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Chemical Structure| 221006-70-8 Chemical Structure| 221006-70-8
Chemical Structure| 221006-70-8

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Product Details of 2,6-Dimethoxypyridine-3-boronic acid

CAS No. :221006-70-8
Formula : C7H10BNO4
M.W : 182.97
SMILES Code : OB(C1=CC=C(OC)N=C1OC)O
MDL No. :MFCD03788239
InChI Key :ADGHSWFUZUADDH-UHFFFAOYSA-N
Pubchem ID :2762707

Safety of 2,6-Dimethoxypyridine-3-boronic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 2,6-Dimethoxypyridine-3-boronic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 221006-70-8 ]

[ 221006-70-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1458-01-1 ]
  • [ 221006-70-8 ]
  • 3,5-diamino-N-carbamimidoyl-6-(2,6-dimethoxypyridin-3-yl)pyrazine-2-carboxamide [ No CAS ]
  • 2
  • [ 1458-01-1 ]
  • [ 221006-70-8 ]
  • methyl 3,5-diamino-6-(2,6-dimethoxypyridin-3-yl)pyrazine-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
47% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In methanol; toluene;Inert atmosphere; Reflux; General procedure: <strong>[1458-01-1]Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate</strong> 2 (1 eq.) was combined with K2CO3 (10 eq.), the appropriate (het)aryl boronic acid (1.5 eq.) and Pd(PPh3)4 (5 mol%) in a two-neck round bottom flask. The flask was connected to a condenser and purged with nitrogen. A 4:1 mixture of anhydrous toluene: MeOH (60 mL) was added via syringe and the reaction mixture was heated at reflux for 0.5-18 h. The mixture was allowed to cool to room temperature and filtered through Celite (10 x 3 cm, eluting with 3 x 20 mL EtOAc). The filtrate was evaporated to dryness and the residue purified by silica gel flash column chromatography using EtOAc/pet spirit.
 

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