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Chemical Structure| 210169-19-0 Chemical Structure| 210169-19-0

Structure of 210169-19-0

Chemical Structure| 210169-19-0

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Product Details of [ 210169-19-0 ]

CAS No. :210169-19-0
Formula : C8H11F2NSi
M.W : 187.26
SMILES Code : C[Si](C1=C(F)C=NC=C1F)(C)C

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Application In Synthesis of [ 210169-19-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 210169-19-0 ]

[ 210169-19-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 75-77-4 ]
  • [ 71902-33-5 ]
  • [ 210169-19-0 ]
YieldReaction ConditionsOperation in experiment
In a 500 mL round-bottomed flask was added <strong>[71902-33-5]3,5-difluoropyridine</strong> (4.22 g, 36.67 mmol) in tetrahydrofuran (147 ml) to give a colorless solution. The solution was cooled to -78 0C before LDA (20.37 ml, 36.67 mmol) was added. After kept at -78 0C for 10 min, chlorotrimethylsilane (4.64 ml, 36.67 mmol) was added slowly. The reaction mixture was kept at -78 0C for another 10 min, LDA (50.9 ml, 91.67 mmol) was slowly added and the mixture was allowed to stir for 0.5 h before (R)-(E)-N-(2-(tert-butyldimethylsilyloxy)ethylidene)-2-methylpropane-2-sulfinamide (10.18 g, 36.67 mmol) was added in THF (20 mL). Sat. NH4Cl (80 mL) was added to quench the reaction after 0.5 hours. Partition, extraction with EtOAc (2 X 50 mL), drying (Na2SO4), and concentration gave the crude product. The crude product was added to a silica gel column and was eluted with EtOAc/hexanes (0-40percent). Collected fractions were concentrated to give the product at 41.1percent yield.
 

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