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Chemical Structure| 21156-84-3 Chemical Structure| 21156-84-3

Structure of 21156-84-3

Chemical Structure| 21156-84-3

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Product Details of [ 21156-84-3 ]

CAS No. :21156-84-3
Formula : C8H17NO
M.W : 143.23
SMILES Code : CN1CCC(CCO)CC1
MDL No. :MFCD13188565
InChI Key :PGPXRIFFCBCWEO-UHFFFAOYSA-N
Pubchem ID :15434835

Safety of [ 21156-84-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 21156-84-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 21156-84-3 ]

[ 21156-84-3 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 21156-84-3 ]
  • [ 858629-06-8 ]
  • [ 1613516-27-0 ]
YieldReaction ConditionsOperation in experiment
30% With di-tert-butyl dicarbonate; triphenylphosphine; In tetrahydrofuran; at 20℃; for 16h; General procedure: 5-Fluoro-3-iodo-indazole (524 mg, 2.0 mmol), 2-cylcopropylethanol (344 mg, 4.0 mmol), and triphenylphosphine (1.05 g, 4.0 mmol) were combined in dry THF (40 mL). Di-tert-butyl azodicarboxylate (921 mg, 4.0 mmol) was added, and the reaction was stirred for 16 h at rt. The solution was concentrated and purified by silica gel chromatography (0% to 20% EtOAc/hexanes) to give two product isomers: 1-(cyclopropylethyl)-<strong>[858629-06-8]5-fluoro-3-iodo-1H-indazole</strong> (390 mg, 59%) was isolated as the major isomer eluting first. The title compound was prepared from 5-fluoro-3-iodo-indazole and 1-methyl-4-(hydroxyethyl)piperidine in 30% yield according to the general procedure for Preparation 31A. The minor isomer was not isolated or characterized. 1H NMR (300 MHz, CDCl3): δ 1.23-1.42 (3H, m), 1.72-1.76 (2H, m), 1.84-1.91 (4H, m), 2.56 (3H, s), 2.82-2.86 (2H, m), 4.41 (2H, t, J=7.8 Hz), 7.13 (1H, dd, J=2.4, 8.4 Hz), 7.22 (1H, td, J=2.4, 8.7 Hz), 7.33 (1H, dd, J=3.9, 9.0 Hz).
 

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