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Chemical Structure| 216097-69-7 Chemical Structure| 216097-69-7

Structure of 216097-69-7

Chemical Structure| 216097-69-7

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Product Details of [ 216097-69-7 ]

CAS No. :216097-69-7
Formula : C9H8N2O
M.W : 160.17
SMILES Code : OC1=NC=CC2=C1C(N)=CC=C2
English Name :8-Aminoisoquinolin-1-ol
MDL No. :MFCD22380561

Safety of [ 216097-69-7 ]

Application In Synthesis of [ 216097-69-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 216097-69-7 ]

[ 216097-69-7 ] Synthesis Path-Downstream   1~8

  • 2
  • [ 119-65-3 ]
  • [ 216097-69-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: sulfuric acid; N-Bromosuccinimide / 24 h / -10 - 20 °C 1.2: Cooling with ice 2.1: sulfuric acid; potassium nitrate / 0 - 20 °C 2.2: Cooling with ice 3.1: dihydrogen peroxide; acetic acid / water / 3 h / Reflux 4.1: acetic anhydride / 3 h / Reflux 4.2: 1 h / 20 °C 5.1: hydrogen; 10% Pd/C / methanol / 18 h
  • 3
  • [ 34784-04-8 ]
  • [ 216097-69-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: sulfuric acid; potassium nitrate / 0 - 20 °C 1.2: Cooling with ice 2.1: dihydrogen peroxide; acetic acid / water / 3 h / Reflux 3.1: acetic anhydride / 3 h / Reflux 3.2: 1 h / 20 °C 4.1: hydrogen; 10% Pd/C / methanol / 18 h
  • 4
  • [ 63927-23-1 ]
  • [ 216097-69-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: dihydrogen peroxide; acetic acid / water / 3 h / Reflux 2.1: acetic anhydride / 3 h / Reflux 2.2: 1 h / 20 °C 3.1: hydrogen; 10% Pd/C / methanol / 18 h
  • 5
  • [ 1353970-10-1 ]
  • [ 216097-69-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: acetic anhydride / 3 h / Reflux 1.2: 1 h / 20 °C 2.1: hydrogen; 10% Pd/C / methanol / 18 h
  • 7
  • [ 216097-69-7 ]
  • [ 2648907-88-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: pyridine / tetrahydrofuran / 2 h / 0 - 20 °C 2: triethylamine / N,N-dimethyl-formamide / 15 h / 50 °C
  • 8
  • [ 147-85-3 ]
  • [ 475994-60-6 ]
  • [ 216097-69-7 ]
YieldReaction ConditionsOperation in experiment
Compound 164 Compounds Synthesized by Method E Compound 164 To a pressure vessel containing 8-bromo-2H-isoquinolin-1-one (1.00 g, 4.46 mmol), Copper (I) iodide (90 mg, 472 μmol) and L-Proline (104 mg, 903 μmol) was added concentrated ammonium hydroxide (25 mL). The vessel was capped and stirred at 110° C. for 18 h. The mixture was cooled to RT, concentrated to dryness and the residue purified by silica gel chromatography eluting with a gradient of 0 to 10% MeOH in DCM to provide 8-amino-2H-isoquinolin-1-one (632 mg) as a greenish-gray solid. ESI-MS: m/z 161.2 (M+H)+. 1H NMR (400 MHz, DMSO-d6) δ 10.76 (br s, 1H), 7.37-7.13 (m, 3H), 6.93 (dd, J=7.1, 5.8 Hz, 1H), 6.56 (dd, J=7.7, 1.2 Hz, 1H), 6.51 (dd, J=8.1, 1.1 Hz, 1H), 6.27 (dd, J=7.1, 1.5 Hz, 1H).
 

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