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Chemical Structure| 458532-96-2 Chemical Structure| 458532-96-2
Chemical Structure| 458532-96-2

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Product Details of 2-Chloropyridine-4-boronic acid

CAS No. :458532-96-2
Formula : C5H5BClNO2
M.W : 157.36
SMILES Code : C1=C(Cl)N=CC=C1B(O)O
MDL No. :MFCD03788416
InChI Key :WJYRVVDXJMJLTN-UHFFFAOYSA-N
Pubchem ID :5151595

Safety of 2-Chloropyridine-4-boronic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 2-Chloropyridine-4-boronic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 458532-96-2 ]

[ 458532-96-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 886371-28-4 ]
  • [ 458532-96-2 ]
  • [ 1146615-85-1 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; at 100.0℃; for 16.0h; To a solution of <strong>[886371-28-4]3-bromo-6-chloro-imidazo[1,2-a]pyridine</strong> (1 eq, 18.1 mmol, 4.2 g), 2- chloropyridin-4-yl boronic acid (1.05 eq, 19 mmol, 3 g), Na2COs (2 eq, 36.2 mmol, 3.84 g) in dioxane (30 ml) and water (10 ml), under an inert atmosphere of argon is added bis(triphenylphosphine)palladium II chloride (1.23 g). The reaction mixture is heated at 100 C for 16 hours. The mixture is diluted with H2O (50 ml) and extracted with EtOAc. The combined organic portions are washed with brine, dried (MgStheta4) and concentrated in vacuo. The residue is purified by flash chromatography on silica eluting with 0-50% EtOAc in iso-hexane to afford the title compound; [M+H]+ =264 (266).
 

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