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[ CAS No. 234-95-7 ] {[proInfo.proName]}

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Chemical Structure| 234-95-7
Chemical Structure| 234-95-7
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Product Details of [ 234-95-7 ]

CAS No. :234-95-7 MDL No. :MFCD00004950
Formula : C11H8N2 Boiling Point : -
Linear Structure Formula :- InChI Key :IEOUSWADWJLLCH-UHFFFAOYSA-N
M.W :168.19 Pubchem ID :67476
Synonyms :

Safety of [ 234-95-7 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:
Hazard Statements:H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 234-95-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 234-95-7 ]

[ 234-95-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1003-29-8 ]
  • [ 615-43-0 ]
  • [ 234-95-7 ]
YieldReaction ConditionsOperation in experiment
92% With copper(l) iodide; caesium carbonate; 2-Hydroxybenzoylhydrazine In N,N-dimethyl-formamide at 120℃; for 24h; Sealed tube;
89% With copper(II) oxide; sodium hydroxide; ascorbic acid In glycerol at 120℃; for 12h;
83% With potassium phosphate; copper(l) iodide; (-)-sparteine In 1-methyl-pyrrolidin-2-one at 130℃; for 24h;
61% With 1-(2-methylhydrazine-1-carbonyl)isoquinoline 2-oxide; tetrabutylammomium bromide; copper; sodium hydroxide In ethanol; water at 120℃; for 12h; Schlenk technique; 11 Example 11: Synthesis of pyrroloquinoline 3.2 mg (0.05 mmol) of Cu,21.7 mg (0.1 mmol) of ligand,49.0 mg (0.5 mmol) 2-formaldehyde pyrrole,168.0 mg (0.75 mmol) of o-iodoaniline,40 mg (1.0 mmol) NaOH,32.3 mg (0.1 mmol) of TBAB,1.0 ml EtOH:H2O(v/v)=1:1 was added to a 10 ml Schlenk reaction tube.Stir the reaction by heating with a hot plate.The reaction was carried out at 120 ° C for 12 hours.After the reaction stops,Add 10ml of water,Extract with ethyl acetate (3 x 20 ml),Combine the organic phase,Washed with saturated saline,After drying over anhydrous sodium sulfate, it was filtered.Distilling the solvent under reduced pressure,The obtained reaction mixture is separated and purified by silica gel column chromatography [eluent:Petroleum ether/ethyl acetate (150:1)],Pyrroloquinoquinone 52 mg was obtained in a yield of 61%.
61% With copper(I) oxide; 1-(2-methylhydrazine-1-carbonyl)isoquinoline 2-oxide; tetrabutylammomium bromide; sodium hydroxide In ethanol; water at 120℃; for 12h; Schlenk technique; 4.2. General procedure for the synthesis of 3a-3w and 6 General procedure: A 25 mL Schlenk tube was charged with Cu2O (0.05 mmol), ArX (0.5 mmol), NHR1R2 (0.75 mmol), NaOH (1 mmol), TBAB (0.1 mmol), L2 (0.1 mmol) and H2O/EtOH (1 mL, 1/1, v/v). The mixture was stirred at 120 °C for 12 h. The reaction mixture was extracted with ethyl acetate (3 10 mL), washed with water and brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by flash column chromatograph on silica gel(ethyl acetate/petroleum ether as the eluent) to provide the target products 3a-3w and 6.
With potassium phosphate; copper(l) iodide; (-)-sparteine In 1-methyl-pyrrolidin-2-one at 130℃; for 24h; Inert atmosphere;

  • 2
  • [ 1003-29-8 ]
  • [ 615-36-1 ]
  • [ 234-95-7 ]
YieldReaction ConditionsOperation in experiment
93% With C14H22B10CuIN2; potassium carbonate In toluene at 50℃; for 6h; 1 Using cuprous complex I as a catalyst to catalyze the synthesis of pyrrole[1,2-a]quinoxaline derivatives: Dissolve 2-bromoaniline (1mmol), aldehyde compound (1mmol), K2CO3 (1.5mmol) and cuprous complex Cu (0.01mmol) in 3mL of toluene, react at 50°C for 6 hours, and concentrate the reaction solution directly after completion. It was separated by silica gel column chromatography and dried to the same quality to obtain the corresponding product C11H8N2 (yield 93%).
68% With copper(l) iodide; caesium carbonate; 2-Hydroxybenzoylhydrazine In N,N-dimethyl-formamide at 120℃; for 24h; Sealed tube;
With potassium phosphate; copper(l) iodide; (-)-sparteine In 1-methyl-pyrrolidin-2-one at 130℃; for 48h;
  • 3
  • [ 50626-25-0 ]
  • [ 234-95-7 ]
  • 1-(phenylsulfonyl)-3-(p-tolyl)-1,12b-dihydropyrrolo[1,2-a][1,2,4]triazolo[3,4-c]quinoxaline [ No CAS ]
YieldReaction ConditionsOperation in experiment
68% With tert.-butylhydroperoxide; potassium iodide In dichloromethane at 25℃; for 24h; Schlenk technique;
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