[ CAS No. 223127-24-0 ] {[proInfo.proName]}

Name: 223127-24-0|6-(4-Fluorophenyl)nicotinic acid|95%
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SKU: A251306
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Quality Control of [ 223127-24-0 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 223127-24-0 ]

SDS Specification

Alternatived Products of [ 223127-24-0 ]

Product Details of [ 223127-24-0 ]

CAS No. :	223127-24-0	MDL No. :	MFCD06410388
Formula :	C₁₂H₈FNO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	217.20	Pubchem ID :	-
Synonyms :

Calculated chemistry of [ 223127-24-0 ]

Physicochemical Properties

Num. heavy atoms :	16
Num. arom. heavy atoms :	12
Fraction Csp3 :	0.0
Num. rotatable bonds :	2
Num. H-bond acceptors :	4.0
Num. H-bond donors :	1.0
Molar Refractivity :	56.59
TPSA :	50.19 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.11 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.73
Log Po/w (XLOGP3) :	2.14
Log Po/w (WLOGP) :	3.01
Log Po/w (MLOGP) :	0.9
Log Po/w (SILICOS-IT) :	2.77
Consensus Log Po/w :	2.11

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.56

Water Solubility

Log S (ESOL) :	-2.96
Solubility :	0.239 mg/ml ; 0.0011 mol/l
Class :	Soluble
Log S (Ali) :	-2.83
Solubility :	0.324 mg/ml ; 0.00149 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.2
Solubility :	0.0136 mg/ml ; 0.0000628 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.86

Safety of [ 223127-24-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 223127-24-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 223127-24-0 ]
Downstream synthetic route of [ 223127-24-0 ]

[ 223127-24-0 ] Synthesis Path-Upstream 1~4

1
[ 149500-84-5 ]
[ 223127-24-0 ]

Yield	Reaction Conditions	Operation in experiment
37%	With sodium hydroxide; water In tetrahydrofuran at 20℃; for 15 h;	Combine 6-bromopyridine-3-carboxylic acid methyl ester (1.03 g, 4.78 MMOL), 4- fluorophenylboronic acid (1.88 g, 13.41 mmol), and cesium fluoride (2.55 g, 16.78 mmol) in DMF (25 mL) and water (4 mL) with stirring. Place the hetereogeneous reaction mixture, open to the air, in an oil bath maintained at 80°C. After 5 minutes of heating, add Pd (OAC) 2 (150 mg, 0.67 mmol) in one portion. After 17 hours, cool the reaction to room temperature, dilute with ethyl acetate and filter through a short plug of celite with additional ethyl acetate. Wash the organics with water, dry over MgS04, filter and evaporate. Purification by flash column chromatography yields 6- (4- fluorophenyl) pyridine-3-carboxylic acid methyl ester as a yellow solid. Dissolve the purified ester in THF (0.25 M) and add an equal volume of 1 M NaOH. Stir vigorously at room temperature for 15 hours. Upon completion, acidify the reaction with conc. HCI and collect the white precipitate by filtration. Drying under vacuum yields 385 mg (37percent) of the title compound. MS (ES): M/Z 218.1 (M+H).
37%	With sodium hydroxide; water In tetrahydrofuran at 20℃; for 15 h;	Combine 6-bromopyridine-3-carboxylic acid methyl ester (1.03 g, 4.78 MMOL), 4- fluorophenylboronic acid (1.88 g, 13.41 mmol), and cesium fluoride (2.55 g, 16.78 mmol) in DMF (25 mL) and water (4 mL) with stirring. Place the heterogeneous reaction mixture, open to the air, in an oil bath maintained at 80°C. After 5 minutes of heating, add Pd (OAC) 2 (150 mg, 0.67 mmol) in one portion. After 17 hours, cool the reaction to room temperature, dilute with ethyl acetate and filter through a short plug of celite with additional ethyl acetate. Wash the organics with water, dry over MGS04, filter and evaporate. Purification by flash column chromatography yields 6- (4- fluorophenyl) pyridine-3-carboxylic acid methyl ester as a yellow solid. Dissolve the purified ester in THF (0.25 M) and add an equal volume of 1 M NAOH. Stir vigorously at room temperature for 15 hours. Upon completion, acidify the reaction with conc. HCI and collect the white precipitate by filtration. Drying under vacuum yields 385 mg (37percent) of the title compound. MS (ES): M/Z 218.1 (MH+)

Reference： [1] Patent: WO2004/94363, 2004, A1, . Location in patent: Page 21
[2] Patent: WO2004/94382, 2004, A1, . Location in patent: Page 21
[3] Patent: US6528525, 2003, B1,
[4] Patent: WO2005/9941, 2005, A1, . Location in patent: Page 21-22

2
[ 73781-91-6 ]
[ 223127-24-0 ]

Reference： [1] Patent: WO2004/94382, 2004, A1,

3
[ 5326-23-8 ]
[ 1765-93-1 ]
[ 223127-24-0 ]

Reference： [1] Patent: EP1657242, 2006, A1, . Location in patent: Page/Page column 31

4
[ 26218-78-0 ]
[ 1765-93-1 ]
[ 223127-24-0 ]

Reference： [1] Patent: WO2004/94382, 2004, A1,

[ 223127-24-0 ] Synthesis Path-Downstream 1~14

1
[ 223127-24-0 ]
[ 913182-52-2 ]
[ 913182-58-8 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 5207 - 5211

2
[ 223127-24-0 ]
[ 925242-62-2 ]
[ 925242-79-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 814 - 818

3
[ 223127-24-0 ]
[ 913712-39-7 ]
6-(4-fluorophenyl)pyridine-3-carboxylic acid (6-dimethylaminomethyl-1,2,3,4-tetrahydronaphthalen-2-yl)methylamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; at 20.0℃; for 0.5h;	Preparation of 5-(4-fluorophenyl)pyridine-2-carboxylic acid (6-dimethylamino- methyl-l,2,3,4-tetrahydronaphthalen-2-yl)-methylamide (13): A mixture of 6-[(dimethyl- amino)methyl]-N-methyl-l,2,3,4-tetrahydro-naphthalen-2-amine, 12, (0.362 g, 1.244 mmol), <strong>[223127-24-0]6-(4-fluorophenyl)nicotinic acid</strong> (0.270 g, 1 eq.), lH-benzotriazol-1- yloxytripyrrolidinophosphonium hexafluorophosphate (PyBop) (0.841 g, 1.3 eq.) and triethylamine (0.52 mL, 3 eq.) is stirred at room temperature for 30 min. The crude reaction solution is directly purified by prep-etaPLC reversed phase chromatography to afford 28 mg of the desired product as a white solid. LRMS: 418.48 (M+eta); etaRMS: calcd for C26eta29FN3O+: 418.2295, found: 418.2303.

Reference： [1]Patent: WO2008/1160,2008,A1 .Location in patent: Page/Page column 49-50

4
[ 223127-24-0 ]
[ 925243-16-9 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 814 - 818

5
[ 223127-24-0 ]
6-(4-fluoro-phenyl)-<i>N</i>-methyl-<i>N</i>-[6-(3-oxo-piperazin-1-ylmethyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-nicotinamide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 814 - 818

6
[ 149500-84-5 ]
[ 223127-24-0 ]

Yield	Reaction Conditions	Operation in experiment
37%	With sodium hydroxide; water; In tetrahydrofuran; at 20.0℃; for 15.0h;	Combine 6-bromopyridine-3-carboxylic acid methyl ester (1.03 g, 4.78 MMOL), 4- fluorophenylboronic acid (1.88 g, 13.41 mmol), and cesium fluoride (2.55 g, 16.78 mmol) in DMF (25 mL) and water (4 mL) with stirring. Place the hetereogeneous reaction mixture, open to the air, in an oil bath maintained at 80C. After 5 minutes of heating, add Pd (OAC) 2 (150 mg, 0.67 mmol) in one portion. After 17 hours, cool the reaction to room temperature, dilute with ethyl acetate and filter through a short plug of celite with additional ethyl acetate. Wash the organics with water, dry over MgS04, filter and evaporate. Purification by flash column chromatography yields 6- (4- fluorophenyl) pyridine-3-carboxylic acid methyl ester as a yellow solid. Dissolve the purified ester in THF (0.25 M) and add an equal volume of 1 M NaOH. Stir vigorously at room temperature for 15 hours. Upon completion, acidify the reaction with conc. HCI and collect the white precipitate by filtration. Drying under vacuum yields 385 mg (37%) of the title compound. MS (ES): M/Z 218.1 (M+H).
37%	With sodium hydroxide; water; In tetrahydrofuran; at 20.0℃; for 15.0h;	Combine 6-bromopyridine-3-carboxylic acid methyl ester (1.03 g, 4.78 MMOL), 4- fluorophenylboronic acid (1.88 g, 13.41 mmol), and cesium fluoride (2.55 g, 16.78 mmol) in DMF (25 mL) and water (4 mL) with stirring. Place the heterogeneous reaction mixture, open to the air, in an oil bath maintained at 80C. After 5 minutes of heating, add Pd (OAC) 2 (150 mg, 0.67 mmol) in one portion. After 17 hours, cool the reaction to room temperature, dilute with ethyl acetate and filter through a short plug of celite with additional ethyl acetate. Wash the organics with water, dry over MGS04, filter and evaporate. Purification by flash column chromatography yields 6- (4- fluorophenyl) pyridine-3-carboxylic acid methyl ester as a yellow solid. Dissolve the purified ester in THF (0.25 M) and add an equal volume of 1 M NAOH. Stir vigorously at room temperature for 15 hours. Upon completion, acidify the reaction with conc. HCI and collect the white precipitate by filtration. Drying under vacuum yields 385 mg (37%) of the title compound. MS (ES): M/Z 218.1 (MH+)
	With sodium hydroxide;	Reference Example 27 6-(4-Fluorophenyl)nicotinic acid In a similar manner to that described in Example 2, a reaction was carried out using methyl 6-(4-fluorophenyl)nicotinate (390 mg) and aqueous sodium hydroxide solution (1N, 5.00 ml) and the reaction mixture was treated to afford the title compound (345 mg) as a pale yellow solid. 1H-NMR (270 MHz, CDCl3): delta ppm 7.35 (2H, t, J=8.5 Hz), 8.11 (1H, d, J=8.5 Hz), 8.15-8.29 (2H, m), 8.32 (1H, dd, J=2.0, 8.5 Hz), 9.13 (1H, d, J=2.0Hz).

Combine 6-bromopyridine-3-carboxylic acid methyl ester (1.03 g, 4. 78 MMOL), 4- fluorophenylboronic acid (1.88 g, 13.41 mmol), and cesium fluoride (2.55 g, 16. 78 mmol) in dimethylformamide (25 mL) and water (4 mL) with stirring. Place the hetereogeneous reaction mixture, open to the air, in an oil bath maintained at 80 C. After 5 minutes of heating, add Pd (OAc) 2 (150 mg, 0.67 mmol) in one portion. After 17 hours, cool the reaction to room temperature, dilute with ethyl acetate and filter through a short plug of celite with additional ethyl acetate. Wash the organics with water, dry over magnesium sulfate, filter and evaporate. Purification by flash column chromatography yields 6- (4- fluorophenyl)pyridine-3-carboxylic acid methyl ester as a yellow solid. Dissolve the purified ester in tetrahydrofuran (0.25M) and add an equal volume of 1M sodium hydroxide. Stir vigorously at room temperature for 15 hours. Upon completion, acidify the reaction with conc. HCI and collect the white precipitate by filtration. Drying under vacuum yields 385 mg (37%) of the title compound. MS (m/e): 218.1 (MH+) The following compound is prepared essentially as described above. 6- (Thien-2-yl) pyridine-3-carbox ic acid MS 205. 9 (MH+)

Reference： [1]Patent: WO2004/94363,2004,A1 .Location in patent: Page 21
[2]Patent: WO2004/94382,2004,A1 .Location in patent: Page 21
[3]Patent: US6528525,2003,B1
[4]Patent: WO2005/9941,2005,A1 .Location in patent: Page 21-22

7
[ 5326-23-8 ]
[ 1765-93-1 ]
[ 223127-24-0 ]

Yield	Reaction Conditions	Operation in experiment
		Production Example 28 6-(4-Fluorophenyl)nicotinic acid Operations similar to those of Production Example 14 were conducted using 6-chloronicotinic acid and 4-fluorophenylboronic acid, to provide the title compound as white solid. 1H-NMR(400MHz,DMSO-d6,deltappm):7.30-7.37(2H,m), 8.03(1H,d,J=8.0Hz),8.16-8.22(2H,m),8.26(1H,d,J=8.0Hz), 9.07(1H,s) ESI-MS Found:m/z 218[M+H]+

Reference： [1]Patent: EP1657242,2006,A1 .Location in patent: Page/Page column 31

8
[ 223127-24-0 ]
[ 892841-20-2 ]
rac-6-(4-fluoro-phenyl)-N-{2-[methyl-(1-methyl-pyrrolidin-3-ylmethyl)-amino]-benzooxazol-5-yl}-nicotinamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%	With HATU; In dichloromethane; at 20.0℃;	Combine r°c-N2-Methyl-N2-(l-methyl-pyrrolidin-3-ylmethyl)-benzooxazole-2,5-diamine (0.034 g, 0.131 mmol), <strong>[223127-24-0]6-(4-fluoro-phenyl)-nicotinic acid</strong> (0.043 g, 0.198 mmol), HATU (0.050 g, 0.131 mmol), polystyrene-bound diisopropylamine (0.327 g, loading: 2.0 to 3.5 mmol/g), and CH2Cl2 (10 mL). Shake the mixture overnight at room temperature. Filter the mixture and wash the polystyrene resin with 1:1 CH2Cl2MeOH. Concentrate the solution in vacuo. Dilute with CH2Cl2, wash with 1.0M NaOH (2x25 mL), dry over Na2SO4, filter, and concentrate in vacuo. Subject the residue to silica gel flash column chromatography (4g column, eluting with 10% 2N NH3 in MeOH/CH2Cl2) to yield the desired product as an impure mixture. Re-subject the mixture to silica gel flash column chromatography (3x4g columns, 5% 2N NH3 in MeOHZCH2Cl2) to yield the desired product as a white oil (0.030 g, 51%). mass spectrum (m/e): 460.0 (M+l), 458.0 (M-I). 1H NMR (400 MHz, CDCl3): delta 9.10 (s, IH), 8.31 (s, IH), 8.22 (dd, J = 8.0, 2.4 Hz, IH), 8.03-7.97 (m, 2H), 7.72 (d, J = 8.4 Hz, IH), 7.53 (s, IH), 7.34 (d, J = 8.4 Hz, IH), 7.20-7.11 (m, 3H), 3.58-3.46 (m, 2H), 3.16 (s, 3H), 2.72-2.56 (m, 3H), 2.55-2.48 (m, IH), 2.38-2.32 (m, IH), 2.33 (s, 3H), 2.04-1.95 (m, IH), 1.57-1.48 (m, IH).

Reference： [1]Patent: WO2006/66173,2006,A2 .Location in patent: Page/Page column 57-58

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 298B 6-(4-fluorophenyl)nicotinic acid The desired product was prepared by substituting Example 298A for Example 252F in Example 252G. MS (ESI) m/e 218, 216 (M+H)+, 216(M-H)-.
		Example 298B 6-(4-fluorophenyl)nicotinic acid The desired product was prepared by substituting Example 298A for Example 252F in Example 252G. MS (ESI) m/e 218, 216 (M+H)+, 216(M-H)-.

10
[ 223127-24-0 ]
[ 2942-58-7 ]
[ 223127-22-8 ]
[ 223125-56-2 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine;	EXAMPLE 100 Ethyl 3-[4-[2-[2-(4-fluorophenyl)pyridine-5-carbonylamino]ethoxy]phenyl]-2-(4-isopropylphenoxy)propionate (ethyl ester of exemplification No. 7-231 compound) In a similar manner to that described in Example 73, a reaction was carried out using ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-(4-isopropylphenoxy)propionate (718 mg), which is the product of Reference example 25, <strong>[223127-24-0]6-(4-fluorophenyl)nicotinic acid</strong> (330 mg), which is the product of Reference example 27, diethyl cyanophosphonate (0.25 ml) and triethylamine (0.47 ml) and the reaction mixture was treated to give the title compound (560 mg) as a white powder. mp 117-118 C. 1H-NMR (270 MHz, CDCl3): delta ppm 1.18 (6H, d, J=7.0 Hz), 1.21 (3H, t, J=7.0 Hz), 2.82 (1H, septet, J=7.0 Hz), 3.15-3.20 (2H, m), 3.90 (2H, q, J=5.0 Hz), 4.13-422 (4H, m), 4.69 (1H, dd, J=5.5, 7.0 Hz), 6.66 (1H, t, J=5.0 Hz), 6.75 (2H, d, J=8.5 Hz), 6.86 (2H, d, J=8.5 Hz), 7.08 (2H, d, J=8.5 Hz), 7.14-7.25 (4H, m), 7.76 (1H, d, J=8.5 Hz), 8.00-8.07 (2H, m), 8.16 (1H, dd, J=2.0, 8.5 Hz), 9.03 (1H, d, J=2.0 Hz).

Reference： [1]Patent: US6528525,2003,B1

11
[ 223127-24-0 ]
[ 869184-20-3 ]
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-6-(4-fluorophenyl)nicotinamide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 4589 - 4593

12
[ 223127-24-0 ]
[ 521073-96-1 ]
[ 521070-56-4 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 2353 - 2366

13
[ 73781-91-6 ]
[ 223127-24-0 ]

Reference： [1]Patent: WO2004/94382,2004,A1

14
[ 26218-78-0 ]
[ 1765-93-1 ]
[ 223127-24-0 ]

Reference： [1]Patent: WO2004/94382,2004,A1

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P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 223127-24-0 ] {[proInfo.proName]}

Quality Control of [ 223127-24-0 ]

Related Doc. of [ 223127-24-0 ]

Product Details of [ 223127-24-0 ]

Calculated chemistry of [ 223127-24-0 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 223127-24-0 ]

Application In Synthesis of [ 223127-24-0 ]

[ 223127-24-0 ] Synthesis Path-Upstream 1~4

[ 223127-24-0 ] Synthesis Path-Downstream 1~14

Related Functional Groups of [ 223127-24-0 ]

Fluorinated Building Blocks

Aryls

Carboxylic Acids

Related Parent Nucleus of [ 223127-24-0 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 223127-24-0 ]

Related Parent Nucleus of
[ 223127-24-0 ]