[ CAS No. 20469-89-0 ] {[proInfo.proName]}

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Quality Control of [ 20469-89-0 ]

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Product Details of [ 20469-89-0 ]

CAS No. :	20469-89-0	MDL No. :	MFCD00060274
Formula :	C₄H₆BrClO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	185.45	Pubchem ID :	-
Synonyms :

Safety of [ 20469-89-0 ]

Signal Word:	Danger	Class:	8,3
Precautionary Statements:	P210-P280-P370+P378-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310	UN#:	2920
Hazard Statements:	H226-H314	Packing Group:	Ⅱ
GHS Pictogram:

Application In Synthesis of [ 20469-89-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 20469-89-0 ]
Downstream synthetic route of [ 20469-89-0 ]

[ 20469-89-0 ] Synthesis Path-Upstream 1~4

1
[ 64-17-5 ]
[ 20469-89-0 ]
[ 600-00-0 ]

Reference： [1] Journal of the American Pharmaceutical Association (1912-1977), 1949, vol. 38, p. 599,601
[2] Bulletin de la Societe Chimique de France, 1958, p. 678,683

2
[ 67-56-1 ]
[ 20469-89-0 ]
[ 23426-63-3 ]

Reference： [1] Bulletin de la Societe Chimique de France, 1958, p. 678,683

3
[ 20469-89-0 ]
[ 7462-74-0 ]

Reference： [1] Journal of the American Chemical Society, 1939, vol. 61, p. 3386

4
[ 20469-89-0 ]
[ 100-46-9 ]
[ 60110-37-4 ]

Reference： [1] Liebigs Annalen der Chemie, 1979, p. 74 - 82

[ 20469-89-0 ] Synthesis Path-Downstream 1~13

1
[ 20469-89-0 ]
[ 7462-74-0 ]

Yield	Reaction Conditions	Operation in experiment
135 g	With ammonia; In water;	Add 150 g of 2-bromo-2-methylpropionic acid (A1) to the reaction kettle,Add 375 g of dichloromethane and 1200 g of N, N-dimethylformamide to dissolve it,During the dissolution process, the temperature of the reactor was maintained at 0 C, and 125 g of oxalyl chloride was added.Increase the temperature to 20 C for 10 hours;After the reaction is completed, the reaction solution is poured into ammonia water, stirred, filtered, and dried.135 g of 2-bromo-2-methylpropanamide was obtained, and the purity was 99.1%.The yield was 90.6%.

Reference： [1]Journal of the American Chemical Society,1939,vol. 61,p. 3386
[2]Patent: CN110437062,2019,A .Location in patent: Paragraph 0067-0073; 0088-0093; 0109-0115

2
[ 20469-89-0 ]
[ 67-63-0 ]
[ 51368-55-9 ]

Reference： [1]Jacques et al. [Bulletin de la Societe Chimique de France, 1958, p. 678,683]

3
[ 20469-89-0 ]
[ 74-89-5 ]
[ 69959-88-2 ]

Reference： [1]Safir et al. [Journal of the American Chemical Society, 1955, vol. 77, p. 4840,4842]

4
[ 20469-89-0 ]
[ 100-46-9 ]
[ 60110-37-4 ]

Reference： [1]Liebigs Annalen der Chemie,1979,p. 74 - 82

5
[ 20469-89-0 ]
[ 36725-28-7 ]
[ 69635-74-1 ]

Reference： [1]Journal of Medicinal Chemistry,1983,vol. 26,p. 800 - 807

6
[ 20469-89-0 ]
[ 107-21-1 ]
[ 189324-13-8 ]

Yield	Reaction Conditions	Operation in experiment
	for 4h; Heating;

Reference： [1]Haddleton, David M.; Waterson, Carl; Derrick, Peter J.; Jasieczek, Christina B.; Shooter, Andrew J. [Chemical Communications, 1997, # 7, p. 683 - 684]

7
[ 55809-36-4 ]
[ 20469-89-0 ]
[ 1004770-54-0 ]

Yield	Reaction Conditions	Operation in experiment
97%	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 18h;	To a solution of 4.2 g (30 mmol) of <strong>[55809-36-4]3-amino-5-tert-butylisoxazole</strong> and 5.2 mL (30 mmol) of N,N-diisopropylethylamine in DCM (20 mL) was added dropwise the acid chloride, as solution in DCM (15 mL). The reaction was stirred at room temperature for 18 h. The reaction mixture was washed with saturated aqueous NaHCO3 solution (2×15 mL) and the layers were separated. The organic layer was further washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The crude was purified by dry flash column chromatography (silica, eluent DCM, 0-20% ethyl acetate) to yield 8.5 g of 2-bromo-N-(5-tert-butyl-isoxazol-3-yl)-2-methyl-propionamide.
	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 18h;	Activation of 5 g (30 mmol) of 2-bromo-2-methylpropionic acid as its acid chloride was achieved by treatment with thionyl chloride (10 mL) at 60 C. for 2 h. The reaction was cooled and excess thionyl chloride was removed under reduced pressure to afford the desired acid chloride. To a solution of 4.2 g (30 mmol) of <strong>[55809-36-4]3-amino-5-tert-butylisoxazole</strong> and 5.2 mL (30 mmol) of N,N-diisopropylethylamine in DCM (20 mL) was added dropwise the acid chloride, as solution in DCM (15 mL). The reaction was stirred at room temperature for 18 h. The reaction mixture was washed with saturated aqueous NaHCO3 solution (2×15 mL) and the layers were separated. The organic layer was further washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The crude was purified by dry flash column chromatography (silica, eluent DCM, 0-20% ethyl acetate) to yield 8.5 g of 2-bromo-N-(5-tert-butyl-isoxazol-3-yl)-2-methyl-propionamide.
	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃;	To a solution of 3-amino-5-tert-butyl isoxazole (4.19 g, 29.9 mmol) and N5N- diisopropylamine (5.2 mL, 29.9 mmol) in DCM (20 mL) at room temperature is added the acid chloride (-29.9 mmol) as a solution in DCM (15 mL) dropwise. The reaction is stirred for 16 h. After this time, the mixture is washed with saturated aqueous NaHCO3 solution (x 2), brine and the organic layer is separated, dried (MgSO4) and concentrated under reduced pressure. The crude product is purified by chromatography on silica eluting with 0% to 25% ethyl acetate/DCM to provide the title compound (8.49 g, 97%). m/z 289/291 [M+H+].Using a similar procedure, the amides listed in Table 3 are synthesized.

Reference： [1]Patent: US2008/81822,2008,A1 .Location in patent: Page/Page column 12-13
[2]Patent: US2008/39464,2008,A1 .Location in patent: Page/Page column 20
[3]Patent: WO2009/105509,2009,A1 .Location in patent: Page/Page column 41

8
[ 861841-90-9 ]
[ 20469-89-0 ]
N-(3-acetyl-5-benzyloxy-2-hydroxy-phenyl)-2-bromo-2-methyl-propionamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84%	With pyridine at 5 - 20℃; for 0.25h;
84%	With pyridine at 5 - 20℃; for 0.25h;	9.a EXAMPLE 9; 4,4-diethyl-1-{3-[2-hydroxy-2-(6-hydroxy-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-ethylamino]-3-methyl-butyl}-1 4-dihydro-benzo[d][1,3]oxazin-2-one; a) N-(3-acetyl-5-benzyloxy-2-hydroxy-3phenyl)-2-bromo-2-methyl-propionamide; 4.64 g (25 mmol) 2-bromo-2-methyl-propionyl chloride are added dropwise to a solution of 5.15 g (20 mmol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 20 mL pyridine at 5-20° C. After the addition has ended the mixture is stirred for 15 minutes, combined with ice water and 100 mL ethyl acetate and acidified with conc. hydrochloric acid. The organic phase is separated off, washed with water and dried with sodium sulphate. After the solvent has been distilled off the residue is crystallised from a diethyl ether/petroleum ether mixture. Yield: 6.8 g (84%)
84%	With pyridine at 5 - 20℃; for 0.25h;	11.a a) N-(3-acetyl-5-benzyloxy-2-hydroxy-phenyl)-2-bromo-2-methyl-propionamide; 4.64 g (25 mmol) 2-bromo-2-methyl-propionyl chloride are added dropwise at 5-20° C. to a solution of 5.15 g (20 mmol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 20 mL pyridine. After the addition has ended the mixture is stirred for 15 minutes, combined with ice water and 100 mL ethyl acetate and acidified with conc. hydrochloric acid. The organic phase is separated off, washed with water and dried with sodium sulphate. After the solvent has been distilled off the residue is crystallised from a diethyl ether/petroleum ether mixture. Yield: 6.8 g (84%); melting range: 88-90° C.

84%	With pyridine at 5 - 20℃; for 0.25h;
84%	With pyridine at 5 - 20℃; for 0.25h;	2.a 4.64 g (25 mmol) 2-bromo-2-methyl-propionyl chloride are added dropwise at 5 to 20° C. to a solution of 5.15 g (20 mmol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 20 mL pyridine. After the addition has ended the mixture is stirred for 15 minutes, combined with ice water and 100 mL ethyl acetate and acidified with conc. hydrochloric acid. The organic phase is separated off, washed with water and dried with sodium sulphate. After the solvent has been distilled off the residue is crystallised from a diethyl ether/petroleum ether mixture. Yield: 6.8 g (84%); melting range: 88-90° C.
84%	With pyridine at 5 - 20℃;	a Salt precursor 11: 8-{2-[3-(3-benzo[1,3]dioxol-5-yl-5-methyl-[1,2,4]triazol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-6-hydroxy-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one a) N-(3-acetyl-5-benzyloxy-2-hydroxy-phenyl)-2-bromo-2-methyl-propionamide: 4.64 g (25 mmol) 2-bromo-2-methyl-propionyl chloride are added dropwise at 5-20° C. to a solution of 5.15 g (20 mmol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 20 mL pyridine. After the addition has ended the mixture is stirred for 15 minutes, combined with ice water and 100 mL ethyl acetate and acidified with conc. hydrochloric acid. The organic phase is separated off, washed with water and dried on sodium sulphate. After the solvent has been distilled off the residue is crystallised from a diethyl ether/petroleum ether mixture. Yield: 6.8 g (84%); melting range: 88-90° C.
84%	With pyridine at 5 - 20℃; for 0.25h;	a 4.64 g (25 mmol) 2-bromo-2-methyl-propionyl chloride are added dropwise at 5 to 20° C. to a solution of 5.15 g (20 mmol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 20 mL pyridine. After the addition has ended the mixture is stirred for 15 minutes, combined with ice water and 100 mL ethyl acetate and acidified with conc. hydrochloric acid. The organic phase is separated off, washed with water and dried with sodium sulphate. After the solvent has been distilled off the residue is crystallised from a diethyl ether/petroleum ether mixture. Yield: 6.8 g (84%); melting range: 88-90° C.
84%	In pyridine at 5 - 20℃; for 0.25h;	9.a 4.64 g (25 mmol) 2-bromo-2-methyl-propionyl chloride are added dropwise at 5-20° C. to a solution of 5.15 g (20 mmol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 20 mL pyridine. After the addition has ended the mixture is stirred for 15 minutes, combined with ice water and 100 mL ethyl acetate and acidified with conc. hydrochloric acid. The organic phase is separated off, washed with water and dried with sodium sulphate. After the solvent has been distilled off the residue is crystallized from a diethyl ether/petroleum ether mixture. Yield: 6.8 g (84%); melting range: 88-90° C.
84%	With pyridine at 5 - 20℃; for 0.25h;	a a) N-(3-acetyl-5-benzyloxy-2-hydroxy-phenyl)-2-bromo-2-methyl-propionamide 4.64 g (25 mmol) 2-bromo-2-methyl-propionyl chloride are added dropwise at 5 to 20° C. to a solution of 5.15 g (20 mmol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 20 mL pyridine. After the addition has ended the mixture is stirred for 15 minutes, combined with ice water and 100 mL ethyl acetate and acidified with conc. hydrochloric acid. The organic phase is separated off, washed with water and dried with sodium sulphate. After the solvent has been distilled off the residue is recrystallized from a diethyl ether/petroleum ether mixture. Yield: 6.8 g (84%); Melting range: 88-90° C.
6.8 g (84%)	In pyridine; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethyl acetate	11.a 8-{2-[3-(3-benzo[1,3]dioxol-5-yl-5-methyl-[1,2,4]triazol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-6-hydroxy-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one a) N-(3-acetyl-5-benzyloxy-2-hydroxy-phenyl)-2-bromo-2-methyl-propionamide 4.64 g (25 mmol) 2-bromo-2-methyl-propionyl chloride are added dropwise at 5-20° C. to a solution of 5.15 g (20 mmol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 20 mL pyridine. After the addition has ended the mixture is stirred for 15 minutes, combined with ice water and 100 mL ethyl acetate and acidified with conc. hydrochloric acid. The organic phase is separated off, washed with water and dried on sodium sulphate. After the solvent has been distilled off the residue is crystallized from a diethyl ether/petroleum ether mixture. Yield: 6.8 g (84%); melting range: 88-90° C.

Reference： [1]Current Patent Assignee: C.H. Boehringer Sohn AG & Co. KG; BASF SE - WO2005/70908, 2005, A1 Location in patent: Page/Page column 26-27
[2]Current Patent Assignee: C.H. Boehringer Sohn AG & Co. KG; BASF SE - US2005/227975, 2005, A1 Location in patent: Page/Page column 13
[3]Current Patent Assignee: C.H. Boehringer Sohn AG & Co. KG - US2006/189607, 2006, A1 Location in patent: Page/Page column 13
[4]Current Patent Assignee: C.H. Boehringer Sohn AG & Co. KG - WO2005/110990, 2005, A1 Location in patent: Page/Page column 23
[5]Current Patent Assignee: C.H. Boehringer Sohn AG & Co. KG - US2005/277632, 2005, A1 Location in patent: Page/Page column 9
[6]Current Patent Assignee: C.H. Boehringer Sohn AG & Co. KG - US2010/222336, 2010, A1 Location in patent: Page/Page column 12-13
[7]Current Patent Assignee: C.H. Boehringer Sohn AG & Co. KG - US2006/63817, 2006, A1 Location in patent: Page/Page column 10
[8]Current Patent Assignee: C.H. Boehringer Sohn AG & Co. KG - US2007/37781, 2007, A1 Location in patent: Page/Page column 39
[9]Current Patent Assignee: C.H. Boehringer Sohn AG & Co. KG - US2007/203125, 2007, A1 Location in patent: Page/Page column 34
[10]Current Patent Assignee: C.H. Boehringer Sohn AG & Co. KG - US2009/324510, 2009, A1

9
[ 59669-59-9 ]
[ 20469-89-0 ]
2-bromo-N-(3-tert-butyl-isoxazol-5-yl)-2-methyl-propionamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 16h;	The crude acid chloride is redissolved in DCM (300 mL) N5N- diisopropylethylamine (46.9 mL, 0.27 mol) and 3-tert-butyl-isoxazol-5-ylamine (12.6 g, 89.8 mmol) are introduced. The reaction is stirred at room temperature for 16 h. After this time, the mixture is washed with saturated aqueous NaHCO3 solution, brine and the organic layer is separated, dried (Na2SO4) and concentrated under reduced pressure. The crude product is purified by recrystallisation using heptanes/isopropyl alcohol to give the title compound 1(11.0 g, 43percent). IH NMR (400 MHz, CHLOROFORM-d) delta ppm 1.33 (9 H, s), 2.04 (6 H, s), 6.32 (1 H, s), 9.05 (1 H, br s).

Reference： [1]Patent: WO2009/105509,2009,A1 .Location in patent: Page/Page column 38

10
[ 20469-89-0 ]
[ 207679-81-0 ]
[ 1390644-50-4 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 5℃; for 0.5h;Inert atmosphere;	Example-47: Preparation of (R)-2-(3-(diisopropylamino)-l-phenylpropyl)-4- (hydroxymethyl)phenyl-2-bromo-2-methyl propanoate (Formula-37)5.0 gm of (R)-2-(3-diisopropylamino-l-phenylpropyl)-4-hydroxymethyl -phenol (formula-8) and dichloromethane (150 ml) were charged into a clean and dry RBF at 25-30C under nitrogen atmosphere. Cooled the reaction mixture to 0-5C and a solution of sodium bicarbonate (0.6 gm) in water (25 ml) was added. 2-Bromo-2- methyl propanoyl chloride (1.8 ml) was drop wise added to the reaction mixture at 0- 5C and stirred for 30 min at the same temperature. After the completion of the reaction, separated the organic and aqueous layers and the organic layer was washed with 5% sodium bicarbonate solution followed by water. Distilled off the solvent completely from the organic layer under reduced pressure and then co-distilled with ethyl acetate. The obtained compound is purified by column chromatography to get the title compound. Yield: 1.2 gm.

Reference： [1]Patent: WO2012/98560,2012,A2 .Location in patent: Page/Page column 70

11
[ 20469-89-0 ]
[ 103-73-1 ]
1-(4-ethoxyphenyl)-2-bromo-2-methyl-1-propanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95.2%	With aluminum (III) chloride In dichloromethane at -10 - 10℃; for 1h; Inert atmosphere;	6.1 (1) Friedel-crafts acylation reaction preparation 4 - ethoxy -2 - methyl -2 - bromo -1 - acetone under the protection of argon gas, to the three-mouth bottle adding phenetole (20.0 g, 0 . 16 µM) and anhydrous aluminum chloride (24.0 g, 0 . 18 µM) and chloroform 200 ml, cooling to 10 °C, stirring next adds by drops α - bromo isobutyryl chloride (33.2 g, 0 . 18 µM), control drop acceleration, to keep the temperature of the reaction solution -10 °C -0 °C, and absorbing the escaping hydrogen bromide gas, gas phase chromatographic detection until the phenetole content is lower than 1%. Yield 95.2%.

Reference： [1]Current Patent Assignee: QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY - CN105037059, 2017, B Location in patent: Paragraph 0083

12
[ 20469-89-0 ]
[ 75980-60-8 ]
C₂₆H₂₇O₄P [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
17.4 g	With aluminum (III) chloride; In nitrobenzene; at 0 - 40℃; for 2h;	1) The photoinitiator TPO (34.8 g, 0.1 mol) was dissolved in 200 ml of nitrobenzene,The control solution temperature is in the range of 0 to 10 C,Was added aluminum trichloride (82.7g, 0.62mol) After the stir,A solution of alpha-bromoisobutyryl chloride (18.5 g, 0.1 mol) was added dropwise,Slowly heated to 30-40 reaction 2h,Stop the reaction,The reaction solution was poured into 800 g of water and 130 ml of concentrated hydrochloric acid,Stirring 0.5h,Static separation of organic phase,Slowly washed with 200 ml of saturated sodium bicarbonate solution,To the organic phase pH is neutral,dry,The solvent was recovered by distillation under reduced pressure,To give a pale yellow oil,It is also possible not to recover the solvent,Directly to the next step.2) To the organic phase obtained in step 1) was added 150 mL of a 10% sodium hydroxide solution to carry out the reaction,To complete reaction,Standing,The organic phase is separated,Recovery solvent,A yellow oil,Recrystallization from methanol gave 17.4 g of a pale yellow solid.

Reference： [1]Patent: CN106349285,2017,A .Location in patent: Paragraph 0037; 0038; 0039

13
[ 20469-89-0 ]
[ 75980-60-8 ]
C₃₀H₃₃O₆P [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
21.4 g	With aluminum (III) chloride; In nitrobenzene; at 0 - 40℃; for 2h;	1) the photoinitiator TPO (34.8g, 0.1mol) was dissolved in 200ml of nitrobenzene,The control solution temperature is in the range of 0 to 10 C,After addition of aluminum trichloride (110.7 g, 0.83 mol)Alpha-bromoisobutyryl chloride (37.0 g, 0.2 mol) was added dropwise,Drop finished,Slowly heated to 30-40 reaction 2h,Stop the reaction,The reaction solution was poured into 800 g of water and 173 ml of concentrated hydrochloric acid,Stirring 0.5h,Static separation of organic phase,Slowly washed with 200 ml of saturated sodium bicarbonate solution,To the organic phase pH is neutral,dry,The solvent was recovered by distillation under reduced pressure,To give a pale yellow oil,It is also possible not to recover the solvent,Directly to the next step.2) To the organic phase obtained in step 1) was added 200 mL of 10% sodium hydroxide solution to carry out the reaction,To complete reaction,Standing,The organic phase is separated,Recovery solvent,A yellow oil,Recrystallization from methanol gave 21.4 g of a pale yellow solid.

Reference： [1]Patent: CN106349285,2017,A .Location in patent: Paragraph 0040; 0041; 0042

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P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 20469-89-0 ] {[proInfo.proName]}

Quality Control of [ 20469-89-0 ]

Related Doc. of [ 20469-89-0 ]

Product Details of [ 20469-89-0 ]

Safety of [ 20469-89-0 ]

Application In Synthesis of [ 20469-89-0 ]

[ 20469-89-0 ] Synthesis Path-Upstream 1~4

[ 20469-89-0 ] Synthesis Path-Downstream 1~13

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry