207799-86-8|2-(4-Chlorophenyl)-2,2-difluoroethanol| Ambeed

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CAS No. :	207799-86-8
Formula :	C₈H₇ClF₂O
M.W :	192.59
SMILES Code :	OCC(F)(F)C1=CC=C(Cl)C=C1
MDL No. :	MFCD28038847

Yield	Reaction Conditions	Operation in experiment
95%	With sodium tetrahydroborate; ethanol; at 20℃; for 0.5h;	To a stirred solution of ethyl 2(4chiorophenyTh22difluoroacetate (6.7 g, 29 mmoi) in EtOH (1 0 mLj wa added NaBH4 (1 S5 g 41 mmol) at toom temperature The susptnsion was slowly transformed tO a clear solution. After stirring for 30mm at rt. the: ester was consumed. The reaction mixture wa.s quenched with aqueous IN HG under icewater bath cooling The mixturc %JS ttrctcttd with EtOAc [he organic phasts were washed w nh biuie dried O et Na2SO4 aim concentmted to attoid the title compound as s colni less liquid iS S) 95%). 11 NMR (400 MHz C 003) ii 7.46 (d. qi 8 Hz, 2.1:1). 7.42 (d.. J::; 8.8 Hz. 211), 3.95 (tJ 13.1 Hz,ZH).
	With sodium hydroxide; In diethyl ether; water;	Step A Synthesis of 2,2-difluoro-2-(4-chlorophenyl)ethanol as an intermediate Lithium aluminum hydride, 2.4 grams (0.063 mole), is placed in a reaction vessel, and 200 mL of diethyl ether is added dropwise with stirring. To this is added dropwise a solution of 22.8 grams (0.097 mole) of <strong>[130754-19-7]ethyl 4-chlorophenyldifluoroacetate</strong> (prepared by methods taught by W. J. Middleton et al., J. Org. Chem., (1980), 45, 2883-2887) in 100 mL of diethyl ether, while maintaining the reaction mixture temperature at about 25 C. Upon completion of addition, the reaction mixture is stirred at ambient temperature for about 36 hours. The reaction is then quenched by the careful dropwise addition of an aqueous solution of 10% sodium hydroxide. The reaction mixture is slowly made acidic with aqueous 2N hydrochloric acid and then is diluted with 200 mL of water. The organic layer is separated, and the aqueous layer is washed with two 300 mL portions of diethyl ether. The organic layer and the diethyl ether washes are combined and washed with one 250 mL portion of an aqueous solution saturated with sodium chloride. The organic layer is dried with magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure, yielding 2,2-difluoro-2-(4-chlorophenyl)ethanol.

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Response
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P378
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P401
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Disposal
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H226	Flammable liquid and vapour
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H228	Flammable solid
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
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H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
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Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
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H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
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H315	Causes skin irritation
H316	Causes mild skin irritation
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H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
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H336	May cause drowsiness or dizziness
H340	May cause genetic defects
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H351	Suspected of causing cancer
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H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 207799-86-8

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CAS No.: 207799-86-8

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