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Chemical Structure| 220509-85-3 Chemical Structure| 220509-85-3

Structure of 220509-85-3

Chemical Structure| 220509-85-3

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Product Details of [ 220509-85-3 ]

CAS No. :220509-85-3
Formula : C14H16N2O5S
M.W : 324.35
SMILES Code : O=C1NC2=C(C=C(S(=O)(N3[C@@H](COC)CCC3)=O)C=C2)C1=O

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Application In Synthesis of [ 220509-85-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 220509-85-3 ]

[ 220509-85-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 63126-47-6 ]
  • [ 132898-96-5 ]
  • [ 220509-85-3 ]
YieldReaction ConditionsOperation in experiment
63.8% With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; at 0℃; for 2.5h; Step 1: 5-[(2R)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl}-1H-indole-2,3-dione To a stirred cold suspension of 2,3-dioxo-2,3-dihydro-1H-indol-5-sulfonyl chloride (5.00 g, 20.4 mmol) in a 1:1 mixture of THF: CHCl3 (140 mL) was added dropwise, via syringe pump, a solution of N,N-diisopropylethylamine (7.11 mL, 40.8 mmol, 2 eq) and (R)-2-(Methoxymethyl)pyrrolidine (3.27 mL, 26.5 mmol, 1.3 eq) in CHCl3 (60 mL) over a period of 1.5 hours with cooling in an ice bath. After stirring an additional 1 h, the reaction was concentrated. The crude product was purified on Biotage KP silica gel eluding with 95/5 CH2Cl2/CH3OH followed by a second chromatography on silica gel eluding with EtOAc to give 4.21 g (63.8%) of the title compound. NMR (400 MHz, DMSO-d6): consistent.
 

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