400 MHz) d (ppm) 8.65 (s, 1H), 7.70 (d, J = 8.0 Hz, 1H), 7.35- 7.31 (m, 4H), 5.29 (d, J= 9.2 Hz, 1H), 5.06-5.01 (m, 1H), 4.67 (t, J= 8.0 Hz, 1H), 4.46- 4.44 (m, 1H), 4.22-4.19 (m, 1H), 3.91 (d, J = 17.2 Hz, 1H), 3.61-3.58 (m, 1H), 2.46 (s, 3H), 2.37-2.30 (m, 1H), 2.04-1.99 (m, 1H), 1.44 (d, J= 7.2 Hz, 3H), 1.35 (s, 9H), 0.96 (s, 9H); 13C NMR (CDCI3, 100 MHz) d (ppm) 172.22, 170.13, 156.15, 150.56, 148.21, 143.43, 131.74, 130.59, 129.49, 126.46, 80.18, 69.91, 58.86, 56.58, 48.74, 38.60, 36.02, 35.48, 28.34, 26.39, 22.17, 15.95; UPLC-MS (ESF) calc for C28H41N4O5S [M+l]+: 545.28, found 545.35.
510 mg	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 20℃;	F Step F: Add (S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutyric acid (293 mg, 1.3 mmol), compounds INT-5-5 (420 mg, 1.3 mmol), ), 2-(7-aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (483 mg, 1.3 mmol) and N-Diisopropylethylamine (818 mg, 6.3 mmol) to tetrahydrofuran (5 ml) solution, respectively, and stir at 20 degrees Celsius for 18 hours. LCMS monitoring shows that raw materials are gone. After quenching the reaction solution with purified water (200 ml), it was extracted with ethyl acetate (100 ml×3). The organic phase was combined and dried with anhydrous sodium sulfate and filtered and concentrated. The resulting mixture was purified by silica gel column chromatography to obtain 510 mg of compound INT-5-6.

	With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃;
	With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃;	4.1.20. tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl) carbamoyl) pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl) carbamate (P13) This solid material (P12), obtained as described above was dissolvedin 2 M HCl in EA (20 mL, 40 mmol), and the mixture was stirred atambient temperature for 12 h. The mixture was then concentrated, andthe residue was dried under vacuum to afford intermediate, which wasused in next step without further purification. HATU (8.50 g, 22.5 mmol,1.4 equiv) was added to a solution of this intermediate (5.80 g, 16.0mmol, 1.0 equiv), (S)-2-((tert-butoxycarbonyl) amino)-3,3- dimethylbutanoicacid (3.46 g, 16.0 mmol, 1.0 equiv), and DIPEA (8.8 mL,48.0 mmol, 3.0 equiv) in DMF (30 mL) at 0 C. The mixture was stirredat ambient temperature for 12 h when TLC showed that the reaction wascomplete. The reaction mixture was quenched with H2O (120 mL) andextracted with EtOAc (75 mL × 2). The combined organic layer waswashed with brine (100 mL) and dried over Na2SO4. The organic solutionwas filtered and concentrated. The residue was purified by silica gelflash column chromatography (DCM: MeOH 30:1) to afford the desiredcompound.
	With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃;	4.1.20. tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl) carbamoyl) pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl) carbamate (P13) This solid material (P12), obtained as described above was dissolvedin 2 M HCl in EA (20 mL, 40 mmol), and the mixture was stirred atambient temperature for 12 h. The mixture was then concentrated, andthe residue was dried under vacuum to afford intermediate, which wasused in next step without further purification. HATU (8.50 g, 22.5 mmol,1.4 equiv) was added to a solution of this intermediate (5.80 g, 16.0mmol, 1.0 equiv), (S)-2-((tert-butoxycarbonyl) amino)-3,3- dimethylbutanoicacid (3.46 g, 16.0 mmol, 1.0 equiv), and DIPEA (8.8 mL,48.0 mmol, 3.0 equiv) in DMF (30 mL) at 0 C. The mixture was stirredat ambient temperature for 12 h when TLC showed that the reaction wascomplete. The reaction mixture was quenched with H2O (120 mL) andextracted with EtOAc (75 mL × 2). The combined organic layer waswashed with brine (100 mL) and dried over Na2SO4. The organic solutionwas filtered and concentrated. The residue was purified by silica gelflash column chromatography (DCM: MeOH 30:1) to afford the desiredcompound.
	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;
84 %	With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at -10 - 20℃;
15 %	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 16 - 20℃;	6.f Synthesis of Int. 28 Into a 100 mL round-bottom flask were added (2S,4R)-4-hydroxy-N-[(1S)-1-[4-(4-methyl- 1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide (2.5 g, 7.543 mmol, 1.2 equiv), (2S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutanoic acid (1.45 g, 6.286 mmol, 1 equiv), DMF (25 mL), HATU (3.59 g, 9.429 mmol, 1.5 equiv), and DIEA (2.44 g, 18.858 mmol, 3 equiv) and the mixture stirred for 1 h at 16 °C. The reaction was quenched with water at 16 °C. The residue was purified by reversed-phase flash chromatography on a C18 column eluting with a 5% to 60% gradient of MeCN in water (10 mmol/L NH4HCO3) over 40 min with UV (254 nm) detection. This resulted in tert-butyl N-[(2S)-1-[(2S,4R)-4-hydroxy-2-[(1S)- 1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl}pyrrolidin-1-yl]-3,3-dimethyl-1- oxobutan-2-yl]carbamate (509.4 mg, 15% yield) as a white solid. LCMS: (ES, m/z): [M+H]+ = 545 (LCMS condition: Column: Shim-pack Scepter C18-120; Mobile phase A: Water/5 mM NH4HCO3; Mobile phase B: Acetonitrile; Flow rate: 1.5 mL/min; RT: 0.965 min)

References: [1]Hu, Jiantao; Hu, Biao; Wang, Mingliang; Xu, Fuming; Miao, Bukeyan; Yang, Chao-Yie; Wang, Mi; Liu, Zhaomin; Hayes, Daniel F.; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng [Journal of Medicinal Chemistry, 2019, vol. 62, # 3, p. 1420 - 1442].
[2]Current Patent Assignee: UNIVERSITY OF MICHIGAN - WO2020/142227, 2020, A1 Location in patent: Paragraph 0192-0193.
[3]Current Patent Assignee: SHANGHAI QILU PHARMACEUTICAL RES AND DEVELOPMENT CENTRE - WO2023/143249, 2023, A1 Location in patent: Page/Page column 32-33.
[4]Wang, Xiaohua; Xin, Lilan; Deng, Xiaofei; Dong, Chune; Hu, Guoyuan; Zhou, Hai-Bing [European Journal of Medicinal Chemistry, 2024, vol. 267].
[5]Yao, Xiaoxuan; Mao, Jianping; Zhang, Haoyu; Xiao, Yi; Wang, Yongjun; Liu, Hongzhuo [European Journal of Medicinal Chemistry, 2024, vol. 272].
[6]Yao, Xiaoxuan; Mao, Jianping; Zhang, Haoyu; Xiao, Yi; Wang, Yongjun; Liu, Hongzhuo [European Journal of Medicinal Chemistry, 2024, vol. 272].
[7]Xin, Lilan; Wang, Chao; Cheng, Yan; Wang, Hongli; Guo, Xinyi; Deng, Xiaofei; Deng, Xiangping; Xie, Baohua; Hu, Hankun; Min, Chang; Dong, Chune; Zhou, Hai-Bing [Journal of Medicinal Chemistry, 2024, vol. 67, # 11, p. 8913 - 8931].
[8]Soto-Martínez, Diana M.; Clements, Garrett D.; Díaz, John E.; Becher, Joy; Reynolds, Robert C.; Ochsenbauer, Christina; Snowden, Timothy S. [RSC Advances, 2024, vol. 14, # 24, p. 17077 - 17090].
[9]Current Patent Assignee: KESMALEA THERAPEUTICS LTD - WO2024/175905, 2024, A1 Location in patent: Page/Page column 37; 39.

12
[ 13726-69-7 ]
[ 1997302-16-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride / methanol; 1,4-dioxane / 12 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C 2: hydrogenchloride / methanol / 2 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C
	Multi-step reaction with 3 steps 1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C 3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C 2: hydrogenchloride / methanol / 2 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C
	Multi-step reaction with 2 steps 1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dimethyl sulfoxide / 24 h / 20 °C 2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 2.2: 24 h / 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C 2: methanol; hydrogenchloride / ethyl acetate / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
	Multi-step reaction with 3 steps 1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C 2: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 25 °C 3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 3 steps 1.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide; dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 2.1: hydrogenchloride / 1,4-dioxane / 18 h / 0 - 20 °C 3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere 3.2: 18 h / 20 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride / ethyl acetate / 12 h / 20 °C 3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 20 °C 2: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 20 °C
	Multi-step reaction with 5 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 18 h / -10 - 20 °C 2: potassium carbonate; Trimethylacetic acid; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / N,N-dimethyl acetamide / 125 °C 3: hydrogenchloride / methanol / 2 h / 4 °C 4: sodium hydroxide / methanol; dichloromethane; water / 4 °C / pH 12.5 - 13 5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / -10 - 20 °C

References: [1]Hu, Jiantao; Hu, Biao; Wang, Mingliang; Xu, Fuming; Miao, Bukeyan; Yang, Chao-Yie; Wang, Mi; Liu, Zhaomin; Hayes, Daniel F.; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng [Journal of Medicinal Chemistry, 2019, vol. 62, # 3, p. 1420 - 1442].
[2]Current Patent Assignee: YALE UNIVERSITY - WO2019/195609, 2019, A2.
[3]Current Patent Assignee: UNIVERSITY OF MICHIGAN - WO2020/142227, 2020, A1.
[4]Current Patent Assignee: YALE UNIVERSITY - WO2021/207172, 2021, A1.
[5]Xu, Chenxi; Meng, Fanye; Park, Kwang-Su; Storey, Aaron J.; Gong, Weida; Tsai, Yi-Hsuan; Gibson, Elisa; Byrum, Stephanie D.; Li, Dongxu; Edmondson, Rick D.; Mackintosh, Samuel G.; Vedadi, Masoud; Cai, Ling; Tackett, Alan J.; Kaniskan, H. Ümit; Jin, Jian; Wang, Gang Greg [Cell Chemical Biology, 2022, vol. 29, # 3, p. 386 - 9,397].
[6]Current Patent Assignee: JIANGSU YAHONG MEDITECH - WO2022/161166, 2022, A1.
[7]Current Patent Assignee: SHANGHAI QILU PHARMACEUTICAL RES AND DEVELOPMENT CENTRE - WO2023/143249, 2023, A1.
[8]Wang, Xiaohua; Xin, Lilan; Deng, Xiaofei; Dong, Chune; Hu, Guoyuan; Zhou, Hai-Bing [European Journal of Medicinal Chemistry, 2024, vol. 267].
[9]Desantis, Jenny; Bazzacco, Alessandro; Eleuteri, Michela; Tuci, Sara; Bianconi, Elisa; Macchiarulo, Antonio; Mercorelli, Beatrice; Loregian, Arianna; Goracci, Laura [European Journal of Medicinal Chemistry, 2024, vol. 268].
[10]Yao, Xiaoxuan; Mao, Jianping; Zhang, Haoyu; Xiao, Yi; Wang, Yongjun; Liu, Hongzhuo [European Journal of Medicinal Chemistry, 2024, vol. 272].
[11]Xin, Lilan; Wang, Chao; Cheng, Yan; Wang, Hongli; Guo, Xinyi; Deng, Xiaofei; Deng, Xiangping; Xie, Baohua; Hu, Hankun; Min, Chang; Dong, Chune; Zhou, Hai-Bing [Journal of Medicinal Chemistry, 2024, vol. 67, # 11, p. 8913 - 8931].
[12]Soto-Martínez, Diana M.; Clements, Garrett D.; Díaz, John E.; Becher, Joy; Reynolds, Robert C.; Ochsenbauer, Christina; Snowden, Timothy S. [RSC Advances, 2024, vol. 14, # 24, p. 17077 - 17090].

13
[ 2313528-38-8 ]
[ 1997302-16-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: hydrogenchloride / methanol; 1,4-dioxane / 12 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: hydrogenchloride / methanol / 2 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C
	Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 20 °C 2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

	Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane / 16 h / 25 °C / Inert atmosphere 2: triethylamine; HATU / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: hydrogenchloride / methanol / 2 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C
	Multi-step reaction with 2 steps 1: methanol; hydrogenchloride / ethyl acetate / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
	Multi-step reaction with 2 steps 1: dichloromethane / 18 h / 20 °C 2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C
	Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 25 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C
	Multi-step reaction with 2 steps 1: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 2 steps 1.1: hydrogenchloride / 1,4-dioxane / 18 h / 0 - 20 °C 2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere 2.2: 18 h / 20 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: hydrogenchloride / ethyl acetate / 12 h / 20 °C 2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
	Multi-step reaction with 2 steps 1: trifluoroacetic acid / dichloromethane / 30 min / 20 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 30 min / 20 °C
	Multi-step reaction with 3 steps 1: hydrogenchloride / methanol / 2 h / 4 °C 2: sodium hydroxide / methanol; dichloromethane; water / 4 °C / pH 12.5 - 13 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / -10 - 20 °C
	Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane / 1 h / 16 °C 2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 16 - 20 °C
8.06 g	Stage #1: tert-butyl (2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carboxylate With trifluoroacetic acid for 1h; Cooling with ice; Stage #2: With N-tert-butyloxycarbonyl-L-tert-leucine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 3h;	Further, step S9 can specifically be: take a 50mL single-necked flask and add DCM (50mL), then add the reaction mixture.(8)The prepared raw material (compound 12, 7.80 g, 18.07 mmol) was slowly added dropwise with TFA (8.24 g, 72.30 mmol) under ice bath conditions. After the addition was complete, the mixture was stirred for 1 h. The reaction was monitored by TLC. After the raw material disappeared, DCM and TFA in the system were removed by rotary evaporation. The residue was dissolved in an appropriate amount of DCM, and the pH was adjusted to alkaline with ammonia. The mixture was extracted with DCM, dried, and most of the DCM was removed by rotary evaporation. An appropriate amount of anhydrous DCM (30 mL) was added, followed by DIPEA (0.09 g, 72.30 mmol), HATU (7.56 g, 19.88 mmol), and Boc-Tle-OH (4.60 g, 19.88 mmol). After the addition was complete, the mixture was stirred at room temperature for 3 h. After the raw material was completely eliminated by TLC monitoring, it was extracted with DCM, dried by rotary evaporation, and then purified by column chromatography with dichloromethane/methanol (V/V=30:1) as the mobile phase, yielding a white solid product Boc-VHL (8.06 g, 14.79 mmol).

References: [1]Hu, Jiantao; Hu, Biao; Wang, Mingliang; Xu, Fuming; Miao, Bukeyan; Yang, Chao-Yie; Wang, Mi; Liu, Zhaomin; Hayes, Daniel F.; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng [Journal of Medicinal Chemistry, 2019, vol. 62, # 3, p. 1420 - 1442].
[2]Current Patent Assignee: YALE UNIVERSITY - WO2019/195609, 2019, A2.
[3]Current Patent Assignee: UNIVERSITY OF MICHIGAN - WO2020/142227, 2020, A1.
[4]Current Patent Assignee: KYMERA THERAPEUTICS - WO2020/206424, 2020, A1.
[5]Current Patent Assignee: YALE UNIVERSITY - WO2021/207172, 2021, A1.
[6]Current Patent Assignee: JIANGSU YAHONG MEDITECH - WO2022/161166, 2022, A1.
[7]Current Patent Assignee: HINOVA PHARMACEUTICALS - WO2023/280237, 2023, A1.
[8]Current Patent Assignee: SHANGHAI QILU PHARMACEUTICAL RES AND DEVELOPMENT CENTRE - WO2023/143249, 2023, A1.
[9]Wang, Xiaohua; Xin, Lilan; Deng, Xiaofei; Dong, Chune; Hu, Guoyuan; Zhou, Hai-Bing [European Journal of Medicinal Chemistry, 2024, vol. 267].
[10]Desantis, Jenny; Bazzacco, Alessandro; Eleuteri, Michela; Tuci, Sara; Bianconi, Elisa; Macchiarulo, Antonio; Mercorelli, Beatrice; Loregian, Arianna; Goracci, Laura [European Journal of Medicinal Chemistry, 2024, vol. 268].
[11]Yao, Xiaoxuan; Mao, Jianping; Zhang, Haoyu; Xiao, Yi; Wang, Yongjun; Liu, Hongzhuo [European Journal of Medicinal Chemistry, 2024, vol. 272].
[12]Xin, Lilan; Wang, Chao; Cheng, Yan; Wang, Hongli; Guo, Xinyi; Deng, Xiaofei; Deng, Xiangping; Xie, Baohua; Hu, Hankun; Min, Chang; Dong, Chune; Zhou, Hai-Bing [Journal of Medicinal Chemistry, 2024, vol. 67, # 11, p. 8913 - 8931].
[13]Soto-Martínez, Diana M.; Clements, Garrett D.; Díaz, John E.; Becher, Joy; Reynolds, Robert C.; Ochsenbauer, Christina; Snowden, Timothy S. [RSC Advances, 2024, vol. 14, # 24, p. 17077 - 17090].
[14]Current Patent Assignee: KESMALEA THERAPEUTICS LTD - WO2024/175905, 2024, A1.
[15]Current Patent Assignee: WUHAN UNIVERSITY - CN120247870, 2025, A Location in patent: Paragraph 0051-0053.

14
[ 62965-35-9 ]
[ 2086301-13-3 ]
[ 1997302-16-5 ]

Yield	Reaction Conditions	Operation in experiment
85.6%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 3h;	1.1.3 (2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazole-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine hydrochloride (Compound C-9) (14.15g, 39mmol), (S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutyric acid (compound C-10) (9.79g, 43mmol), diisopropylethylamine (30.83g, 240mmol) was added to N, N-Dimethylformamide (70mL), stir well. At room temperature, HATU (17.55g, 47mmol) was added to the system and stirred for 3 hours. Add 200mL of water to the reaction solution to quench, there is a white solid product precipitation, filtration, filtrate with ethyl acetate extraction, organic phase and then washed with saturated sodium chloride aqueous solution 2-3 times, organic phase with anhydrous sodium sulfate drying, filtering, concentrated filtrate, to obtain oily crude products. Column chromatography purification (petroleum ether: ethyl acetate = 1:1~0:1) was combined with a white solid product to give a product ((S)-1-((2S,4R)-4-hydroxy-2-((S)-1-(4-(4-methylthiazole-5-yl)phenyl)ethyl) carbamoyl)pyrrolidine-1-yl)-3,3-dimethyl-1-oxobutane-2-yl) carbamic acid tert-butyl ester (compound C-11) (17.94g, yield 85.6%).
84%	With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 12h;	6 Step 6: Preparation of tert- butyl ((S)-l-((2S,4R)-4-hydroxy-2-(((S)-l-(4-(4- methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-l-yl)-3, 3-dimethyl- l-oxobutan-2- yl)carbamate Into a 25-mL round-bottom flask, was placed (2S)-2-[(tert-butoxy)carbonyl] amino- 3, 3 -dimethylbutanoic acid (2.0 g, 8.65 mmol, 0.99 equiv) in N,N-dimethylformamide (30 mL). N-ethyl-N-isopropylpropan-2-amine (3.4 g, 3.00 equiv), o-(7- Azabenzotriazol- 1 -yl)-N,N,N',N’- te-tramethyluronmm hexafluorophosphate (5.0 g, 1.50 equiv), (2S,4R)-4-hydroxy-N-[(lS)-l-[4- (4-methyl-l,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride (3.2 g, 8.70 mmol, 1.00 equiv). The resulting solution was stirred for 12 hours at room temperature. The resulting solution was extracted with ethyl acetate (60 mL x 3) and washed with water (100 mL x 2). The organic layers combined and dried, concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:3). This resulted in 4.0 g (84%) of tert-butyl N - [(2S )- 1 - [(2S ,4R)-4-hydroxy-2- [ [( 1 S )- 1 - [4-(4-methyl- 1 ,3 -thiazol-5- yl)phenyl]ethyl]carbamoyl]pyrrolidin-l-yl]-3, 3-dimethyl- l-oxobutan-2-yl]carbamate as a yellow solid. LC/MS (ESI) m/z: 545.30 [M+l] +.
84%	With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 12h;	6 Step 6: Preparation of tert- butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4- methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2- yl)carbamate Into a 25-mL round-bottom flask, was placed (2S)-2-[(tert-butoxy)carbonyl]amino- 3,3-dimethylbutanoic acid (2.0 g, 8.65 mmol, 0.99 equiv) in N,N-dimethylformamide (30 mL). N-ethyl-N-isopropylpropan-2-amine (3.4 g, 3.00 equiv), o-(7-Azabenzotriazol-1-yl)-N,N,N',N'- te-tramethyluronium hexafluorophosphate (5.0 g, 1.50 equiv), (2S,4R)-4-hydroxy-N-[(1S)-1-[4- (4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride (3.2 g, 8.70 mmol, 1.00 equiv). The resulting solution was stirred for 12 h at room temperature. The resulting solution was extracted with ethyl acetate (60 mL x 3) and washed with water (100 mL x 2). The organic layers combined and dried, concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:3). This resulted in 4.0 g (84%) of tert- butyl N-[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5- yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate as a yellow solid. LC/MS (ESI) m/z: 545.30 [M+1] +.

84%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 12h;	6 Step 6: Preparation of tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate Into a 25-mL round-bottom flask, was placed (2S)-2-[(tert-butoxy)carbonyl]amino-3,3-dimethylbutanoic acid (2.0 g, 8.65 mmol, 0.99 equiv) in N,N-dimethylformamide (30 mL). N-ethyl-N-isopropylpropan-2-amine (3.4 g, 3.00 equiv), o-(7-Azabenzotriazol-1-yl)-N,N,N',N'-te-tramethyluronium hexafluorophosphate (5.0 g, 1.50 equiv), (2S,4R)-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride (3.2 g, 8.70 mmol, 1.00 equiv). The resulting solution was stirred for 12 hours at room temperature. The resulting solution was extracted with ethyl acetate (60 mL x 3) and washed with water (100 mL x 2). The organic layers combined and dried, concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:3). This resulted in 4.0 g (84%) of tert-butyl N-[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate as a yellow solid. LC/MS (ESI) m/z: 545.30 [M+1] +
76%	With triethylamine; HATU In N,N-dimethyl-formamide at 0 - 25℃; Inert atmosphere;	5 Step 5: Tert-butyl N-[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol- 5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate. To a stirred mixture of (2S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutanoic acid (27.7 g, 120 mmol) and TEA (45.3 mL, 448 mmol) in DMF (400 mL) were added (2S,4R)-4-hydroxy-N-[(1S)- 1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride (40.0 g, 109 mmol) and HATU (53.7 g, 142 mmol) in portions at 0 °C under nitrogen atmosphere. The resulting mixture was stirred for 3 h at 25 °C under nitrogen atmosphere. The reaction was quenched by the addition of water (300 mL) at 25 °C. The resulting mixture was extracted with EtOAc (3 x 300 mL). The combined organic layers were washed with brine (3 x 300 mL), dried over anhydrous Na2SO4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by trituration with EtOAc (300 mL). The precipitated solids were collected by filtration and washed with EtOAc (2 x 40.0 mL). This resulted in the title compound as a light yellow solid (50.0 g, 76%): 1H NMR (400 MHz, CD3OD) d 8.90 (s, 1H), 7.50-7.36 (m, 4H), 6.40 (d, J = 9.3 Hz, 1H), 5.02 (p, J = 7.0 Hz, 1H), 4.62 (t, J = 8.3 Hz, 1H), 4.46 (s, 1H), 4.34-4.27 (m, 1H), 3.87 (d, J = 11.1 Hz, 1H), 3.76 (dd, J = 10.9, 4.0 Hz, 1H), 2.50 (s, 3H), 2.24 (dd, J = 13.2, 7.8 Hz, 1H), 2.06-1.93 (m, 1H), 1.56-1.48 (m, 3H), 1.46 (s, 9H), 1.03 (s, 9H); LC/MS (ESI, m/z): [(M + H)]+ = 545.40.
66.6%	With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 25 - 30℃; for 16h; Inert atmosphere; Alkaline conditions;
9.8 g	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 16h;	Step-f: Synthesis of tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (17f) To a solution of (2S,4R)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride (10.0 g, 27.24 mmol) and (S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoic acid (6.29 g, 27.24 mmol) in DCM (150 mL) at 0 °C was added HATU (12.4 g, 32,69 mmol) followed by dropwise addition of DIPEA (25.0 mL, 136.2 mmol) and stirred for 16 h at RT. Then the reaction mixture was poured into ice cold water and the resulting mixture was extracted with DCM (2 X 500 mL). The combined organic layer was washed with water (200 mL), saturated sodium bicarbonate solution (100 mL), brine (200 mL), dried over anhydrous sodium sulphate and concentrated under vacuum to give the crude product which was washed with chilled acetone and filtered to afford the title compound (9.8 g, 67.5 %) which was used in the next step without further purification. 1H NMR (400 MHz, DMSO-d6): d 8.97 (s, 1H), 8.38 (d, J = 6.4 Hz, 1H), 7.44-7.31 (m, 4H), 6.38 (d, / = 8.4 Hz, 1H), 5.10 (s, 1H), 4.91-4.88 (m, 1H), 4.28 (bs, 1H), 4.14 (d, / = 8.8 Hz, 1H), 3.62-3.58 (m, 2H), 2.45 (s, 3H), 2.08-2.00 (m, 2H), 1.78-1.76 (m, 1H), 1.48 (s, 9H), 1.44 (d, J = 6.9 Hz, 3H), 0.93 (s, 9H); LC-MS: m/z 545.3 (M+l)+.
1.873 g	Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; Inert atmosphere; Stage #2: (2S,4R)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride In dichloromethane at 20℃; Inert atmosphere;	4.6.6. Tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (54) Under nitrogen atmosphere, to a stirred solution of (S)-2-((tertbutoxycarbonyl)amino)-3,3-dimethylbutanoic acid (0.953 g, 4.123mmol) in dry DCM (10.5 mL), DIPEA (1.8 mL, 10.307 mmol) and HATU(1.834 g, 4.824 mmol) were added at 0 C. After 1 h, 52 (0.910 g, 2.473mmol) was added slowly. The mixture was stirred for 18 h at roomtemperature. Then, DCM (50 mL) was added to the reaction mixture andwas washed with 10 % citric acid (12 mL) twice, saturated NaHCO3solution (12 mL) twice, water (12 mL) twice, and brine (20 mL) once.The organic phase was dried over anhydrous Na2SO4 and concentratedunder reduced pressure to afford the desired compound as a yellow oil(1.873 g) which was used directly for the next step.
1.873 g	Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; Inert atmosphere; Stage #2: (2S,4R)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride In dichloromethane at 20℃; Inert atmosphere;	4.6.6. Tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (54) Under nitrogen atmosphere, to a stirred solution of (S)-2-((tertbutoxycarbonyl)amino)-3,3-dimethylbutanoic acid (0.953 g, 4.123mmol) in dry DCM (10.5 mL), DIPEA (1.8 mL, 10.307 mmol) and HATU(1.834 g, 4.824 mmol) were added at 0 C. After 1 h, 52 (0.910 g, 2.473mmol) was added slowly. The mixture was stirred for 18 h at roomtemperature. Then, DCM (50 mL) was added to the reaction mixture andwas washed with 10 % citric acid (12 mL) twice, saturated NaHCO3solution (12 mL) twice, water (12 mL) twice, and brine (20 mL) once.The organic phase was dried over anhydrous Na2SO4 and concentratedunder reduced pressure to afford the desired compound as a yellow oil(1.873 g) which was used directly for the next step.

References: [1]Current Patent Assignee: JIANGSU YAHONG MEDITECH - WO2022/161166, 2022, A1 Location in patent: Page/Page column 30; 32-34.
[2]Current Patent Assignee: YALE UNIVERSITY - WO2019/195609, 2019, A2 Location in patent: Paragraph 00485-00486.
[3]Current Patent Assignee: YALE UNIVERSITY - WO2020/51564, 2020, A1 Location in patent: Paragraph 1069; 1070.
[4]Current Patent Assignee: YALE UNIVERSITY - WO2021/207172, 2021, A1 Location in patent: Paragraph 00237.
[5]Current Patent Assignee: KYMERA THERAPEUTICS - WO2020/206424, 2020, A1 Location in patent: Paragraph 0001129.
[6]Li, Zhenwu; Harikrishnan, Lalgudi S.; Xu, Guozhang; Samanta, Debangshu; Clemente, Jose C.; Leng, Lingying; Tu, Wenbin; Yang, Lin; Huang, Liyue; Wang, Mi; Wang, Shaomeng; Deng, Qiaolin; Behshad, Elham; Nagilla, Rakesh; Orth, Peter; Rice, Cory; Strickland, Corey; Mohammad, Helai P.; Priestley, E. Scott; Sui, Zhihua [Journal of Medicinal Chemistry, 2025, vol. 68, # 2, p. 1134 - 1154].
[7]Current Patent Assignee: AURIGENE ONCOLOGY - WO2019/207538, 2019, A1 Location in patent: Page/Page column 85-86.
[8]Desantis, Jenny; Bazzacco, Alessandro; Eleuteri, Michela; Tuci, Sara; Bianconi, Elisa; Macchiarulo, Antonio; Mercorelli, Beatrice; Loregian, Arianna; Goracci, Laura [European Journal of Medicinal Chemistry, 2024, vol. 268].
[9]Desantis, Jenny; Bazzacco, Alessandro; Eleuteri, Michela; Tuci, Sara; Bianconi, Elisa; Macchiarulo, Antonio; Mercorelli, Beatrice; Loregian, Arianna; Goracci, Laura [European Journal of Medicinal Chemistry, 2024, vol. 268].

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P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

✕

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere