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Chemical Structure| 216481-87-7 Chemical Structure| 216481-87-7

Structure of 216481-87-7

Chemical Structure| 216481-87-7

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Product Details of [ 216481-87-7 ]

CAS No. :216481-87-7
Formula : C11H17NO4
M.W : 227.26
SMILES Code : O=C(O)C1C=CC(C1)NC(OC(C)(C)C)=O
MDL No. :MFCD18075610

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Application In Synthesis of [ 216481-87-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 216481-87-7 ]

[ 216481-87-7 ] Synthesis Path-Downstream   1~1

YieldReaction ConditionsOperation in experiment
Example 3 Preparation of (1S-cis)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic acid (5) To a suspension of (1S-cis)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic acid (4), compound with (R)-(+)-1-phenylethylamine (34.84 g) in toluene (100 ml) and water (100 ml) was added dropwise, over 5 min, phosphoric acid (11.53 g). Ethyl acetate (200 ml) was added and a clear biphasic mixture obtained. The phases were separated and the organic layer concentrated in vacuo at approximately 50 C. to about one quarter of the original volume. The solution was cooled to ambient temperature and the resulting solid filtered off, washed with toluene (50 ml) followed by 2,2,4-trimethylpentane (50 ml) then dried in vacuo at 35 C. The yield of (1S-cis)-4-[[(1,1-dimethyl ethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic acid was 21.01 g, 92% of theory, Mp=153-5 C.
 

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