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Structure of 223671-15-6
*Storage: {[sel_prStorage]}
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
4.5
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| CAS No. : | 223671-15-6 |
| Formula : | C9H6BrNO |
| M.W : | 224.05 |
| SMILES Code : | OC1=NC=CC2=C1C=C(Br)C=C2 |
| English Name : | 7-Bromoisoquinolin-1-ol |
| MDL No. : | MFCD02093963 |
| InChI Key : | DSOKREQUHLPVFR-UHFFFAOYSA-N |
| Pubchem ID : | 11276133 |
| GHS Pictogram: | |
| Signal Word: | |
| Hazard Statements: | |
| Precautionary Statements: | |
| Class: | |
| UN#: | |
| Packing Group: |
| Num. heavy atoms | 12 |
| Num. arom. heavy atoms | 10 |
| Fraction Csp3 | 0.0 |
| Num. rotatable bonds | 0 |
| Num. H-bond acceptors | 2.0 |
| Num. H-bond donors | 1.0 |
| Molar Refractivity | 51.47 |
| TPSA ? Topological Polar Surface Area: Calculated from |
33.12 Ų |
| Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
2.06 |
| Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
2.77 |
| Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
2.7 |
| Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
2.31 |
| Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
2.64 |
| Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
2.5 |
| Log S (ESOL):? ESOL: Topological method implemented from |
-3.59 |
| Solubility | 0.0575 mg/ml ; 0.000257 mol/l |
| Class? Solubility class: Log S scale |
Soluble |
| Log S (Ali)? Ali: Topological method implemented from |
-3.12 |
| Solubility | 0.17 mg/ml ; 0.000757 mol/l |
| Class? Solubility class: Log S scale |
Soluble |
| Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-3.98 |
| Solubility | 0.0232 mg/ml ; 0.000104 mol/l |
| Class? Solubility class: Log S scale |
Soluble |
| GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
| BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
| P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
| CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
Yes |
| CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
| CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
| CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
| CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
| Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-5.7 cm/s |
| Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
| Ghose? Ghose filter: implemented from |
None |
| Veber? Veber (GSK) filter: implemented from |
0.0 |
| Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
| Muegge? Muegge (Bayer) filter: implemented from |
0.0 |
| Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
| PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
| Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
| Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
| Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.46 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.


| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With ammonium acetate at 150℃; for 14h; | ||
| Multi-step reaction with 2 steps 1: trichlorophosphate / 3 h / 100 °C / Inert atmosphere 2: ammonium hydroxide; 1-methyl-pyrrolidin-2-one / water / 20 h / 148 °C / Sealed tube |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With phosphorus pentachloride at 140℃; | ||
| 1.13 g | With phosphorus pentachloride at 140℃; for 5h; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 85.4% | With triethylamine In methanol at 100℃; for 20h; | 23.1 A solution of 7-bromo-1-hydroxyisoquinoline (2. 00g, 8. [93MMOL)] in MeOH (50mL) was treated with triethylamine (2.6mL, 18.7mmol), and [1,] [1'-] Bis (diphenylphosphino) ferrocene (0.15g, 0. [27MMOL)] in a sealed reactor and heated to [100XB0;C] for 20 hours. The mixture was cooled to room temperature, the tan slurry filtered, the solid washed with MeOH, then ethyl acetate, and dried. This afforded 1.55g of the product as a gray solid (85.4% yield). [H-NMR] [(DMSO-D6)] ; 11.48 (s, [1H),] 8.72 (s, 1H), 8.14-8. 12 (d, 1H), 7.74-7. 72 (d, 1H), 7.31-7. 28 (t, [1H),] 3.86 (s, [3H)] MS: [M+ +1= 204.] 1 Da |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With phosphorus pentachloride | 1 Preparation 1 1 H NMR (DMSO-d6, 300 MHz) δ 6.55 (1H, d), 7.25-7.15 (1H, m), 7.6 (1H, d), 7.8 (1H, d), 8.25 (1H, s), 11.4 (1H, br s) ppm. STR102 A mixture of 7-bromo-1(2H)-isoquinolone (1.28 g, 5.69 mmol) and PCl5 (2.04 g, 9.80 mmol) was heated at 140° C. for 5 h. The cooled mixture was quenched with ice (50 g) and 0.880NH3 was added until alkaline by litmus paper. The aqueous mixture was extracted with CH2 Cl2 (3*50 mL) and the combined organic phases were dried (MgSO4) and evaporated in vacuo. The residue was purified by column chromatography upon silica gel using hexanes-EtOAc (97:3 to 95:5) as eluant to give 7-bromo-1,4-dichloroisoquinoline (1.13 g, 4.08 mmol) as a white solid. mp 133.5-135° C. 1 H (CDCl3, 300 MHz) δ 7.9 (1H, d), 8.1 (1H, d), 8.35 (1H, s), 8.5 (1H, s). LRMS 276, 278 (MH+). Anal. Found: C, 39.04; H, 1.32; N, 5.06. Calc for C9 H4 BrCl2 N: C, 39.03; H, 1.46; N, 5.06. | |
| With phosphorus pentachloride | 1 7-Bromo-1,4-dichloroisoquinoline A mixture of 7-bromo-1(2H)-isoquinolone (1.28 g, 5.69 mmol) and PCl5 (2.04 g, 9.80 mmol) was heated at 140° C. for 5 h. The cooled mixture was quenched with ice (50 g) and 0.880NH3 was added until alkaline by litmus paper. The aqueous mixture was extracted with CH2Cl2 (3*50 mL) and the combined organic phases were dried (MgSO4) and evaporated in vacuo. The residue was purified by column chromatography upon silica gel using hexanes-EtOAc (97:3 to 95:5) as eluant to give 7-bromo-1,4-dichloroisoquinoline (1.13 g, 4.08 mmol) as a white solid. mp 133.5-135° C. 1H (CDCl3, 300 MHz) δ7.9 (1H, d), 8.1 (1H, d), 8.35 (1H, s), 8.5 (1H, s). LRMS 276, 278 (MH+). Anal. Found: C, 39.04; H, 1.32; N, 5.06. Calc for C9H4BrCl2N: C, 39.03; H, 1.46; N, 5.06. | |
| With phosphorus pentachloride | 1 7-Bromo-1,4-dichloroisoquinoline A mixture of 7-bromo-1(2H)-isoquinolone (1.28 g, 5.69 mmol) and PCl5 (2.04 g, 9.80 mmol) was heated at 140 °C for 5 h. The cooled mixture was quenched with ice (50 g) and 0.880NH3 was added until alkaline by litmus paper. The aqueous mixture was extracted with CH2Cl2 (3x50 mL) and the combined organic phases were dried (MgSO4) and evaporated in vacuo. The residue was purified by column chromatography upon silica gel using hexanes-EtOAc (97:3 to 95:5) as eluant to give 7-bromo-1,4-dichloroisoquinoline (1.13 g, 4.08 mmol) as a white solid. mp 133.5-135 °C. 1H (CDCl3, 300 MHz) δ 7.9 (1H, d), 8.1 (1H, d), 8.35 (1H, s), 8.5 (1H, s). LRMS 276, 278 (MH+). Anal. Found: C, 39.04; H, 1.32; N, 5.06. Calc for C9H4BrCl2N: C, 39.03; H, 1.46; N, 5.06. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 83% | With triethylamine In dimethyl sulfoxide at 70℃; for 18h; Inert atmosphere; | 1 Example 1Methyl 1-oxo-1,2-dihydroisoquinoline-7-carboxylate; Intermediate-1 A solution of 7-bromoisoquinolin-1(2H)-one (2.78 g, 12.4 mmol) in triethylamine (17.29 mL, 124.1 mmol), methanol (70 mL) and DMSO (70 mL) was thoroughly degassed with nitrogen then 1,3-bis(diphenylphosphino)propane (1.02 g, 2.48 mmol) and palladium(II)acetate (0.557 g, 2.48 mmol) were added. After purging the solution four times with CO gas, the reaction mixture was heated at 70° C. for 18 h under 1 atm of CO. The reaction mixture was cooled to rt, methanol was removed before EtOAc (100 mL) and water (50 mL) were added to the remaining DMSO residue. After separation, the organic layer was washed with water and the combined aqueous phases were extracted with EtOAc (100 mL, 2×). The organic phases were then washed with 1N HCl, brine, dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by flash silica gel chromatography (0% to 50% EtOAc/hexanes) to afford methyl 1-oxo-1,2-dihydroisoquinoline-7-carboxylate (2.10 g, 83%). LC-MS: (FA) ES+204; 1H NMR (400 MHz, CDCl3) δ 9.56 (s, 1H), 9.08 (d, J=1.7 Hz, 1H), 8.29 (dd, J=8.3, 1.8 Hz, 1H), 7.61 (d, J=8.3 Hz, 1H), 7.21-7.16 (m, 1H), 6.57 (d, J=7.2 Hz, 1H), 3.97 (s, 3H). |
| 66.16% | With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine at 120℃; for 3h; | 1 Step 1. Into a 50-mL pressure tank reactor, was placed 7-bromo-2H-isoquinolin-1-one (200.00 mg, 0.893 mmol, 1.00 equiv), MeOH (5.0 mL), TEA (270.98 mg, 2.678 mmol, 3 equiv), Pd(dppf)Cl2(32.66 mg, 0.045 mmol, 0.05 equiv). This was followed by the addition of CO (5 atm). The resulting solution was stirred for 3h at 120 °C. The solids were filtered out. The resulting mixture was concentrated. This resulted in 120 mg (66.16%) of methyl 1-oxo-2H- isoquinoline-7-carboxylate as a brown solid. LCMS: [M+1]+=204. |
| 80 mg | With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In N,N-dimethyl-formamide at 80℃; Autoclave; | 14-15.1 0229 Synthesis of methyl 1-oxo-1,2-dihydroisoquinoline-7-carboxylate, 36 [Step 1]: To a solution of 7-bromoisoquinolin-1(2H)-one (35, 2.0 g, 8.9 mmol), dppp (220 mg, 0.5 mmol), and triethylamine (3.1 mL, 22.3 mmol) in MeOH (20 mL) and DMF (20 mL) was added Pd(OAc)2 (80 mg, 0.4 mmol) under N2. The reaction mixture was degassed, purged with CO (x3), and kept at 100 psi CO. The mixture was stirred at 80°C in an autoclave for 16 h. The reaction mixture was filtered through celite and washed with MeOH. The filtrate was concentrated under reduced pressure to afford methyl 1-oxo-1,2- dihydroisoquinoline-7-carboxylate (36, 1.8 g). The product was used in the next step without further purification. LCMS (ESI) Calcd. for C11H9NO3: 203, found [M+H]+ = 204. |
| 80 mg | With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In N,N-dimethyl-formamide at 80℃; Autoclave; | 14-15.1 0229 Synthesis of methyl 1-oxo-1,2-dihydroisoquinoline-7-carboxylate, 36 [Step 1]: To a solution of 7-bromoisoquinolin-1(2H)-one (35, 2.0 g, 8.9 mmol), dppp (220 mg, 0.5 mmol), and triethylamine (3.1 mL, 22.3 mmol) in MeOH (20 mL) and DMF (20 mL) was added Pd(OAc)2 (80 mg, 0.4 mmol) under N2. The reaction mixture was degassed, purged with CO (x3), and kept at 100 psi CO. The mixture was stirred at 80°C in an autoclave for 16 h. The reaction mixture was filtered through celite and washed with MeOH. The filtrate was concentrated under reduced pressure to afford methyl 1-oxo-1,2- dihydroisoquinoline-7-carboxylate (36, 1.8 g). The product was used in the next step without further purification. LCMS (ESI) Calcd. for C11H9NO3: 203, found [M+H]+ = 204. |

| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 89% | for 22h; Inert atmosphere; Glovebox; Alkaline conditions; Reflux; | |
| 88% | With caesium carbonate In N,N-dimethyl acetamide at 50℃; for 3h; | 11.1 7-Bromo-2-methylisoquinolin-1(2H)-one 7-Bromo-2-methylisoquinolin-1(2H)-one To a solution of 7-bromoisoquinolin- 1(2H)-one (500 mg, 2.23 mmol, 1.0 equiv) and Cs2CO3 (1.1 g, 3.35 mmol, 1.5 equiv) in DMA (10 m L) was added CH3I (475 mg, 3.35 mmol, 1.5 equiv) at rt. The mixture was stirred at 50 C for 3 hours. Upon completion, the reaction was cooled to rt and diluted with water (50 mL). The mixture was extracted with EtOAc (3 x 10 mL). The combined organic layers were washed with water (2 x 10 mL) and saturated brine (10 mL), and dried over anhydrous Na2SO4. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluting with EtOAc in PE (0~30%) to afford the title compound (470 mg, 88% yield) as a light yellow solid. 1H NMR (300 MHz, CDCl3) δ: 8.57 (d, J = 2.1 Hz, 1H), 7.70 (dd, J = 8.4 Hz, 2.1 Hz, 1H), 7.38 (d, J = 8.4 Hz, 1H), 7.08 (d, J = 7.2 Hz, 1H), 6.44 (d, J = 7.5 Hz, 1H), 3.60 (s, 3H). ESI-MS [M+H]+ calcd for (C10H8BrNOH+) 238.1, found 237.8, 239.8. |
| 98.39 % | With caesium carbonate In N,N-dimethyl acetamide at 25 - 60℃; | 74.1 Step 1: Preparation of 7-bromo-2-methylisoquinolin-1(2H)-one (Intermediate H) To a solution of 7-bromo-2H-isoquinolin-1-one (22 g, 98.19 mmol) and CS2CO3 (47.99 g, 147.29 mmol) in DMA (400 mL) was added Mel (20.91 g, 147.29 mmol, 9.17 mL) at 25°C. The mixture was stirred at 60°C for 4 hr. The reaction mixture was pour into ice water (500 mL). The crude product was triturated with H2O (500 mL) at 0 °C for 10 min, then filtered and dried in vacuum to give Intermediate H (23 g, 96.61 mmol, 98.39% yield) as a white solid. LCMS (ESI) m/z [M+H]+ = 240.0. 1H NMR (400 MHz, chloroform-d) δ = 8.55 (d, J=2.0 Hz, 1 H), 7.68 (d, J=2.0 Hz, 1 H), 7.38-7.36 (m, 1 H), 7.09-7.07 (m, 1 H), 6.44 (d, J=7.2 Hz, 1 H), 3.60 (s, 3H) ppm. |
| 94 % | With caesium carbonate In N,N-dimethyl acetamide at 50℃; | 48 Manufacturing Example 48: 7-Bromo-2-methylisoquinolin-1(2H)-one (Intermediate I-48) To a solution of 7-bromoisoquinolin-1-ol (600 mg, 2.68 mmol) in DMA (8 mL) was added Cs2CO3(2.62 g, 8.03 mmol) and MeI (760 mg, 5.36 mmol). The mixture was stirred at 50 °C for 3 h. After stirring was complete, the reaction mixture was quenched by the addition of aqueous ammonium chloride solution (20 mL) at 25 °C, diluted with water (30 mL) and extracted with EA (3 x 50 mL). The combined organic layers were washed with brine (3 x 20 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain a residue. The residuewas purified bycolumn chromatography (SiO2 , petroleum ether/ethyl acetate = 2/1 to 1/1) to giveintermediate I-48(600 mg, 94% yield) as a white solid. |

[ 89830-98-8 ]
[ 223671-15-6 ]
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With potassium phosphate; copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In N,N-dimethyl-formamide; at 150℃; for 1h;Microwave irradiation; Inert atmosphere; Sealed tube; | [0415] Into a 20-mL microwave tube was added Example 55a (300 mg, 1.339 mmol), Example 55b (173 mg, 1,61 mmol), Cul (100 mg, 0.53mmol), K3P04 (567 mg, 2.68 mmol) and Nu',Nu2- dimethylcyclohexane-l,2-diamine (75 mg, 0.53mmol) successively. DMF (6 mL) was added by syringe. The mixture was degassed by nitrogen for three times and sealed. The reaction was heated up to 150C by microwave for lh. LC-MS showed reaction completed. The reaction was filtered, washed by MeOH and purified by flash chromatography to afford Example 55c (110 mg, yield: 32.6%, crude) as a yellow solid. LCMS [M+l]+ = 252.0 |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With potassium phosphate; copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane In N,N-dimethyl-formamide at 120℃; for 1h; Microwave irradiation; Inert atmosphere; Sealed tube; | 78.1 Step 1: Example 78d [0472] Into a 20-mL microwave tube was added Example 78a (1.0 g, 4.46 mmol), Example 78b (171 mg, 6.43 mmol), Cul (511 mg, 2.68 mmol), K3P04 (2.3 g, 10.71 mmol) and Example 78c (380 mg, 2.68 mmol) successively. DMF (10 mL) was added by syringe. The mixture was degassed by nitrogen for three times and sealed. The reaction was heated up to 120°C by microwave for 60 min. LCMS showed reaction completed. The mixture was added into 100 mL of H20 and extracted with ether acetate. The combined organic layers were washed by brine, dried over Na2S04 and concentrated. The residue was purified by flash chromatography to afford Example 78d (950 mg, crude, yield: 51.9%) as a brown solid. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 43% | With Selectfluor In acetonitrile at 80℃; for 6h; | 193; 237 Preparation of 7-bromo-4-fluoro-2H-isoquinolin-1-one (237a): To a solution of 7-bromo-2H-isoquinolin-l-one (3 g, 13.4 mmol) in ACN (30 mL) was added selectfluor (4.8 g,13.4 mmol) at rt. The reaction mixture was heated to 80 °C and stirred for 6 h. The resulting mixture was cooled to rt and purified by reversed-phase flash chromatography directly to afford the title compound as a yellow solid (1.4 g, 43%). LCMS ESI-MS m/z = 241 [M+H]+. |
| Multi-step reaction with 2 steps 1: Selectfluor / acetonitrile; water / 96 h / 20 °C 2: methanesulfonic acid / dichloromethane / 16 h / 20 °C | ||
| Multi-step reaction with 2 steps 1: Selectfluor / water; acetonitrile / 30 °C 2: methanesulfonic acid / dichloromethane / 20 °C |
| Multi-step reaction with 2 steps 1: Selectfluor; water / acetonitrile / 30 °C 2: methanesulfonic acid / dichloromethane |

| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With methanesulfonyl chloride In water at 20℃; | ||
| With methanesulfonyl chloride In water at 20℃; Inert atmosphere; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 91% | With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 4h; | Intermediate 47-Bromo-2-methyl-isoquinolin-1-one To a solution of 7-bromo-1-hydroxyisoquinoline (500 mg, 2.23 mmol) in THF (20 mL) at rt was added NaH (60% in mineral oil, 107 mg, 2.68 mmol) and MeI (0.42 mL, 6.69 mmol) and the mixture was stirred for 4 h at rt. The solution was diluted with EtOAc (100 mL) and quenched with sat. NH4Cl (aq). After separation of the layers, the aqueous layer was extracted with EtOAc (2 x40mL) and the combined organic layers were washed with brine (40 mL), dried (Na2SO4) and filtered. The solvent was removed to give the product. Flash chromatography (silica, 0 - 80% EtOAc in heptane) afforded the product (550 mg, 91% yield).[M+H]+= 238.0/240.01H NMR (DMSO-d6, 400 MHz) δ 3.51 (3H, s), 6.64 (1H, dd, J = 7.3, 0.7 Hz), 7.53 (1H, d, J = 7.3 Hz), 7.64 (1H, d, J = 8.5 Hz), 7.85 (1H, dd, J = 8.5, 2.2 Hz), 8.28 - 8.30 (1H, m) |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 89% | With caesium carbonate In tetrahydrofuran at 25℃; for 1h; | Step 2. Synthesis of (rac)-3-(7-bromo-1-oxoisoquinolin-2(1H)-yl)-1-(4-methoxybenzyl)piperidine-2,6-dione To a solution of (rac)-1-(4-methoxybenzyl)-2,6-dioxopiperidin-3-yl trifluoromethanesulfonate (Step 1, 511 mg, 1.34 mmol) in tetrahydrofuran (5 mL) was added cesium carbonate (436 mg, 1.34 mmol) and 7-bromoisoquinolin-1(2H)-one (100 mg, 446 pmol) and the mixture stirred at 25 °C for 1 h. On completion, the mixture was diluted with w ater (20 mL) and extracted with EtOAc (3x 20 mL). The combined organics were washed with brine (60 mL), dried (Na2SO4) and concentrated under reduced pressure. The residue was purified by reverse-phase chromatography (51% MeCN/ftO (0.1% FA)) to give the title compound as a white solid (0.20 g, 89%). LCMS m/z = 457 [M+H]+. |
Tags: 223671-15-6 | 7-Bromoisoquinolin-1-ol | Bromides | Alcohols | Ketones | Isoquinolines | Organic Building Blocks | Heterocyclic Building Blocks

A627422 [1227578-85-9]
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Precautionary Statements-General | |
| Code | Phrase |
| P101 | If medical advice is needed,have product container or label at hand. |
| P102 | Keep out of reach of children. |
| P103 | Read label before use |
Prevention | |
| Code | Phrase |
| P201 | Obtain special instructions before use. |
| P202 | Do not handle until all safety precautions have been read and understood. |
| P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
| P211 | Do not spray on an open flame or other ignition source. |
| P220 | Keep/Store away from clothing/combustible materials. |
| P221 | Take any precaution to avoid mixing with combustibles |
| P222 | Do not allow contact with air. |
| P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
| P230 | Keep wetted |
| P231 | Handle under inert gas. |
| P232 | Protect from moisture. |
| P233 | Keep container tightly closed. |
| P234 | Keep only in original container. |
| P235 | Keep cool |
| P240 | Ground/bond container and receiving equipment. |
| P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
| P242 | Use only non-sparking tools. |
| P243 | Take precautionary measures against static discharge. |
| P244 | Keep reduction valves free from grease and oil. |
| P250 | Do not subject to grinding/shock/friction. |
| P251 | Pressurized container: Do not pierce or burn, even after use. |
| P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
| P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
| P262 | Do not get in eyes, on skin, or on clothing. |
| P263 | Avoid contact during pregnancy/while nursing. |
| P264 | Wash hands thoroughly after handling. |
| P265 | Wash skin thouroughly after handling. |
| P270 | Do not eat, drink or smoke when using this product. |
| P271 | Use only outdoors or in a well-ventilated area. |
| P272 | Contaminated work clothing should not be allowed out of the workplace. |
| P273 | Avoid release to the environment. |
| P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
| P281 | Use personal protective equipment as required. |
| P282 | Wear cold insulating gloves/face shield/eye protection. |
| P283 | Wear fire/flame resistant/retardant clothing. |
| P284 | Wear respiratory protection. |
| P285 | In case of inadequate ventilation wear respiratory protection. |
| P231 + P232 | Handle under inert gas. Protect from moisture. |
| P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
| Code | Phrase |
| P301 | IF SWALLOWED: |
| P304 | IF INHALED: |
| P305 | IF IN EYES: |
| P306 | IF ON CLOTHING: |
| P307 | IF exposed: |
| P308 | IF exposed or concerned: |
| P309 | IF exposed or if you feel unwell: |
| P310 | Immediately call a POISON CENTER or doctor/physician. |
| P311 | Call a POISON CENTER or doctor/physician. |
| P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
| P313 | Get medical advice/attention. |
| P314 | Get medical advice/attention if you feel unwell. |
| P315 | Get immediate medical advice/attention. |
| P320 | |
| P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
| P321 | |
| P322 | |
| P330 | Rinse mouth. |
| P331 | Do NOT induce vomiting. |
| P332 | IF SKIN irritation occurs: |
| P333 | If skin irritation or rash occurs: |
| P334 | Immerse in cool water/wrap n wet bandages. |
| P335 | Brush off loose particles from skin. |
| P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
| P337 | If eye irritation persists: |
| P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
| P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P342 | If experiencing respiratory symptoms: |
| P350 | Gently wash with plenty of soap and water. |
| P351 | Rinse cautiously with water for several minutes. |
| P352 | Wash with plenty of soap and water. |
| P353 | Rinse skin with water/shower. |
| P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
| P361 | Remove/Take off immediately all contaminated clothing. |
| P362 | Take off contaminated clothing and wash before reuse. |
| P363 | Wash contaminated clothing before reuse. |
| P370 | In case of fire: |
| P371 | In case of major fire and large quantities: |
| P372 | Explosion risk in case of fire. |
| P373 | DO NOT fight fire when fire reaches explosives. |
| P374 | Fight fire with normal precautions from a reasonable distance. |
| P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
| P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
| P378 | |
| P380 | Evacuate area. |
| P381 | Eliminate all ignition sources if safe to do so. |
| P390 | Absorb spillage to prevent material damage. |
| P391 | Collect spillage. Hazardous to the aquatic environment |
| P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
| P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
| P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
| P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
| P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
| P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
| P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
| P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
| P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
| P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
| P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
| P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
| P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
| P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
| P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
| P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
| P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
| P370 + P376 | In case of fire: Stop leak if safe to Do so. |
| P370 + P378 | In case of fire: |
| P370 + P380 | In case of fire: Evacuate area. |
| P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
| P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
| Code | Phrase |
| P401 | |
| P402 | Store in a dry place. |
| P403 | Store in a well-ventilated place. |
| P404 | Store in a closed container. |
| P405 | Store locked up. |
| P406 | Store in corrosive resistant/ container with a resistant inner liner. |
| P407 | Maintain air gap between stacks/pallets. |
| P410 | Protect from sunlight. |
| P411 | |
| P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
| P413 | |
| P420 | Store away from other materials. |
| P422 | |
| P402 + P404 | Store in a dry place. Store in a closed container. |
| P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
| P403 + P235 | Store in a well-ventilated place. Keep cool. |
| P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
| P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
| P411 + P235 | Keep cool. |
Disposal | |
| Code | Phrase |
| P501 | Dispose of contents/container to ... |
| P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
| Code | Phrase |
| H200 | Unstable explosive |
| H201 | Explosive; mass explosion hazard |
| H202 | Explosive; severe projection hazard |
| H203 | Explosive; fire, blast or projection hazard |
| H204 | Fire or projection hazard |
| H205 | May mass explode in fire |
| H220 | Extremely flammable gas |
| H221 | Flammable gas |
| H222 | Extremely flammable aerosol |
| H223 | Flammable aerosol |
| H224 | Extremely flammable liquid and vapour |
| H225 | Highly flammable liquid and vapour |
| H226 | Flammable liquid and vapour |
| H227 | Combustible liquid |
| H228 | Flammable solid |
| H229 | Pressurized container: may burst if heated |
| H230 | May react explosively even in the absence of air |
| H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
| H240 | Heating may cause an explosion |
| H241 | Heating may cause a fire or explosion |
| H242 | Heating may cause a fire |
| H250 | Catches fire spontaneously if exposed to air |
| H251 | Self-heating; may catch fire |
| H252 | Self-heating in large quantities; may catch fire |
| H260 | In contact with water releases flammable gases which may ignite spontaneously |
| H261 | In contact with water releases flammable gas |
| H270 | May cause or intensify fire; oxidizer |
| H271 | May cause fire or explosion; strong oxidizer |
| H272 | May intensify fire; oxidizer |
| H280 | Contains gas under pressure; may explode if heated |
| H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
| H290 | May be corrosive to metals |
Health hazards | |
| Code | Phrase |
| H300 | Fatal if swallowed |
| H301 | Toxic if swallowed |
| H302 | Harmful if swallowed |
| H303 | May be harmful if swallowed |
| H304 | May be fatal if swallowed and enters airways |
| H305 | May be harmful if swallowed and enters airways |
| H310 | Fatal in contact with skin |
| H311 | Toxic in contact with skin |
| H312 | Harmful in contact with skin |
| H313 | May be harmful in contact with skin |
| H314 | Causes severe skin burns and eye damage |
| H315 | Causes skin irritation |
| H316 | Causes mild skin irritation |
| H317 | May cause an allergic skin reaction |
| H318 | Causes serious eye damage |
| H319 | Causes serious eye irritation |
| H320 | Causes eye irritation |
| H330 | Fatal if inhaled |
| H331 | Toxic if inhaled |
| H332 | Harmful if inhaled |
| H333 | May be harmful if inhaled |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
| H335 | May cause respiratory irritation |
| H336 | May cause drowsiness or dizziness |
| H340 | May cause genetic defects |
| H341 | Suspected of causing genetic defects |
| H350 | May cause cancer |
| H351 | Suspected of causing cancer |
| H360 | May damage fertility or the unborn child |
| H361 | Suspected of damaging fertility or the unborn child |
| H361d | Suspected of damaging the unborn child |
| H362 | May cause harm to breast-fed children |
| H370 | Causes damage to organs |
| H371 | May cause damage to organs |
| H372 | Causes damage to organs through prolonged or repeated exposure |
| H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
| Code | Phrase |
| H400 | Very toxic to aquatic life |
| H401 | Toxic to aquatic life |
| H402 | Harmful to aquatic life |
| H410 | Very toxic to aquatic life with long-lasting effects |
| H411 | Toxic to aquatic life with long-lasting effects |
| H412 | Harmful to aquatic life with long-lasting effects |
| H413 | May cause long-lasting harmful effects to aquatic life |
| H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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