Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 21617-15-2 | MDL No. : | MFCD00795494 |
Formula : | C9H8ClNO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | HOLTZTRNTRXTNX-UHFFFAOYSA-N |
M.W : | 181.62 | Pubchem ID : | 88974 |
Synonyms : |
|
Num. heavy atoms : | 12 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.22 |
Num. rotatable bonds : | 0 |
Num. H-bond acceptors : | 1.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 51.77 |
TPSA : | 29.1 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -5.97 cm/s |
Log Po/w (iLOGP) : | 1.76 |
Log Po/w (XLOGP3) : | 2.02 |
Log Po/w (WLOGP) : | 1.77 |
Log Po/w (MLOGP) : | 1.62 |
Log Po/w (SILICOS-IT) : | 2.73 |
Consensus Log Po/w : | 1.98 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.61 |
Solubility : | 0.447 mg/ml ; 0.00246 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.26 |
Solubility : | 1.0 mg/ml ; 0.00552 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -3.78 |
Solubility : | 0.0299 mg/ml ; 0.000165 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.55 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
a degree of conversion of the <strong>[21617-15-2]7-chloro-1,2,3,4-tetrahydroquinolin-4-one</strong> of 98.7%, and a yield of 7-chloro-4-hydroxyquinoline of 96.2% relative to the <strong>[21617-15-2]7-chloro-1,2,3,4-tetrahydroquinolin-4-one</strong> converted. The starting <strong>[21617-15-2]7-chloro-1,2,3,4-tetrahydroquinolin-4-one</strong> can be prepared in the following manner: |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridine; In dichloromethane; water; | EXAMPLE 1 Preparation of 7-chloro-2,3-dihydro-1-(2-methyl-benzoyl)-4(1H)-quinolinone To a mixture of <strong>[21617-15-2]7-chloro-2,3-dihydro-4(1H)-quinolinone</strong> (20.0 g), pyridine (26 g) and dichloromethane (200 mg) was added dropwise 2-methylbenzoyl chloride (26 g) at room temperature with stirring. The mixture was stirred under reflux for 4 hours. The reaction mixture was poured into 500 ml of water, then shaken with additional dichloromethane (1000 ml). The organic layer was washed once with 1 N HCl (100 ml), twice with water (200 ml each) and once with saturated aqueous NaCl solution, then dried over anhydrous sodium sulfate. Solvent was removed in vacuo and the residue was recrystallized to obtain 7-chloro-2,3 -dihydro-1-(2methylbenzoyl)-4(1H)-quinolinone (yield 28 g) as white crystal. Melting point: 106.5-108.1 C. IR (KBr, cm-1): 1695, 1655, 1405, 1380 NMR (CDCl3, ppm): 2.34 (3H, s), 2.80 (2H, t), 4.16 (2H, t), 7.00-8.00 (7H, m, aromatic) | |
With pyridine; In dichloromethane; water; | Example 1 Preparation of 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone To a mixture of <strong>[21617-15-2]7-chloro-2,3-dihydro-4(1H)-quinolinone</strong> (20.0 g), pyridine (26 g) and dichloromethane (200 ml) was added dropwise 2-methylbenzoyl chloride (26 g) at room temperature with stirring. The mixture was stirred under reflux for 4 hours. The reaction mixture was poured into 500 ml of water, then shaken with additional dichloromethane (1000 ml). The organic layer was washed once with 1 N HCl (100 ml), twice with water (200 ml each) and once with saturated aqueous NaCl solution, then dried over anhydrous sodium sulfate. Solvent was removed in vacuo and the residue was recrystallized to obtain 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone (yield 28 g) as white crystal. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
7.6 g | B) 7-Chloro-2,3-dihydroquinolin-4(1H)-one To a solution of N-(3-chlorophenyl)-N-((4-methylphenyl)sulfonyl)-beta-alanine (30.00 g) in THF (500 mL), a catalytic amount of DMF and oxalyl chloride (17.5 mL) were added at 0C. After stirring at room temperature for 1 hour, the solvent was distilled off under reduced pressure. The obtained solid was dissolved in nitroethane (400 mL). To the solution, aluminum chloride (47.60 g) was added at 0C, and then, the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured to ice, followed by extraction with ethyl acetate. The extract was washed with water and saturated brine and dried over anhydrous magnesium sulfate, and then, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to obtain the title compound (7.60 g). MS: [M+H]+ 182.0. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
The anisole-containing solution produced by the first filtration is washed with a 2 N aqueous solution of sulphuric acid. The following is determined in the organic phase by gas phase chromatography: The aqueous phase is brought to pH 8. After concentration and extraction, p-aminophenol (3.685 millimols) is determined (which corresponds to a degree of conversion of 81.9%) and, after crystallisation from an aqueous-alcoholic medium, 4-(4-hydroxyphenyl)-amino-7-chloroquinoline (0.310 g), melting at 255 C., is isolated. The yield of 4-(4-hydroxyphenyl)-amino-7-chloroquinoline is 74.35% relative to the 7-chloro-1,2,3,4-tetrahydroquinolin-4-one converted, and 86.6% relative to the p-aminophenol converted. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
3.5% | 4-(4-diethylamino-1-methylbutylamino)-quinoline: estimated yield of 3.5% relative to the 7-chloro-1,2,3,4-tetrahydroquinolin-4-one converted. | |
1% | 4-(4-diethylamino-1-methylbutylamino)-quinoline: estimated yield of 1% relative to the 7-chloro-1,2,3,4-tetrahydroquinolin-4-one converted. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81.6% | With sodium hydroxide; sodium chloride; sulfur trioxide; | EXAMPLE 1 A 250 cc three-necked, round-bottom flask, fitted with a stirrer and a reflux condenser surmounted by an argon inlet, is placed in a bath thermostated at 20 C. The apparatus is purged with argon and 20% oleum (containing 0.470 mol of SO3 and 1.534 mols of H2 SO4; 188 g) is introduced. This is stirred for 30 minutes to bring the temperature to 20 C. 3-m-Chloroanilinopropionic acid (10.146 g; 5.086*10-2 mols) is then introduced in small portions in the course of 5 minutes. The temperature rises to 24.5 C. and then drops to 20 C. again in the course of 10 minutes. The reaction mixture is stirred for 16 at 20 C., after which it is poured onto ice (88.6 g) in such a way that the temperature does not exceed 25 C. The solution is then heated for 30 minutes at a temperature between 138 and 140 C. under an argon atmosphere. After cooling, the reaction mixture is poured onto ice (420 g). The yellow solution obtained is extracted with methylene chloride (100 cc) and then with the same solvent again (5*50 cc). A gummy, insoluble material is filtered off. The methylene chloride solution is washed with a saturated solution of sodium chloride (2*25 cc), then with a 2N solution of sodium hydroxide (7*25 cc) and finally with a saturated solution of sodium chloride (5*25 cc), and is then dried over sodium sulphate, treated with decolorising charcoal and finally filtered. After the solvent has been evaporated off, 7-chloro-1,2,3,4-tetrahydroquinolin-4-one (7.535 g) is obtained in the form of a crystalline product melting at 133 C. (Kofler bench). The degree of conversion is 100% and the yield is 81.6%. The proportion of the 5-chloro isomer is estimated by thin layer chromatography to be 2.5%. The starting 3-m-chloroanilinopropionic acid can be prepared in the following manner: |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88.3% | a degree of conversion of the <strong>[21617-15-2]7-chloro-1,2,3,4-tetrahydroquinolin-4-one</strong> of 88.3%, a yield of 4-hydroxy-7-chloroquinoline of 69.8% relative to the <strong>[21617-15-2]7-chloro-1,2,3,4-tetrahydroquinolin-4-one</strong> converted, and a yield of 4-hydroxyquinoline of 15% relative to the <strong>[21617-15-2]7-chloro-1,2,3,4-tetrahydroquinolin-4-one</strong> converted. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
10.3 g | C) tert-Butyl 7-chloro-4-hydroxy-3,4-dihydroquinoline-1 (2H)-carboxylate To a solution of <strong>[21617-15-2]7-chloro-2,3-dihydroquinolin-4(1H)-one</strong> (7.60 g) in THF (100 mL), di-tert-butyl dicarbonate (10.1 mL) and N,N-dimethyl-4-aminopyridine (2.10 g) were added at room temperature. After stirring at the same temperature as above for 14 hours, the reaction mixture was concentrated under reduced pressure, and water was added thereto, followed by extraction with ethyl acetate. The extract was washed with water and saturated brine and dried over anhydrous magnesium sulfate. Then, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane). To a solution of the obtained oil in THF (150 mL) and methanol (75 mL), sodium borohydride (1.60 g) was added at 0C. After stirring at the same temperature as above for 1 hour, the mixture was further stirred at room temperature for 1 hour. Water was added to the reaction mixture, and then, the reaction mixture was concentrated under reduced pressure, followed by extraction with ethyl acetate. The extract was washed with water and saturated brine and dried over anhydrous magnesium sulfate, and then, the solvent was distilled off under reduced pressure to obtain the title compound (10.30 g). 1H NMR (300 MHz, CDCl3) delta 1.54 (9H, s), 1.71-1.85 (1H, m), 1.86-2.12 (1H, m), 3.47-3.75 (1H, m), 3.89-4.08 (1H, m), 4.65-4.78 (1H, m), 7.04 (1H, dd, J = 8.3, 2.1 Hz), 7.30 (1H, d, J = 8.3 Hz), 7.91 (1H, d, J = 1.9 Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With dmap; In tetrahydrofuran; at 20℃; for 14h; | Boc2O (10.1 mL, 44.1 mmol) and DMAP (2.1 g, 17.2 mmol) wereadded to a stirred solution of 6 (7.6 g, 41.8 mmol) in THF (100 mL)at room temperature, and the mixture was stirred at room temperature for 14 h. The mixture was concentrated in vacuo,diluted with water, and extracted with EtOAc. The organic layerwas washed with water and brine, dried over MgSO4, and filtered.The filtrate was concentrated in vacuo, and the residue was purifiedby column chromatography (silica gel, eluted with 50% EtOAcin hexane) to give 7 (13.1 g, quant) as a yellow oil. This productwas used in the next step without further purification. 1H NMR(300 MHz, CDCl3) d 1.57 (9H, s), 2.70-2.81 (2H, m), 4.11-4.20(2H, m), 7.12 (1H, dd, J = 8.5, 2.1 Hz), 7.87 (1H, d, J = 1.9 Hz), 7.93(1H, d, J = 8.5 Hz). |
Tags: 21617-15-2 synthesis path| 21617-15-2 SDS| 21617-15-2 COA| 21617-15-2 purity| 21617-15-2 application| 21617-15-2 NMR| 21617-15-2 COA| 21617-15-2 structure
[ 21617-20-9 ]
6-Chloro-2,3-dihydroquinolin-4(1H)-one
Similarity: 0.97
[ 160129-45-3 ]
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Similarity: 0.94
[ 1022-13-5 ]
(5-Chloro-2-(methylamino)phenyl)(phenyl)methanone
Similarity: 0.88
[ 21617-20-9 ]
6-Chloro-2,3-dihydroquinolin-4(1H)-one
Similarity: 0.97
[ 160129-45-3 ]
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Similarity: 0.94
[ 1022-13-5 ]
(5-Chloro-2-(methylamino)phenyl)(phenyl)methanone
Similarity: 0.88
[ 21617-20-9 ]
6-Chloro-2,3-dihydroquinolin-4(1H)-one
Similarity: 0.97
[ 71412-22-1 ]
2,3-Dihydroquinolin-4(1H)-one hydrochloride
Similarity: 0.84
[ 113961-88-9 ]
1-(1,2,3,4-Tetrahydroquinolin-6-yl)ethanone
Similarity: 0.79
[ 90562-35-9 ]
7-Chloro-1,2,3,4-tetrahydroquinoline
Similarity: 0.79
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :