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Chemical Structure| 22082-92-4 Chemical Structure| 22082-92-4

Structure of 22082-92-4

Chemical Structure| 22082-92-4

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Product Details of [ 22082-92-4 ]

CAS No. :22082-92-4
Formula : C16H11Cl
M.W : 238.71
SMILES Code : ClC1=C2C=CC=CC2=CC=C1C3=CC=CC=C3
MDL No. :N/A

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Application In Synthesis of [ 22082-92-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22082-92-4 ]

[ 22082-92-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 59046-72-9 ]
  • [ 536-74-3 ]
  • [ 22082-92-4 ]
YieldReaction ConditionsOperation in experiment
70% With N-chloro-succinimide; copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 80℃; for 8h;Inert atmosphere; General procedure: A solution of <strong>[59046-72-9]2-(phenylethynyl)benzaldehyde</strong> (1) (0.90 mmol, 0.185 g), alkyne (0.60 mmol), Cu(OTf)2 (0.045 mmol, 0.016 g), NXS (NBS, NCS, or NIS; 0.90 mmol) in ClCH2CH2Cl (4.0 mL) was stirred at 80 C for 8 h under a nitrogen atmosphere. The reaction mixture was diluted with CHCl3 and washed with saturated NaHCO3 aq. and brine. The organic layer was dried over MgSO4. After removal of the solvent under reduced pressure, the residue was purified by chromatography on SiO2 to give the 1-halonaphthalenes 3. Further purification was carried out a recyclable preparative HPLC, if necessary.
 

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