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Chemical Structure| 21668-34-8 Chemical Structure| 21668-34-8

Structure of 21668-34-8

Chemical Structure| 21668-34-8

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Product Details of [ 21668-34-8 ]

CAS No. :21668-34-8
Formula : C10H11ClO2
M.W : 198.65
SMILES Code : O=C(Cl)C1=CC(C)=C(OC)C(C)=C1
MDL No. :MFCD11111050

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Application In Synthesis of [ 21668-34-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 21668-34-8 ]

[ 21668-34-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 7321-93-9 ]
  • [ 21668-34-8 ]
  • [ 1417618-36-0 ]
YieldReaction ConditionsOperation in experiment
100% With pyridine; In dichloromethane; at 0℃; for 2h; (a) N-(4,6-Dichloropyridin-3-yl)-4-methoxy-3,5-dimethylbenzamide With ice cooling, 1.20 g of 4-methoxy-3,5-dimethylbenzoyl chloride, dissolved in 1 ml of dry dichloromethane were initially added dropwise to a solution of 0.82 g of <strong>[7321-93-9]4,6-dichloropyridin-3-ylamine</strong> in 8 ml of dry dichloromethane. A solution of 0.4 ml of absolute pyridine in 1 ml of dry dichloromethane was then added, and the reaction was stirred at 0° C. for 2 h, the product partially precipitating slowly. Approx. 10 ml of 10percent strength aqueous sodium bisulfate solution were then added, and the mixture was stirred for five minutes. The aqueous phase was then decanted off and the solid-containing organic phase was concentrated under reduced pressure and freeze-dried. This gave 1.63 g (100percent) of the product, which was used for the next step without any further purification. LC/MS (Method LC1): Rt=0.92 min; m/z=325.05 [M+H]+
 

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