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Chemical Structure| 20691-53-6 Chemical Structure| 20691-53-6

Structure of 20691-53-6

Chemical Structure| 20691-53-6

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Product Details of [ 20691-53-6 ]

CAS No. :20691-53-6
Formula : C11H22O
M.W : 170.29
SMILES Code : OCC1CCC(C(C)(C)C)CC1
MDL No. :MFCD11847598

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Application In Synthesis of [ 20691-53-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 20691-53-6 ]

[ 20691-53-6 ] Synthesis Path-Downstream   1~1

  • 1
  • B2 H6 [ No CAS ]
  • [ 5451-55-8 ]
  • [ 20691-53-6 ]
YieldReaction ConditionsOperation in experiment
With benzophenone; sodium hydrogencarbonate; sodium chloride; In tetrahydrofuran; hexane; EXAMPLE 53 4-(1,1-Dimethylethyl)cyclohexanemethanol To a solution of <strong>[5451-55-8]4-tert-butylcyclohexane carboxylic acid</strong> (10.0 g, 54.3 mmol of a mixture of cis and trans isomers) in anhydrous THF (distilled over Na/benzophenone) (44 mL) at 0 C., under argon were added dropwise B2 H6 in THF (66.5 mL of 0.98M, 65.2 mmol). The reaction mixture was stirred at 0 C. for 2 hrs and then placed in the freezer overnight. The reaction was quenched by addition of saturated NaCl solution (50 mL) and was concentrated. The aqueous residue was extracted with EtOAc (3*200 mL) and the combined organic extracts were washed with sat. NaHCO3 solution (250 mL), followed by saturated brine (250 mL), dried over Na2 SO4, and filtered. Concentration to dryness yielded 9.96 g of crude product which was purified via flash chromatography eluding with 25% EtOAc in hexane to yield an amorphous 4-(1,1-dimethylethyl)cyclohexanemethanol (9.18 g, 53.9 mmol) as a mixture of cis and trans isomers in 99% yield.
 

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