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Chemical Structure| 203434-46-2 Chemical Structure| 203434-46-2

Structure of 203434-46-2

Chemical Structure| 203434-46-2

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Product Details of [ 203434-46-2 ]

CAS No. :203434-46-2
Formula : C14H25NO5
M.W : 287.35
SMILES Code : O=C(N1CC(C(OC(C)(C)C)=O)C(O)C1)OC(C)(C)C

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Application In Synthesis of [ 203434-46-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 203434-46-2 ]

[ 203434-46-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 190141-99-2 ]
  • [ 203434-46-2 ]
YieldReaction ConditionsOperation in experiment
62% In dichloromethane; for 4.0h; Preparation Example 1-114-23-tert-Butoxycarbonylamino-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester To 2.93 g (15.80 mmol) of the compound obtained from Preparation Example 1-114-1 was added 25 mL of ammonia water and stirred at 60 C. for 15 hours. The reaction solution was distilled in vacuo, diluted with dichloromethane and washed with water. The organic layer was dried over anhydrous magnesium sulfate (MgSO4) and distilled in vacuo. To the residue was added 30 mL of dichloromethane and 14.21 g (65.10 mmol) of di tert-butyl dicarbonate and stirred for 4 hours. The reaction solution was distilled in vacuo and purified by column chromatography using a mixed solution of dichloromethane and methanol in the ratio of 95:5 to obtain the title compound 2.95 g (2-step 62%).1H NMR (400 MHz, CDCl3); delta 4.67 (1H, br), 4.21 (1H, br), 3.91 (1H, br), 3.76 (2H, br), 3.27 (1H, br), 3.17 (1H, br), 1.44 (18H, s)
 

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