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Chemical Structure| 2199-85-1 Chemical Structure| 2199-85-1

Structure of 2199-85-1

Chemical Structure| 2199-85-1

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Product Details of [ 2199-85-1 ]

CAS No. :2199-85-1
Formula : C16H9BrO3
M.W : 329.15
SMILES Code : O=C1C(C(C2=CC=CC=C2)=O)=CC3=C(O1)C=CC(Br)=C3

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Application In Synthesis of [ 2199-85-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2199-85-1 ]

[ 2199-85-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 19063-55-9 ]
  • [ 100-52-7 ]
  • [ 2199-85-1 ]
  • 2
  • [ 19063-55-9 ]
  • [ 591-50-4 ]
  • [ 201230-82-2 ]
  • [ 2199-85-1 ]
YieldReaction ConditionsOperation in experiment
78% With silver(I) acetate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100℃; under 760.051 Torr; for 24h;Schlenk technique; Sealed tube; General procedure: In an oven-dried Schlenk tube equipped with a stir bar, 3-substituted coumarin 2 (0.3 mmol), iodoaren 1 (0.33 mmol), Pd(OAc)2 (10 mol%, 0.0067 g), BINAP (10 mol%, 0.0186 g), and AgOAc (0.6 mmol, 0.1 g), a balloon filled with CO (1 atm) was connected to the Schlenk tube by the side tube and the system was purged three times. Toluene (2 mL) was then added to the tube by using a syringe. The Schlenk tube was heated at 100 C for 10 h. When the reaction was complete (detected by TLC), the mixture was cooled to r.t., and the reaction was quenched with H2O (10 mL) and extracted with CH2Cl2 (3 × 10 mL). The combined organic layer was dried over anhydrous Na2SO4 and evaporatedin vacuum. The residue was purified by column chromatography on silica gel to afford the corresponding product 3.
 

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