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Chemical Structure| 230301-86-7 Chemical Structure| 230301-86-7

Structure of 230301-86-7

Chemical Structure| 230301-86-7

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Product Details of [ 230301-86-7 ]

CAS No. :230301-86-7
Formula : C13H19NO2S
M.W : 253.36
SMILES Code : CC1=CSC2=C1CN(C(OC(C)(C)C)=O)CC2

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Application In Synthesis of [ 230301-86-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 230301-86-7 ]

[ 230301-86-7 ] Synthesis Path-Downstream   1~1

  • 1
  • tert-butyl 3-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate [ No CAS ]
  • [ 94242-85-0 ]
  • [ 230301-86-7 ]
YieldReaction ConditionsOperation in experiment
86.2% With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In 1,4-dioxane; water; at 100℃; for 2h; The mixture of crude tert-butyl 3-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)- carboxylate (4.7 g, 14.8 mmol) and <strong>[94242-85-0]2,4,4,5,5-<strong>[94242-85-0]pentamethyl-1,3,2-dioxaborolane</strong></strong> (3.15 g, 22.2 mmol), H20 (360 mg, 22 mmol), Pd(dppf)2Cl2 (0.5 g, 10percentw) in dioxane (100 mL) was stirred at 100 °C for 2 hours. The reaction mixture was concentrated and the residue was purified by column chromatography to give 2.0 g (yield: 86.2percent) of tert-butyl 3-methyl-6,7- dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate as white solid. ?H NMR (400MHz, CDCl3) (ppm): 6.75 (s, 1H), 4.39 (br. s, 2H), 3.72 (br. s, 2H), 2.83 (br. s, 2H), 2.13 (s, 3H), 1.5 17 (m, 9H). LCMS (mlz): 254.2 [M+H]+
 

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