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Chemical Structure| 226920-32-7 Chemical Structure| 226920-32-7

Structure of 226920-32-7

Chemical Structure| 226920-32-7

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Product Details of [ 226920-32-7 ]

CAS No. :226920-32-7
Formula : C9H10ClNO3
M.W : 215.63
SMILES Code : O=C(OCC)CN1C=C(Cl)C=CC1=O

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Application In Synthesis of [ 226920-32-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 226920-32-7 ]

[ 226920-32-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4214-79-3 ]
  • [ 105-36-2 ]
  • [ 226920-32-7 ]
YieldReaction ConditionsOperation in experiment
90% With potassium carbonate; In acetonitrile; at 50℃; for 1.25h; Example 2Synthesis of compound Ia-24Step 1 <strong>[4214-79-3]5-chloro-2-hydroxypyridine</strong> 7 (4.00 g, 30.9 mmol) was suspended in acetonitrile (61 mL), and added with potassium carbonate (8.53 g, 61.7 mmol) and ethyl bromoacetate (5.14 ml, 46.4 mmol), and the mixture was stirred for 1 hour and 15 minutes with heating at 50° C. The reaction mixture was poured into brine, and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was purified using silica gel chromatography to yield the desired ester 8 (6.000 g, yield 90percent).1H-NMR (d5-DMSO) deltappm: 1.21 (t, 3H, J=7.2 Hz), 4.15 (q, 2H, J=7.2 Hz), 4.66 (s, 2H), 6.47 (d, 1H, J=9.9 Hz), 7.55 (dd, 1H, J=3.0 Hz and 9.9 Hz), 7.98 (d, 1H, J=3.0 Hz).
 

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